$81 Cheap Flights from Des Moines (DSM) to Memphis (MEM)

View $81 flight on Tue, Nov 18, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Memphis International Airport (MEM)

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Cheap Flights from Des Moines to Memphis (DSM-MEM)

Prices were available within the past 7 days and start at $81 for one-way flights and $175 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Tue, Nov 18 - Sat, Nov 22
DSM
Des Moines
MEM
Memphis
$175 Roundtrip, found 6 days ago
$175
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Tue, Nov 18 from Des Moines to Memphis, returning Sat, Nov 22, priced at $175 found 6 days ago
Southwest Airlines
Tue, Nov 18 - Sat, Nov 22
DSM
Des Moines
MEM
Memphis
$190 Roundtrip, found 6 days ago
$190
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Tue, Nov 18 from Des Moines to Memphis, returning Sat, Nov 22, priced at $190 found 6 days ago
United
Tue, Oct 21 - Sat, Oct 25
DSM
Des Moines
MEM
Memphis
$191 Roundtrip, found 6 days ago
$191
Roundtrip
found 6 days ago
Select United flight, departing Tue, Oct 21 from Des Moines to Memphis, returning Sat, Oct 25, priced at $191 found 6 days ago
American Airlines
Wed, Dec 3 - Sat, Dec 6
DSM
Des Moines
MEM
Memphis
$193 Roundtrip, found 6 days ago
$193
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Dec 3 from Des Moines to Memphis, returning Sat, Dec 6, priced at $193 found 6 days ago
Delta
Tue, Nov 18 - Sat, Nov 22
DSM
Des Moines
MEM
Memphis
$194 Roundtrip, found 6 days ago
$194
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Nov 18 from Des Moines to Memphis, returning Sat, Nov 22, priced at $194 found 6 days ago
Delta
Wed, Dec 3 - Sat, Dec 6
DSM
Des Moines
MEM
Memphis
$197 Roundtrip, found 6 days ago
$197
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Dec 3 from Des Moines to Memphis, returning Sat, Dec 6, priced at $197 found 6 days ago
Southwest Airlines
Wed, Dec 3 - Sat, Dec 6
DSM
Des Moines
MEM
Memphis
$198 Roundtrip, found 6 days ago
$198
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Wed, Dec 3 from Des Moines to Memphis, returning Sat, Dec 6, priced at $198 found 6 days ago
United
Wed, Oct 29 - Sat, Nov 1
DSM
Des Moines
MEM
Memphis
$199 Roundtrip, found 6 days ago
$199
Roundtrip
found 6 days ago
Select United flight, departing Wed, Oct 29 from Des Moines to Memphis, returning Sat, Nov 1, priced at $199 found 6 days ago
United
Tue, Oct 14 - Sat, Oct 18
DSM
Des Moines
MEM
Memphis
$201 Roundtrip, found 6 days ago
$201
Roundtrip
found 6 days ago
Select United flight, departing Tue, Oct 14 from Des Moines to Memphis, returning Sat, Oct 18, priced at $201 found 6 days ago
United
Wed, Oct 29 - Sat, Nov 1
DSM
Des Moines
MEM
Memphis
$201 Roundtrip, found 6 days ago
$201
Roundtrip
found 6 days ago
Select United flight, departing Wed, Oct 29 from Des Moines to Memphis, returning Sat, Nov 1, priced at $201 found 6 days ago

Find the cheapest month to fly from Des Moines (DSM) to Memphis (MEM)

August is typically the cheapest month to fly

From $158 - $482 per traveler.

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Memphis Intl. Airport (MEM) cost?
Lock in a cheap one-way flight from $81 or cheap return flight from $175 from Des Moines Intl. Airport (DSM) to Memphis Intl. Airport (MEM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Memphis Intl. Airport (MEM)?
November is the cheapest month to fly from DSM to MEM. Planning your trip for the off-season is often the key to finding better deals on flights.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Memphis Intl. Airport (MEM)?
Use the filters on Expedia to compare airlines and find the cheapest carrier that'll take you from DSM to MEM. Then, sort your results by "Price (lowest to highest)" to score a good deal.
How many flights per day from Des Moines Intl. Airport (DSM) to Memphis Intl. Airport (MEM)?
Direct flights from Des Moines Intl. Airport (DSM) to Memphis Intl. Airport (MEM) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DSM to MEM?
Generally you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* But this can vary based on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Memphis Intl. Airport (MEM)?
To touch down at Memphis Intl. Airport (MEM) without delays, choose a flight that leaves from Des Moines Intl. Airport (DSM) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Memphis Intl. Airport (MEM) last-minute?
Holding off until right before your break to book a flight from DSM to MEM generally means paying more. While it's possible to find some last-minute offers, they aren't always guaranteed. Keep your travel plans flexible for the best chance of landing a bargain.
Is it cheaper to book a DSM to MEM flight and hotel package?
You'll generally save money by booking a DSM to MEM flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one place. After choosing your ideal flights and accommodations, consider other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Memphis Intl. Airport (MEM)?
Typically, you can modify or cancel your DSM to MEM flight. However, there may be additional fees, especially if you made your booking more than 24 hours ago. Double-check your itinerary for the airline's guidelines and fees on flight changes, or if you'd like more details, go to our Customer Service portal.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
Memphis Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$175
Distance
490 mi

Book with confidence

Book with confidence

Des Moines to Memphis Flights

The cheapest times to fly from Des Moines to Memphis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Memphis are during the month of November. You can find some of the cheapest flights from Des Moines to Memphis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Memphis

Sunday is one of the best days to book for cheap flights from Des Moines to Memphis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Memphis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Memphis in 2025. You can also book with separate airlines for your outbound and return journeys, from $81 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Memphis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Memphis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Memphis Flights

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