Santa Isabel Vacations from $844

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The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
San Francisco
Price was $1,296, price is now $844 per person
$844
per person
Sep 26 - Oct 3
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
8.6/10 Excellent! (1,697 reviews)

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,979, price is now $1,556 per person
$1,556
per person
Aug 19 - Aug 26
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9.2/10 Wonderful! (1,001 reviews)
Rooms were very clean and staff respectful and helpful at all times, views from the pool rooftop are stunning and can see the city, breakfast was great with several options to chose from. Will definetely come back it was a great place to stay in the City for me and my family.

Reviewed on Jul 19, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Save 100% on your flight
Price was $2,672, price is now $1,578 per person
$1,578
per person
Aug 19 - Aug 26
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
8.4/10 Very Good! (1,574 reviews)
I highly recommend this hotel….. from the buffet breakfast straight to the cleanliness 9.5/10

Reviewed on Jul 19, 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was $1,937, price is now $1,364 per person
$1,364
per person
Aug 19 - Aug 26
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
8.4/10 Very Good! (1,818 reviews)
si tienes que hacer escala en panama. este lugar es perfecto. super cerca. te da transporte de aeropuerto hotel y viceversa. Y me toco comer ahi y todo rico. Dormi bien y volveria para ir de compras a panama

Reviewed on Jul 19, 2026

Las Clementinas

Las Clementinas

3.5 out of 5
Casco Viejo
Price was $1,366, price is now $1,006 per person
$1,006
per person
Sep 11 - Sep 16
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9.4/10 Exceptional! (198 reviews)
Great food and location

Reviewed on Jul 11, 2026

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Santa Isabel Hotel Deals

Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
$1,953 nightly
The price is $2,158 total per night from Aug 20 to Aug 21
$2,158 total
Aug 20 - Aug 21
Total with taxes and fees
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
$188 nightly
The price is $207 total per night from Aug 18 to Aug 19
$207 total
Aug 18 - Aug 19
Total with taxes and fees
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
Caribbean Haven Of Nature 'Preci Beach'

Caribbean Haven Of Nature 'Preci Beach'

Nombre de Dios Colon
10/10 Exceptional! (31 reviews)
Beautiful
"This place is special. The inside of the house could use a deep cleaning. But the outdoor area and beach area are incredible. We explored tide pools and snorkeled open areas and crevices all week long. Our one negative experience was fishing with some young men from the nearby town; they did not ..."

Reviewed on Mar 17, 2025

Get rates
Caribbean Haven Of Nature 'Preci Beach'
See all 39 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Isabel Vacation Packages

Santa Isabel Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
260
Max Temp Winter
80ºF
Max Temp Summer
80ºF

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Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $844 on Expedia for your Santa Isabel getaway. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
You can typically find lower prices and better availability in August, November and December. Take a look at our cheap Santa Isabel vacation packages and you could land some excellent off-season deals.
How many days is enough for Santa Isabel?
Typically, a handful of days is enough to visit the major attractions during your Santa Isabel vacation. However, if you want to have some time to kick back or go on day trips, consider extending your itinerary.
How to find the best Santa Isabel package deals?
Finding a cheap Santa Isabel package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your maximum budget, add a few filters and see what's available. You can personalize your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Isabel package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Isabel vacation as a package?
You can enjoy significant savings on your Santa Isabel break by booking a personalized vacation package. Click on the "Package" heading, then select your travel dates and destination to browse some great airfares and hotel prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Isabel?
Enjoy incredible bargains by reserving your flights early with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for a spur-of-the-moment Santa Isabel getaway.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Set off on your dream escape to Santa Isabel with help from our Book Now, Pay Later vacations. There's no need to save up or hold off until your next paycheck — we've partnered with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can split the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, it's easy to stay on budget and snap up travel deals before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.