Title: Santa Isabel Vacation Packages 2026 from $665 | Expedia.com

[Santa Isabel Travel Guide](https://expedia.com/Santa-Isabel.dx6203540)[Hotels in Santa Isabel](https://expedia.com/Santa-Isabel-Hotels.d6203540.Travel-Guide-Hotels)[Vacation Rentals in Santa Isabel](https://expedia.com/Santa-Isabel-Vacation-Rentals.d6203540.Travel-Guide-VacationRentals)[Flights to Santa Isabel](https://expedia.com/Cheap-Flights-To-Santa-Isabel.d6203540.Travel-Guide-Flights)[Car Rentals in Santa Isabel](https://expedia.com/Car-Rentals-In-Santa-Isabel.d6203540.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Santa Isabel Vacations from $665

## Book a Hotel + Flight or Car together to unlock savings

## The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.

![Villa Botero By Casa Mojito B&B](https://images.trvl-media.com/lodging/12000000/11930000/11927200/11927153/393d35f8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Villa Botero By Casa Mojito B&B

Save 100% on your flight

$665

per person

May 4 - May 11

found 7 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

9.8/10 Exceptional! (60 reviews)

We stayed one night and it exceeded our expectations. The owners were incredibly friendly and easy to contact, making us feel right at home. Everything was spotless, and the atmosphere was warm and inviting. The homemade breakfast was a highlight—absolutely delicious and full of flavor. We will stay again longer next time.

Reviewed on Jan 22, 2026

![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$1,179

per person

May 7 - May 13

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (1,002 reviews)

Breakfast is continental buffet and AMAZING. The fruit, the many options, the omelettes, truly delicious. The room was spotless, the location more than convenient to walk and explore Casco Viejo, the staff was very kind and helpful. The only downside is that the room we needed (family) was ready a bit after check in time (3:20 pm instead of 3 pm). I would stay again here.

Reviewed on Feb 23, 2026

![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel Riu Plaza Panama

Bella Vista

$823

per person

May 7 - May 13

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9/10 Wonderful! (4,515 reviews)

The room smells musty.

Reviewed on Feb 24, 2026

![Yoo by Wynwood House](https://images.trvl-media.com/lodging/104000000/103610000/103606300/103606257/f526e4da_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Yoo by Wynwood House

Calidonia

$1,225

per person

Apr 29 - May 5

found 16 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9.2/10 Wonderful! (5 reviews)

Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone.

Reviewed on Jul 26, 2025

![Playa Caracol](https://images.trvl-media.com/lodging/91000000/90130000/90127300/90127274/b180bfb9_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Playa Caracol

Save 100% on your flight

$1,039

per person

May 4 - May 11

found 7 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

8/10 Very Good! (5 reviews)

Don't see what you're looking for?

See all available trips from Columbus to Santa Isabel

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-24/2026-03-31/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_6203540)

## Santa Isabel Hotel Deals

![Cocoloco - Catamaran Lagoon 52F SAN BLAS](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/1b4156f6_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Cocoloco - Catamaran Lagoon 52F SAN BLAS

El Porvenir Narganá Guna Yala

Fully refundableReserve now, pay when you stay

$1,824 nightly

$2,020 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=95807391&PinnedHotelID=95807391&HadPinnedHotel=true&regionId=6203540)

![Private Ocean-Front Cabin with private bathroom on San Blas Island](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/ede84b95_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala

$188 nightly

$207 total

Mar 3 - Mar 4

Total with taxes and fees

[](https://expedia.com/Hotel-Search?startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&selected=37766985&PinnedHotelID=37766985&HadPinnedHotel=true&regionId=6203540)

![Trips Guna Yala](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/9e5e20c9_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Trips Guna Yala

Urgandi, Mamardub Narganá Guna Yala

Fully refundableReserve now, pay when you stay

$214 nightly

$236 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=103726734&PinnedHotelID=103726734&HadPinnedHotel=true&regionId=6203540)

[See all 41 properties in Santa Isabel](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F25%2F2026&endDate=2%2F26%2F2026&regionId=6203540)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Santa Isabel Vacation Packages

## Santa Isabel Essential Information

| Language        | Spanish            |
| --------------- | ------------------ |
| Currency        | Panamanian balboas |
| Local Welcome   | ¡Hola!             |
| Local Goodbye   | Adiós              |
| Population      | 260                |
| Max Temp Winter | 80ºF               |
| Max Temp Summer | 80ºF               |

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## Frequently asked questions

### How much does a Santa Isabel vacation package cost?

### What are the cheapest months to go to Santa Isabel?

### How many days is enough for Santa Isabel?

### How to find the best Santa Isabel package deals?

### Is it cheaper to book a Santa Isabel vacation as a package?

### When to book a vacation package to Santa Isabel?

### Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?

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\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.