Santa Isabel Vacations from $811

Book a Hotel + Flight or Car together to unlock savings

The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
Nowhere

Nowhere

3 out of 5
Price was $1,247, price is now $811 per person
$811
per person
Dec 14 - Dec 19
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
9.2/10 Wonderful! (17 reviews)
Not a single thing negative about this magical jungle paradise!!! If you’ve ever said “ I wish I was in the middle of NOWHERE so nobody can stress me out “ then THIS IS YOUR PLACE!!! Private individual Casitas tucked into the jungle with pathways to common areas, pool, gym, fire pit, even a separate meeting facility equipped with projector/screens large table. Great for any retreat … working or not!! Clean Courtious Fabulous restaurants and budget friendly. A word: PERFECT!

Reviewed on Nov 7, 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,469, price is now $1,354 per person
$1,354
per person
Jan 30 - Feb 6
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (1,005 reviews)
Staffs were wonderful.

Reviewed on Oct 28, 2025

Central Hotel Bocas del Toro

Central Hotel Bocas del Toro

3 out of 5
Save 100% on your flight
Price was $2,668, price is now $1,557 per person
$1,557
per person
Jan 19 - Jan 23
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
No reviews
Hotel Panamonte

Hotel Panamonte

3.5 out of 5
Price was $1,492, price is now $890 per person
$890
per person
Dec 14 - Dec 19
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
9.4/10 Exceptional! (121 reviews)
This is a classic, elegant property that lives up to its reputation. Quality in every regard. On par with some of the finest historic hotels in the country (and I’ve stayed at a few).

Reviewed on Sep 4, 2025

Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B

3 out of 5
Price was $1,376, price is now $851 per person
$851
per person
Dec 14 - Dec 19
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
Host was excellent. Great communication and very helpful. The rooms were nice and great value.

Reviewed on Apr 18, 2025

Don't see what you're looking for?
See all available trips from Columbus to Santa Isabel
View all trips

Santa Isabel Hotel Deals

San Blas Paradise Private Cabins on Shipwreck Island - meals included

San Blas Paradise Private Cabins on Shipwreck Island - meals included

2 out of 5
Perro Island, Narganá, Guna Yala
$169 nightly
The price is $186 total per night from Nov 9 to Nov 10
$186 total
Nov 9 - Nov 10
Total with taxes and fees
San Blas Paradise Private Cabins on Shipwreck Island - meals included
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island, Narganá, Guna Yala
$188 nightly
The price is $207 total per night from Nov 9 to Nov 10
$207 total
Nov 9 - Nov 10
Total with taxes and fees
Private Ocean-Front Cabin with private bathroom on San Blas Island
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir, Narganá, Guna Yala
Fully refundableReserve now, pay when you stay
$2,026 nightly
The price is $2,234 total per night from Nov 9 to Nov 10
$2,234 total
Nov 9 - Nov 10
Total with taxes and fees
Cocoloco - Catamaran Lagoon 52F SAN BLAS
See all 44 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Isabel Vacation Packages

Santa Isabel Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
260
Max Temp Winter
80ºF
Max Temp Summer
80ºF

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $811 on Expedia for your Santa Isabel getaway. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
You can typically find lower prices and better availability in August, November and December. Take a look at our cheap Santa Isabel vacation packages and you could land some excellent off-season deals.
How many days is enough for Santa Isabel?
Typically, a handful of days is enough to visit the major attractions during your Santa Isabel vacation. However, if you want to have some time to kick back or go on day trips, consider extending your itinerary.
How to find the best Santa Isabel package deals?
Finding a cheap Santa Isabel package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your maximum budget, add a few filters and see what's available. You can personalize your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Isabel package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Isabel vacation as a package?
You can enjoy significant savings on your Santa Isabel break by booking a personalized vacation package. Click on the "Package" heading, then select your travel dates and destination to browse some great airfares and hotel prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Isabel?
Enjoy incredible bargains by reserving your flights early with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for a spur-of-the-moment Santa Isabel getaway.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Set off on your dream escape to Santa Isabel with help from our Book Now, Pay Later vacations. There's no need to save up or hold off until your next paycheck — we've partnered with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can split the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, it's easy to stay on budget and snap up travel deals before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.