Title: The Best 5 Star Hotels in Anderson, SC from $217 | Expedia.com

[Anderson Travel Guide](https://expedia.com/Anderson.dx6058009)[Hotels in Anderson](https://expedia.com/Anderson-Hotels.d6058009.Travel-Guide-Hotels)[Vacation Rentals in Anderson](https://expedia.com/Anderson-Vacation-Rentals.d6058009.Travel-Guide-VacationRentals)[Flights to Anderson](https://expedia.com/Cheap-Flights-To-Anderson.d6058009.Travel-Guide-Flights)[Car Rentals in Anderson](https://expedia.com/Car-Rentals-In-Anderson.d6058009.Car-Rental-Guide)[Anderson Vacation Packages](https://expedia.com/Anderson.d6058009.Destination-Travel-Guides)

![aerial view of the city](https://images.trvl-media.com/place/6058009/478fa9d4-3485-457a-98cf-34f5ad2bbfc8.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6058009/478fa9d4-3485-457a-98cf-34f5ad2bbfc8.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

## Check availability on Anderson 5 Star Hotels

Tonight

[Mar 2 - Mar 3](https://www.expedia.com/Hotel-Search?regionId=6058009&startDate=2026-03-02&endDate=2026-03-03&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 3 - Mar 4](https://www.expedia.com/Hotel-Search?regionId=6058009&startDate=2026-03-03&endDate=2026-03-04&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6058009&startDate=2026-03-06&endDate=2026-03-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6058009&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Anderson.

![The Shepherd Hotel Downtown Clemson](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/bd45b45c_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### The Shepherd Hotel Downtown Clemson

110 Sloan St Clemson SC

$219 nightly

$243 total

Mar 15 - Mar 16

Total with taxes and fees

9.8/10 Exceptional! (763 reviews)

[](https://expedia.com/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information)

![Liberty Hall Bed and Breakfast](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/286fc023_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Liberty Hall Bed and Breakfast

621 S Mechanic St Pendleton SC

$196 nightly

$217 total

Mar 7 - Mar 8

Total with taxes and fees

10/10 Exceptional! (83 reviews)

[](https://expedia.com/Pendleton-Hotels-Liberty-Hall-Bed-And-Breakfast.h83025265.Hotel-Information)

![Lake Keowee Condo: Resort Pools & Lake Access!](https://images.trvl-media.com/lodging/99000000/98560000/98554500/98554423/352b8327_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Lake Keowee Condo: Resort Pools & Lake Access!

 Salem SC

[Get rates](https://expedia.com/Hotel-Search?startDate=3%2F16%2F2026&endDate=3%2F17%2F2026&selected=98554423&PinnedHotelID=98554423&HadPinnedHotel=true&regionId=6058009)

[](https://expedia.com/Salem-Hotels-Lake-Keowee-Condo-Resort-Pools-Lake-Access.h98554423.Hotel-Information)

Still don't see what you're looking for?

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[Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&regionId=6058009&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&regionId=6058009&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&regionId=6058009&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&regionId=6058009&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&regionId=6058009&star=50&star=50&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Anderson and related destinations

- Anderson
- Columbus
- Auburn - Opelika
- Altoona
- Pullman

Downtown's historic district buzzes with local shops and the Electric City Playhouse draws theater lovers from across the region. Lake Hartwell offers prime fishing spots, while the Anderson County Museum reveals fascinating stories about South Carolina's upcountry heritage.

[See all hotels in Anderson](https://www.expedia.com/Hotel-Search?startDate=2026-03-16&endDate=2026-03-17&adults=2&regionId=6058009)

![aerial view of the city](https://images.trvl-media.com/place/6058009/478fa9d4-3485-457a-98cf-34f5ad2bbfc8.jpg?impolicy=fcrop&w=900&h=505&p=1&q=high)

## Top Anderson Hotel Reviews

## Find out more about Anderson

Ready for an incredible adventure? Add even more luxury on your next trip to Anderson by treating yourself to the best of the best when it comes to accommodation. It's an ideal combination. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Anderson so popular in the last year. There's no reason to delay a getaway to Anderson any longer. Besides, the hotels in this area receive high marks for customer service, so you know you'll want for nothing during your getaway. Book one of Expedia's luxurious 5-star hotels in Anderson and get ready to be pampered like never before. What are you waiting for?

### Book the Best Anderson 5-Star Hotels

Don't be afraid to live the high life while you're on vacation. Top-notch customer care, spacious rooms, and fabulous spa offerings are waiting for you. You're sure to find exactly the accommodation you need. We should also mention, the hotels in this area receive fantastic marks for guest services, so you know you'll want for nothing during your getaway. What creature comforts do you want in your lodging? A rejuvenating facial treatment to help your cares fall away? A concierge to help you plan every detail of your day? Fluffy down pillows, piping hot coffees, and even spectacular views...these hotels will astonish you. 

Ready for experiences outside your hotel room? You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Anderson are waiting for you to rest up after an exciting day. Ready to learn more? Then explore the 216 reviews various guests have left on Expedia and get to know these places. 

### Your Getaway Starts Today

The results are in, and Anderson 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Expedia can help you land a great deal on accommodation. It's time to plan your next great escape. Decide on one of the 5-star hotels in Anderson today and settle down in complete comfort tomorrow.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Anderson?

> - Search for the lowest price per night from $217

### What makes a hotel 5 stars in Anderson?

### Are there any 5-star all-inclusive resorts in Anderson?

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- [Visit Anderson County ](https://www.expedia.com/Anderson-County.dx553248635996998401)
- [Anderson County Museum ](https://www.expedia.com/Anderson-County-Museum-Anderson.d6308393.Vacation-Attraction)
- [Anderson University ](https://www.expedia.com/Anderson-University-Anderson.d6308387.Vacation-Attraction)
- [Anderson Mall ](https://www.expedia.com/Anderson-Mall-Anderson.d553248621587587036.Vacation-Attraction)
- [Visit Northlake ](https://www.expedia.com/Northlake.dx6348002)
- [Newspring Church ](https://www.expedia.com/NewSpring-Church-Anderson.d553248621532656690.Vacation-Attraction)
- [Welcome Vacations ](https://www.expedia.com/Welcome.d3000353249.Destination-Travel-Guides)

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- [Things to do in Anderson County ](https://www.expedia.com/Things-To-Do-In-Anderson-County.d553248635996998401.Travel-Guide-Activities)