$319 Cheap Flights from Florence (FLO) to Charlotte (CLT)

View $319 flight on Tue, Sep 16, 2025Opens in a new window

Popular airlines from Florence, SC (FLO-Florence Regional) to Charlotte-Douglas Intl. Airport (CLT)

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Cheap Flights from Florence to Charlotte (FLO-CLT)

Prices were available within the past 7 days and start at $319 for one-way flights and $367 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Sep 11 - Sun, Sep 14
FLO
Florence
CLT
Charlotte
$367 Roundtrip, found 1 day ago
$367
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Sep 11 from Florence to Charlotte, returning Sun, Sep 14, priced at $367 found 1 day ago
American Airlines
Sat, Sep 13 - Tue, Sep 16
FLO
Florence
CLT
Charlotte
$387 Roundtrip, found 20 hours ago
$387
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Sat, Sep 13 from Florence to Charlotte, returning Tue, Sep 16, priced at $387 found 20 hours ago
American Airlines
Sat, Sep 13 - Sun, Sep 14
FLO
Florence
CLT
Charlotte
$407 Roundtrip, found 20 hours ago
$407
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Sat, Sep 13 from Florence to Charlotte, returning Sun, Sep 14, priced at $407 found 20 hours ago
American Airlines
Sun, Sep 14 - Sun, Sep 21
FLO
Florence
CLT
Charlotte
$427 Roundtrip, found 20 hours ago
$427
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Sun, Sep 14 from Florence to Charlotte, returning Sun, Sep 21, priced at $427 found 20 hours ago
American Airlines
Wed, Jul 16 - Tue, Jul 22
FLO
Florence
CLT
Charlotte
$447 Roundtrip, found 1 day ago
$447
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 16 from Florence to Charlotte, returning Tue, Jul 22, priced at $447 found 1 day ago
American Airlines
Wed, Jul 16 - Thu, Jul 24
FLO
Florence
CLT
Charlotte
$468 Roundtrip, found 1 day ago
$468
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 16 from Florence to Charlotte, returning Thu, Jul 24, priced at $468 found 1 day ago
American Airlines
Fri, Jul 18 - Fri, Jul 25
FLO
Florence
CLT
Charlotte
$489 Roundtrip, found 1 day ago
$489
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jul 18 from Florence to Charlotte, returning Fri, Jul 25, priced at $489 found 1 day ago
American Airlines
Thu, Sep 11 - Sun, Sep 14
FLO
Florence
CLT
Charlotte
$527 Roundtrip, found 1 day ago
$527
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Sep 11 from Florence to Charlotte, returning Sun, Sep 14, priced at $527 found 1 day ago
American Airlines
Thu, Sep 11 - Sun, Sep 14
FLO
Florence
CLT
Charlotte
$549 Roundtrip, found 1 day ago
$549
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Sep 11 from Florence to Charlotte, returning Sun, Sep 14, priced at $549 found 1 day ago
American Airlines
Thu, Sep 11 - Sun, Sep 14
FLO
Florence
CLT
Charlotte
$577 Roundtrip, found 1 day ago
$577
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Sep 11 from Florence to Charlotte, returning Sun, Sep 14, priced at $577 found 1 day ago
Flights from Florence (FLO) to Charlotte (CLT)
Origin airport
Florence Regional
Destination airport
Charlotte-Douglas Intl.
Airlines serving
American Airlines
Roundtrip price
$367
Distance
99 mi
Average flight time
1 hour 7 mins

Florence to Charlotte Flights

The cheapest times to fly from Florence to Charlotte

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Charlotte are during the month of September. You can find some of the cheapest flights from Florence to Charlotte with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Charlotte

Sunday is one of the best days to book for cheap flights from Florence to Charlotte: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Charlotte

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Charlotte in 2025. You can also book with separate airlines for your outbound and return journeys, from $319 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Charlotte flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Charlotte airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT) cost?
Pick up cheap return flights starting from $489 from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT). This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a American Airlines flight leaving FLO on July 11 2025 and touching down at CLT. The price was last updated on July 5 2025 and has not changed since.
What is the cheapest month to fly from FLO to CLT?
The cheapest flights from FLO to CLT are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
You can fly nonstop from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT) on an American Airlines flight.
What is the cheapest airline that flies from FLO to CLT?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from FLO to CLT. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
Every day on average, 2 direct flights take off from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT). Choose the departure date that best suits your travel plans.
What are the most popular departure times for flights from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
More people fly between FLO and CLT at 6 AM than at any other time of day. Rather go when it's quieter? Pick a flight outside the busiest times and it's possible you'll save on your fare as well.
What day of the week has the most flights from FLO to CLT?
Depart on a Friday if you're looking for the best selection of flights from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT).
What is the earliest flight from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
The earliest flight leaving from Florence Regional Airport (FLO) is at around 6:52AM UTC-5. Catch this flight and you'll land at Charlotte-Douglas Intl. Airport (CLT) at approximately 8:19AM UTC-5. The entire trip takes 1h 27m.
How long does it take to fly from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
It takes about 1 hour and 19 minutes to travel the 100 mi from FLO to CLT.
What airline has the least delays from FLO to CLT?
American Airlines has the best performance for on-time direct flights from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT), with an on-time rating of 81%. Use the Expedia App to view your journey status before you leave and get immediate updates about any changes.
What is the best time to fly from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
To avoid potential delays on the Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT) route, travel before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Charlotte from Florence Regional Airport (FLO)?
If you're boarding a direct flight from Florence Regional Airport (FLO) to Charlotte, Charlotte-Douglas Intl. Airport (CLT) is the only airport you can land at.
Is it cheaper to buy a plane ticket from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT) last-minute?
Waiting until just before your departure to book your flight from FLO to CLT generally means paying more. While you may find some last-minute discounts, there's no guarantee. Keep your travel plans flexible for the best chance of landing a bargain.
Is it cheaper to book a FLO to CLT flight and hotel package?
Compared with arranging flights and hotels separately, booking a FLO to CLT flight and hotel package with Expedia could lead to significant savings. Better still, having it all in one place takes the hassle out of planning your trip. Just pick your flights and select from our extensive range of stays, then personalize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Florence Regional Airport (FLO) to Charlotte-Douglas Intl. Airport (CLT)?
If you booked your FLO to CLT flight in the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

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*Available to One Key members.