$375 Cheap Flights from La Crosse (LSE) to Harrisburg (MDT)

View $375 flight on Tue, Dec 2, 2025Opens in a new window

Popular airlines from La Crosse, WI (LSE-La Crosse Municipal) to Harrisburg Intl. Airport (MDT)

Cheap Flights from La Crosse to Harrisburg (LSE-MDT)

Prices were available within the past 7 days and start at $375 for one-way flights and $472 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Dec 2 - Sat, Dec 6
LSE
La Crosse
MDT
Harrisburg
$472 Roundtrip, found 6 days ago
$472
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Dec 2 from La Crosse to Harrisburg, returning Sat, Dec 6, priced at $472 found 6 days ago
American Airlines
Thu, Oct 16 - Sat, Oct 18
LSE
La Crosse
MDT
Harrisburg
$484 Roundtrip, found 7 hours ago
$484
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Thu, Oct 16 from La Crosse to Harrisburg, returning Sat, Oct 18, priced at $484 found 7 hours ago
American Airlines
Fri, Oct 31 - Wed, Nov 5
LSE
La Crosse
MDT
Harrisburg
$487 Roundtrip, found 15 hours ago
$487
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Fri, Oct 31 from La Crosse to Harrisburg, returning Wed, Nov 5, priced at $487 found 15 hours ago
American Airlines
Sat, Oct 18 - Wed, Oct 22
LSE
La Crosse
MDT
Harrisburg
$502 Roundtrip, found 13 hours ago
$502
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Sat, Oct 18 from La Crosse to Harrisburg, returning Wed, Oct 22, priced at $502 found 13 hours ago
American Airlines
Mon, Dec 22 - Mon, Dec 29
LSE
La Crosse
MDT
Harrisburg
$507 Roundtrip, found 3 days ago
$507
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Dec 22 from La Crosse to Harrisburg, returning Mon, Dec 29, priced at $507 found 3 days ago
American Airlines
Tue, Dec 2 - Sun, Dec 7
LSE
La Crosse
MDT
Harrisburg
$510 Roundtrip, found 6 days ago
$510
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Dec 2 from La Crosse to Harrisburg, returning Sun, Dec 7, priced at $510 found 6 days ago
American Airlines
Wed, Nov 26 - Thu, Nov 27
LSE
La Crosse
MDT
Harrisburg
$516 Roundtrip, found 6 days ago
$516
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Nov 26 from La Crosse to Harrisburg, returning Thu, Nov 27, priced at $516 found 6 days ago
American Airlines
Wed, Nov 26 - Sat, Dec 6
LSE
La Crosse
MDT
Harrisburg
$522 Roundtrip, found 6 days ago
$522
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Nov 26 from La Crosse to Harrisburg, returning Sat, Dec 6, priced at $522 found 6 days ago
American Airlines
Fri, Oct 31 - Thu, Nov 6
LSE
La Crosse
MDT
Harrisburg
$525 Roundtrip, found 15 hours ago
$525
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Fri, Oct 31 from La Crosse to Harrisburg, returning Thu, Nov 6, priced at $525 found 15 hours ago
American Airlines
Fri, Oct 31 - Sat, Nov 8
LSE
La Crosse
MDT
Harrisburg
$528 Roundtrip, found 15 hours ago
$528
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Fri, Oct 31 from La Crosse to Harrisburg, returning Sat, Nov 8, priced at $528 found 15 hours ago

Frequently asked questions

How much does a flight from La Crosse Municipal Airport (LSE) to Harrisburg Intl. Airport (MDT) cost?
Get a cheap one-way flight from $375 or cheap return flight from $472 from La Crosse Municipal Airport (LSE) to Harrisburg Intl. Airport (MDT) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from La Crosse Municipal Airport (LSE) to Harrisburg Intl. Airport (MDT)?
The cheapest month to fly from LSE to MDT is December, when there's less demand. Off-peak season is often when airlines offer better prices between these airports.
What is the cheapest airline that flies from La Crosse Municipal Airport (LSE) to Harrisburg Intl. Airport (MDT)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest LSE to MDT flight.
How many flights per day from La Crosse Municipal Airport (LSE) to Harrisburg Intl. Airport (MDT)?
You'll have to book a flight with a layover when traveling from La Crosse Municipal Airport (LSE) to Harrisburg Intl. Airport (MDT). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from LSE to MDT?
Typically you'll have the most choice when it comes to flights on a Friday. Tuesdays tend to be the quietest.* But this can change depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from La Crosse Municipal Airport (LSE) to Harrisburg Intl. Airport (MDT)?
To avoid possible delays on the La Crosse Municipal Airport (LSE) to Harrisburg Intl. Airport (MDT) route, fly before 3 PM. Later flights are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from La Crosse Municipal Airport (LSE) to Harrisburg Intl. Airport (MDT) last-minute?
Last-minute bookings from LSE to MDT are generally more expensive. To secure the lowest rates, start searching for flights as early as possible. That being said, if you're flexible with your travel dates, it's possible to find a cheap fare right before you leave.
Is it cheaper to book a LSE to MDT flight and hotel package?
Booking a LSE to MDT flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Choose from our wide range of hotels and then add activities, flights and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from La Crosse Municipal Airport (LSE) to Harrisburg Intl. Airport (MDT)?
In most instances, you can modify or cancel your LSE to MDT flight. However, additional fees may apply, especially if your booking was made more than 24 hours ago. Double-check your itinerary for the airline's fees and policies on flight changes, or if you need more details, visit our Customer Service portal.

Travel information

Origin airport
La Crosse Municipal
Destination airport
Harrisburg Intl.
Airlines serving
American Airlines
Roundtrip price
$472
Distance
785 mi

Book with confidence

La Crosse to Harrisburg Flights

The cheapest times to fly from La Crosse to Harrisburg

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from La Crosse to Harrisburg are during the month of December. You can find some of the cheapest flights from La Crosse to Harrisburg with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from La Crosse to Harrisburg

Sunday is one of the best days to book for cheap flights from La Crosse to Harrisburg: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from La Crosse to Harrisburg

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from La Crosse to Harrisburg in 2025. You can also book with separate airlines for your outbound and return journeys, from $375 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap La Crosse to Harrisburg flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your La Crosse to Harrisburg airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

La Crosse to Harrisburg Flights

Explore a world of travel with Expedia

*Available to One Key members.