Title: Visit Santa Isabel: 2026 Travel Guide for Santa Isabel, Colón | Expedia.com [Hotels in Santa Isabel](https://expedia.com/Santa-Isabel-Hotels.d6203540.Travel-Guide-Hotels)[Vacation Rentals in Santa Isabel](https://expedia.com/Santa-Isabel-Vacation-Rentals.d6203540.Travel-Guide-VacationRentals)[Flights to Santa Isabel](https://expedia.com/Cheap-Flights-To-Santa-Isabel.d6203540.Travel-Guide-Flights)[Car Rentals in Santa Isabel](https://expedia.com/Car-Rentals-In-Santa-Isabel.d6203540.Car-Rental-Guide)[Santa Isabel Vacation Packages](https://expedia.com/Santa-Isabel.d6203540.Destination-Travel-Guides) # Santa Isabel ## Travel Guide ![Scenic Coiba Island Aerial View](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Scenic Coiba Island Aerial View](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Canales de Afuera island, Coiba National Park, Panama, Central America - stock photo](https://images.trvl-media.com/place/6203540/b625de84-9bfd-4ed7-ad62-799eb10488ca.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Parque nacional isla Coiba ](https://images.trvl-media.com/place/6203540/d1d76c62-bf49-44b4-8aaf-3419599d68c4.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Santa Isabel ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX_SPRING_PROMO_6203540) - Santa Isabel Hotel Deals - Vacation Rentals in Santa Isabel ![Cocoloco - Catamaran Lagoon 52F SAN BLAS](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/1b4156f6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Cocoloco - Catamaran Lagoon 52F SAN BLAS El Porvenir Narganá Guna Yala $1,875 nightly $2,072 total Feb 26 - Feb 27 Total with taxes and fees Stay at this property in San Blas Islands. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions Porvenir Museum and Isla Chichime are ... [](https://expedia.com/Hotel-Search?startDate=2%2F26%2F2026&endDate=2%2F27%2F2026&selected=95807391&PinnedHotelID=95807391&HadPinnedHotel=true®ionId=6203540) ![Private Ocean-Front Cabin with private bathroom on San Blas Island](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/ede84b95_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Private Ocean-Front Cabin with private bathroom on San Blas Island Diablo Island Narganá Guna Yala $188 nightly $207 total Mar 3 - Mar 4 Total with taxes and fees Stay at this hotel in San Blas Islands. Enjoy free breakfast, an airport shuttle (surcharge), and a garden. Popular attractions Isla Diablo and Isla Chichime ... [](https://expedia.com/Hotel-Search?startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&selected=37766985&PinnedHotelID=37766985&HadPinnedHotel=true®ionId=6203540) ![Trips Guna Yala](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/9e5e20c9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Trips Guna Yala Urgandi, Mamardub Narganá Guna Yala Fully refundableReserve now, pay when you stay $214 nightly $236 total Feb 26 - Feb 27 Total with taxes and fees Stay at this B&B in Narganá. Enjoy free breakfast, daily housekeeping, and an outdoor pool. Popular attraction Museum is located nearby. [](https://expedia.com/Hotel-Search?startDate=2%2F26%2F2026&endDate=2%2F27%2F2026&selected=103726734&PinnedHotelID=103726734&HadPinnedHotel=true®ionId=6203540) [See all 41 properties in Santa Isabel](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=2%2F26%2F2026&endDate=2%2F27%2F2026®ionId=6203540) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Caribbean getaway: beach cottage just on the sand](https://images.trvl-media.com/lodging/72000000/71150000/71150000/71149949/24e34d16_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Caribbean getaway: beach cottage just on the sand Palenque Provincia de Colón Book a stay at this beach cottage in Palenque. Enjoy free WiFi, a beach locale, and a garden. 10/10 Exceptional! (1 review) The beach view was perfect! I loved hearing the waves all day and throughout the night. My dog and I enjoyed everything and felt very comfortable. Reviewed on Oct 15, 2025 [](https://expedia.com/Palenque-Hotels-Caribbean-Getaway-Beach-Cottage-Just-On-The-Sand.h71149949.Hotel-Information) ![ Paradise Over the Water Cabins in San Blas](https://images.trvl-media.com/lodging/47000000/46950000/46948400/46948372/fe0394dd_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Paradise Over the Water Cabins in San Blas G4V2 48 Narganá Guna Yala Book a stay at this beach cabin in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Porvenir Museum ... 6/10 (1 review) 29/22 i stay with my family for three nights and 4 days the beds are not comfortable and the fan doesn't work the bathroom need cleaning, the worst part is the sandflyies we got bitten all over our bodies, the owners can do better with proper new nets and fan and maybe spray the place, after the ... Reviewed on Sep 4, 2022 [](https://expedia.com/El-Porvenir-Hotels-Newly-Built-Paradise-Cabins-In-San-Blas.h46948372.Hotel-Information) ![BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES](https://images.trvl-media.com/lodging/31000000/30800000/30792300/30792236/afc188ba_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES Santa Isabel Colon Book a stay at this beach villa in Palenque. Enjoy free WiFi, a beach locale, and breakfast (surcharge). 10/10 Exceptional! (31 reviews) This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful ... Reviewed on Jan 1, 2026 [](https://expedia.com/Palenque-Hotels-Palenque-Spectacular-Caribbean-Ocean-Front-Property-In-Panama.h30792236.Hotel-Information) [See all properties in Santa Isabel](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6203540&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Santa Isabel hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6203540&startDate=2026-02-25&endDate=2026-02-26)[Feb 25 - Feb 26](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6203540&startDate=2026-02-25&endDate=2026-02-26) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6203540&startDate=2026-02-26&endDate=2026-02-27)[Feb 26 - Feb 27](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6203540&startDate=2026-02-26&endDate=2026-02-27) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6203540&startDate=2%2F27%2F2026&endDate=3%2F1%2F2026)[Feb 27 - Mar 1](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6203540&startDate=2%2F27%2F2026&endDate=3%2F1%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6203540&startDate=3%2F6%2F2026&endDate=3%2F8%2F2026)[Mar 6 - Mar 8](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6203540&startDate=3%2F6%2F2026&endDate=3%2F8%2F2026) ## Cities near Santa Isabel ![Islands of San Blas , Panama; Shutterstock ID 687617053; Purchase Order: -](https://images.trvl-media.com/place/6024116/aba78afe-1be5-4d43-bdc0-318dfbedec76.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### San Blas Islands ![Isla Grande Panama Tropen Strand](https://images.trvl-media.com/place/6053183/3ddb22e8-2245-453b-b3ca-3467e9b3943f.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Isla Grande ![Adobe](https://images.trvl-media.com/place/6053184/fef85501-8014-492d-aede-9500c1e1b289.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Tocumen ![#lifeatexpedia Beautiful Portobelo is full of history and culture. Located on the Caribbean coast it has a variety of world class attractions. The historic town of Portobelo is one of the most scenic spots in Panama. Set on a turquoise Caribbean bay, it was Spanish Empires' s trade epicenter in the 16th and 17th century. Don´t miss the Portobello Fortress and the Cristo Negro Church! ](https://images.trvl-media.com/place/6145607/ff6a8501-0761-475b-9eb5-4aa1941844ac.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Portobelo ## Explore a world of travel with Expedia - Lodging - Packages - [4 Star Hotels in Playa Chiquita ](https://www.expedia.com/4Star-Playa-Chiquita-Hotels.s40-0-d553248635975847835.Travel-Guide-Filter-Hotels) - [Playa Chiquita Hotels ](https://www.expedia.com/Playa-Chiquita-Hotels.d553248635975847835.Travel-Guide-Hotels) - [Visit Playa Chiquita ](https://www.expedia.com/Playa-Chiquita.dx553248635975847835) - Cities near Santa Isabel - Places of interest [San Blas Islands](https://expedia.com/San-Blas-Islands.dx6024116)[Isla Grande](https://expedia.com/Isla-Grande.dx6053183)[Tocumen](https://expedia.com/Tocumen.dx6053184)[Cerro Azul](https://expedia.com/Cerro-Azul.dx6053185)[Portobelo](https://expedia.com/Portobelo.dx6145607)[Puerto Lindo](https://expedia.com/Puerto-Lindo.dx3000007427)[El Porvenir](https://expedia.com/El-Porvenir.dx3000007455)[Buenaventura](https://expedia.com/Buenaventura.dx3000409855)[La Guaira](https://expedia.com/La-Guaira.dx3000439511)[Nombre de Dios](https://expedia.com/Nombre-De-Dios.dx3000462548)[Chepo](https://expedia.com/Chepo.dx553248622834396118)[Miramar](https://expedia.com/Miramar.dx553248623282266307)[Palenque](https://expedia.com/Palenque.dx553248623282267036)[Carti](https://expedia.com/Carti.dx553248635974498100)[Playa Chiquita](https://expedia.com/Playa-Chiquita.dx553248635975847835)[Cabuya](https://expedia.com/Cabuya.dx553248635975851905)[Mandinga](https://expedia.com/Mandinga.dx553248635975856894)[Nusatupo](https://expedia.com/Nusatupo.dx553248635996711305)[San Martín](https://expedia.com/San-Martin.dx705719064429240320)[Pacora](https://expedia.com/Pacora.dx705719212110229504)[Santa Cruz de Chinina](https://expedia.com/Santa-Cruz-De-Chinina.dx829297598788558848)[Cañita](https://expedia.com/Canita.dx829297618541613056)[Las Margaritas](https://expedia.com/Las-Margaritas.dx829297622907908096)[24 de Diciembre](https://expedia.com/24-De-Diciembre.dx829297636442910720)[Las Mañanitas](https://expedia.com/Las-Mananitas.dx829297652521791488) - [Chagres National Park ](https://expedia.com/Chagres-National-Park-Panama.d6252818.Vacation-Attraction) - [Porvenir Museum ](https://expedia.com/Porvenir-Museum-Nargana.d553248621532964866.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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