Santa Isabel Vacations from $916

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The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,373, price is now $916 per person
$916
per person
Jul 13 - Jul 20
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (5,374 reviews)
My stayed at this hotel was beautiful the staff, First, when we arrived at the hotel, the room we were given smelled very musty and the pillows were a little stained. We called reception and they immediately changed our room. They even sent chocolates and prosecco to the room to apologize. I loved it — thanks to the management team for the attention and care.

Reviewed on May 7, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,684, price is now $1,663 per person
$1,663
per person
Jul 11 - Jul 18
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9.2/10 Wonderful! (1,005 reviews)
Excelente localización personal del hotel muy bueno. La crítica.: hotel no te tiene los útiles básicos como crema para la piel, gorro de baño. Cepillo dental etc. Hay q estar en la recepción para recordar y solicitarlo

Reviewed on May 4, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Save 100% on your flight
Price was $1,753, price is now $1,118 per person
$1,118
per person
Jul 11 - Jul 18
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
8.4/10 Very Good! (1,524 reviews)
Good value for the dollar

Reviewed on May 4, 2026

Hilton Panama

Hilton Panama

5 out of 5
Bella Vista
Price was $1,728, price is now $1,229 per person
$1,229
per person
Jul 11 - Jul 18
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (1,007 reviews)
First class hotel in downtown with excellent view from pool and restaurant area on high floor (really pleasant at night). Many dining options and not far from Panama Canal and old city.

Reviewed on Apr 30, 2026

Irresistible City Center

Irresistible City Center

3.5 out of 5
San Francisco
Price was $1,274, price is now $932 per person
$932
per person
Jun 13 - Jun 20
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
8/10 Very Good! (2 reviews)
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Santa Isabel Hotel Deals

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
10/10 Exceptional! (1 review)
Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door.

Reviewed on Mar 15, 2026

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Private Ocean-Front Cabin with private bathroom on San Blas Island
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
$1,974 nightly
The price is $2,178 total per night from May 15 to May 16
$2,178 total
May 15 - May 16
Total with taxes and fees
Cocoloco - Catamaran Lagoon 52F SAN BLAS
BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

Santa Isabel Colon
10/10 Exceptional! (31 reviews)
This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful ...

Reviewed on Jan 1, 2026

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BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES
See all 40 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Isabel Vacation Packages

Santa Isabel Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
260
Max Temp Winter
80ºF
Max Temp Summer
80ºF

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Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $916 on Expedia for your Santa Isabel getaway. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
You can typically find lower prices and better availability in August, November and December. Take a look at our cheap Santa Isabel vacation packages and you could land some excellent off-season deals.
How many days is enough for Santa Isabel?
Typically, a handful of days is enough to visit the major attractions during your Santa Isabel vacation. However, if you want to have some time to kick back or go on day trips, consider extending your itinerary.
How to find the best Santa Isabel package deals?
Finding a cheap Santa Isabel package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your maximum budget, add a few filters and see what's available. You can personalize your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Isabel package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Isabel vacation as a package?
You can enjoy significant savings on your Santa Isabel break by booking a personalized vacation package. Click on the "Package" heading, then select your travel dates and destination to browse some great airfares and hotel prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Isabel?
Enjoy incredible bargains by reserving your flights early with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for a spur-of-the-moment Santa Isabel getaway.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Set off on your dream escape to Santa Isabel with help from our Book Now, Pay Later vacations. There's no need to save up or hold off until your next paycheck — we've partnered with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can split the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, it's easy to stay on budget and snap up travel deals before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.