$254 Cheap Flights from Myrtle Beach (MYR) to Santa Fe (SAF)

View $254 flight on Thu, Dec 25, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Santa Fe Municipal Airport (SAF)

Cheap Flights from Myrtle Beach to Santa Fe (MYR-SAF)

Prices were available within the past 7 days and start at $254 for one-way flights and $374 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Nov 1 - Tue, Nov 18
MYR
Myrtle Beach
SAF
Santa Fe
$374 Roundtrip, found 2 days ago
$374
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Nov 1 from Myrtle Beach to Santa Fe, returning Tue, Nov 18, priced at $374 found 2 days ago
American Airlines
Tue, Apr 21 - Sat, May 2
MYR
Myrtle Beach
SAF
Santa Fe
$384 Roundtrip, found 2 days ago
$384
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Apr 21 from Myrtle Beach to Santa Fe, returning Sat, May 2, priced at $384 found 2 days ago
American Airlines
Wed, Jan 21 - Tue, Jan 27
MYR
Myrtle Beach
SAF
Santa Fe
$389 Roundtrip, found 3 days ago
$389
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jan 21 from Myrtle Beach to Santa Fe, returning Tue, Jan 27, priced at $389 found 3 days ago
American Airlines
Fri, Jan 23 - Sun, Jan 25
MYR
Myrtle Beach
SAF
Santa Fe
$428 Roundtrip, found 1 day ago
$428
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jan 23 from Myrtle Beach to Santa Fe, returning Sun, Jan 25, priced at $428 found 1 day ago
American Airlines
Sat, Nov 1 - Sat, Nov 15
MYR
Myrtle Beach
SAF
Santa Fe
$465 Roundtrip, found 2 days ago
$465
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Nov 1 from Myrtle Beach to Santa Fe, returning Sat, Nov 15, priced at $465 found 2 days ago
American Airlines
Thu, Dec 4 - Mon, Dec 15
MYR
Myrtle Beach
SAF
Santa Fe
$474 Roundtrip, found 2 days ago
$474
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Dec 4 from Myrtle Beach to Santa Fe, returning Mon, Dec 15, priced at $474 found 2 days ago
American Airlines
Thu, Apr 30 - Tue, May 5
MYR
Myrtle Beach
SAF
Santa Fe
$475 Roundtrip, found 2 days ago
$475
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Apr 30 from Myrtle Beach to Santa Fe, returning Tue, May 5, priced at $475 found 2 days ago
American Airlines
Fri, Oct 31 - Wed, Nov 19
MYR
Myrtle Beach
SAF
Santa Fe
$480 Roundtrip, found 2 days ago
$480
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Oct 31 from Myrtle Beach to Santa Fe, returning Wed, Nov 19, priced at $480 found 2 days ago
American Airlines
Fri, Jan 23 - Sun, Jan 25
MYR
Myrtle Beach
SAF
Santa Fe
$480 Roundtrip, found 1 day ago
$480
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jan 23 from Myrtle Beach to Santa Fe, returning Sun, Jan 25, priced at $480 found 1 day ago
United
Sat, Oct 25 - Tue, Nov 11
MYR
Myrtle Beach
SAF
Santa Fe
$498 Roundtrip, found 2 days ago
$498
Roundtrip
found 2 days ago
Select United flight, departing Sat, Oct 25 from Myrtle Beach to Santa Fe, returning Tue, Nov 11, priced at $498 found 2 days ago

Alternative airports near Santa Fe

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Santa Fe Municipal SAF. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $500
SAF
Santa Fe Municipal
CheapestClosest
Average driving time to city center17 min
Flights from $500

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Santa Fe Municipal Airport (SAF) cost?
Lock in a cheap one-way flight from $254 or cheap return flight from $374 from Myrtle Beach Intl. Airport (MYR) to Santa Fe Municipal Airport (SAF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Santa Fe Municipal Airport (SAF)?
November is the most affordable month to fly from MYR to SAF. Avoiding peak travel times is often the key to finding better fares.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Santa Fe Municipal Airport (SAF)?
Use the filters on Expedia to compare airlines and find the most affordable carrier that'll fly you from MYR to SAF. Then, sort your results by "Price (lowest to highest)" to snap up a good deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Santa Fe Municipal Airport (SAF)?
There aren't any daily nonstop flights available from Myrtle Beach Intl. Airport (MYR) to Santa Fe Municipal Airport (SAF). But you can choose flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be on your way in no time.
What day of the week has the most flights from MYR to SAF?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change depending on a number of factors, including the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Santa Fe Municipal Airport (SAF)?
Book a flight from Myrtle Beach Intl. Airport (MYR) to Santa Fe Municipal Airport (SAF) that takes off before 3 PM to reduce the risk of cancellations. Departures after this hour are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Santa Fe Municipal Airport (SAF) last-minute?
Waiting until just before your trip to book a ticket from MYR to SAF generally means paying more. While it's possible to find some last-minute discounts, there's no guarantee. Keep your travel schedule open for the best chance of getting a bargain.
Is it cheaper to book a MYR to SAF flight and hotel package?
Opting for a MYR to SAF flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Select from our impressive range of stays and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Santa Fe Municipal Airport (SAF)?
If you reserved your MYR to SAF flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more details.

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Santa Fe Municipal
Airlines serving
American Airlines, United
Roundtrip price
$374
Distance
1544 mi

Book with confidence

Myrtle Beach to Santa Fe Flights

The cheapest times to fly from Myrtle Beach to Santa Fe

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Santa Fe are during the month of November. You can find some of the cheapest flights from Myrtle Beach to Santa Fe with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Santa Fe

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Santa Fe: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Santa Fe

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Santa Fe in 2025. You can also book with separate airlines for your outbound and return journeys, from $254 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Santa Fe flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Santa Fe airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Santa Fe Flights

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*Available to One Key members.