Santa Isabel Vacations from $668

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The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
Nomada Republic Hotel El Valle

Nomada Republic Hotel El Valle

3 out of 5
per person
Sep 28 - Oct 3
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
9/10 Wonderful! (32 reviews)
An excellent hotel with great views (on a sunny day). The drive into town is pretty short, so it's a good spot that's both convenient and quiet

Reviewed on Jul 2, 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
per person
Sep 11 - Sep 16
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (925 reviews)
Love the location and the restaurant inside the hotel was phenomenal.

Reviewed on Jul 11, 2025

Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B

3 out of 5
per person
Sep 28 - Oct 3
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
Host was excellent. Great communication and very helpful. The rooms were nice and great value.

Reviewed on Apr 18, 2025

Casa Fofo Family House

Casa Fofo Family House

3 out of 5
per person
Sep 28 - Oct 3
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
No reviews
Nomada Republic Hotel Punta Chame

Nomada Republic Hotel Punta Chame

3 out of 5
per person
Aug 30 - Sep 4
found 10 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.4/10 Exceptional! (25 reviews)
Unique stay for sure. We stayed in one of the smaller “containers”. It was fine for us, others might find it tight. The larger units looked like they had some dining area and a bit more space. A few extra hooks on the wall or in the very tiny bathroom would be nice for towels. The first floor units are great for pool side, second floor units have a porch but you have to go around the building to access your door. A few extra chairs on the first floor entry decks would be nice as we had to share. Fantastic restaurant on site, not a huge menu but we had 4 great meals. No breakfast menu but we heard from another guest it was available? The manager (Carlos) lives on site and was amazing. You do not need to kite surf to appreciate the skill and we spent hours watching the show with a front row seat. New stairs for access to the beach were being build while we were there. Be prepared for an abundance of plastic refuse brought in by the tide that lines the beach. Definitely recommend a stay here.

Reviewed on Mar 1, 2024

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Santa Isabel Hotel Deals

Private Ocean-Front Cabin with private bathroom on San Blas Island
Private Ocean-Front Cabin with private bathroom on San Blas Island
2 out of 5
Diablo Island, Narganá, Guna Yala
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Private Ocean-Front Cabin with private bathroom on San Blas Island
Private Over the Water Cabin on San Blas Island
Private Over the Water Cabin on San Blas Island
2 out of 5
9.542876, -78.899058, Narganá, San Blas
"Communication was good and highly organized. We felt safe and didn’t need to lock up our bags or valuables at all times. Weather was rough (not their fault) so the stay was a challenge with super high winds and rain. The island was covered in trash nearly all the way around. Our cabin doors were ..."

Reviewed on Feb 16, 2022

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Private Over the Water Cabin on San Blas Island
San Blas Paradise Private Cabins on Shipwreck Island - meals included
San Blas Paradise Private Cabins on Shipwreck Island - meals included
2 out of 5
Perro Island, Narganá, Guna Yala
$169 nightly
The price is $186 total per night from Jul 13 to Jul 14
$186 total
Jul 13 - Jul 14
Total includes taxes and fees
San Blas Paradise Private Cabins on Shipwreck Island - meals included
See all 44 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Isabel Vacation Packages

Santa Isabel Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
260
Max Temp Winter
80ºF
Max Temp Summer
80ºF

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Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $668 on Expedia for your Santa Isabel getaway. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
You can typically find lower prices and better availability in August, November and December. Take a look at our cheap Santa Isabel vacation packages and you could land some excellent off-season deals.
How many days is enough for Santa Isabel?
Typically, a handful of days is enough to visit the major attractions during your Santa Isabel vacation. However, if you want to have some time to kick back or go on day trips, consider extending your itinerary.
How to find the best Santa Isabel package deals?
Finding a cheap Santa Isabel package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your maximum budget, add a few filters and see what's available. You can personalize your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Isabel package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Isabel vacation as a package?
You can enjoy significant savings on your Santa Isabel break by booking a personalized vacation package. Click on the "Package" heading, then select your travel dates and destination to browse some great airfares and hotel prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Isabel?
Enjoy incredible bargains by reserving your flights early with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for a spur-of-the-moment Santa Isabel getaway.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Set off on your dream escape to Santa Isabel with help from our Book Now, Pay Later vacations. There's no need to save up or hold off until your next paycheck --- we've partnered with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can split the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, it's easy to stay on budget and snap up travel deals before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.