$489 Cheap Flights from Prague (PRG) to Santiago (SCL)

View $489 flight on Sat, Nov 15, 2025Opens in a new window

Popular airlines from Vaclav Havel Airport (PRG) to Santiago Intl. Airport (SCL)

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Cheap Flights from Prague to Santiago (PRG-SCL)

Prices were available within the past 7 days and start at $489 for one-way flights and $747 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air Canada
Thu, Jan 15 - Mon, Jan 26
PRG
Prague
SCL
Santiago
$747 Roundtrip, found 2 days ago
$747
Roundtrip
found 2 days ago
Select Air Canada flight, departing Thu, Jan 15 from Prague to Santiago, returning Mon, Jan 26, priced at $747 found 2 days ago
Air Canada
Thu, Jan 15 - Mon, Jan 26
PRG
Prague
SCL
Santiago
$754 Roundtrip, found 2 days ago
$754
Roundtrip
found 2 days ago
Select Air Canada flight, departing Thu, Jan 15 from Prague to Santiago, returning Mon, Jan 26, priced at $754 found 2 days ago
Air Canada
Mon, Feb 9 - Wed, Feb 18
PRG
Prague
SCL
Santiago
$777 Roundtrip, found 5 days ago
$777
Roundtrip
found 5 days ago
Select Air Canada flight, departing Mon, Feb 9 from Prague to Santiago, returning Wed, Feb 18, priced at $777 found 5 days ago
Air Canada
Mon, Feb 9 - Wed, Feb 18
PRG
Prague
SCL
Santiago
$781 Roundtrip, found 5 days ago
$781
Roundtrip
found 5 days ago
Select Air Canada flight, departing Mon, Feb 9 from Prague to Santiago, returning Wed, Feb 18, priced at $781 found 5 days ago
Air Canada
Mon, Feb 9 - Tue, Feb 17
PRG
Prague
SCL
Santiago
$782 Roundtrip, found 5 days ago
$782
Roundtrip
found 5 days ago
Select Air Canada flight, departing Mon, Feb 9 from Prague to Santiago, returning Tue, Feb 17, priced at $782 found 5 days ago
Air Canada
Mon, Feb 9 - Wed, Feb 18
PRG
Prague
SCL
Santiago
$784 Roundtrip, found 5 days ago
$784
Roundtrip
found 5 days ago
Select Air Canada flight, departing Mon, Feb 9 from Prague to Santiago, returning Wed, Feb 18, priced at $784 found 5 days ago
Lufthansa
Wed, Nov 26 - Thu, Dec 11
PRG
Prague
SCL
Santiago
$809 Roundtrip, found 4 days ago
$809
Roundtrip
found 4 days ago
Select Lufthansa flight, departing Wed, Nov 26 from Prague to Santiago, returning Thu, Dec 11, priced at $809 found 4 days ago
Swiss International Air Lines
Sat, Nov 29 - Thu, Dec 11
PRG
Prague
SCL
Santiago
$821 Roundtrip, found 4 days ago
$821
Roundtrip
found 4 days ago
Select Swiss International Air Lines flight, departing Sat, Nov 29 from Prague to Santiago, returning Thu, Dec 11, priced at $821 found 4 days ago
British Airways
Thu, Jan 15 - Mon, Jan 26
PRG
Prague
SCL
Santiago
$909 Roundtrip, found 2 days ago
$909
Roundtrip
found 2 days ago
Select British Airways flight, departing Thu, Jan 15 from Prague to Santiago, returning Mon, Jan 26, priced at $909 found 2 days ago
American Airlines
Mon, Feb 9 - Mon, Feb 16
PRG
Prague
SCL
Santiago
$1,147 Roundtrip, found 5 days ago
$1,147
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Feb 9 from Prague to Santiago, returning Mon, Feb 16, priced at $1,147 found 5 days ago
Flights from Prague (PRG) to Santiago (SCL)
Origin airport
Vaclav Havel
Destination airport
Arturo Merino Benitez
Airlines serving
Air Canada, British Airways, Iberia, LATAM Airlines Group, Turkish Airlines
Roundtrip price
$747
Distance
7745 mi

Prague to Santiago Flights

The cheapest times to fly from Prague to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Prague to Santiago are during the month of January. You can find some of the cheapest flights from Prague to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Prague to Santiago

Sunday is one of the best days to book for cheap flights from Prague to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Prague to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Prague to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $489 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Prague to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Prague to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Vaclav Havel Airport (PRG) to Arturo Merino Benitez Airport (SCL) cost?
Get a cheap one-way flight from $489 or cheap return flight from $747 from Vaclav Havel Airport (PRG) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Vaclav Havel Airport (PRG) to Arturo Merino Benitez Airport (SCL)?
Traveling in January is a great way to save, as it's the cheapest month for flights between PRG and SCL. You'll often find the lowest prices during off-peak months.
What is the cheapest airline that flies from Vaclav Havel Airport (PRG) to Arturo Merino Benitez Airport (SCL)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest PRG to SCL flight.
How many flights per day from Vaclav Havel Airport (PRG) to Arturo Merino Benitez Airport (SCL)?
There aren't any daily direct flights available from Vaclav Havel Airport (PRG) to Arturo Merino Benitez Airport (SCL). But you can opt for flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be on your way in no time.
What day of the week has the most flights from PRG to SCL?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change depending on various factors, including the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Vaclav Havel Airport (PRG) to Arturo Merino Benitez Airport (SCL)?
To avoid potential delays on the Vaclav Havel Airport (PRG) to Arturo Merino Benitez Airport (SCL) route, travel before 3 PM. Departures after this hour have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Vaclav Havel Airport (PRG) to Arturo Merino Benitez Airport (SCL) last-minute?
Last-minute fares from PRG to SCL are typically more expensive. To secure the best prices, start searching for flights as soon as possible. That said, if your travel plans are flexible, it's possible to score a cheap fare right before you leave.
Is it cheaper to book a PRG to SCL flight and hotel package?
You'll typically save money by securing a PRG to SCL flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one place. Once you've chosen your preferred accommodations and flights, consider adding extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Vaclav Havel Airport (PRG) to Arturo Merino Benitez Airport (SCL)?
It's usually possible to cancel or reschedule your PRG to SCL flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.