Santa Isabel

Travel Guide

A tropical island with a beach, clear turquoise waters, and lush greenery.
A boat on a turquoise sea with lush green islands in the background.
A tropical island with turquoise waters, a sandy beach, and lush greenery.
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
$188 nightly
The price is $207 total per night from Oct 13 to Oct 14
$207 total
Oct 13 - Oct 14
Total with taxes and fees
Stay at this hotel in San Blas Islands. Enjoy free breakfast, an airport shuttle (surcharge), and a garden. Popular attractions Isla Diablo and Isla Chichime ...
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
$1,943 nightly
The price is $2,148 total per night from Nov 10 to Nov 11
$2,148 total
Nov 10 - Nov 11
Total with taxes and fees
Stay at this cruise ship in San Blas Islands. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions Porvenir Museum and Isla Chichime ...
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Caribbean Haven Of Nature 'Preci Beach'

Caribbean Haven Of Nature 'Preci Beach'

Nombre de Dios Colon
Book a stay at this beach vacation home in Nombre de Dios. Enjoy free WiFi, a beach locale, and a garden.
10/10 Exceptional! (32 reviews)
"This is a great place to slow down and enjoy the sea and on-site amenities, including a pool, hot tub, sand volleyball court, and kid-friendly play spaces. This is very much a home that the owners make available to guests. Cone, the on-site custodian, is available and helpful. It is somewhat remote ..."

Reviewed on Oct 2, 2026

Get rates
Caribbean Haven Of Nature 'Preci Beach'
See all 39 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Caribbean Haven Of Nature 'Preci Beach'

Caribbean Haven Of Nature 'Preci Beach'

Nombre de Dios Colon
Book a stay at this beach vacation home in Nombre de Dios. Enjoy free WiFi, a beach locale, and a garden.
10/10 Exceptional! (32 reviews)
"This is a great place to slow down and enjoy the sea and on-site amenities, including a pool, hot tub, sand volleyball court, and kid-friendly play spaces. This is very much a home that the owners make available to guests. Cone, the on-site custodian, is available and helpful. It is somewhat remote ..."

Reviewed on Oct 2, 2026

Caribbean Haven Of Nature 'Preci Beach'
BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

Santa Isabel Colon
Book a stay at this beach villa in Palenque. Enjoy free WiFi, a beach locale, and breakfast (surcharge).
10/10 Exceptional! (31 reviews)
"This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful ..."

Reviewed on Jan 1, 2026

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES
Caribbean getaway: beach cottage just on the sand

Caribbean getaway: beach cottage just on the sand

Palenque Provincia de Colón
Book a stay at this beach cottage in Palenque. Enjoy free WiFi, a beach locale, and a garden.
9/10 Wonderful! (4 reviews)
"the view is beautiful! We were taken care of well."

Reviewed on Jul 26, 2026

Caribbean getaway: beach cottage just on the sand
See all properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

When is the best time to visit Santa Isabel?
The best time to visit Santa Isabel is from January through March, when the climate is typically most pleasant. For travelers seeking fewer crowds and better value, the quieter months of May through August are a good option, offering a more relaxed experience.
What cuisines can you find in Santa Isabel?
In Santa Isabel you can find South American cuisine, featuring dishes such as arepas, empanadas, feijoada, and ceviche. Travelers can also enjoy a variety of Latin American, Italian, and fresh seafood options, as well as Asian and North American fare.
Can I book a refundable hotel in Santa Isabel?
Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in Santa Isabel by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.
Why book a trip to Santa Isabel with Expedia?
Expedia makes it easier to plan your Santa Isabel trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.
Should I stay in a hotel or vacation rental in Santa Isabel?
The best choice depends on your travel style. Hotels in Santa Isabel can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.
How can I manage my Santa Isabel trip on Expedia?
Once you've booked your Santa Isabel trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.
What if I need help during my Santa Isabel trip?
Expedia offers customer support before, during, and after your Santa Isabel trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.
How can Expedia help me plan my first trip to Santa Isabel?
If it's your first trip to Santa Isabel, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.
How can I save on my Santa Isabel hotel booking with Expedia?
Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your Santa Isabel hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

Cities near Santa Isabel

An aerial view of two small islands with clear turquoise waters and sandy beaches.

San Blas Islands

A calm lake with a small boat, a dock with colorful buildings, and a forested hill in the background.

Isla Grande

A city skyline with high-rise buildings, a calm waterfront, and a sunset sky.

Tocumen

A coastal archaeological site with ruins and a clear blue sea.

Portobelo