Cuyo Luxury Vacations 2026

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Top Luxury vacation packages in Cuyo

Price found within the past 48 hours. Click for updated prices.

Park Hyatt Mendoza

Mendoza City Center

$345

per person

Dec 14 - Dec 16

found 1 day ago

Roundtrip flight included

Santiago (SCL) to Mendoza (MDZ)

9.2/10 Wonderful! (1,001 reviews)

Amérian Mendoza

Mendoza City Center

$438

per person

Nov 4 - Nov 8

found 1 day ago

Roundtrip flight included

Buenos Aires (BUE) to Mendoza (MDZ)

8.6/10 Excellent! (806 reviews)

Enjoyed a lot of fruits for breakfast

Reviewed on Sep 22, 2026

Diplomatic Hotel

Mendoza City Center

$703

per person

Nov 4 - Nov 8

found 7 hours ago

Roundtrip non-stop flight included

Asuncion (ASU) to Mendoza (MDZ)

9.4/10 Exceptional! (1,011 reviews)

Clean luxury hotel, the view from the room was amazing, perfect location, walking distance to restaurants, bars and parks, the courtesy glass of wine daily was a big plus, breakfast plenty to choose from, the gym and spa is great, staff was wonderful and made us feel like family couldn’t say anything bad about this hotel.

Reviewed on Sep 22, 2026

Entre Cielos Wine & Wellness Hotel

Save 100% on your flight

$1,665

per person

Nov 4 - Nov 8

found 1 day ago

Roundtrip flight included

Buenos Aires (BUE) to Mendoza (MDZ)

9.4/10 Exceptional! (280 reviews)

Everything was perfect! Great place to stay near many of the main the wineries.

Reviewed on Sep 26, 2026

Auberge Du Vin, Tupungato, Mendoza

$664

per person

Nov 4 - Nov 8

found 7 hours ago

Roundtrip non-stop flight included

Asuncion (ASU) to Mendoza (MDZ)

8.6/10 Excellent! (321 reviews)

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5* Luxury vacations in Cuyo

Price found within the past 48 hours. Click for updated prices.

Park Hyatt Mendoza

Mendoza City Center

$345

per person

Dec 14 - Dec 16

found 1 day ago

Roundtrip flight included

Santiago (SCL) to Mendoza (MDZ)

9.2/10 Wonderful! (1,001 reviews)

Don't see what you're looking for?

See all available trips from Columbus to Cuyo

View all trips

3 Night Luxury vacations in Cuyo

Price found within the past 48 hours. Click for updated prices.

Raices Aconcagua Mendoza

Mendoza City Center

$265

per person

Nov 7 - Nov 10

found 21 hours ago

Roundtrip flight included

Buenos Aires (BUE) to Mendoza (MDZ)

7.8/10 Good! (669 reviews)

Great location and free breakfast plus gym

Reviewed on Sep 22, 2026

Park Hyatt Mendoza

Mendoza City Center

Save 100% on your flight

$433

per person

Nov 7 - Nov 10

found 21 hours ago

Roundtrip flight included

Buenos Aires (BUE) to Mendoza (MDZ)

9.2/10 Wonderful! (1,001 reviews)

Amérian Mendoza

Mendoza City Center

$315

per person

Nov 7 - Nov 10

found 21 hours ago

Roundtrip flight included

Buenos Aires (BUE) to Mendoza (MDZ)

8.6/10 Excellent! (806 reviews)

Enjoyed a lot of fruits for breakfast

Reviewed on Sep 22, 2026

Don't see what you're looking for?

See all available trips from Columbus to Cuyo

View all trips

4 Night Luxury vacations in Cuyo

Price found within the past 48 hours. Click for updated prices.

Amérian Mendoza

Mendoza City Center

$438

per person

Nov 4 - Nov 8

found 1 day ago

Roundtrip flight included

Buenos Aires (BUE) to Mendoza (MDZ)

8.6/10 Excellent! (806 reviews)

Enjoyed a lot of fruits for breakfast

Reviewed on Sep 22, 2026

Park Hyatt Mendoza

Mendoza City Center

$806

per person

Nov 4 - Nov 8

found 7 hours ago

Roundtrip non-stop flight included

Asuncion (ASU) to Mendoza (MDZ)

9.2/10 Wonderful! (1,001 reviews)

Diplomatic Hotel

Mendoza City Center

$703

per person

Nov 4 - Nov 8

found 7 hours ago

Roundtrip non-stop flight included

Asuncion (ASU) to Mendoza (MDZ)

9.4/10 Exceptional! (1,011 reviews)

Reviewed on Sep 22, 2026

Don't see what you're looking for?

See all available trips from Columbus to Cuyo

View all trips

What can I expect from a luxury Cuyo vacation?

Luxury means the very finest of the things you enjoy most. Indulge your every waking moment—and restful night—with a luxury Cuyo vacation. Sip handcrafted cocktails by an infinity pool, sink into bliss at a full-service spa with a massage cabana on the beach, and chat, cheers, and laugh through exquisite breakfasts, lunches, and dinners with spectacular views. 

How can I find all-inclusive luxury vacation packages in Cuyo?

By refining your filters, the most opulent all-inclusive vacation packages will appear before your eyes. Check the 5* filter to find truly sensational stays. You barely need to lift a finger. 

Can I book a cheap Cuyo luxury vacation?

Affordable luxury is only ever a few clicks away. Enter your travel dates and sort the grandiose getaways on offer by price to see the most fiscally friendly retreats first. Filter by budget, too, to find your perfect balance of luxury. Right now, luxury vacations start at $265. Prices and availability are subject to change. Additional terms may apply.

How can I book a luxury family vacation in Cuyo?

Tailor your luxury family escape by checking the filters that set the whole family’s hearts a-flutter. Whether that’s wet and wild water parks, heavenly hot tubs, or the kid-quieting magic of free Wi-Fi. 

Can I book a package in Cuyo with a luxury vacation home?

A private paradise is true luxury! Filter by property type for houses, villas, and apartments. For an amazingly affordable all-in-one luxury experience, book your accommodation, airfare, and car rental as a package.   

How can I find the best luxury vacation deals in Cuyo?

Find absolute delight in the dropdown! Simply sort your tempting search results by deals to find that lean-budget luxury. For a budget conscious stay, consider booking a stay away from big cities or outside the peak months.

Can I book a luxury holiday in Cuyo with free cancellation and/or flexible dates?

Freedom and flexibility are the greatest luxuries of all. Get both when you filter by payment option and book a trip with free cancellation or on a buy now, pay later plan. 

Why should I book my luxury trip to Cuyo with Expedia?

A luxurious trip follows a stress-free booking experience. Find, build, and book the most glorious of getaways in seconds—with ATOL protection for added peace of mind.

Top Luxury Cuyo Hotels

Entre Cielos Wine & Wellness Hotel

Guardia Vieja 1998, Vistalba Luján de Cuyo Mendoza

26 min drive from Catena Zapata Winery

Entre Cielos Wine & Wellness Hotel is one of the Luján de Cuyo luxury 4.5-star boutique properties where you can pamper yourself with Champagne service, pillowtop ...

9.4/10 Exceptional! (281 reviews)

"Everything was perfect! Great place to stay near many of the main the wineries."

Reviewed on Sep 26, 2026

Auberge Du Vin, Tupungato, Mendoza

Calle la Costa s/n Tupungato Mendoza

39 min drive from Catena Zapata Winery

Be treated to luxurious accommodations at Auberge Du Vin, Tupungato, Mendoza, where you can enjoy amenities like rainfall showers, plush bedding, and more. Deluxe ...

Park Hyatt Mendoza

Chile 1124 Mendoza Mendoza

47 min drive from Catena Zapata Winery

Pamper yourself with an extravagant stay at Park Hyatt Mendoza, where you'll find deep soaking bathtubs and a champagne service. The spa, winery, and casino ...

See all 1,205 properties in Cuyo

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.