$130 Cheap Delta flights Knoxville (TYS) to Chicago (ORD)

Apply the “Price (lowest to highest)” filter on Expedia to search for cheap Delta Air Lines return flights from $209 from TYS to ORD. Affordable one-way tickets from $130 are available as well.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Delta Air Lines flights to Chicago are generally cheaper in the off-peak months of January and February. Whether you’re after a one-way or a return ticket, you could score a better deal then.

Start searching one to three months ahead of your departure date to get cheap fares on Delta Air Lines flights from McGhee Tyson Airport (TYS) to O’Hare Intl. Airport (ORD). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Get your timing spot on, and you can enjoy significant savings on domestic journeys.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Use the “Nonstop” filter when browsing for direct Delta Air Lines flights from TYS to ORD. You’ll also be able to compare other airlines servicing the same nonstop route.

To find the earliest departures from TYS to ORD with Delta Air Lines, filter your results by “Early Morning” and “Morning.” Choosing an early flight generally means you’re less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

O’Hare Intl. Airport (ORD) is the primary Chicago gateway for Delta Air Lines flights from McGhee Tyson Airport (TYS).

With a rewarding loyalty program and an excellent in-flight experience, Delta Air Lines is a popular option for many passengers heading from TYS to ORD. What’s more, if you’re a Delta SkyMiles and One Key™ member booking with Expedia, you could earn OneKeyCash™* on eligible flights on top of your airline miles, which you can put toward future travel.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

Depending on the ticket type you purchased, a fee will generally apply if you cancel or change your flight more than 24 hours after it’s been confirmed. To secure plane tickets with more flexibility, select our “Changes included” or “No cancel fee” filter when looking for flights. To learn more about modifying or canceling your reservation, visit “Trips,” select your flight and tick “Manage Booking.”