$216 Cheap Flights from Tupelo (TUP) to Columbus (CMH)

View $216 flight on Wed, Nov 19, 2025Opens in a new window

Popular airlines from Tupelo, MS (TUP-Tupelo Regional) to John Glenn Columbus Intl. Airport (CMH)

Cheap Flights from Tupelo to Columbus (TUP-CMH)

Prices were available within the past 7 days and start at $216 for one-way flights and $435 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Contour Airlines
Thu, Nov 27 - Thu, Dec 4
TUP
Tupelo
CMH
Columbus
$435 Roundtrip, found 5 days ago
$435
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Thu, Nov 27 from Tupelo to Columbus, returning Thu, Dec 4, priced at $435 found 5 days ago
Contour Airlines
Wed, Dec 3 - Sat, Dec 13
TUP
Tupelo
CMH
Columbus
$447 Roundtrip, found 3 days ago
$447
Roundtrip
found 3 days ago
Select Contour Airlines flight, departing Wed, Dec 3 from Tupelo to Columbus, returning Sat, Dec 13, priced at $447 found 3 days ago
Contour Airlines
Tue, Dec 2 - Sat, Dec 13
TUP
Tupelo
CMH
Columbus
$456 Roundtrip, found 3 days ago
$456
Roundtrip
found 3 days ago
Select Contour Airlines flight, departing Tue, Dec 2 from Tupelo to Columbus, returning Sat, Dec 13, priced at $456 found 3 days ago
Contour Airlines
Tue, Nov 25 - Thu, Nov 27
TUP
Tupelo
CMH
Columbus
$459 Roundtrip, found 5 days ago
$459
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Tue, Nov 25 from Tupelo to Columbus, returning Thu, Nov 27, priced at $459 found 5 days ago
Contour Airlines
Tue, Nov 25 - Sat, Dec 6
TUP
Tupelo
CMH
Columbus
$465 Roundtrip, found 3 days ago
$465
Roundtrip
found 3 days ago
Select Contour Airlines flight, departing Tue, Nov 25 from Tupelo to Columbus, returning Sat, Dec 6, priced at $465 found 3 days ago
Contour Airlines
Mon, Nov 24 - Thu, Nov 27
TUP
Tupelo
CMH
Columbus
$470 Roundtrip, found 5 days ago
$470
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Mon, Nov 24 from Tupelo to Columbus, returning Thu, Nov 27, priced at $470 found 5 days ago
Contour Airlines
Tue, Nov 25 - Tue, Dec 16
TUP
Tupelo
CMH
Columbus
$474 Roundtrip, found 4 days ago
$474
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Tue, Nov 25 from Tupelo to Columbus, returning Tue, Dec 16, priced at $474 found 4 days ago
Contour Airlines
Thu, Nov 27 - Sat, Dec 13
TUP
Tupelo
CMH
Columbus
$476 Roundtrip, found 3 days ago
$476
Roundtrip
found 3 days ago
Select Contour Airlines flight, departing Thu, Nov 27 from Tupelo to Columbus, returning Sat, Dec 13, priced at $476 found 3 days ago
Contour Airlines
Fri, Nov 28 - Thu, Dec 4
TUP
Tupelo
CMH
Columbus
$479 Roundtrip, found 5 days ago
$479
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Fri, Nov 28 from Tupelo to Columbus, returning Thu, Dec 4, priced at $479 found 5 days ago
Contour Airlines
Thu, Nov 27 - Thu, Dec 4
TUP
Tupelo
CMH
Columbus
$481 Roundtrip, found 4 days ago
$481
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Thu, Nov 27 from Tupelo to Columbus, returning Thu, Dec 4, priced at $481 found 4 days ago

Alternative airports near Columbus

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to John Glenn Columbus Intl. CMH. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $516
CMH
John Glenn Columbus Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $516

Frequently asked questions

How much does a flight from Tupelo Regional Airport (TUP) to John Glenn Columbus Intl. Airport (CMH) cost?
Get a cheap one-way flight from $216 or cheap return flight from $435 from Tupelo Regional Airport (TUP) to John Glenn Columbus Intl. Airport (CMH) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Tupelo Regional Airport (TUP) to John Glenn Columbus Intl. Airport (CMH)?
The cheapest month to fly from TUP to CMH is November, when there's less demand. Off-peak season is usually when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Tupelo Regional Airport (TUP) to John Glenn Columbus Intl. Airport (CMH)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest TUP to CMH flight.
How many flights per day from Tupelo Regional Airport (TUP) to John Glenn Columbus Intl. Airport (CMH)?
Nonstop flights from Tupelo Regional Airport (TUP) to John Glenn Columbus Intl. Airport (CMH) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from TUP to CMH?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tupelo Regional Airport (TUP) to John Glenn Columbus Intl. Airport (CMH)?
Opt for a flight from Tupelo Regional Airport (TUP) to John Glenn Columbus Intl. Airport (CMH) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tupelo Regional Airport (TUP) to John Glenn Columbus Intl. Airport (CMH) last-minute?
Last-minute fares from TUP to CMH are generally more expensive. To secure the best rates, start searching for flights as soon as possible. That being said, if you can play around with your travel dates, it's possible to find a cheap fare right before you leave.
Is it cheaper to book a TUP to CMH flight and hotel package?
Compared with arranging hotels and flights separately, booking a TUP to CMH flight and hotel package with Expedia could result in significant savings. Better still, having it all in one place will take the hassle out of travel planning. Just secure your flights and choose from our wide range of hotels, then tailor your trip with other add-ons like tours and car rentals.
Can I cancel or change the date of my flight from Tupelo Regional Airport (TUP) to John Glenn Columbus Intl. Airport (CMH)?
Typically, you can cancel or reschedule your TUP to CMH flight. However, there may be additional fees, especially if you made your booking more than 24 hours ago. Double-check your itinerary for the airline's fees and rules on flight changes, or if you want more details, go to our Customer Service portal.

Travel information

Origin airport
Tupelo Regional
Destination airport
John Glenn Columbus Intl.
Roundtrip price
$435
Distance
511 mi

Book with confidence

Tupelo to Columbus Flights

The cheapest times to fly from Tupelo to Columbus

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Tupelo to Columbus are during the month of November. You can find some of the cheapest flights from Tupelo to Columbus with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Tupelo to Columbus

Sunday is one of the best days to book for cheap flights from Tupelo to Columbus: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Tupelo to Columbus

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Tupelo to Columbus in 2025. You can also book with separate airlines for your outbound and return journeys, from $216 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Tupelo to Columbus flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Tupelo to Columbus airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Tupelo to Columbus Flights

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*Available to One Key members.