$234 Cheap Flights from Florence (FLO) to Tampa (TPA)

View $234 flight on Fri, Dec 5, 2025Opens in a new window

Popular airlines from Florence, SC (FLO-Florence Regional) to Tampa Intl. Airport (TPA)

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Cheap Flights from Florence to Tampa (FLO-TPA)

Prices were available within the past 7 days and start at $234 for one-way flights and $411 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, Jan 12 - Tue, Jan 13
FLO
Florence
TPA
Tampa
$411 Roundtrip, found 2 days ago
$411
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Jan 12 from Florence to Tampa, returning Tue, Jan 13, priced at $411 found 2 days ago
American Airlines
Tue, Nov 4 - Tue, Nov 11
FLO
Florence
TPA
Tampa
$417 Roundtrip, found 3 days ago
$417
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Nov 4 from Florence to Tampa, returning Tue, Nov 11, priced at $417 found 3 days ago
American Airlines
Thu, Jan 15 - Mon, Jan 19
FLO
Florence
TPA
Tampa
$418 Roundtrip, found 2 days ago
$418
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 15 from Florence to Tampa, returning Mon, Jan 19, priced at $418 found 2 days ago
American Airlines
Thu, Jan 15 - Mon, Jan 19
FLO
Florence
TPA
Tampa
$426 Roundtrip, found 2 days ago
$426
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 15 from Florence to Tampa, returning Mon, Jan 19, priced at $426 found 2 days ago
American Airlines
Sat, May 2 - Sun, May 17
FLO
Florence
TPA
Tampa
$431 Roundtrip, found 1 day ago
$431
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, May 2 from Florence to Tampa, returning Sun, May 17, priced at $431 found 1 day ago
American Airlines
Mon, Dec 22 - Fri, Dec 26
FLO
Florence
TPA
Tampa
$435 Roundtrip, just found
$435
Roundtrip
just found
Select American Airlines flight, departing Mon, Dec 22 from Florence to Tampa, returning Fri, Dec 26, priced at $435 just found
American Airlines
Sat, Dec 20 - Wed, Dec 24
FLO
Florence
TPA
Tampa
$447 Roundtrip, just found
$447
Roundtrip
just found
Select American Airlines flight, departing Sat, Dec 20 from Florence to Tampa, returning Wed, Dec 24, priced at $447 just found
American Airlines
Wed, Dec 3 - Sat, Dec 20
FLO
Florence
TPA
Tampa
$452 Roundtrip, found 6 days ago
$452
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Dec 3 from Florence to Tampa, returning Sat, Dec 20, priced at $452 found 6 days ago
American Airlines
Tue, Jan 13 - Wed, Jan 21
FLO
Florence
TPA
Tampa
$454 Roundtrip, found 2 days ago
$454
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Jan 13 from Florence to Tampa, returning Wed, Jan 21, priced at $454 found 2 days ago
American Airlines
Wed, Nov 12 - Tue, Nov 25
FLO
Florence
TPA
Tampa
$457 Roundtrip, found 6 days ago
$457
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Nov 12 from Florence to Tampa, returning Tue, Nov 25, priced at $457 found 6 days ago

Alternative airports near Tampa

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tampa Intl. TPA. Cheapest option available. Average driving time to city center is 10 minutes. Flights from $462
TPA
Tampa Intl.
Cheapest
Average driving time to city center10 min
Flights from $462

Frequently asked questions

How much does a flight from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA) cost?
Secure a cheap one-way flight from $234 or cheap return flight from $411 from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA)?
The cheapest month to fly from FLO to TPA is January, when demand is low. Off-peak months are usually when airlines offer lower prices between these airports.
Which airlines fly direct from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA)?
Direct flights aren't available from Florence, SC (FLO-Florence Regional) to Tampa Intl. Airport (TPA). However, you can find other airports offering nonstop flights. Start your journey at Myrtle Beach Intl. Airport (MYR) and fly straight to Tampa without any detours.
What is the cheapest airline that flies from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA)?
To find the cheapest airline that'll fly you from FLO to TPA, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA)?
There aren't any daily direct flights departing from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA). But you can opt for flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from FLO to TPA?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA)?
Select a flight from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA) that takes off before 3 PM to reduce the risk of cancellations and delays. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA) last-minute?
Waiting until just before your departure to book your flight from FLO to TPA often results in higher prices. While you might find some last-minute deals, there's no guarantee. Allow some flexibility in your schedule to maximize your chances of getting a bargain.
Is it cheaper to book a FLO to TPA flight and hotel package?
You can save money by booking a FLO to TPA flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one convenient place. Once you've chosen your ideal accommodations and flights, consider adding extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA)?
Typically, you can modify or cancel your FLO to TPA flight. However, there may be additional charges, especially if your booking was made more than 24 hours ago. Double-check your itinerary for the airline's fees and guidelines on flight changes, or if you'd like further details, go to our Customer Service portal.

Travel information

Origin airport
Florence Regional
Destination airport
Tampa Intl.
Airlines serving
American Airlines
Roundtrip price
$410
Distance
460 mi

Book with confidence

Florence to Tampa Flights

The cheapest times to fly from Florence to Tampa

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Tampa are during the month of January. You can find some of the cheapest flights from Florence to Tampa with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Tampa

Sunday is one of the best days to book for cheap flights from Florence to Tampa: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Tampa

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Tampa in 2025. You can also book with separate airlines for your outbound and return journeys, from $234 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Tampa flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Tampa airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Florence to Tampa Flights

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