$256 Cheap Flights from Florence (FLO) to Charlotte (CLT)

View $256 flight on Fri, Dec 26, 2025Opens in a new window

Popular airlines from Florence, SC (FLO-Florence Regional) to Charlotte-Douglas Intl. Airport (CLT)

Cheap Flights from Florence to Charlotte (FLO-CLT)

Prices were available within the past 7 days and start at $256 for one-way flights and $367 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, Apr 6 - Thu, Apr 23
FLO
Florence
CLT
Charlotte
$367 Roundtrip, found 2 days ago
$367
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Apr 6 from Florence to Charlotte, returning Thu, Apr 23, priced at $367 found 2 days ago
American Airlines
Wed, Apr 8 - Sat, Apr 25
FLO
Florence
CLT
Charlotte
$387 Roundtrip, found 1 day ago
$387
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Apr 8 from Florence to Charlotte, returning Sat, Apr 25, priced at $387 found 1 day ago
American Airlines
Wed, Apr 8 - Mon, Apr 27
FLO
Florence
CLT
Charlotte
$407 Roundtrip, found 1 day ago
$407
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Apr 8 from Florence to Charlotte, returning Mon, Apr 27, priced at $407 found 1 day ago
American Airlines
Tue, Oct 21 - Sat, Nov 1
FLO
Florence
CLT
Charlotte
$417 Roundtrip, found 2 days ago
$417
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Oct 21 from Florence to Charlotte, returning Sat, Nov 1, priced at $417 found 2 days ago
American Airlines
Wed, Apr 8 - Sun, Apr 26
FLO
Florence
CLT
Charlotte
$427 Roundtrip, found 1 day ago
$427
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Apr 8 from Florence to Charlotte, returning Sun, Apr 26, priced at $427 found 1 day ago
American Airlines
Tue, Oct 21 - Mon, Nov 3
FLO
Florence
CLT
Charlotte
$437 Roundtrip, found 2 days ago
$437
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Oct 21 from Florence to Charlotte, returning Mon, Nov 3, priced at $437 found 2 days ago
American Airlines
Thu, Oct 23 - Sat, Nov 1
FLO
Florence
CLT
Charlotte
$438 Roundtrip, found 2 days ago
$438
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Oct 23 from Florence to Charlotte, returning Sat, Nov 1, priced at $438 found 2 days ago
American Airlines
Thu, Apr 9 - Sun, Apr 26
FLO
Florence
CLT
Charlotte
$447 Roundtrip, found 1 day ago
$447
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Apr 9 from Florence to Charlotte, returning Sun, Apr 26, priced at $447 found 1 day ago
American Airlines
Thu, Oct 23 - Mon, Nov 3
FLO
Florence
CLT
Charlotte
$458 Roundtrip, found 2 days ago
$458
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Oct 23 from Florence to Charlotte, returning Mon, Nov 3, priced at $458 found 2 days ago
American Airlines
Sun, Apr 12 - Sun, Apr 26
FLO
Florence
CLT
Charlotte
$467 Roundtrip, found 1 day ago
$467
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Apr 12 from Florence to Charlotte, returning Sun, Apr 26, priced at $467 found 1 day ago
Flights from Florence (FLO) to Charlotte (CLT)
Origin airport
Florence Regional
Destination airport
Charlotte-Douglas Intl.
Airlines serving
American Airlines
Roundtrip price
$367
Distance
99 mi

Florence to Charlotte Flights

The cheapest times to fly from Florence to Charlotte

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Charlotte are during the month of April. You can find some of the cheapest flights from Florence to Charlotte with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Charlotte

Sunday is one of the best days to book for cheap flights from Florence to Charlotte: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Charlotte

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Charlotte in 2025. You can also book with separate airlines for your outbound and return journeys, from $256 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Charlotte flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Charlotte airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT) cost?
Lock in a cheap one-way flight from $256 or cheap return flight from $367 from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
The cheapest month to fly from FLO to CLT is April, when there's less demand. Off-peak season is usually when better flight deals are available between these airports.
Which airlines fly direct from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
You can fly nonstop from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT) on an American Airlines flight.
What is the cheapest airline that flies from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest FLO to CLT flight.
How many flights per day from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
Every day on average, 2 direct flights take off from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT). Choose the departure date that best suits your travel plans.
What are the most popular departure times for flights from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
More people fly between FLO and CLT at 6 AM than at any other time of day. Rather go when it's quieter? Pick a flight outside the busiest times and it's possible you'll save on your fare as well.
What day of the week has the most flights from FLO to CLT?
Depart on a Friday if you're looking for the best selection of flights from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT).
What is the earliest flight from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
The earliest flight leaving from Florence Regional Airport (FLO) is at around 6:52AM UTC-5. Catch this flight and you'll land at Charlotte-Douglas Intl. Airport (CLT) at approximately 8:19AM UTC-5. The entire trip takes 1h 27m.
How long does it take to fly from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
It takes about 1 hour and 19 minutes to travel the 100 mi from FLO to CLT.
What airline has the least delays from FLO to CLT?
American Airlines has the best performance for on-time direct flights from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT), with an on-time rating of 81%. Use the Expedia App to view your journey status before you leave and get immediate updates about any changes.
What is the best time to fly from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
To avoid potential delays on the Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT) route, travel before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Charlotte from Florence Regional Airport (FLO)?
If you're boarding a direct flight from Florence Regional Airport (FLO) to Charlotte, Charlotte-Douglas Intl. Airport (CLT) is the only airport you can land at.
Is it cheaper to buy a plane ticket from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT) last-minute?
Waiting until just before your departure to book your flight from FLO to CLT generally means paying more. While you may find some last-minute discounts, there's no guarantee. Keep your travel plans flexible for the best chance of landing a bargain.
Is it cheaper to book a FLO to CLT flight and hotel package?
Compared with arranging flights and hotels separately, booking a FLO to CLT flight and hotel package with Expedia could lead to significant savings. Better still, having it all in one place takes the hassle out of planning your trip. Just pick your flights and select from our extensive range of stays, then personalize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
If you booked your FLO to CLT flight in the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

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*Available to One Key members.