--- title: "Buffalo to Wiscasset cheap flights (BUF to ISS) - Expedia" description: "Cheap Flights from Buffalo (BUF) to Wiscasset (ISS) start at for one-way and for round trip. Earn your airline miles on top of our rewards!" canonical: "https://www.expedia.com/lp/flights/buf/iss/buffalo-to-wiscasset" language: en-US market: US currency: USD prices_as_of: 2026-11-13T07:44:21Z --- # Cheap Flights from Buffalo (BUF) to Wiscasset (ISS) ![A coastal town with houses, a rocky shoreline, and the ocean.](https://images.trvl-media.com/place/6334295/966c1223-fdb4-4152-81f6-e95b7053575e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Popular airlines from Buffalo Niagara Intl. Airport (BUF) to Wiscasset, ME (ISS) [American Airlines](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:ISS,departure:11/27/2026TANYT&leg2=from:ISS,to:BUF,departure:12/4/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) [United](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:ISS,departure:11/27/2026TANYT&leg2=from:ISS,to:BUF,departure:12/4/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"UA"}}]) [Southwest Airlines](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:ISS,departure:11/27/2026TANYT&leg2=from:ISS,to:BUF,departure:12/4/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"WN"}}]) [Delta](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:ISS,departure:11/27/2026TANYT&leg2=from:ISS,to:BUF,departure:12/4/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"DL"}}]) [Frontier Airlines](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:ISS,departure:11/27/2026TANYT&leg2=from:ISS,to:BUF,departure:12/4/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"F9"}}]) [JetBlue Airways](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:ISS,departure:11/27/2026TANYT&leg2=from:ISS,to:BUF,departure:12/4/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"B6"}}]) [Alaska Airlines](https://www.expedia.com/Flights-Search?leg1=from:BUF,to:ISS,departure:11/27/2026TANYT&leg2=from:ISS,to:BUF,departure:12/4/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AS"}}]) ### Be in the know Get alerts if flight prices drop or rise\* ### Book smarter Save up to 30% on select hotels after you book a flight\* ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## Book with confidence ### Buffalo to Wiscasset Flights #### The cheapest times to fly from Buffalo to Wiscasset On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Buffalo to Wiscasset are during the month of . You can find some of the cheapest flights from Buffalo to Wiscasset with Expedia's search tool and vast selection of airlines. #### The best time to book a flight from Buffalo to Wiscasset Sunday is one of the best days to book for cheap flights from Buffalo to Wiscasset: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance. #### How to find cheap round-trip tickets from Buffalo to Wiscasset Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Buffalo to Wiscasset in 2026\. You can also book with separate airlines for your outbound and return journeys, from one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference\*. This is available for a small fee, and is free to One Key Gold and Platinum tier members. Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Buffalo to Wiscasset flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps. You could also save big by booking one of Expedia's [vacation packages](https://www.expedia.com/package-deals). Bundling together your Buffalo to Wiscasset airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures. *\*Terms apply.* *Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023\. The percentages you see are averages.* ## Frequently Asked Questions ### How much does a flight from Buffalo Niagara Intl. Airport (BUF) to Wiscasset, ME (ISS) cost? Lock in a cheap one-way flight or cheap return flight from Buffalo Niagara Intl. Airport (BUF) to Wiscasset, ME (ISS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route. ### What is the cheapest month to fly from Buffalo Niagara Intl. Airport (BUF) to Wiscasset, ME (ISS)? Planning your trip for is a great way to save, as it's the cheapest month for flights between BUF and ISS. You'll usually find the lowest fares during the off-season. ### What is the cheapest airline that flies from Buffalo Niagara Intl. Airport (BUF) to Wiscasset, ME (ISS)? Use the filters on Expedia to compare airlines and find the most affordable carrier that'll fly you from BUF to ISS. Then, sort your results by "Price (lowest to highest)" to score a great deal. ### How many flights per day from Buffalo Niagara Intl. Airport (BUF) to Wiscasset, ME (ISS)? There aren't any daily nonstop flights departing from Buffalo Niagara Intl. Airport (BUF) to Wiscasset, ME (ISS). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be cruising above the clouds in no time. ### What day of the week has the most flights from BUF to ISS? Typically you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.\* However, this can change based on the season, airline and other factors. *\*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.* ### What is the best time to fly from Buffalo Niagara Intl. Airport (BUF) to Wiscasset, ME (ISS)? Select a flight from Buffalo Niagara Intl. Airport (BUF) to Wiscasset, ME (ISS) that takes off before 3 PM to reduce the likelihood of delays. Departures after this time are on average 22% more likely to be canceled.\* *\*Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.* ### Is it cheaper to buy a plane ticket from Buffalo Niagara Intl. Airport (BUF) to Wiscasset, ME (ISS) last-minute? Booking your plane ticket from BUF to ISS shortly before your journey is generally more expensive. But if there's some wiggle room with your travel times and dates, you could land a cheap last-minute fare. ### Is it cheaper to book a BUF to ISS flight and hotel package? You'll generally save money by securing a BUF to ISS [flight and hotel package](https://www.expedia.com/Wiscasset.d183305.Destination-Travel-Guides) compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. Once you've selected your ideal accommodations and flights, consider adding extras such as activities, car rentals and tours. ### Can I cancel or change the date of my flight from Buffalo Niagara Intl. Airport (BUF) to Wiscasset, ME (ISS)? If you booked your BUF to ISS flight in the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in [your itinerary](https://www.expedia.com/trips) or confirmation email. Or, visit our [Customer Service portal](https://www.expedia.com/helpcenter) for more information. ## Travel information | Origin airport | Buffalo Niagara Intl. Airport | | ------------------- | ----------------------------- | | Destination airport | Wiscasset, ME | | Distance | 457 miles away | ## Explore a world of travel with Expedia - [Flights](?equalTargetTab=tab-0) - [Flights from Bridgeport (BDR) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/bdr/iss/bridgeport-to-wiscasset) - [Flights from Detroit (DTW) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/dtw/nhz/detroit-to-brunswick) - [Flights from Elmira (ELM) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/elm/nhz/elmira-to-brunswick) - [Flights from Calgary (YYC) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/yyc/nhz/calgary-to-brunswick) - [Flights from White Plains (HPN) to Portland (PWM)](https://www.expedia.com/lp/flights/hpn/pwm/white-plains-to-portland) - [Flights from Cincinnati (CVG) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/cvg/nhz/cincinnati-to-brunswick) - [Flights from Greensboro (GSO) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/gso/nhz/greensboro-to-brunswick) - [Flights from New York (NYC) to Portland (PWM)](https://www.expedia.com/lp/flights/nyc/pwm/new-york-to-portland) - [Flights from New Orleans (MSY) to Augusta (AUG)](https://www.expedia.com/lp/flights/msy/aug/new-orleans-to-augusta) - [Flights from Akron (CAK) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/cak/nhz/akron-to-brunswick) - [Flights from Charlotte (CLT) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/clt/nhz/charlotte-to-brunswick) - [Flights from Salt Lake City (SLC) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/slc/nhz/salt-lake-city-to-brunswick) - [Flights from Wilmington (ILM) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/ilm/nhz/wilmington-to-brunswick) - [Flights from Cairo (CAI) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/cai/iss/cairo-to-wiscasset) - [Flights from Toronto (YTO) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/yto/nhz/toronto-to-brunswick) - [Flights from Asheville (AVL) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/avl/nhz/asheville-to-brunswick) - [Flights from Denver (DEN) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/den/iss/denver-to-wiscasset) - [Flights from Houston (HOU) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/hou/nhz/houston-to-brunswick) - [Flights from Buffalo (BUF) to Portland (PWM)](https://www.expedia.com/lp/flights/buf/pwm/buffalo-to-portland) - [Flights from Boston (BOS) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/bos/iss/boston-to-wiscasset) - [Flights from Philadelphia (PHL) to Portland (PWM)](https://www.expedia.com/lp/flights/phl/pwm/philadelphia-to-portland) - [Flights from Knoxville (TYS) to Portland (PWM)](https://www.expedia.com/lp/flights/tys/pwm/knoxville-to-portland) - [Flights from Miami (MIA) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/mia/iss/miami-to-wiscasset) - [Flights from Knoxville (TYS) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/tys/nhz/knoxville-to-brunswick) - [Flights from Lansing (LAN) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/lan/nhz/lansing-to-brunswick) - [Flights from Fort Myers (RSW) to Portland (PWM)](https://www.expedia.com/lp/flights/rsw/pwm/fort-myers-to-portland) - [Flights from New Haven (HVN) to Augusta (AUG)](https://www.expedia.com/lp/flights/hvn/aug/new-haven-to-augusta) - [Flights from Hartford (BDL) to Portland (PWM)](https://www.expedia.com/lp/flights/bdl/pwm/hartford-to-portland) - [Flights from Fort Lauderdale (FLL) to Portland (PWM)](https://www.expedia.com/lp/flights/fll/pwm/fort-lauderdale-to-portland) - [Flights from Washington (IAD) to Portland (PWM)](https://www.expedia.com/lp/flights/iad/pwm/washington-to-portland) - [Flights from Gainesville (GNV) to Augusta (AUG)](https://www.expedia.com/lp/flights/gnv/aug/gainesville-to-augusta) - [Flights from Newark Liberty Intl. 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Airport (EWR) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/ewr/iss/newark-liberty-intl-airport-to-wiscasset) - [Flights from Orlando (SFB) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/sfb/iss/orlando-to-wiscasset) - [Flights from Minneapolis (MSP) to Augusta (AUG)](https://www.expedia.com/lp/flights/msp/aug/minneapolis-to-augusta) - [Flights from Portland (PDX) to Augusta (AUG)](https://www.expedia.com/lp/flights/pdx/aug/portland-to-augusta) - [Flights from Washington (DCA) to Portland (PWM)](https://www.expedia.com/lp/flights/dca/pwm/washington-to-portland) - [Flights from Des Moines (DSM) to Portland (PWM)](https://www.expedia.com/lp/flights/dsm/pwm/des-moines-to-portland) - [Flights from Seattle (SEA) to Augusta (AUG)](https://www.expedia.com/lp/flights/sea/aug/seattle-to-augusta) - [Flights from Atlanta (ATL) to Portland (PWM)](https://www.expedia.com/lp/flights/atl/pwm/atlanta-to-portland) - [Flights from Philadelphia (PHL) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/phl/iss/philadelphia-to-wiscasset) - [Flights from Seattle (SEA) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/sea/nhz/seattle-to-brunswick) - [Flights from Chicago (ORD) to Portland (PWM)](https://www.expedia.com/lp/flights/ord/pwm/chicago-to-portland) - [Flights from San Francisco (SFO) to Portland (PWM)](https://www.expedia.com/lp/flights/sfo/pwm/san-francisco-to-portland) - [Flights from Hartford (BDL) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/bdl/nhz/hartford-to-brunswick) - [Flights from San Diego (SAN) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/san/iss/san-diego-to-wiscasset) - [Flights from Savannah (SAV) to Augusta (AUG)](https://www.expedia.com/lp/flights/sav/aug/savannah-to-augusta) - [Flights from New York (LGA) to Portland (PWM)](https://www.expedia.com/lp/flights/lga/pwm/new-york-to-portland) - [Flights from San Francisco (SFO) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/sfo/iss/san-francisco-to-wiscasset) - [Flights from Grand Rapids (GRR) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/grr/nhz/grand-rapids-to-brunswick) - [Flights from Munich (MUC) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/muc/nhz/munich-to-brunswick) - [Flights from Richmond (RIC) to Portland (PWM)](https://www.expedia.com/lp/flights/ric/pwm/richmond-to-portland) - [Flights from Miami (MIA) to Portland (PWM)](https://www.expedia.com/lp/flights/mia/pwm/miami-to-portland) - [Flights from Miami (MIA) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/mia/nhz/miami-to-brunswick) - [Flights from Kansas City (MCI) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/mci/nhz/kansas-city-to-brunswick) - [Flights from Montreal (YUL) to Augusta (AUG)](https://www.expedia.com/lp/flights/yul/aug/montreal-to-augusta) - [Flights from Minneapolis (MSP) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/msp/iss/minneapolis-to-wiscasset) - [Flights from Atlanta (ATL) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/atl/iss/atlanta-to-wiscasset) - [Flights from Columbus (CMH) to Augusta (AUG)](https://www.expedia.com/lp/flights/cmh/aug/columbus-to-augusta) - [Flights from Jacksonville (JAX) to Augusta (AUG)](https://www.expedia.com/lp/flights/jax/aug/jacksonville-to-augusta) - [Flights from Manchester (MHT) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/mht/iss/manchester-to-wiscasset) - [Flights from Phoenix (PHX) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/phx/nhz/phoenix-to-brunswick) - [Flights from Providence (PVD) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/pvd/nhz/providence-to-brunswick) - [Flights from Kansas City (MCI) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/mci/iss/kansas-city-to-wiscasset) - [Flights from Las Vegas (LAS) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/las/nhz/las-vegas-to-brunswick) - [Flights from Raleigh (RDU) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/rdu/nhz/raleigh-to-brunswick) - [Flights from Washington (DCA) to Wiscasset (ISS)](https://www.expedia.com/lp/flights/dca/iss/washington-to-wiscasset) - [Flights from Pittsburgh (PIT) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/pit/nhz/pittsburgh-to-brunswick) - [Flights from Albuquerque (ABQ) to Brunswick (NHZ)](https://www.expedia.com/lp/flights/abq/nhz/albuquerque-to-brunswick) - [Flights from San Diego (SAN) to Augusta (AUG)](https://www.expedia.com/lp/flights/san/aug/san-diego-to-augusta) \*Available to One Key members. ## Other language versions ```yaml hreflang: x-default: https://www.expedia.com/lp/flights/buf/iss/buffalo-to-wiscasset ar: https://www.expedia.sa/lp/flights/buf/iss/buffalo-to-wiscasset id-ID: https://www.expedia.co.id/lp/flights/buf/iss/buffalo-to-wiscasset en-US: https://www.expedia.com/lp/flights/buf/iss/buffalo-to-wiscasset ```