Santa Isabel Vacations from $812

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to $1,045 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
per person
Oct 11 - Oct 18
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (4,141 reviews)
We were disappointed by the fact that the pool was being renovated (therefore closed) and we were not notified until we were checking in at the hotel.

Reviewed on Aug 18, 2025

La Coralina Island House

La Coralina Island House

3.5 out of 5
Save 100% on your flight
per person
Nov 7 - Nov 12
found 3 hours ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
9.4/10 Exceptional! (83 reviews)
Wow! This resort is absolutely amazing! Bekar went above and beyond for us! He even brought in a TV to the lobby so we could watch the NHL playoff game! Food is 10/10 as well. We will definitely go back!

Reviewed on May 18, 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
per person
Sep 24 - Oct 1
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (965 reviews)
Perfectly located for seeing Casco Viejo, and beautifully maintained as an historic building. Staff was absolutely accommodating and responsive to all requests (and we had a few!).

Reviewed on Aug 18, 2025

Isla Palenque Member of the Cayuga Collection

Isla Palenque Member of the Cayuga Collection

4 out of 5
Save 100% on your flight
per person
Nov 12 - Nov 16
found 1 day ago
Roundtrip flight included
New York (NYC) to Panama City (PTY)
10/10 Exceptional! (6 reviews)
Villa Marina Lodge & Condos

Villa Marina Lodge & Condos

3.5 out of 5
per person
Nov 7 - Nov 12
found 3 hours ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
9/10 Wonderful! (127 reviews)
Love that this property is at the other end of the beach from the late night partying. Walkable beach. Great restaurants nearby. The property was adding coffee makers and mini fridges the day we were leaving. Great staff, restaurant and drinks. We’ve been twice with our pooches. Will be back

Reviewed on Jul 14, 2025

Don't see what you're looking for?
See all available trips from Columbus to Santa Isabel
View all trips

Santa Isabel Hotel Deals

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island, Narganá, Guna Yala
Get rates
Private Ocean-Front Cabin with private bathroom on San Blas Island
Private Over the Water Cabin on San Blas Island

Private Over the Water Cabin on San Blas Island

2 out of 5
9.542876, -78.899058, Narganá, San Blas
7/10 Good! (6 reviews)
"Very nice. And I liked the food"

Reviewed on Aug 14, 2025

Get rates
Private Over the Water Cabin on San Blas Island
San Blas Paradise Private Cabins on Shipwreck Island - meals included

San Blas Paradise Private Cabins on Shipwreck Island - meals included

2 out of 5
Perro Island, Narganá, Guna Yala
$169 nightly
The price is $186 total per night from Aug 19 to Aug 20
$186 total
Aug 19 - Aug 20
Total includes taxes and fees
San Blas Paradise Private Cabins on Shipwreck Island - meals included
See all 45 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $812 on Expedia for your Santa Isabel getaway. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
You can typically find lower prices and better availability in August, November and December. Take a look at our cheap Santa Isabel vacation packages and you could land some excellent off-season deals.
How many days is enough for Santa Isabel?
Typically, a handful of days is enough to visit the major attractions during your Santa Isabel vacation. However, if you want to have some time to kick back or go on day trips, consider extending your itinerary.
How to find the best Santa Isabel package deals?
Finding a cheap Santa Isabel package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your maximum budget, add a few filters and see what's available. You can personalize your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Isabel package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Isabel vacation as a package?
You can enjoy significant savings on your Santa Isabel break by booking a personalized vacation package. Click on the "Package" heading, then select your travel dates and destination to browse some great airfares and hotel prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Isabel?
Enjoy incredible bargains by reserving your flights early with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for a spur-of-the-moment Santa Isabel getaway.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Set off on your dream escape to Santa Isabel with help from our Book Now, Pay Later vacations. There's no need to save up or hold off until your next paycheck — we've partnered with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can split the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, it's easy to stay on budget and snap up travel deals before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.