$25 Cheap Flights from La Serena (LSC) to Santiago (SCL)

View $25 flight on Fri, Oct 10, 2025Opens in a new window

Popular airlines from La Serena (LSC-La Florida) to Santiago Intl. Airport (SCL)

Cheap Flights from La Serena to Santiago (LSC-SCL)

Prices were available within the past 7 days and start at $25 for one-way flights and $49 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

SKY AIRLINE
Fri, Sep 5 - Sat, Sep 6
LSC
La Serena
SCL
Santiago
$49 Roundtrip, found 3 hours ago
$49
Roundtrip
found 3 hours ago
Select SKY AIRLINE flight, departing Fri, Sep 5 from La Serena to Santiago, returning Sat, Sep 6, priced at $49 found 3 hours ago
SKY AIRLINE
Fri, Oct 10 - Mon, Oct 13
LSC
La Serena
SCL
Santiago
$56 Roundtrip, just found
$56
Roundtrip
just found
Select SKY AIRLINE flight, departing Fri, Oct 10 from La Serena to Santiago, returning Mon, Oct 13, priced at $56 just found
SKY AIRLINE
Fri, Oct 10 - Mon, Oct 13
LSC
La Serena
SCL
Santiago
$59 Roundtrip, just found
$59
Roundtrip
just found
Select SKY AIRLINE flight, departing Fri, Oct 10 from La Serena to Santiago, returning Mon, Oct 13, priced at $59 just found
SKY AIRLINE
Sat, Aug 2 - Tue, Aug 12
LSC
La Serena
SCL
Santiago
$62 Roundtrip, found 5 days ago
$62
Roundtrip
found 5 days ago
Select SKY AIRLINE flight, departing Sat, Aug 2 from La Serena to Santiago, returning Tue, Aug 12, priced at $62 found 5 days ago
SKY AIRLINE
Fri, Aug 8 - Sat, Aug 23
LSC
La Serena
SCL
Santiago
$64 Roundtrip, found 3 hours ago
$64
Roundtrip
found 3 hours ago
Select SKY AIRLINE flight, departing Fri, Aug 8 from La Serena to Santiago, returning Sat, Aug 23, priced at $64 found 3 hours ago
SKY AIRLINE
Fri, Oct 10 - Mon, Oct 13
LSC
La Serena
SCL
Santiago
$65 Roundtrip, just found
$65
Roundtrip
just found
Select SKY AIRLINE flight, departing Fri, Oct 10 from La Serena to Santiago, returning Mon, Oct 13, priced at $65 just found
SKY AIRLINE
Thu, Aug 14 - Sat, Aug 23
LSC
La Serena
SCL
Santiago
$68 Roundtrip, found 3 hours ago
$68
Roundtrip
found 3 hours ago
Select SKY AIRLINE flight, departing Thu, Aug 14 from La Serena to Santiago, returning Sat, Aug 23, priced at $68 found 3 hours ago
SKY AIRLINE
Fri, Sep 5 - Tue, Sep 16
LSC
La Serena
SCL
Santiago
$70 Roundtrip, found 6 days ago
$70
Roundtrip
found 6 days ago
Select SKY AIRLINE flight, departing Fri, Sep 5 from La Serena to Santiago, returning Tue, Sep 16, priced at $70 found 6 days ago
Jetsmart SPA
Fri, Oct 10 - Mon, Oct 13
LSC
La Serena
SCL
Santiago
$71 Roundtrip, just found
$71
Roundtrip
just found
Select Jetsmart SPA flight, departing Fri, Oct 10 from La Serena to Santiago, returning Mon, Oct 13, priced at $71 just found
LATAM Airlines Group
Fri, Oct 10 - Mon, Oct 13
LSC
La Serena
SCL
Santiago
$78 Roundtrip, just found
$78
Roundtrip
just found
Select LATAM Airlines Group flight, departing Fri, Oct 10 from La Serena to Santiago, returning Mon, Oct 13, priced at $78 just found

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $64
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $64
0
Flights from La Serena (LSC) to Santiago (SCL)
Origin airport
La Florida
Destination airport
Arturo Merino Benitez
Airlines serving
LATAM Airlines Group, SKY AIRLINE
Roundtrip price
$49
Distance
241 mi

La Serena to Santiago Flights

The cheapest times to fly from La Serena to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from La Serena to Santiago are during the month of September. You can find some of the cheapest flights from La Serena to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from La Serena to Santiago

Sunday is one of the best days to book for cheap flights from La Serena to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from La Serena to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from La Serena to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $25 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap La Serena to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your La Serena to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL) cost?
Snag cheap return fares starting from $61 from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL). This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Sky Airlines flight leaving LSC on July 28 2025 and touching down at SCL. The price was last updated on July 23 2025 and has not changed since.
What is the cheapest month to fly from LSC to SCL?
The cheapest flights from LSC to SCL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL)?
Take your pick of 3 airlines that operate direct flights from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL). Including:

  • LATAM Airlines
  • Sky Airline
  • JetSMART

What is the cheapest airline that flies from LSC to SCL?
With tickets starting at $31 for a one-way journey from LSC to SCL, Sky Airlines is currently the cheapest carrier operating this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from LSC on August 9 2025. Prices were last updated on July 23 2025 and have not changed since.
How many flights per day from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL)?
When flying out of La Florida Airport (LSC), you can pick from an average of 9 daily nonstop flights to Arturo Merino Benitez Airport (SCL).
What are the most popular departure times for flights from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL)?
Flights between LSC and SCL are their busiest at 2 PM. If you want a more relaxed atmosphere and potentially cheaper prices, choose a time outside the usual busy windows.
What day of the week has the most flights from LSC to SCL?
Jet off on a Monday if you're after the biggest selection of flights from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL).
What is the earliest flight from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL)?
Hop on the earliest flight at around 9:32AM UTC-3, leaving from La Florida Airport (LSC). You'll be in the air for around 55m, arriving at Arturo Merino Benitez Airport (SCL) at approximately 10:27AM UTC-3.
How long does it take to fly from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL)?
Flights from LSC to SCL have an average travel time of 56 minutes. The total distance between these two airports is 240 mi.
What is the best time to fly from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL)?
To avoid possible delays on the La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL) route, aim to fly before 3 PM. Departures after this hour have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santiago from La Florida Airport (LSC)?
Explore your flight options from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL). This is the only airport in Santiago you can jet into if you're taking a direct flight.
Is it cheaper to buy a plane ticket from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL) last-minute?
Booking your plane ticket from LSC to SCL just before your journey is generally more expensive. However, if you're flexible with your departure dates and times, you could land a cheap last-minute fare.
Is it cheaper to book a LSC to SCL flight and hotel package?
You'll typically save money by booking a LSC to SCL flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. Once you've chosen your preferred flights and accommodations, consider adding extras including tours, activities and car rentals.
Can I cancel or change the date of my flight from La Florida Airport (LSC) to Arturo Merino Benitez Airport (SCL)?
If you booked your LSC to SCL flight in the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Explore a world of travel with Expedia

*Available to One Key members.