$171 Cheap Flights from Cali (CLO) to Panama City (PTY)

View $171 flight on Wed, Nov 19, 2025Opens in a new window

Popular airlines from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Cali to Panama City (CLO-PTY)

Prices were available within the past 7 days and start at $171 for one-way flights and $256 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Fri, Aug 8 - Fri, Aug 15
CLO
Cali
PTY
Panama City
$256 Roundtrip, found 3 days ago
$256
Roundtrip
found 3 days ago
Select Copa flight, departing Fri, Aug 8 from Cali to Panama City, returning Fri, Aug 15, priced at $256 found 3 days ago
Copa
Wed, May 20 - Wed, Jun 3
CLO
Cali
PTY
Panama City
$257 Roundtrip, found 4 hours ago
$257
Roundtrip
found 4 hours ago
Select Copa flight, departing Wed, May 20 from Cali to Panama City, returning Wed, Jun 3, priced at $257 found 4 hours ago
Copa
Thu, Dec 4 - Tue, Dec 9
CLO
Cali
PTY
Panama City
$268 Roundtrip, found 5 days ago
$268
Roundtrip
found 5 days ago
Select Copa flight, departing Thu, Dec 4 from Cali to Panama City, returning Tue, Dec 9, priced at $268 found 5 days ago
Copa
Fri, Aug 8 - Fri, Aug 15
CLO
Cali
PTY
Panama City
$296 Roundtrip, found 3 days ago
$296
Roundtrip
found 3 days ago
Select Copa flight, departing Fri, Aug 8 from Cali to Panama City, returning Fri, Aug 15, priced at $296 found 3 days ago
Copa
Thu, Sep 18 - Sun, Sep 21
CLO
Cali
PTY
Panama City
$300 Roundtrip, just found
$300
Roundtrip
just found
Select Copa flight, departing Thu, Sep 18 from Cali to Panama City, returning Sun, Sep 21, priced at $300 just found
avianca
Fri, Oct 3 - Mon, Oct 13
CLO
Cali
PTY
Panama City
$306 Roundtrip, found 4 days ago
$306
Roundtrip
found 4 days ago
Select avianca flight, departing Fri, Oct 3 from Cali to Panama City, returning Mon, Oct 13, priced at $306 found 4 days ago
avianca
Wed, Oct 1 - Wed, Oct 8
CLO
Cali
PTY
Panama City
$307 Roundtrip, found 6 days ago
$307
Roundtrip
found 6 days ago
Select avianca flight, departing Wed, Oct 1 from Cali to Panama City, returning Wed, Oct 8, priced at $307 found 6 days ago
Copa
Tue, Aug 12 - Sat, Aug 16
CLO
Cali
PTY
Panama City
$308 Roundtrip, found 5 days ago
$308
Roundtrip
found 5 days ago
Select Copa flight, departing Tue, Aug 12 from Cali to Panama City, returning Sat, Aug 16, priced at $308 found 5 days ago
Copa
Mon, Jul 28 - Sat, Aug 2
CLO
Cali
PTY
Panama City
$310 Roundtrip, found 2 days ago
$310
Roundtrip
found 2 days ago
Select Copa flight, departing Mon, Jul 28 from Cali to Panama City, returning Sat, Aug 2, priced at $310 found 2 days ago
avianca
Fri, Oct 3 - Mon, Oct 13
CLO
Cali
PTY
Panama City
$316 Roundtrip, found 4 days ago
$316
Roundtrip
found 4 days ago
Select avianca flight, departing Fri, Oct 3 from Cali to Panama City, returning Mon, Oct 13, priced at $316 found 4 days ago

Find the cheapest month to fly from Cali (CLO) to Panama City (PTY)

November is typically the cheapest month to fly

From $227 - $420 per traveler.

Graph displaying average flight prices per month

Flights from Cali (CLO) to Panama City (PTY)
Origin airport
Alfonso Bonilla Aragon Intl.
Destination airport
Tocumen Intl.
Airlines serving
Copa, avianca
Roundtrip price
$256
Distance
434 mi
Average flight time
1 hour 33 mins

Cali to Panama City Flights

The cheapest times to fly from Cali to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cali to Panama City are during the month of August. You can find some of the cheapest flights from Cali to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cali to Panama City

Sunday is one of the best days to book for cheap flights from Cali to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cali to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cali to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $171 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cali to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cali to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY) cost?
Score cheap return flights from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY) starting at $256. Reserve your seat and set off on your next adventure. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Copa flight leaving CLO on July 24 2025 and touching down at PTY. The price was last updated on July 10 2025 and has not changed since.
What is the cheapest month to fly from CLO to PTY?
The cheapest flights from CLO to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY)?
When flying out of Alfonso Bonilla Aragon Intl. Airport (CLO), you can get on a direct flight to Tocumen Intl. Airport (PTY) with Copa Airlines.
What is the cheapest airline that flies from CLO to PTY?
With tickets starting at $176 for a one-way flight from CLO to PTY, Copa is currently the cheapest carrier on this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from CLO on August 3 2025. Prices were last updated on July 10 2025 and have not changed since.
How many flights per day from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY)?
With an average of 3 direct flights departing from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY) every day, you'll be jetting off in no time.
What are the most popular departure times for flights from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY)?
The 4 AM departures from CLO to PTY are typically the busiest. They can also be more expensive. If you want to save on your trip, choose a less crowded time to fly.
What day of the week has the most flights from CLO to PTY?
Thursday offers the most flights from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY). Consider taking off on this day and you'll have a greater chance of finding a departure that works with your plans.
What is the earliest flight from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY)?
Catch the earliest flight at around 4:42AM UTC-5, leaving from Alfonso Bonilla Aragon Intl. Airport (CLO). You'll be flying for approximately 1h 32m, reaching Tocumen Intl. Airport (PTY) at approximately 6:14AM UTC-5.
How long does it take to fly from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY)?
It takes about 1 hour and 33 minutes to cover the 430 mi from CLO to PTY.
What airline has the least delays from CLO to PTY?
With 94% of flights usually arriving on time, Copa Airlines has the best on-time performance for direct flights from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY). To check your flight status and get notified if anything changes, head to the Expedia App.
What is the best time to fly from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY)?
Choose a flight from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY) that leaves before 3 PM to reduce the risk of cancellations. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Panama City from Alfonso Bonilla Aragon Intl. Airport (CLO)?
You can land at Tocumen Intl. Airport (PTY) or Panama Pacifico Intl. Airport (BLB) when traveling to Panama City on a direct flight from Alfonso Bonilla Aragon Intl. Airport (CLO).
Is it cheaper to buy a plane ticket from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY) last-minute?
Booking your ticket from CLO to PTY shortly before your journey is typically more expensive. But if you're flexible with your schedule, you could grab a cheap last-minute fare.
Is it cheaper to book a CLO to PTY flight and hotel package?
Opting for a CLO to PTY flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Pick from our impressive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Alfonso Bonilla Aragon Intl. Airport (CLO) to Tocumen Intl. Airport (PTY)?
It's usually possible to reschedule or cancel your CLO to PTY flight. However, if it's been more than 24 hours since booking, additional fees may apply. Check your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find further details on our Customer Service portal.

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