$551 Cheap Flights from Chicago (MDW) to La Serena (LSC)

View $551 flight on Tue, Jan 6, 2026Opens in a new window

Popular airlines from Chicago Midway Airport (MDW) to La Serena (LSC-La Florida)

Cheap Flights from Chicago to La Serena (MDW-LSC)

Prices were available within the past 7 days and start at $551 for one-way flights and $1,141 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Jan 6 - Thu, Jan 22
MDW
Chicago
LSC
La Serena
$1,141 Roundtrip, found 2 days ago
$1,141
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Jan 6 from Chicago to La Serena, returning Thu, Jan 22, priced at $1,141 found 2 days ago
LATAM Airlines Group
Tue, Jan 13 - Tue, Jan 27
MDW
Chicago
LSC
La Serena
$1,236 Roundtrip, found 3 days ago
$1,236
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Tue, Jan 13 from Chicago to La Serena, returning Tue, Jan 27, priced at $1,236 found 3 days ago
Delta
Tue, Jan 6 - Thu, Jan 22
MDW
Chicago
LSC
La Serena
$1,351 Roundtrip, found 2 days ago
$1,351
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Jan 6 from Chicago to La Serena, returning Thu, Jan 22, priced at $1,351 found 2 days ago
LATAM Airlines Group
Tue, Jan 13 - Tue, Jan 27
MDW
Chicago
LSC
La Serena
$1,446 Roundtrip, found 3 days ago
$1,446
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Tue, Jan 13 from Chicago to La Serena, returning Tue, Jan 27, priced at $1,446 found 3 days ago
Delta
Tue, Jan 13 - Tue, Jan 27
MDW
Chicago
LSC
La Serena
$1,484 Roundtrip, found 3 days ago
$1,484
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Jan 13 from Chicago to La Serena, returning Tue, Jan 27, priced at $1,484 found 3 days ago
Delta
Tue, Jan 6 - Thu, Jan 22
MDW
Chicago
LSC
La Serena
$1,531 Roundtrip, found 2 days ago
$1,531
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Jan 6 from Chicago to La Serena, returning Thu, Jan 22, priced at $1,531 found 2 days ago
LATAM Airlines Group
Tue, Jan 13 - Tue, Jan 27
MDW
Chicago
LSC
La Serena
$1,626 Roundtrip, found 3 days ago
$1,626
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Tue, Jan 13 from Chicago to La Serena, returning Tue, Jan 27, priced at $1,626 found 3 days ago
Delta
Tue, Jan 13 - Tue, Jan 27
MDW
Chicago
LSC
La Serena
$1,694 Roundtrip, found 3 days ago
$1,694
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Jan 13 from Chicago to La Serena, returning Tue, Jan 27, priced at $1,694 found 3 days ago
Delta
Tue, Jan 13 - Tue, Jan 27
MDW
Chicago
LSC
La Serena
$1,939 Roundtrip, found 3 days ago
$1,939
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Jan 13 from Chicago to La Serena, returning Tue, Jan 27, priced at $1,939 found 3 days ago
LATAM Airlines Group
Sat, Nov 22 - Wed, Nov 26
MDW
Chicago
LSC
La Serena
$2,351 Roundtrip, found 2 days ago
$2,351
Roundtrip
found 2 days ago
Select LATAM Airlines Group flight, departing Sat, Nov 22 from Chicago to La Serena, returning Wed, Nov 26, priced at $2,351 found 2 days ago

Frequently asked questions

How much does a flight from Midway Intl. Airport (MDW) to La Florida Airport (LSC) cost?
Secure a cheap one-way flight from $551 or cheap return flight from $1,141 from Midway Intl. Airport (MDW) to La Florida Airport (LSC) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Midway Intl. Airport (MDW) to La Florida Airport (LSC)?
The cheapest month to fly from MDW to LSC is January, when demand is low. Off-peak months are usually when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Midway Intl. Airport (MDW) to La Florida Airport (LSC)?
Use the filter tool on Expedia to compare airlines and find the most affordable carrier that'll fly you from MDW to LSC. Then, sort your results by "Price (lowest to highest)" to score a great deal.
How many flights per day from Midway Intl. Airport (MDW) to La Florida Airport (LSC)?
Direct flights from Midway Intl. Airport (MDW) to La Florida Airport (LSC) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MDW to LSC?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Midway Intl. Airport (MDW) to La Florida Airport (LSC)?
To avoid possible delays on the Midway Intl. Airport (MDW) to La Florida Airport (LSC) route, fly before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Midway Intl. Airport (MDW) to La Florida Airport (LSC) last-minute?
Last-minute bookings from MDW to LSC are generally more expensive. To secure the lowest prices, start searching for flights well in advance. That said, if you're flexible with your travel plans, you may score a cheap ticket right before you leave.
Is it cheaper to book a MDW to LSC flight and hotel package?
Compared with arranging flights and hotels separately, booking a MDW to LSC flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one place takes the hassle out of travel planning. Just secure your flights and choose from our wide range of stays, then tailor your trip with other add-ons like car rentals and activities.
Can I cancel or change the date of my flight from Midway Intl. Airport (MDW) to La Florida Airport (LSC)?
You can usually cancel or reschedule your MDW to LSC flight. However, for bookings made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Origin airport
Midway Intl.
Destination airport
La Florida
Roundtrip price
$1,140
Distance
5065 mi

Book with confidence

Chicago to La Serena Flights

The cheapest times to fly from Chicago to La Serena

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Chicago to La Serena are during the month of January. You can find some of the cheapest flights from Chicago to La Serena with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Chicago to La Serena

Sunday is one of the best days to book for cheap flights from Chicago to La Serena: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Chicago to La Serena

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Chicago to La Serena in 2025. You can also book with separate airlines for your outbound and return journeys, from $551 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Chicago to La Serena flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Chicago to La Serena airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Chicago to La Serena Flights

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*Available to One Key members.