Santa Isabel Vacations from $689

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The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
Casa Love by Wynwood House

Casa Love by Wynwood House

Casco Viejo
$689
per person
Oct 19 - Oct 23
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
8.6/10 Excellent! (32 reviews)
The unit we stayed in was large and fully equipped, with a balcony and a full kitchen. The building was secure and conveniently located within walking distance to everything in casco viejo. There are lots of shops and restaurants nearby and we felt mostly safe walking around. The only issue we had was that the code to our lockbox didn’t work when we arrived. However, we texted the property staff and they were able to give us another code that worked right away. The internet in the unit worked fine, but be sure to have a data plan or eSIM so that you can connect with the property and order Ubers, especially when you first get in, as the WiFi in the airport can be very spotty.

Reviewed on Aug 19, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Casco Viejo
Save 100% on your flight
$1,364
per person
Nov 10 - Nov 16
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,001 reviews)
Staff was amazing

Reviewed on Sep 6, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

San Francisco
$969
per person
Oct 14 - Oct 18
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,692 reviews)
Casa La Costa By Wynwood House

Casa La Costa By Wynwood House

Casco Viejo
$769
per person
Oct 19 - Oct 23
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
8/10 Very Good! (33 reviews)
The bed was fine, but the closet and the floor were quite dirty. There was also an unpleasant smell in my room.

Reviewed on Jul 25, 2026

Mini Design By Wynwood House

Mini Design By Wynwood House

Bella Vista
$727
per person
Oct 19 - Oct 23
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
10/10 Exceptional! (3 reviews)
This place was absolutely ADORABLE and AMAZING to stay in! From the moment I booked, I knew I had made the right choice. They immediately thanked me for choosing them, and their communication was outstanding from start to finish. They were friendly, responsive, and made the entire process stress-free. The night before check-in, they sent detailed instructions, so I knew exactly what to expect. When we arrived, we were greeted by a representative from the building who personally checked us in and escorted us to the elevator. We stayed in Apartment 11F, and let me tell you—it was even cuter than the pictures! The apartment was spotless, beautifully decorated, and stocked with just about everything you could need for a comfortable vacation. One of my favorite features was that it had TWO bathrooms! That’s almost unheard of for a one-bedroom apartment and was one of the biggest reasons I booked it. (Just remember to pack your own washcloths and a towel for the pool.) The location couldn’t have been better. There’s a casino directly across the street, and you’ll find restaurants, cafés, and plenty of places to eat in every direction you walk. We felt safe exploring the area, and honestly, Panama as a whole made us feel very comfortable. If you’re thinking about booking this place, DO IT! You won’t regret it. The hospitality, cleanliness, location, and overall experience were top-notch. I’ll definitely be looking for this host anytime I vacation overseas again. They truly made

Reviewed on Jul 12, 2026

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Santa Isabel Hotel Deals

Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
$1,698 nightly
$1,902 total
Oct 7 - Oct 8
Total with taxes and fees
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala
$188 nightly
$207 total
Sep 8 - Sep 9
Total with taxes and fees
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
Caribbean getaway: beach cottage just on the sand

Caribbean getaway: beach cottage just on the sand

Palenque Provincia de Colón
9/10 Wonderful! (4 reviews)
"the view is beautiful! We were taken care of well."

Reviewed on Jul 26, 2026

Get rates
Caribbean getaway: beach cottage just on the sand
See all 40 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Isabel Vacation Packages

Santa Isabel Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
260
Max Temp Winter
80ºF
Max Temp Summer
80ºF

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Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $689 on Expedia for your Santa Isabel getaway. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
You can typically find lower prices and better availability in August, November and December. Take a look at our cheap Santa Isabel vacation packages and you could land some excellent off-season deals.
How many days is enough for Santa Isabel?
Typically, a handful of days is enough to visit the major attractions during your Santa Isabel vacation. However, if you want to have some time to kick back or go on day trips, consider extending your itinerary.
How to find the best Santa Isabel package deals?
Finding a cheap Santa Isabel package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your maximum budget, add a few filters and see what's available. You can personalize your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Isabel package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Isabel vacation as a package?
You can enjoy significant savings on your Santa Isabel break by booking a personalized vacation package. Click on the "Package" heading, then select your travel dates and destination to browse some great airfares and hotel prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Isabel?
Enjoy incredible bargains by reserving your flights early with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for a spur-of-the-moment Santa Isabel getaway.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Set off on your dream escape to Santa Isabel with help from our Book Now, Pay Later vacations. There's no need to save up or hold off until your next paycheck — we've partnered with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can split the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, it's easy to stay on budget and snap up travel deals before they disappear.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.