
Santa Isabel Vacations from $581
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The Latest Santa Isabel vacation packages
Price found within the past 48 hours. Click for updated prices.

Mahogany Suites
Price was $1,080, price is now $581 per person
$581
per person
May 27 - Jun 1
found 19 hours ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9.2/10 Wonderful! (5 reviews)
Gréât location and the staff at the gate. Rom had everything except extra towells and cleaning liquids. Love to come again to stay in this property!
Reviewed on Mar 8, 2026

Megapolis Hotel Panamá
San Francisco
Save 100% on your flight
Price was $1,618, price is now $1,042 per person
$1,042
per person
Apr 29 - May 6
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
8.4/10 Very Good! (1,441 reviews)
The room are nice and clean the pool is too much noise. It’s a mess
Reviewed on Mar 10, 2026

Hotel Riu Plaza Panama
Bella Vista
Price was $1,278, price is now $876 per person
$876
per person
May 22 - May 29
found 24 hours ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (5,057 reviews)
The hotel was marketed as a 5-star property, but it didn’t quite live up to that standard. The restaurants and buffet were pretty underwhelming, and the hotel overall felt a bit dated. The pool area was decent, but the staff there were noticeably rude, which hurt the experience.
That said, there were some positives. The front desk staff were friendly, the housekeeping team did a great job, and everything throughout the hotel was very clean. The room itself was well laid out and comfortable, and the bed was great for our 8-night stay.
Overall, it’s a clean and comfortable hotel, but it doesn’t feel like a true 5-star experience.
Reviewed on Mar 10, 2026

Central Hotel Panama Casco Viejo
Casco Viejo
Save 100% on your flight
Price was $2,122, price is now $1,455 per person
$1,455
per person
May 15 - May 22
found 23 hours ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (1,010 reviews)
Great location clean safe and walkable!! Wonderful hotel
Reviewed on Mar 10, 2026

Yoo by Wynwood House
Calidonia
Price was $1,834, price is now $1,264 per person
$1,264
per person
Apr 27 - May 4
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9.2/10 Wonderful! (5 reviews)
Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone.
Reviewed on Jul 26, 2025
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See all available trips from Columbus to Santa Isabel
View all tripsSanta Isabel Hotel Deals

Cocoloco - Catamaran Lagoon 52F SAN BLAS
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
$1,746 nightly
The price is $1,926 total per night from Apr 9 to Apr 10
$1,926 total
Apr 9 - Apr 10
Total with taxes and fees

Private Ocean-Front Cabin with private bathroom on San Blas Island
Diablo Island Narganá Guna Yala
$188 nightly
The price is $207 total per night from Mar 11 to Mar 12
$207 total
Mar 11 - Mar 12
Total with taxes and fees

Trips Guna Yala
Urgandi, Mamardub Narganá Guna Yala
Fully refundableReserve now, pay when you stay
$213 nightly
The price is $235 total per night from Mar 17 to Mar 18
$235 total
Mar 17 - Mar 18
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Santa Isabel Vacation Packages
Santa Isabel Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Population | 260 |
Max Temp Winter | 80ºF |
Max Temp Summer | 80ºF |
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