$191 Cheap Flights from Des Moines (DSM) to Manzanillo (ZLO)

View $191 flight on Tue, Jan 6, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Manzanillo, Colima (ZLO-Playa de Oro Intl.)

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Cheap Flights from Des Moines to Manzanillo (DSM-ZLO)

Prices were available within the past 7 days and start at $191 for one-way flights and $401 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Sun, Nov 30 - Wed, Dec 3
DSM
Des Moines
ZLO
Manzanillo
$401 Roundtrip, found 2 days ago
$401
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, Nov 30 from Des Moines to Manzanillo, returning Wed, Dec 3, priced at $401 found 2 days ago
Aeromexico
Sun, Feb 1 - Fri, Feb 13
DSM
Des Moines
ZLO
Manzanillo
$406 Roundtrip, found 2 days ago
$406
Roundtrip
found 2 days ago
Select Aeromexico flight, departing Sun, Feb 1 from Des Moines to Manzanillo, returning Fri, Feb 13, priced at $406 found 2 days ago
Delta
Sun, Nov 30 - Mon, Dec 8
DSM
Des Moines
ZLO
Manzanillo
$446 Roundtrip, found 2 days ago
$446
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, Nov 30 from Des Moines to Manzanillo, returning Mon, Dec 8, priced at $446 found 2 days ago
Delta
Fri, Jan 23 - Fri, Feb 6
DSM
Des Moines
ZLO
Manzanillo
$455 Roundtrip, found 4 hours ago
$455
Roundtrip
found 4 hours ago
Select Delta flight, departing Fri, Jan 23 from Des Moines to Manzanillo, returning Fri, Feb 6, priced at $455 found 4 hours ago
United
Fri, Jan 23 - Fri, Feb 6
DSM
Des Moines
ZLO
Manzanillo
$460 Roundtrip, found 4 hours ago
$460
Roundtrip
found 4 hours ago
Select United flight, departing Fri, Jan 23 from Des Moines to Manzanillo, returning Fri, Feb 6, priced at $460 found 4 hours ago
American Airlines
Fri, Jan 23 - Fri, Feb 6
DSM
Des Moines
ZLO
Manzanillo
$468 Roundtrip, found 4 hours ago
$468
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, Jan 23 from Des Moines to Manzanillo, returning Fri, Feb 6, priced at $468 found 4 hours ago
United
Fri, Jan 23 - Fri, Feb 6
DSM
Des Moines
ZLO
Manzanillo
$471 Roundtrip, found 4 hours ago
$471
Roundtrip
found 4 hours ago
Select United flight, departing Fri, Jan 23 from Des Moines to Manzanillo, returning Fri, Feb 6, priced at $471 found 4 hours ago
United
Fri, Jan 23 - Fri, Feb 6
DSM
Des Moines
ZLO
Manzanillo
$477 Roundtrip, found 4 hours ago
$477
Roundtrip
found 4 hours ago
Select United flight, departing Fri, Jan 23 from Des Moines to Manzanillo, returning Fri, Feb 6, priced at $477 found 4 hours ago
American Airlines
Thu, Dec 4 - Tue, Dec 9
DSM
Des Moines
ZLO
Manzanillo
$484 Roundtrip, found 2 days ago
$484
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Dec 4 from Des Moines to Manzanillo, returning Tue, Dec 9, priced at $484 found 2 days ago
American Airlines
Tue, Jan 6 - Wed, Jan 21
DSM
Des Moines
ZLO
Manzanillo
$486 Roundtrip, found 2 days ago
$486
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Jan 6 from Des Moines to Manzanillo, returning Wed, Jan 21, priced at $486 found 2 days ago

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Playa de Oro Intl. Airport (ZLO) cost?
Grab a cheap one-way flight from $191 or cheap return flight from $401 from Des Moines Intl. Airport (DSM) to Playa de Oro Intl. Airport (ZLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Playa de Oro Intl. Airport (ZLO)?
Flying in November can help you save, as it's the cheapest month for flights between DSM and ZLO. You'll often find the lowest prices during the off-season.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Playa de Oro Intl. Airport (ZLO)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest DSM to ZLO flight.
How many flights per day from Des Moines Intl. Airport (DSM) to Playa de Oro Intl. Airport (ZLO)?
You'll have to take a flight with a layover when traveling from Des Moines Intl. Airport (DSM) to Playa de Oro Intl. Airport (ZLO). There are no daily direct flights on this route. However, just filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from DSM to ZLO?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change depending on a range of factors, including the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Playa de Oro Intl. Airport (ZLO)?
Choose a flight from Des Moines Intl. Airport (DSM) to Playa de Oro Intl. Airport (ZLO) that takes off before 3 PM to reduce the risk of cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Playa de Oro Intl. Airport (ZLO) last-minute?
Holding off until just before your departure to book a flight from DSM to ZLO often results in higher prices. Although you may find some last-minute discounts, there's no guarantee. Allow some flexibility in your schedule to maximize your chances of landing a bargain.
Is it cheaper to book a DSM to ZLO flight and hotel package?
Compared with arranging hotels and flights separately, booking a DSM to ZLO flight and hotel package with Expedia could result in significant savings. Better still, having everything in one place takes the hassle out of planning your trip. Just secure your flights and choose from our wide range of stays, then personalize your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Playa de Oro Intl. Airport (ZLO)?
In most instances, you can modify or cancel your DSM to ZLO flight. However, there may be additional charges, especially if you booked over 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you need further details, head to our Customer Service portal.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
Playa de Oro Intl.
Airlines serving
Aeromexico, Delta
Roundtrip price
$400
Distance
1674 mi

Book with confidence

Book with confidence

Des Moines to Manzanillo Flights

The cheapest times to fly from Des Moines to Manzanillo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Manzanillo are during the month of November. You can find some of the cheapest flights from Des Moines to Manzanillo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Manzanillo

Sunday is one of the best days to book for cheap flights from Des Moines to Manzanillo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Manzanillo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Manzanillo in 2025. You can also book with separate airlines for your outbound and return journeys, from $191 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Manzanillo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Manzanillo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Manzanillo Flights

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*Available to One Key members.