$55 Cheap Flights from Des Moines (DSM) to Cleveland (CLE)

View $55 flight on Mon, Nov 17, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Cleveland Hopkins International Airport (CLE)

  • notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
  • deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Des Moines to Cleveland (DSM-CLE)

Prices were available within the past 7 days and start at $55 for one-way flights and $120 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Mon, Nov 17 - Thu, Dec 4
DSM
Des Moines
CLE
Cleveland
$120 Roundtrip, found 5 days ago
$120
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Mon, Nov 17 from Des Moines to Cleveland, returning Thu, Dec 4, priced at $120 found 5 days ago
Frontier Airlines
Mon, Nov 17 - Mon, Dec 8
DSM
Des Moines
CLE
Cleveland
$140 Roundtrip, found 5 days ago
$140
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Mon, Nov 17 from Des Moines to Cleveland, returning Mon, Dec 8, priced at $140 found 5 days ago
Frontier Airlines
Mon, Nov 17 - Fri, Dec 5
DSM
Des Moines
CLE
Cleveland
$153 Roundtrip, found 5 days ago
$153
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Mon, Nov 17 from Des Moines to Cleveland, returning Fri, Dec 5, priced at $153 found 5 days ago
Frontier Airlines
Sun, Nov 16 - Thu, Dec 4
DSM
Des Moines
CLE
Cleveland
$179 Roundtrip, found 5 days ago
$179
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Sun, Nov 16 from Des Moines to Cleveland, returning Thu, Dec 4, priced at $179 found 5 days ago
Frontier Airlines
Fri, Nov 14 - Fri, Dec 5
DSM
Des Moines
CLE
Cleveland
$186 Roundtrip, found 5 days ago
$186
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Fri, Nov 14 from Des Moines to Cleveland, returning Fri, Dec 5, priced at $186 found 5 days ago
Frontier Airlines
Fri, Nov 7 - Thu, Nov 13
DSM
Des Moines
CLE
Cleveland
$193 Roundtrip, found 6 days ago
$193
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Fri, Nov 7 from Des Moines to Cleveland, returning Thu, Nov 13, priced at $193 found 6 days ago
Delta
Sat, Feb 14 - Tue, Feb 17
DSM
Des Moines
CLE
Cleveland
$247 Roundtrip, found 5 days ago
$247
Roundtrip
found 5 days ago
Select Delta flight, departing Sat, Feb 14 from Des Moines to Cleveland, returning Tue, Feb 17, priced at $247 found 5 days ago
Southwest Airlines
Fri, Dec 5 - Mon, Dec 8
DSM
Des Moines
CLE
Cleveland
$259 Roundtrip, found 1 day ago
$259
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Fri, Dec 5 from Des Moines to Cleveland, returning Mon, Dec 8, priced at $259 found 1 day ago
United
Fri, Dec 5 - Mon, Dec 8
DSM
Des Moines
CLE
Cleveland
$264 Roundtrip, found 1 day ago
$264
Roundtrip
found 1 day ago
Select United flight, departing Fri, Dec 5 from Des Moines to Cleveland, returning Mon, Dec 8, priced at $264 found 1 day ago
American Airlines
Mon, Dec 8 - Wed, Dec 10
DSM
Des Moines
CLE
Cleveland
$312 Roundtrip, found 9 hours ago
$312
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Mon, Dec 8 from Des Moines to Cleveland, returning Wed, Dec 10, priced at $312 found 9 hours ago

Find the cheapest month to fly from Des Moines (DSM) to Cleveland (CLE)

January is typically the cheapest month to fly

From $128 - $587 per traveler.

Alternative airports near Cleveland

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Hopkins Intl. CLE. Cheapest option available. Average driving time to city center is 15 minutes. Flights from $372
CLE
Hopkins Intl.
Cheapest
Average driving time to city center15 min
Flights from $372

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Hopkins Intl. Airport (CLE) cost?
Snag a cheap one-way flight from $55 or cheap return flight from $120 from Des Moines Intl. Airport (DSM) to Hopkins Intl. Airport (CLE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Hopkins Intl. Airport (CLE)?
Planning your trip for November may help you find better deals, as it's the cheapest month for flights between DSM and CLE. You'll often find the lowest fares during off-peak months.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Hopkins Intl. Airport (CLE)?
Use the filters on Expedia to compare different airlines and find the most affordable carrier that'll fly you from DSM to CLE. Then, sort your results by "Price (lowest to highest)" to snag a great deal.
How many flights per day from Des Moines Intl. Airport (DSM) to Hopkins Intl. Airport (CLE)?
You'll have to book a flight with a layover when traveling from Des Moines Intl. Airport (DSM) to Hopkins Intl. Airport (CLE). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from DSM to CLE?
Typically you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* However, this can vary based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Hopkins Intl. Airport (CLE)?
Choose a flight from Des Moines Intl. Airport (DSM) to Hopkins Intl. Airport (CLE) that takes off before 3 PM to reduce the risk of cancellations and delays. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Hopkins Intl. Airport (CLE) last-minute?
Booking your flight from DSM to CLE shortly before your journey is typically more expensive. But if there's some wiggle room with your travel dates and times, you could land a cheap last-minute fare.
Is it cheaper to book a DSM to CLE flight and hotel package?
Securing a DSM to CLE flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Pick from our impressive range of accommodations and then add activities, car rentals and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Hopkins Intl. Airport (CLE)?
In most cases, you can cancel or modify your DSM to CLE flight. However, there may be additional charges, especially if you booked over 24 hours ago. Check your itinerary for the airline's fees and rules on flight changes, or if you want further information, head to our Customer Service portal.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Hopkins Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$120
Distance
610 mi

Book with confidence

Des Moines to Cleveland Flights

The cheapest times to fly from Des Moines to Cleveland

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Cleveland are during the month of November. You can find some of the cheapest flights from Des Moines to Cleveland with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Cleveland

Sunday is one of the best days to book for cheap flights from Des Moines to Cleveland: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Cleveland

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Cleveland in 2025. You can also book with separate airlines for your outbound and return journeys, from $55 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Cleveland flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Cleveland airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Cleveland Flights

Explore a world of travel with Expedia

*Available to One Key members.