Santa Isabel Vacations from $629

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The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
Punta Chame Club and Resort

Punta Chame Club and Resort

4 out of 5
Price was $832, price is now $629 per person
$629
per person
Aug 3 - Aug 8
found 21 hours ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9.2/10 Wonderful! (5 reviews)
We Spent 15 days there and had a great time. It's in a great location.

Reviewed on Jan 2, 2020

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $1,913, price is now $1,362 per person
$1,362
per person
Jun 19 - Jun 24
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,010 reviews)
Very nice and clean hotel in the centralized area. It is very safe to walk all over the place.

Reviewed on May 11, 2026

Surfside Beachfront Suites by Playa Caracol Resorts

Surfside Beachfront Suites by Playa Caracol Resorts

3.5 out of 5
Price was $1,517, price is now $1,151 per person
$1,151
per person
Jul 26 - Aug 2
found 4 hours ago
Roundtrip flight included
Georgetown (GEO) to Panama City (PTY)
7.8/10 Good! (39 reviews)
Love this trip your own private paradise we are definitely going again

Reviewed on Mar 27, 2026

Brisas del Mar by Playa Caracol Resorts

Brisas del Mar by Playa Caracol Resorts

4.5 out of 5
Price was $1,005, price is now $765 per person
$765
per person
Aug 3 - Aug 8
found 21 hours ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
2/10 (1 review)
Casa Lefevre By Wynwood House

Casa Lefevre By Wynwood House

3.5 out of 5
Casco Viejo
Price was $1,605, price is now $1,233 per person
$1,233
per person
Jul 17 - Jul 24
found 21 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.6/10 Exceptional! (14 reviews)
Loved the location. Lots of room!

Reviewed on Apr 13, 2026

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Santa Isabel Hotel Deals

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
10/10 Exceptional! (1 review)
Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door.

Reviewed on Mar 15, 2026

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Private Ocean-Front Cabin with private bathroom on San Blas Island
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
$1,953 nightly
The price is $2,158 total per night from May 15 to May 16
$2,158 total
May 15 - May 16
Total with taxes and fees
Cocoloco - Catamaran Lagoon 52F SAN BLAS
BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

Santa Isabel Colon
10/10 Exceptional! (31 reviews)
This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful ...

Reviewed on Jan 1, 2026

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BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES
See all 40 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Isabel Vacation Packages

Santa Isabel Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
260
Max Temp Winter
80ºF
Max Temp Summer
80ºF

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Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $629 on Expedia for your Santa Isabel getaway. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
You can typically find lower prices and better availability in August, November and December. Take a look at our cheap Santa Isabel vacation packages and you could land some excellent off-season deals.
How many days is enough for Santa Isabel?
Typically, a handful of days is enough to visit the major attractions during your Santa Isabel vacation. However, if you want to have some time to kick back or go on day trips, consider extending your itinerary.
How to find the best Santa Isabel package deals?
Finding a cheap Santa Isabel package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your maximum budget, add a few filters and see what's available. You can personalize your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Isabel package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Isabel vacation as a package?
You can enjoy significant savings on your Santa Isabel break by booking a personalized vacation package. Click on the "Package" heading, then select your travel dates and destination to browse some great airfares and hotel prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Isabel?
Enjoy incredible bargains by reserving your flights early with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for a spur-of-the-moment Santa Isabel getaway.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Set off on your dream escape to Santa Isabel with help from our Book Now, Pay Later vacations. There's no need to save up or hold off until your next paycheck — we've partnered with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can split the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, it's easy to stay on budget and snap up travel deals before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.