Santa Isabel Vacations from $741

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The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
Villa Marina Hotel

Villa Marina Hotel

3.5 out of 5
Price was $1,087, price is now $741 per person
$741
per person
Jul 29 - Aug 2
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9/10 Wonderful! (161 reviews)
The room was spotless clean! The staff was always helpful and ready to serve. Breakfast and food in general was very tasty. The Bar is quite complete

Reviewed on Jun 13, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,225, price is now $1,044 per person
$1,044
per person
Aug 30 - Sep 6
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9.2/10 Wonderful! (1,008 reviews)
I really enjoyed the hotel. I enjoyed the food, drinks and entertainment. The pool was another matter, for such a top rated hotel the pool was worse than any other hotel I have stayed. In the pictures it looked beautiful but when we went up, it was very disappointed. Everything else was great. I really picked you guys because of the pool. I wanted to get in a pool but yours like I said disappointed me.

Reviewed on Jun 19, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Save 100% on your flight
Price was $1,725, price is now $948 per person
$948
per person
Aug 30 - Sep 6
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
8.4/10 Very Good! (1,553 reviews)
Convenient location & very good overall!

Reviewed on Jun 20, 2026

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,381, price is now $904 per person
$904
per person
Aug 30 - Sep 6
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (5,582 reviews)
I must say that my experience was excellent. The staff were professional, welcoming, and attentive throughout my stay. The room was clean, comfortable, and well-maintained, and the amenities provided exceeded my expectations. I especially appreciated the peaceful atmosphere and the high level of customer service. Overall, it was a wonderful experience, and I would gladly recommend your hotel to others and look forward to staying again in the future.

Reviewed on Jun 21, 2026

Boutique Apartments Panamá Coco del Mar

Boutique Apartments Panamá Coco del Mar

3.5 out of 5
San Francisco
Save 100% on your flight
Price was $38,399, price is now $25,334 per person
$25,334
per person
Aug 30 - Sep 6
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
7.6/10 Good! (201 reviews)
Always a pleasure to stay with Boutique Apartments. Customer service has always been a good experience.

Reviewed on Jun 20, 2026

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Santa Isabel Hotel Deals

Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
$1,875 nightly
The price is $2,080 total per night from Jun 29 to Jun 30
$2,080 total
Jun 29 - Jun 30
Total with taxes and fees
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

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Private Ocean-Front Cabin with private bathroom on San Blas Island
BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

Santa Isabel Colon
10/10 Exceptional! (31 reviews)
"This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful ..."

Reviewed on Jan 1, 2026

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BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES
See all 39 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Isabel Vacation Packages

Santa Isabel Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
260
Max Temp Winter
80ºF
Max Temp Summer
80ºF

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Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $741 on Expedia for your Santa Isabel getaway. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
You can typically find lower prices and better availability in August, November and December. Take a look at our cheap Santa Isabel vacation packages and you could land some excellent off-season deals.
How many days is enough for Santa Isabel?
Typically, a handful of days is enough to visit the major attractions during your Santa Isabel vacation. However, if you want to have some time to kick back or go on day trips, consider extending your itinerary.
How to find the best Santa Isabel package deals?
Finding a cheap Santa Isabel package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your maximum budget, add a few filters and see what's available. You can personalize your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Isabel package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Isabel vacation as a package?
You can enjoy significant savings on your Santa Isabel break by booking a personalized vacation package. Click on the "Package" heading, then select your travel dates and destination to browse some great airfares and hotel prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Isabel?
Enjoy incredible bargains by reserving your flights early with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for a spur-of-the-moment Santa Isabel getaway.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Set off on your dream escape to Santa Isabel with help from our Book Now, Pay Later vacations. There's no need to save up or hold off until your next paycheck — we've partnered with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can split the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, it's easy to stay on budget and snap up travel deals before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.