$184 Cheap Flights from Myrtle Beach (MYR) to Santiago (STI)

View $184 flight on Tue, Jul 29, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI)

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • one key icon

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Myrtle Beach to Santiago (MYR-STI)

Prices were available within the past 7 days and start at $184 for one-way flights and $452 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Wed, Oct 8 - Sat, Oct 11
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$452 Roundtrip, found 18 hours ago
$452
Roundtrip
found 18 hours ago
Select Spirit Airlines flight, departing Wed, Oct 8 from Myrtle Beach to Santiago de los Caballeros, returning Sat, Oct 11, priced at $452 found 18 hours ago
Spirit Airlines
Wed, Oct 8 - Sat, Oct 11
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$502 Roundtrip, found 1 day ago
$502
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Wed, Oct 8 from Myrtle Beach to Santiago de los Caballeros, returning Sat, Oct 11, priced at $502 found 1 day ago
American Airlines
Sat, Aug 2 - Wed, Aug 6
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$513 Roundtrip, found 14 hours ago
$513
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Sat, Aug 2 from Myrtle Beach to Santiago de los Caballeros, returning Wed, Aug 6, priced at $513 found 14 hours ago
United
Wed, Oct 8 - Sat, Oct 11
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$515 Roundtrip, found 1 day ago
$515
Roundtrip
found 1 day ago
Select United flight, departing Wed, Oct 8 from Myrtle Beach to Santiago de los Caballeros, returning Sat, Oct 11, priced at $515 found 1 day ago
American Airlines
Wed, Jul 23 - Wed, Jul 30
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$517 Roundtrip, found 1 day ago
$517
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 23 from Myrtle Beach to Santiago de los Caballeros, returning Wed, Jul 30, priced at $517 found 1 day ago
Spirit Airlines
Fri, Oct 10 - Mon, Oct 13
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$517 Roundtrip, found 3 days ago
$517
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Fri, Oct 10 from Myrtle Beach to Santiago de los Caballeros, returning Mon, Oct 13, priced at $517 found 3 days ago
Delta
Wed, Oct 8 - Sat, Oct 11
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$519 Roundtrip, found 1 day ago
$519
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Oct 8 from Myrtle Beach to Santiago de los Caballeros, returning Sat, Oct 11, priced at $519 found 1 day ago
American Airlines
Wed, Oct 8 - Sat, Oct 11
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$519 Roundtrip, found 1 day ago
$519
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 8 from Myrtle Beach to Santiago de los Caballeros, returning Sat, Oct 11, priced at $519 found 1 day ago
American Airlines
Sat, Aug 2 - Wed, Aug 6
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$521 Roundtrip, found 14 hours ago
$521
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Sat, Aug 2 from Myrtle Beach to Santiago de los Caballeros, returning Wed, Aug 6, priced at $521 found 14 hours ago
American Airlines
Wed, Jul 23 - Wed, Jul 30
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$522 Roundtrip, found 1 day ago
$522
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 23 from Myrtle Beach to Santiago de los Caballeros, returning Wed, Jul 30, priced at $522 found 1 day ago
Flights from Myrtle Beach (MYR) to Santiago (STI)
Origin airport
Myrtle Beach Intl.
Destination airport
Cibao Intl.
Airlines serving
American Airlines, Delta, Spirit Airlines, United
Roundtrip price
$452
Distance
1111 mi

Myrtle Beach to Santiago Flights

The cheapest times to fly from Myrtle Beach to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Santiago are during the month of October. You can find some of the cheapest flights from Myrtle Beach to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Santiago

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $184 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI) cost?
Discover the latest flight deals from MYR to STI by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MYR to STI?
The cheapest flights from MYR to STI are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MYR to STI?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from MYR to STI. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI)?
There aren't any daily direct flights departing from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be on your way in no time at all.
What day of the week has the most flights from MYR to STI?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary depending on a range of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI)?
To avoid possible delays on the Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI) route, travel before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI) last-minute?
Last-minute fares from MYR to STI are typically more expensive. To secure the cheapest rates, start looking for flights as early as possible. That said, if you can play around with your travel dates, it's possible to land a cheap fare right before your trip.
Is it cheaper to book a MYR to STI flight and hotel package?
You can save money by securing a MYR to STI flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. After selecting your preferred accommodations and flights, consider adding extras like activities, car rentals and tours.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI)?
If you reserved your MYR to STI flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

Explore a world of travel with Expedia

*Available to One Key members.