Title: The Best 5 Star Hotels in Santa Isabel | Expedia.com [Santa Isabel Travel Guide](https://expedia.com/Santa-Isabel.dx6203540)[Hotels in Santa Isabel](https://expedia.com/Santa-Isabel-Hotels.d6203540.Travel-Guide-Hotels)[Vacation Rentals in Santa Isabel](https://expedia.com/Santa-Isabel-Vacation-Rentals.d6203540.Travel-Guide-VacationRentals)[Flights to Santa Isabel](https://expedia.com/Cheap-Flights-To-Santa-Isabel.d6203540.Travel-Guide-Flights)[Car Rentals in Santa Isabel](https://expedia.com/Car-Rentals-In-Santa-Isabel.d6203540.Car-Rental-Guide)[Santa Isabel Vacation Packages](https://expedia.com/Santa-Isabel.d6203540.Destination-Travel-Guides) ![Scenic Coiba Island Aerial View](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Isabel 5 Star Hotels Tonight [Feb 17 - Feb 18](https://www.expedia.com/Hotel-Search?regionId=6203540&startDate=2026-02-17&endDate=2026-02-18&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 18 - Feb 19](https://www.expedia.com/Hotel-Search?regionId=6203540&startDate=2026-02-18&endDate=2026-02-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 20 - Feb 22](https://www.expedia.com/Hotel-Search?regionId=6203540&startDate=2026-02-20&endDate=2026-02-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=6203540&startDate=2026-02-27&endDate=2026-03-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Santa-Isabel-Hotels.s50-0-d6203540.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Santa-Isabel-Hotels.s50-0-d6203540.Travel-Guide-Filter-Hotels) ## Learn more about Santa Isabel Explore pristine beaches along Santa Isabel's coastline where local fishermen can take you to nearby coral reefs for snorkeling. Hike through lush rainforest trails to spot colorful birds, then visit the town's central plaza where vendors sell fresh tropical fruits and handcrafted souvenirs. [See all hotels in Santa Isabel](https://www.expedia.com/Hotel-Search?startDate=2026-03-03&endDate=2026-03-04&adults=2®ionId=6203540) ![Scenic Coiba Island Aerial View](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Santa Isabel Hotel Reviews ## Find out more about Santa Isabel Ready for an incredible adventure? Add further luxury on your next trip to Santa Isabel by treating yourself to the best of the best when it comes to lodging. It's an ideal pairing. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Santa Isabel so popular in the last year. There's no reason to delay a getaway to Santa Isabel any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Reserve one of our 5-star hotels in Santa Isabel and indulge in the finer things in life for a while. Don't wait any longer! ### Book the Best Santa Isabel 5-Star Hotels You'll have a wonderful time at one of these 5-star hotels. Excellent customer care, luxurious bedding, and deeply relaxing spa offerings are all on offer. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. How do you want to relax? A concierge to help you suggest the next attraction to visit? A full-body massage to help your cares fall away? Fluffy down pillows, delectable chocolate desserts, and even spectacular views...these hotels are one-of-a-kind. Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs. You won't sleep and order room service the entire time, though. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Santa Isabel are the perfect place to relax after a busy day. ### Your Getaway Starts Today The results are in, and Santa Isabel 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Your great getaway is just a mouse-click away. Select one of the 5-star hotels in Santa Isabel today and soothe yourself in luxe surroundings tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Santa Isabel? > - Search for the lowest price per night ### What makes a hotel 5 stars in Santa Isabel? ### Are there any 5-star all-inclusive resorts in Santa Isabel? ## Explore a world of travel with Expedia - Lodging - Packages - [4 Star Hotels in Playa Chiquita ](https://www.expedia.com/4Star-Playa-Chiquita-Hotels.s40-0-d553248635975847835.Travel-Guide-Filter-Hotels) - [Playa Chiquita Hotels ](https://www.expedia.com/Playa-Chiquita-Hotels.d553248635975847835.Travel-Guide-Hotels) - [Visit Playa Chiquita ](https://www.expedia.com/Playa-Chiquita.dx553248635975847835)