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Our top choices for Santa Isabel hotels

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island
2.0 star property
Narganá
$188 nightly
The price is $207
Dec 25 - Dec 26
Total with taxes and fees
Private Ocean-Front Cabin with private bathroom on San Blas Island

Cabins on paradise San Blas island

Cabins on paradise San Blas island
2.0 star property
Narganá
Cabins on paradise San Blas island

San Blas Paradise Private Cabins on Shipwreck Island - meals included

San Blas Paradise Private Cabins on Shipwreck Island - meals included
2.0 star property
Narganá
$214 nightly
The price is $235
Dec 25 - Dec 26
Total with taxes and fees
San Blas Paradise Private Cabins on Shipwreck Island - meals included

Cabins in Asserya Island - San Blas paradise - meals included

Cabins in Asserya Island - San Blas paradise - meals included
2.0 star property
Narganá
$132 nightly
The price is $145
Dec 26 - Dec 27
Total with taxes and fees
Cabins in Asserya Island - San Blas paradise - meals included

Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS
3.0 star property
Narganá
$1,915 nightly
The price is $2,112
Jan 11 - Jan 12, 2026
Total with taxes and fees
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Trips Guna Yala

Trips Guna Yala
2.0 star property
Narganá
$216 nightly
The price is $238
Dec 25 - Dec 26
Total with taxes and fees
Trips Guna Yala
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Isabel Hotel Reviews

More cheap stays in Santa Isabel

Find out more about Santa Isabel

Top reasons to visit Santa Isabel

  • Stunning Beaches: Santa Isabel boasts beautiful, serene beaches perfect for relaxation and oceanfront strolls.
  • Outdoor Adventures: Explore hiking trails and national parks, offering abundant opportunities for adventure enthusiasts.
  • Cultural Experiences: Immerse yourself in the vibrant local culture, with authentic dining and traditional customs.
  • Historical Sites: Visit nearby historic attractions, such as Old Havana, for a taste of local history.
  • Comfortable Accommodations: Choose from a variety of hotels and lodges that cater to beach-loving travelers.

Find great hotels near Santa Isabel

Santa Isabel, Colón, Panama, offers a variety of hotel accommodations perfect for beach-loving travelers. Whether you're seeking a cozy lodge or a full-service hotel, you'll find options that cater to your needs. With numerous hotels to choose from, you can easily search for the best deals and read reviews to ensure a memorable stay. Experience the beauty of this coastal destination while enjoying the comforts of your chosen lodging.

  • Cabins on Paradise San Blas Island: Experience an idyllic getaway at Cabins on Paradise San Blas Island, located 16 miles from Santa Isabel. This hotel-style lodging offers a tranquil setting where guests can unwind in cozy cabins surrounded by lush landscapes. Dining options include a restaurant serving local and international cuisine, along with complimentary daily breakfast and a snack bar for light bites. With a focus on relaxation and comfort, this property is ideal for families and couples seeking a serene escape.
  • Cabañas Nalunega San Blas: Nestled 17 miles from Santa Isabel, Cabañas Nalunega San Blas offers a unique lodge experience with a focus on adventure. Guests can enjoy on-site dining with a restaurant that serves breakfast for an additional fee and local specialties. The lodge is perfect for outdoor enthusiasts, featuring various sports and recreational activities, including boat tours that allow you to explore the stunning surroundings. With its blend of comfort and adventure, this accommodation is an excellent choice for those looking to immerse themselves in nature.
  • Cabañas Isla Nubesidub San Blas: For travelers seeking a beach vacation experience, Cabañas Isla Nubesidub San Blas is the perfect destination. Located 17 miles from Santa Isabel, this lodge offers direct access to the pristine beach, allowing guests to enjoy sun-soaked days and breathtaking ocean views. Ideal for those looking to relax by the sea, the property provides a laid-back atmosphere complemented by comfortable accommodations. Whether you wish to swim, sunbathe, or simply unwind, this lodge promises a memorable beach getaway.

Where to stay near Santa Isabel

Santa Isabel, located on Panama's southern coast, offers a delightful mix of beachside relaxation and cultural exploration. Enjoy oceanfront strolls along serene beaches, immerse yourself in the vibrant local culture, and take in stunning city views. Nearby, the historic charm of Old Havana beckons, making it a perfect destination for families and outdoor enthusiasts alike. With its strategic location, Santa Isabel is an ideal base for discovering the beauty of the region.

  • Miramar: Nestled approximately 10 miles from Santa Isabel, Miramar is a vibrant city that attracts travelers seeking a delightful mix of beach, outdoor, and cultural experiences. The peak tourist season from January to March brings a lively atmosphere, perfect for enjoying the stunning beaches and exploring local museums. Visitors can also indulge in the marina, which offers various water activities and stunning views. Whether you're soaking up the sun or immersing yourself in local culture, Miramar is a must-visit destination.
  • Palenque: Located about 12 miles from Santa Isabel, Palenque is an adventure seeker’s paradise. With a steady influx of visitors, especially from January to March, this city offers an array of beach and outdoor activities, along with opportunities for adventure. Explore nearby national parks and museums that showcase the area’s rich history and natural beauty. Palenque is perfect for those looking to combine relaxation on the beach with thrilling outdoor adventures.
  • Carti: Situated around 16 miles from Santa Isabel, Carti is a charming village that offers a unique blend of family-friendly activities and city conveniences. The peak travel times are in April and December to January, drawing visitors for both leisure and business. The village features a shopping center and mall, making it an ideal spot for those looking to shop. With beautiful beaches and a scenic jetty pier, Carti provides a relaxing atmosphere perfect for family outings and exploration.

Things to do near Santa Isabel

Santa Isabel, Colón, Panama, is perfect for beach lovers and outdoor enthusiasts, offering a variety of activities such as hiking trails and authentic cultural experiences. Visitors can enjoy outdoor seating at local eateries, relax with spa services, and immerse themselves in the vibrant local culture. Whether you're seeking adventure or relaxation, Santa Isabel provides a unique blend of experiences for an unforgettable vacation.

Shopping

In Santa Isabel, enjoy local shops for unique gifts and souvenirs. If you're up for a drive, visit Albrook Mall, about 60 miles away, which boasts a wide range of stores, restaurants, and entertainment options, perfect for a full day of shopping.

Recreation

Experience tranquility at Serenity Spa, where you can indulge in rejuvenating massages and holistic treatments surrounded by lush nature. For outdoor fun, visit the nearby beaches for sunbathing, swimming, and beach volleyball, ensuring a perfect mix of relaxation and activity during your stay in Santa Isabel.

Adventure

Experience the Honeycreeper Ridge Trail, located 21 miles from Santa Isabel. This hiking trail offers thrilling outdoor adventures surrounded by breathtaking scenery, perfect for nature lovers seeking an exhilarating trek through lush landscapes and vibrant wildlife.

Nightlife

Experience the vibrant nightlife at La Casa de la Musica, where you can enjoy live salsa music and dance the night away. For a laid-back vibe, visit El Muelle Bar, offering refreshing cocktails and stunning views of the waterfront.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santa Isabel

For a budget-friendly trip to Santa Isabel, consider visiting in January, March, or May when prices are lower. Book your hotel 1-3 months in advance for the best rates, and check for last-minute deals on Expedia. Tuesdays typically offer the cheapest hotel rates, while Wednesdays are the most expensive. Utilize Expedia's filters to find affordable accommodations and consider booking a package for additional savings. Don’t forget to join Expedia’s One Key membership for exclusive discounts and cash rewards on future stays.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Santa Isabel are January, March and May, where the prices are slightly lower. This is in comparison to July and October to November, where prices are slightly higher.
  • The best time to book a hotel: The cheapest time to book a hotel in Santa Isabel is usually 1-3 months out from when you are planning to stay. If you're a little more spontaneous, you could also peruse Expedia's last minute deals which could secure you a cheaper stay. Look out for the green banner below the price to spot the deals.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Santa Isabel is Tuesday. The most expensive day to stay in Santa Isabel is Wednesday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to refine your preferences, such as your budget, desired location, and preferred type of hotel. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by booking a package with Expedia that combines your hotel stay in Santa Isabel with your flights and activities.
  • Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions near Santa Isabel

Santa Isabel, Colón, Panama, offers a vibrant mix of beach, outdoor, and cultural experiences. Visitors can explore national parks, museums, and scenic rivers, making it ideal for those seeking adventure and local culture. Don't miss Santa Isabel Island and consider staying at the best resorts to enhance your vacation. Enjoy the diverse attractions that cater to both scenery lovers and outdoor enthusiasts in this charming destination.

  • Porvenir Museum: Located 14 miles from Santa Isabel, Porvenir Museum offers an immersive experience into the rich cultural heritage of Panama. Visitors can explore artifacts and exhibits that celebrate local history and traditions, making it a perfect spot for culture enthusiasts.
  • Chagres National Park: About 19 miles from Santa Isabel, Chagres National Park is a paradise for outdoor adventurers. With its stunning scenery and diverse wildlife, you can hike, kayak, or simply take in the breathtaking landscapes that this national park has to offer.
  • Local Museum: Situated 17 miles away, this museum showcases the vibrant culture of the region. Visitors can delve into various exhibits that highlight the area's artistic and historical significance, providing a deeper understanding of local life.

The nearest major airports for your trip to Santa Isabel

When traveling to Santa Isabel, Panama, you can choose from several major airports. Tocumen International Airport (PTY) is located 35 miles away, with nearby hotel options like JW Marriott Panama and The Santa Maria, both offering convenient access and transportation services. Marcos A. Gelabert International Airport (PAC) is 46 miles from Santa Isabel, featuring hotels such as The Westin Playa Bonita and Waldorf Astoria Panama, which provide various shuttle services. Lastly, Balboa International Airport (BLB) is 51 miles away, with accommodations like Sofitel Legend Casco Viejo and Bristol Panama, also offering airport transportation. Each airport provides a range of luxurious hotels for a comfortable stay.

Frequently asked questions

Where can I find the best nightlife in Santa Isabel?
Santa Isabel, located in the Colón province of Panama, is a charming area known for its laid-back atmosphere and scenic coastal views.

When it comes to nightlife, options are somewhat limited in Santa Isabel, as it is more of a tranquil destination than a bustling party hub. However, you can find some local bars and eateries that offer a relaxed ambiance for unwinding after a day of exploration.

For a more vibrant nightlife experience, consider venturing into nearby Colón city, where you'll find a range of bars and clubs that cater to various tastes, from lively dance spots to more intimate lounges. This allows you to enjoy the best of both worlds—peaceful days in Santa Isabel and exciting nights just a short drive away.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Isabel.
How can I save on a Santa Isabel hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Santa Isabel hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Santa Isabel hotel?
Prices for hotels in Santa Isabel often vary, but you can find a great deal from $145 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.