$80 Cheap Flights from Knoxville (TYS) to Chicago (ORD)

View $80 flight on Wed, Nov 5, 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Chicago O'Hare Intl. Airport (ORD)

Today's featured flight deals from McGhee Tyson Airport (TYS) to Chicago O'Hare Intl. Airport (ORD)

Nonstop
Carry-on included
Lower price than typical

Cheap Flights from Knoxville to Chicago (TYS-ORD)

Prices were available within the past 7 days and start at $80 for one-way flights and $169 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Nov 1 - Tue, Nov 4
TYS
Knoxville
ORD
Chicago
$169 Roundtrip, found 16 hours ago
$169
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Sat, Nov 1 from Knoxville to Chicago, returning Tue, Nov 4, priced at $169 found 16 hours ago
United
Sat, Nov 1 - Tue, Nov 4
TYS
Knoxville
ORD
Chicago
$172 Roundtrip, found 16 hours ago
$172
Roundtrip
found 16 hours ago
Select United flight, departing Sat, Nov 1 from Knoxville to Chicago, returning Tue, Nov 4, priced at $172 found 16 hours ago
United
Thu, Nov 13 - Sat, Nov 15
TYS
Knoxville
ORD
Chicago
$174 Roundtrip, found 13 hours ago
$174
Roundtrip
found 13 hours ago
Select United flight, departing Thu, Nov 13 from Knoxville to Chicago, returning Sat, Nov 15, priced at $174 found 13 hours ago
American Airlines
Fri, Nov 14 - Sun, Nov 16
TYS
Knoxville
ORD
Chicago
$189 Roundtrip, found 2 hours ago
$189
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Fri, Nov 14 from Knoxville to Chicago, returning Sun, Nov 16, priced at $189 found 2 hours ago
United
Sat, Nov 8 - Wed, Nov 12
TYS
Knoxville
ORD
Chicago
$192 Roundtrip, found 2 days ago
$192
Roundtrip
found 2 days ago
Select United flight, departing Sat, Nov 8 from Knoxville to Chicago, returning Wed, Nov 12, priced at $192 found 2 days ago
Delta
Fri, Dec 12 - Tue, Dec 16
TYS
Knoxville
ORD
Chicago
$194 Roundtrip, found 2 days ago
$194
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Dec 12 from Knoxville to Chicago, returning Tue, Dec 16, priced at $194 found 2 days ago
American Airlines
Sat, Nov 8 - Sat, Nov 15
TYS
Knoxville
ORD
Chicago
$194 Roundtrip, found 3 hours ago
$194
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Sat, Nov 8 from Knoxville to Chicago, returning Sat, Nov 15, priced at $194 found 3 hours ago
United
Sat, Nov 8 - Sat, Nov 15
TYS
Knoxville
ORD
Chicago
$197 Roundtrip, found 3 hours ago
$197
Roundtrip
found 3 hours ago
Select United flight, departing Sat, Nov 8 from Knoxville to Chicago, returning Sat, Nov 15, priced at $197 found 3 hours ago
Frontier Airlines
Thu, Oct 16 - Thu, Nov 6
TYS
Knoxville
ORD
Chicago
$284 Roundtrip, found 2 days ago
$284
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Thu, Oct 16 from Knoxville to Chicago, returning Thu, Nov 6, priced at $284 found 2 days ago
Southwest Airlines
Tue, May 19 - Sat, May 23
TYS
Knoxville
ORD
Chicago
$324 Roundtrip, found 5 days ago
$324
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Tue, May 19 from Knoxville to Chicago, returning Sat, May 23, priced at $324 found 5 days ago

Find the cheapest month to fly from Knoxville (TYS) to Chicago (ORD)

January is typically the cheapest month to fly

From $159 - $403 per traveler.

Alternative airports near Chicago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Midway Intl. MDW. Closest option available. Average driving time to city center is 16 minutes. Flights from $384
MDW
Midway Intl.
Closest
Average driving time to city center16 min
Flights from $384

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD) cost?
Snag a cheap one-way flight from $80 or cheap return flight from $169 from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
The cheapest month to fly from TYS to ORD is November, when there's less demand. Off-peak months are usually when better flight deals are available between these airports.
Which airlines fly direct from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
Jump on a nonstop flight with United Airlines and travel straight from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD).
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
American Airlines and United Airlines are some popular carriers offering competitive fares. Remember that flight prices from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD) can vary based on demand, seasonality and time of booking. With Expedia's filter tool, you can easily find a TYS to ORD flight that works with your plans and budget.
How many flights per day from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
When taking off from McGhee Tyson Airport (TYS), you'll have a choice from an average of 5 daily nonstop flights to O'Hare Intl. Airport (ORD).
What are the most popular departure times for flights from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
Flights between TYS and ORD are busiest at 1 PM. If you're after a more relaxed experience and potentially cheaper tickets, choose a departure outside the usual busy windows.
What day of the week has the most flights from TYS to ORD?
Friday offers the most flights from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD). Consider taking off on this day and you'll have a greater chance of finding a departure that fits your itinerary.
What is the earliest flight from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
Hop on the earliest flight at around 6:20AM UTC-5, leaving from McGhee Tyson Airport (TYS). You'll be traveling for approximately 2h 7m, arriving at O'Hare Intl. Airport (ORD) at approximately 7:27AM UTC-6.
How long does it take to fly from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
It takes roughly 1 hour and 58 minutes to travel the 480 mi from TYS to ORD.
What airline has the least delays from TYS to ORD?
Alaska Airlines has the best performance for on-time direct flights from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD), with an on-time score of 90%. Use the Expedia App to see your flight status before you leave and get real-time updates about any trip changes.
What is the best time to fly from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
Book a flight from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD) that leaves before 3 PM to reduce the risk of cancellations and delays. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Chicago from McGhee Tyson Airport (TYS)?
If you're flying on a direct flight from McGhee Tyson Airport (TYS) to Chicago, O'Hare Intl. Airport (ORD) is the only airport you can land at.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD) last-minute?
Booking your flight from TYS to ORD shortly before your getaway is usually more expensive. However, if you're flexible with your schedule, you could score a cheap last-minute fare.
Is it cheaper to book a TYS to ORD flight and hotel package?
You'll typically save money by booking a TYS to ORD flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one place. Once you've selected your ideal flights and accommodations, you can add extras like car rentals, tours and activities.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
If you booked your TYS to ORD flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more details.

Travel information

Travel information

0
Origin airport
McGhee Tyson
Destination airport
O'Hare Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$169
Distance
475 mi

Book with confidence

Book with confidence

Knoxville to Chicago Flights

The cheapest times to fly from Knoxville to Chicago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Chicago are during the month of November. You can find some of the cheapest flights from Knoxville to Chicago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Chicago

Sunday is one of the best days to book for cheap flights from Knoxville to Chicago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Chicago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Chicago in 2025. You can also book with separate airlines for your outbound and return journeys, from $80 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Chicago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Chicago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to Chicago Flights

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*Available to One Key members.