$289 Cheap Flights from Cusco (CUZ) to Medellín (MDE)

Cusco (CUZ) to Medellin (MDE) at a glance

Travel with a range of airlines on the international short-haul route from Cusco (CUZ) to Medellin (MDE). Evaluate options from both full-service and budget carriers to find the itinerary that suits your budget, schedule, and travel preferences while you discover the iconic sights and neighborhoods of Medellin. Here, you'll find essential details for flights departing from Alejandro Velasco Astete International Airport (CUZ) to José María Córdova International Airport (MDE).

• Fastest flight duration: around 4h 45m in-flight, plus roughly 2h 15m layover with one stop
• Route distance: roughly 1,400 miles (2,250 km)
• Flights per week: around 7 departures on average
• Typical fares (one-way): economy tickets often range from $190–$515, depending on seasonality and how far ahead you book

Flights from Alejandro Velasco Astete International Airport (CUZ) to José María Córdova International Airport (MDE)

According to the latest traveler bookings, here are the top airlines favored for one-stop flights from Cusco to Medellin. Many passengers opt for layovers at Jorge Chávez International Airport (LIM), which has an average layover time of about 2 hours and 30 minutes, or El Dorado International Airport (BOG), with approximately 1 hour and 15 minutes of waiting time. This variety allows you to balance price, total travel duration, and cabin class to craft the ideal travel itinerary.

• LATAM Airlines Group: This full-service airline provides one-stop service, with one-way ticket prices generally falling between $190 and $515. It represents about 78% of the flights on this route, featuring an in-flight duration of 4 hours and 45 minutes, leading to a total travel time of approximately 6 hours and 45 minutes, including layover time.
• Avianca: Another full-service carrier, Avianca offers one-stop journeys with one-way fares typically ranging from $230 to $730. It covers around 22% of departures for this route, with a flying time of 4 hours and 45 minutes, and the overall journey takes about 6 hours and 45 minutes, factoring in the layover.

How to find the best prices for flights from Cusco (CUZ) to Medellin (MDE)

Getting some of the best deals on flights from Cusco to Medellin is all about timing and flexibility. Here are some key tips to help you save:

1. Best times to book and fly: cheaper fares are generally found when booking within two weeks, although most travelers tend to book between two to eight weeks in advance. Morning departures, between 5 AM and 12 PM, usually offer lower prices and are the most popular flight times. Additionally, flying on Fridays not only provides cheaper prices but is also the busiest travel day.
2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at José María Córdova International Airport from Alejandro Velasco Astete International Airport

Medellin welcomes travelers from Cusco with a range of transport options based on price, convenience, and proximity. Medellin city center is approximately a 25-minute drive (covering about 14 miles) from José María Córdova International Airport, depending on traffic. Here's how to reach Medellin efficiently:

• Hotel transfer: Transfers offer a convenient way to reach your hotel in Medellin, with private rides that can be arranged in advance.
• Car rental: Renting a car from José María Córdova International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at José María Córdova International Airport on Expedia.
• Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
• Public transportation: From José María Córdova International Airport, Rionegro Bus Station, a bus station, is located about 7.7 miles away by car, providing convenient access for travelers heading to their next destination.

Cusco to Medellín Flights

The cheapest times to fly from Cusco to Medellín

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cusco to Medellín are during the month of November. You can find some of the cheapest flights from Cusco to Medellín with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Cusco to Medellín

Sunday is one of the best days to book for cheap flights from Cusco to Medellín: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Cusco to Medellín

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cusco to Medellín in 2026. You can also book with separate airlines for your outbound and return journeys, from $289 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cusco to Medellín flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cusco to Medellín airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.