$104 Cheap American Airlines flights Fort Myers (RSW) to Indianapolis (IND)

Landing cheap one-way American Airlines flights from RSW to IND from $104 on Expedia couldn't be easier — just filter by "Price (lowest to highest)." Or check out our budget-friendly round-trip fares from $152 for your next adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Begin your search one to three months before your departure to get cheap fares on American Airlines flights from Southwest Florida Intl. Airport (RSW) to Indianapolis Intl. Airport (IND). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Time it well, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Morning" and "Early Morning" to browse the earliest flights from RSW to IND. Taking off early means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.