$143 Cheap Flights from Mendoza (MDZ) to La Serena (LSC)

View $143 flight on Tue, Nov 11, 2025Opens in a new window

Popular airlines from Mendoza (MDZ-Governor Francisco Gabrielli Intl.) to La Serena (LSC-La Florida)

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Cheap Flights from Mendoza to La Serena (MDZ-LSC)

Prices were available within the past 7 days and start at $143 for one-way flights and $236 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

SKY AIRLINE
Tue, Nov 25 - Wed, Dec 10
MDZ
Mendoza
LSC
La Serena
$236 Roundtrip, found 4 days ago
$236
Roundtrip
found 4 days ago
Select SKY AIRLINE flight, departing Tue, Nov 25 from Mendoza to La Serena, returning Wed, Dec 10, priced at $236 found 4 days ago
SKY AIRLINE
Tue, Nov 25 - Mon, Dec 8
MDZ
Mendoza
LSC
La Serena
$242 Roundtrip, found 4 days ago
$242
Roundtrip
found 4 days ago
Select SKY AIRLINE flight, departing Tue, Nov 25 from Mendoza to La Serena, returning Mon, Dec 8, priced at $242 found 4 days ago
LATAM Airlines Group
Sat, Nov 22 - Sun, Dec 7
MDZ
Mendoza
LSC
La Serena
$250 Roundtrip, found 4 days ago
$250
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Sat, Nov 22 from Mendoza to La Serena, returning Sun, Dec 7, priced at $250 found 4 days ago
SKY AIRLINE
Thu, Nov 20 - Wed, Dec 3
MDZ
Mendoza
LSC
La Serena
$252 Roundtrip, found 4 days ago
$252
Roundtrip
found 4 days ago
Select SKY AIRLINE flight, departing Thu, Nov 20 from Mendoza to La Serena, returning Wed, Dec 3, priced at $252 found 4 days ago
LATAM Airlines Group
Fri, Nov 21 - Sat, Dec 6
MDZ
Mendoza
LSC
La Serena
$257 Roundtrip, found 4 days ago
$257
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Fri, Nov 21 from Mendoza to La Serena, returning Sat, Dec 6, priced at $257 found 4 days ago
SKY AIRLINE
Fri, Nov 21 - Wed, Dec 10
MDZ
Mendoza
LSC
La Serena
$262 Roundtrip, found 4 days ago
$262
Roundtrip
found 4 days ago
Select SKY AIRLINE flight, departing Fri, Nov 21 from Mendoza to La Serena, returning Wed, Dec 10, priced at $262 found 4 days ago
LATAM Airlines Group
Tue, Nov 25 - Sun, Dec 7
MDZ
Mendoza
LSC
La Serena
$265 Roundtrip, found 4 days ago
$265
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Tue, Nov 25 from Mendoza to La Serena, returning Sun, Dec 7, priced at $265 found 4 days ago
LATAM Airlines Group
Thu, Dec 25 - Fri, Jan 2
MDZ
Mendoza
LSC
La Serena
$265 Roundtrip, found 1 day ago
$265
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Thu, Dec 25 from Mendoza to La Serena, returning Fri, Jan 2, priced at $265 found 1 day ago
SKY AIRLINE
Fri, Nov 21 - Mon, Dec 8
MDZ
Mendoza
LSC
La Serena
$268 Roundtrip, found 4 days ago
$268
Roundtrip
found 4 days ago
Select SKY AIRLINE flight, departing Fri, Nov 21 from Mendoza to La Serena, returning Mon, Dec 8, priced at $268 found 4 days ago
Jetsmart SPA
Thu, Nov 13 - Sat, Nov 22
MDZ
Mendoza
LSC
La Serena
$273 Roundtrip, found 4 days ago
$273
Roundtrip
found 4 days ago
Select Jetsmart SPA flight, departing Thu, Nov 13 from Mendoza to La Serena, returning Sat, Nov 22, priced at $273 found 4 days ago

Alternative airports near La Serena

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to La Florida LSC. Cheapest and Closest option available. Average driving time to city center is 7 minutes. Flights from $235
LSC
La Florida
CheapestClosest
Average driving time to city center7 min
Flights from $235

Frequently asked questions

How much does a flight from Governor Francisco Gabrielli Intl. Airport (MDZ) to La Florida Airport (LSC) cost?
Snag a cheap one-way flight from $143 or cheap return flight from $236 from Governor Francisco Gabrielli Intl. Airport (MDZ) to La Florida Airport (LSC) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Governor Francisco Gabrielli Intl. Airport (MDZ) to La Florida Airport (LSC)?
The cheapest month to fly from MDZ to LSC is November, when there's less demand. Off-peak season is often when airlines offer better prices between these airports.
What is the cheapest airline that flies from Governor Francisco Gabrielli Intl. Airport (MDZ) to La Florida Airport (LSC)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest MDZ to LSC flight.
How many flights per day from Governor Francisco Gabrielli Intl. Airport (MDZ) to La Florida Airport (LSC)?
There aren't any daily nonstop flights available from Governor Francisco Gabrielli Intl. Airport (MDZ) to La Florida Airport (LSC). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be cruising above the clouds before you know it.
What day of the week has the most flights from MDZ to LSC?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can change based on a number of factors, including the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Governor Francisco Gabrielli Intl. Airport (MDZ) to La Florida Airport (LSC)?
To avoid potential delays on the Governor Francisco Gabrielli Intl. Airport (MDZ) to La Florida Airport (LSC) route, travel before 3 PM. Departures after this hour are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Governor Francisco Gabrielli Intl. Airport (MDZ) to La Florida Airport (LSC) last-minute?
Booking your plane ticket from MDZ to LSC shortly before your getaway is typically more expensive. However, if there's some wiggle room with your itinerary, you could score a cheap last-minute fare.
Is it cheaper to book a MDZ to LSC flight and hotel package?
Compared with arranging flights and hotels separately, booking a MDZ to LSC flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one place will take the stress out of planning your trip. Just secure your flights and choose from our extensive range of stays, then personalize your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Governor Francisco Gabrielli Intl. Airport (MDZ) to La Florida Airport (LSC)?
If you reserved your MDZ to LSC flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for further details.

Travel information

Origin airport
Governor Francisco Gabrielli Intl.
Destination airport
La Florida
Roundtrip price
$235
Distance
246 mi

Book with confidence

Mendoza to La Serena Flights

The cheapest times to fly from Mendoza to La Serena

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mendoza to La Serena are during the month of November. You can find some of the cheapest flights from Mendoza to La Serena with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mendoza to La Serena

Sunday is one of the best days to book for cheap flights from Mendoza to La Serena: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mendoza to La Serena

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mendoza to La Serena in 2025. You can also book with separate airlines for your outbound and return journeys, from $143 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mendoza to La Serena flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mendoza to La Serena airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Mendoza to La Serena Flights

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*Available to One Key members.