$402 Cheap Flights from Des Moines (DSM) to Santa Cruz (VVI)

View $402 flight on Sun, Nov 30, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Santa Cruz (VVI-Viru Viru Intl.)

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Cheap Flights from Des Moines to Santa Cruz (DSM-VVI)

Prices were available within the past 7 days and start at $402 for one-way flights and $784 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Thu, Dec 4 - Thu, Feb 26
DSM
Des Moines
VVI
Santa Cruz
$784 Roundtrip, found 11 hours ago
$784
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Dec 4 from Des Moines to Santa Cruz, returning Thu, Feb 26, priced at $784 found 11 hours ago
United
Thu, Dec 4 - Thu, Feb 26
DSM
Des Moines
VVI
Santa Cruz
$789 Roundtrip, found 11 hours ago
$789
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Dec 4 from Des Moines to Santa Cruz, returning Thu, Feb 26, priced at $789 found 11 hours ago
United
Thu, Dec 4 - Thu, Feb 26
DSM
Des Moines
VVI
Santa Cruz
$791 Roundtrip, found 11 hours ago
$791
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Dec 4 from Des Moines to Santa Cruz, returning Thu, Feb 26, priced at $791 found 11 hours ago
United
Thu, Dec 4 - Thu, Feb 26
DSM
Des Moines
VVI
Santa Cruz
$791 Roundtrip, found 11 hours ago
$791
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Dec 4 from Des Moines to Santa Cruz, returning Thu, Feb 26, priced at $791 found 11 hours ago
United
Thu, Dec 4 - Thu, Feb 26
DSM
Des Moines
VVI
Santa Cruz
$792 Roundtrip, found 11 hours ago
$792
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Dec 4 from Des Moines to Santa Cruz, returning Thu, Feb 26, priced at $792 found 11 hours ago
United
Thu, Dec 4 - Thu, Feb 26
DSM
Des Moines
VVI
Santa Cruz
$794 Roundtrip, found 11 hours ago
$794
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Dec 4 from Des Moines to Santa Cruz, returning Thu, Feb 26, priced at $794 found 11 hours ago
United
Thu, Dec 4 - Thu, Feb 26
DSM
Des Moines
VVI
Santa Cruz
$798 Roundtrip, found 11 hours ago
$798
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Dec 4 from Des Moines to Santa Cruz, returning Thu, Feb 26, priced at $798 found 11 hours ago
United
Thu, Dec 4 - Thu, Feb 26
DSM
Des Moines
VVI
Santa Cruz
$799 Roundtrip, found 11 hours ago
$799
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Dec 4 from Des Moines to Santa Cruz, returning Thu, Feb 26, priced at $799 found 11 hours ago
United
Thu, Dec 4 - Thu, Feb 26
DSM
Des Moines
VVI
Santa Cruz
$802 Roundtrip, found 11 hours ago
$802
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Dec 4 from Des Moines to Santa Cruz, returning Thu, Feb 26, priced at $802 found 11 hours ago
United
Thu, Dec 4 - Thu, Feb 26
DSM
Des Moines
VVI
Santa Cruz
$804 Roundtrip, found 11 hours ago
$804
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Dec 4 from Des Moines to Santa Cruz, returning Thu, Feb 26, priced at $804 found 11 hours ago

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Viru Viru Intl. Airport (VVI) cost?
Lock in a cheap one-way flight from $402 or cheap return flight from $784 from Des Moines Intl. Airport (DSM) to Viru Viru Intl. Airport (VVI) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Viru Viru Intl. Airport (VVI)?
Planning your getaway for December is a good way to save, as it's the cheapest month for flights between DSM and VVI. You'll typically find the lowest prices during the off-season.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Viru Viru Intl. Airport (VVI)?
To find the cheapest airline flying from DSM to VVI, use Expedia's filter tool. Customize your search based on your travel style, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Des Moines Intl. Airport (DSM) to Viru Viru Intl. Airport (VVI)?
Direct flights from Des Moines Intl. Airport (DSM) to Viru Viru Intl. Airport (VVI) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DSM to VVI?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can vary based on a number of factors, including the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Viru Viru Intl. Airport (VVI)?
Opt for a flight from Des Moines Intl. Airport (DSM) to Viru Viru Intl. Airport (VVI) that takes off before 3 PM to reduce the risk of cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Viru Viru Intl. Airport (VVI) last-minute?
Booking your plane ticket from DSM to VVI shortly before your trip is usually more expensive. However, if there's some wiggle room with your travel times and dates, you could bag a cheap last-minute fare.
Is it cheaper to book a DSM to VVI flight and hotel package?
You'll typically save money by securing a DSM to VVI flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. Once you've selected your preferred flights and accommodations, consider adding extras such as car rentals, tours and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Viru Viru Intl. Airport (VVI)?
Generally, it's possible to cancel or reschedule your DSM to VVI flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Viru Viru Intl.
Airlines serving
United
Roundtrip price
$784
Distance
4530 mi

Book with confidence

Des Moines to Santa Cruz Flights

The cheapest times to fly from Des Moines to Santa Cruz

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Santa Cruz are during the month of December. You can find some of the cheapest flights from Des Moines to Santa Cruz with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Santa Cruz

Sunday is one of the best days to book for cheap flights from Des Moines to Santa Cruz: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Santa Cruz

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Santa Cruz in 2025. You can also book with separate airlines for your outbound and return journeys, from $402 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Santa Cruz flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Santa Cruz airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Santa Cruz Flights

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*Available to One Key members.