Santa Isabel Vacations from $750

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The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel San Pedro de Taboga

Hotel San Pedro de Taboga

3 out of 5
Price was $1,082, price is now $750 per person
$750
per person
Jan 24 - Jan 30
found 21 hours ago
Roundtrip flight included
Georgetown (GEO) to Panama City (PTY)
9.6/10 Exceptional! (5 reviews)
Peronal muy amable y dispuestos ayudar en todo momento.

Reviewed on Sep 21, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $2,226, price is now $1,251 per person
$1,251
per person
Dec 3 - Dec 7
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,015 reviews)
Excelente ubicación, lugar agradable y cómodo.

Reviewed on Nov 2, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $1,621, price is now $982 per person
$982
per person
Jan 11 - Jan 15
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.6/10 Excellent! (1,803 reviews)
The bed sheets were soiled in the room. Fixtures in the shower, lamps and toilet were falling a part. The staff was friendly and the breakfast was amazing. It's situated in an ideal location to get around with Uber and taxi services. The restaurant inside the hotel was nice and food came out in a timely manner.

Reviewed on Nov 2, 2026

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

3.5 out of 5
Casco Viejo
Price was $7,539, price is now $5,290 per person
$5,290
per person
Dec 28 - Jan 2
found 20 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.8/10 Exceptional! (30 reviews)
I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect. The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us. I would stay here again in a heart beat. It’s a must stay!

Reviewed on Sep 16, 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Tocumen Airport
Price was $1,289, price is now $914 per person
$914
per person
Jan 11 - Jan 15
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.6/10 Excellent! (1,824 reviews)
Le personnel très gentil - mais pas d'eau chaude

Reviewed on Nov 2, 2026

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Santa Isabel Hotel Deals

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
$188 nightly
The price is $207 total per night from Nov 4 to Nov 5
$207 total
Nov 4 - Nov 5
Total with taxes and fees
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
Get rates
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Caribbean Haven Of Nature 'Preci Beach'

Caribbean Haven Of Nature 'Preci Beach'

Nombre de Dios Colon
10/10 Exceptional! (32 reviews)
"This is a great place to slow down and enjoy the sea and on-site amenities, including a pool, hot tub, sand volleyball court, and kid-friendly play spaces. This is very much a home that the owners make available to guests. Cone, the on-site custodian, is available and helpful. It is somewhat remote ..."

Reviewed on Oct 2, 2026

Get rates
Caribbean Haven Of Nature 'Preci Beach'
See all 38 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Isabel Vacation Packages

Santa Isabel Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
260
Max Temp Winter
80ºF
Max Temp Summer
80ºF

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Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $750 on Expedia for your Santa Isabel getaway. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
You can typically find lower prices and better availability in August, November and December. Take a look at our cheap Santa Isabel vacation packages and you could land some excellent off-season deals.
How many days is enough for Santa Isabel?
Typically, a handful of days is enough to visit the major attractions during your Santa Isabel vacation. However, if you want to have some time to kick back or go on day trips, consider extending your itinerary.
How to find the best Santa Isabel package deals?
Finding a cheap Santa Isabel package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your maximum budget, add a few filters and see what's available. You can personalize your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Isabel package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Isabel vacation as a package?
You can enjoy significant savings on your Santa Isabel break by booking a personalized vacation package. Click on the "Package" heading, then select your travel dates and destination to browse some great airfares and hotel prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Isabel?
Enjoy incredible bargains by reserving your flights early with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for a spur-of-the-moment Santa Isabel getaway.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Set off on your dream escape to Santa Isabel with help from our Book Now, Pay Later vacations. There's no need to save up or hold off until your next paycheck — we've partnered with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can split the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, it's easy to stay on budget and snap up travel deals before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.