$178 Cheap Flights from Myrtle Beach (MYR) to Santiago (STI)

View $178 flight on Thu, Oct 30, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI)

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Cheap Flights from Myrtle Beach to Santiago (MYR-STI)

Prices were available within the past 7 days and start at $178 for one-way flights and $310 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Thu, Oct 30 - Thu, Nov 6
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$310 Roundtrip, found 4 days ago
$310
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Thu, Oct 30 from Myrtle Beach to Santiago de los Caballeros, returning Thu, Nov 6, priced at $310 found 4 days ago
Spirit Airlines
Thu, Oct 30 - Mon, Nov 3
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$343 Roundtrip, found 4 days ago
$343
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Thu, Oct 30 from Myrtle Beach to Santiago de los Caballeros, returning Mon, Nov 3, priced at $343 found 4 days ago
American Airlines
Mon, Nov 10 - Mon, Nov 17
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$446 Roundtrip, found 4 days ago
$446
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Nov 10 from Myrtle Beach to Santiago de los Caballeros, returning Mon, Nov 17, priced at $446 found 4 days ago
Spirit Airlines
Fri, Oct 24 - Sat, Oct 25
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$448 Roundtrip, found 3 days ago
$448
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Fri, Oct 24 from Myrtle Beach to Santiago de los Caballeros, returning Sat, Oct 25, priced at $448 found 3 days ago
American Airlines
Mon, Nov 10 - Mon, Nov 17
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$452 Roundtrip, found 4 days ago
$452
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Nov 10 from Myrtle Beach to Santiago de los Caballeros, returning Mon, Nov 17, priced at $452 found 4 days ago
American Airlines
Mon, Nov 10 - Mon, Nov 17
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$458 Roundtrip, found 4 days ago
$458
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Nov 10 from Myrtle Beach to Santiago de los Caballeros, returning Mon, Nov 17, priced at $458 found 4 days ago
American Airlines
Mon, Nov 10 - Mon, Nov 17
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$459 Roundtrip, found 4 days ago
$459
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Nov 10 from Myrtle Beach to Santiago de los Caballeros, returning Mon, Nov 17, priced at $459 found 4 days ago
United
Mon, Nov 10 - Mon, Nov 17
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$460 Roundtrip, found 4 days ago
$460
Roundtrip
found 4 days ago
Select United flight, departing Mon, Nov 10 from Myrtle Beach to Santiago de los Caballeros, returning Mon, Nov 17, priced at $460 found 4 days ago
United
Mon, Nov 10 - Mon, Nov 17
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$468 Roundtrip, found 4 days ago
$468
Roundtrip
found 4 days ago
Select United flight, departing Mon, Nov 10 from Myrtle Beach to Santiago de los Caballeros, returning Mon, Nov 17, priced at $468 found 4 days ago
Delta
Wed, Dec 3 - Sat, Dec 13
MYR
Myrtle Beach
STI
Santiago de los Caballeros
$482 Roundtrip, found 3 days ago
$482
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Dec 3 from Myrtle Beach to Santiago de los Caballeros, returning Sat, Dec 13, priced at $482 found 3 days ago

Alternative airports near Santiago de los Caballeros

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Cibao Intl. STI. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $571
STI
Cibao Intl.
CheapestClosest
Average driving time to city center17 min
Flights from $571
Flights from Myrtle Beach (MYR) to Santiago (STI)
Origin airport
Myrtle Beach Intl.
Destination airport
Cibao Intl.
Roundtrip price
$310
Distance
1111 mi

Myrtle Beach to Santiago Flights

The cheapest times to fly from Myrtle Beach to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Santiago are during the month of October. You can find some of the cheapest flights from Myrtle Beach to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Santiago

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $178 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI) cost?
Grab a cheap one-way flight from $178 or cheap return flight from $310 from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI)?
Traveling in October may help you find better deals, as it's the cheapest month for flights between MYR and STI. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest MYR to STI flight.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI)?
There aren't any daily direct flights departing from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be on your way in no time at all.
What day of the week has the most flights from MYR to STI?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary depending on a range of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI)?
To avoid possible delays on the Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI) route, travel before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI) last-minute?
Last-minute fares from MYR to STI are typically more expensive. To secure the cheapest rates, start looking for flights as early as possible. That said, if you can play around with your travel dates, it's possible to land a cheap fare right before your trip.
Is it cheaper to book a MYR to STI flight and hotel package?
You can save money by securing a MYR to STI flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. After selecting your preferred accommodations and flights, consider adding extras like activities, car rentals and tours.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Cibao Intl. Airport (STI)?
If you reserved your MYR to STI flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

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*Available to One Key members.