$418 Cheap Flights from Columbus (CMH) to Santiago (SCL)

View $418 flight on Thu, Dec 11, 2025Opens in a new window

Popular airlines from John Glenn Columbus Intl. Airport (CMH) to Santiago Intl. Airport (SCL)

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Cheap Flights from Columbus to Santiago (CMH-SCL)

Prices were available within the past 7 days and start at $418 for one-way flights and $764 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Jan 20 - Tue, Mar 24
CMH
Columbus
SCL
Santiago
$764 Roundtrip, found 3 hours ago
$764
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jan 20 from Columbus to Santiago, returning Tue, Mar 24, priced at $764 found 3 hours ago
Delta
Tue, Nov 18 - Mon, Dec 8
CMH
Columbus
SCL
Santiago
$764 Roundtrip, found 1 hour ago
$764
Roundtrip
found 1 hour ago
Select Delta flight, departing Tue, Nov 18 from Columbus to Santiago, returning Mon, Dec 8, priced at $764 found 1 hour ago
American Airlines
Tue, Jan 20 - Tue, Mar 24
CMH
Columbus
SCL
Santiago
$769 Roundtrip, found 3 hours ago
$769
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jan 20 from Columbus to Santiago, returning Tue, Mar 24, priced at $769 found 3 hours ago
Delta
Thu, Nov 27 - Sun, Dec 7
CMH
Columbus
SCL
Santiago
$769 Roundtrip, found 3 days ago
$769
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Nov 27 from Columbus to Santiago, returning Sun, Dec 7, priced at $769 found 3 days ago
Delta
Sun, Nov 23 - Mon, Dec 8
CMH
Columbus
SCL
Santiago
$771 Roundtrip, found 1 hour ago
$771
Roundtrip
found 1 hour ago
Select Delta flight, departing Sun, Nov 23 from Columbus to Santiago, returning Mon, Dec 8, priced at $771 found 1 hour ago
American Airlines
Thu, Dec 11 - Thu, Jan 15
CMH
Columbus
SCL
Santiago
$773 Roundtrip, found 20 hours ago
$773
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Thu, Dec 11 from Columbus to Santiago, returning Thu, Jan 15, priced at $773 found 20 hours ago
American Airlines
Tue, Nov 18 - Tue, Dec 9
CMH
Columbus
SCL
Santiago
$774 Roundtrip, found 20 hours ago
$774
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Tue, Nov 18 from Columbus to Santiago, returning Tue, Dec 9, priced at $774 found 20 hours ago
LATAM Airlines Group
Tue, Jan 20 - Tue, Mar 24
CMH
Columbus
SCL
Santiago
$784 Roundtrip, found 3 hours ago
$784
Roundtrip
found 3 hours ago
Select LATAM Airlines Group flight, departing Tue, Jan 20 from Columbus to Santiago, returning Tue, Mar 24, priced at $784 found 3 hours ago
Air Canada
Sat, Jan 10 - Thu, Jan 22
CMH
Columbus
SCL
Santiago
$833 Roundtrip, just found
$833
Roundtrip
just found
Select Air Canada flight, departing Sat, Jan 10 from Columbus to Santiago, returning Thu, Jan 22, priced at $833 just found
United
Tue, Jan 20 - Tue, Mar 24
CMH
Columbus
SCL
Santiago
$890 Roundtrip, found 3 hours ago
$890
Roundtrip
found 3 hours ago
Select United flight, departing Tue, Jan 20 from Columbus to Santiago, returning Tue, Mar 24, priced at $890 found 3 hours ago

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $764
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $764

Frequently asked questions

How much does a flight from John Glenn Columbus Intl. Airport (CMH) to Arturo Merino Benitez Airport (SCL) cost?
Snag a cheap one-way flight from $418 or cheap return flight from $764 from John Glenn Columbus Intl. Airport (CMH) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from John Glenn Columbus Intl. Airport (CMH) to Arturo Merino Benitez Airport (SCL)?
The cheapest month to fly from CMH to SCL is January, when there's less demand. Off-peak months are generally when you'll find cheap fares for travel between these airports.
What is the cheapest airline that flies from John Glenn Columbus Intl. Airport (CMH) to Arturo Merino Benitez Airport (SCL)?
Use the filter tool on Expedia to compare airlines and find the most affordable carrier that'll take you from CMH to SCL. Then, sort your results by "Price (lowest to highest)" to pick up a great deal.
How many flights per day from John Glenn Columbus Intl. Airport (CMH) to Arturo Merino Benitez Airport (SCL)?
Nonstop flights from John Glenn Columbus Intl. Airport (CMH) to Arturo Merino Benitez Airport (SCL) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from CMH to SCL?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* However, this can change depending on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from John Glenn Columbus Intl. Airport (CMH) to Arturo Merino Benitez Airport (SCL)?
To avoid potential delays on the John Glenn Columbus Intl. Airport (CMH) to Arturo Merino Benitez Airport (SCL) route, aim to fly before 3 PM. Later flights are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from John Glenn Columbus Intl. Airport (CMH) to Arturo Merino Benitez Airport (SCL) last-minute?
Waiting until just before your departure to book a ticket from CMH to SCL often results in higher prices. Although you may find some last-minute deals, there's no guarantee. Keep your travel schedule open for a better chance of snagging a bargain.
Is it cheaper to book a CMH to SCL flight and hotel package?
You'll typically save money by booking a CMH to SCL flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. After selecting your ideal flights and accommodations, consider adding extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from John Glenn Columbus Intl. Airport (CMH) to Arturo Merino Benitez Airport (SCL)?
In most cases, you're able to cancel or reschedule your CMH to SCL flight. However, there may be additional charges, especially if your booking was made more than 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you want further details, go to our Customer Service portal.

Travel information

Origin airport
John Glenn Columbus Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Air Canada, American Airlines, Copa, Delta, LATAM Airlines Group, United, avianca
Roundtrip price
$764
Distance
5129 mi

Book with confidence

Columbus to Santiago Flights

The cheapest times to fly from Columbus to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Columbus to Santiago are during the month of January. You can find some of the cheapest flights from Columbus to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Columbus to Santiago

Sunday is one of the best days to book for cheap flights from Columbus to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Columbus to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Columbus to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $418 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Columbus to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Columbus to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Columbus to Santiago Flights

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*Available to One Key members.