$299 Cheap American Airlines flights Panama City (PTY) to Greenville (GSP)

Scoring cheap one-way American Airlines flights from PTY to GSP from $299 on Expedia is simple --- just filter by "Price (lowest to highest)." Alternatively, check out our affordable round-trip fares from $468 for your next getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Start your search for American Airlines flights from PTY to GSP about one month before you want to leave. The most affordable time to book an international flight is usually 18 to 29 days ahead of your departure date when you can save 17% versus booking four to five months in advance. No matter your fare class and itinerary, the best day of the week to book international airfare is usually Sunday. Friday is often the most expensive. Travelers who book on a Sunday can save 17% on average compared to those who book on a Friday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Browse American Airlines's earliest flights from PTY to GSP by selecting the "Morning" and "Early Morning" filters. Not only will you arrive at your destination sooner, early departures are also 20% less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.