$298 Cheap Flights from La Crosse (LSE) to Minneapolis (MSP)

View $298 flight on Wed, Dec 24, 2025Opens in a new window

Popular airlines from La Crosse, WI (LSE-La Crosse Municipal) to Minneapolis - St. Paul Intl. Airport (MSP)

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Cheap Flights from La Crosse to Minneapolis (LSE-MSP)

Prices were available within the past 7 days and start at $298 for one-way flights and $493 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Jan 22 - Mon, Jan 26
LSE
La Crosse
MSP
Minneapolis
$493 Roundtrip, found 5 days ago
$493
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Jan 22 from La Crosse to Minneapolis, returning Mon, Jan 26, priced at $493 found 5 days ago
American Airlines
Thu, Nov 27 - Mon, Dec 1
LSE
La Crosse
MSP
Minneapolis
$539 Roundtrip, found 5 days ago
$539
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Nov 27 from La Crosse to Minneapolis, returning Mon, Dec 1, priced at $539 found 5 days ago
American Airlines
Thu, Nov 27 - Tue, Dec 9
LSE
La Crosse
MSP
Minneapolis
$540 Roundtrip, found 2 days ago
$540
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Nov 27 from La Crosse to Minneapolis, returning Tue, Dec 9, priced at $540 found 2 days ago
American Airlines
Mon, Dec 1 - Tue, Dec 9
LSE
La Crosse
MSP
Minneapolis
$552 Roundtrip, found 4 days ago
$552
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Dec 1 from La Crosse to Minneapolis, returning Tue, Dec 9, priced at $552 found 4 days ago
American Airlines
Sat, Jan 17 - Wed, Jan 28
LSE
La Crosse
MSP
Minneapolis
$555 Roundtrip, found 4 days ago
$555
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Jan 17 from La Crosse to Minneapolis, returning Wed, Jan 28, priced at $555 found 4 days ago
American Airlines
Thu, Nov 27 - Tue, Dec 9
LSE
La Crosse
MSP
Minneapolis
$560 Roundtrip, found 5 days ago
$560
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Nov 27 from La Crosse to Minneapolis, returning Tue, Dec 9, priced at $560 found 5 days ago
American Airlines
Sat, Dec 13 - Sun, Jan 11
LSE
La Crosse
MSP
Minneapolis
$569 Roundtrip, found 15 hours ago
$569
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Sat, Dec 13 from La Crosse to Minneapolis, returning Sun, Jan 11, priced at $569 found 15 hours ago
American Airlines
Tue, Mar 17 - Tue, Mar 24
LSE
La Crosse
MSP
Minneapolis
$571 Roundtrip, found 20 hours ago
$571
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Tue, Mar 17 from La Crosse to Minneapolis, returning Tue, Mar 24, priced at $571 found 20 hours ago
American Airlines
Fri, Dec 5 - Mon, Dec 8
LSE
La Crosse
MSP
Minneapolis
$572 Roundtrip, found 3 days ago
$572
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Dec 5 from La Crosse to Minneapolis, returning Mon, Dec 8, priced at $572 found 3 days ago
American Airlines
Wed, Dec 3 - Tue, Dec 9
LSE
La Crosse
MSP
Minneapolis
$573 Roundtrip, found 3 days ago
$573
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Dec 3 from La Crosse to Minneapolis, returning Tue, Dec 9, priced at $573 found 3 days ago

Frequently asked questions

How much does a flight from La Crosse Municipal Airport (LSE) to Minneapolis - St. Paul Intl. Airport (MSP) cost?
Snag a cheap one-way flight from $298 or cheap return flight from $493 from La Crosse Municipal Airport (LSE) to Minneapolis - St. Paul Intl. Airport (MSP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from La Crosse Municipal Airport (LSE) to Minneapolis - St. Paul Intl. Airport (MSP)?
January is the cheapest month to fly from LSE to MSP. Traveling during an off-peak travel window is often the key to finding better fares.
What is the cheapest airline that flies from La Crosse Municipal Airport (LSE) to Minneapolis - St. Paul Intl. Airport (MSP)?
To find the cheapest airline flying from LSE to MSP, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from La Crosse Municipal Airport (LSE) to Minneapolis - St. Paul Intl. Airport (MSP)?
There aren't any daily direct flights departing from La Crosse Municipal Airport (LSE) to Minneapolis - St. Paul Intl. Airport (MSP). But you can choose flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be on your way in no time at all.
What day of the week has the most flights from LSE to MSP?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary based on a number of factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from La Crosse Municipal Airport (LSE) to Minneapolis - St. Paul Intl. Airport (MSP)?
To avoid possible delays on the La Crosse Municipal Airport (LSE) to Minneapolis - St. Paul Intl. Airport (MSP) route, aim to travel before 3 PM. Departures after this hour have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from La Crosse Municipal Airport (LSE) to Minneapolis - St. Paul Intl. Airport (MSP) last-minute?
Last-minute bookings from LSE to MSP are usually more expensive. To secure the best prices, start searching for flights as soon as possible. That being said, if you can play around with your travel dates, you may land a cheap fare right before your trip.
Is it cheaper to book a LSE to MSP flight and hotel package?
Booking a LSE to MSP flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Select from our wide range of accommodations and then add flights, car rentals and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from La Crosse Municipal Airport (LSE) to Minneapolis - St. Paul Intl. Airport (MSP)?
If you reserved your LSE to MSP flight in the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for further details.

Travel information

Origin airport
La Crosse Municipal
Destination airport
Minneapolis - St. Paul Intl.
Airlines serving
American Airlines
Roundtrip price
$492
Distance
118 mi

Book with confidence

La Crosse to Minneapolis Flights

The cheapest times to fly from La Crosse to Minneapolis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from La Crosse to Minneapolis are during the month of January. You can find some of the cheapest flights from La Crosse to Minneapolis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from La Crosse to Minneapolis

Sunday is one of the best days to book for cheap flights from La Crosse to Minneapolis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from La Crosse to Minneapolis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from La Crosse to Minneapolis in 2025. You can also book with separate airlines for your outbound and return journeys, from $298 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap La Crosse to Minneapolis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your La Crosse to Minneapolis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

La Crosse to Minneapolis Flights

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*Available to One Key members.