Title: The Best 5 Star Hotels in Syracuse from $105 | Expedia.com

[Syracuse Travel Guide](https://expedia.com/Syracuse.dx4912)[Hotels in Syracuse](https://expedia.com/Syracuse-Hotels.d4912.Travel-Guide-Hotels)[Vacation Rentals in Syracuse](https://expedia.com/Syracuse-Vacation-Rentals.d4912.Travel-Guide-VacationRentals)[Flights to Syracuse](https://expedia.com/Cheap-Flights-To-Syracuse.d4912.Travel-Guide-Flights)[Things to do in Syracuse](https://expedia.com/Things-To-Do-In-Syracuse.d4912.Travel-Guide-Activities)[Car Rentals in Syracuse](https://expedia.com/Car-Rentals-In-Syracuse.d4912.Car-Rental-Guide)[Syracuse Vacation Packages](https://expedia.com/Syracuse.d4912.Destination-Travel-Guides)

![Syracuse, panoramic phot of the Roman Amphitheatre at Syracuse (Siracusa), UNESCO World Heritage Site, Sicily, Italy, Europe](https://images.trvl-media.com/place/4912/0fad57c8-f045-437c-be3c-817a684ac32e.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/4912/0fad57c8-f045-437c-be3c-817a684ac32e.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Syracuse 5 Star Hotels

Tonight

[Feb 5 - Feb 6](https://www.expedia.com/Hotel-Search?regionId=4912&startDate=2026-02-05&endDate=2026-02-06&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 6 - Feb 7](https://www.expedia.com/Hotel-Search?regionId=4912&startDate=2026-02-06&endDate=2026-02-07&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 6 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=4912&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=4912&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Syracuse 5-star hotels

![Exterior](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/3b8d7262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, minibar, in-room safe, individually decorated](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/3cd441f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast, lunch served; local and international cuisine](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/d211e44f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/d22de140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ortea Palace Hotel, Sicily, Autograph Collection

[](https://www.expedia.com/Syracuse-Hotels-Ortea-Palace-Luxury-Hotel.h17825841.Hotel-Information)

Ortigia

9.4/10

Exceptional

(256 reviews)

"Great location and very friendly staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

James

$222 nightly

$256 total

Feb 6 - Feb 7

Total with taxes and fees

[](https://www.expedia.com/Syracuse-Hotels-Ortea-Palace-Luxury-Hotel.h17825841.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/ac752df8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private beach nearby, beach shuttle, sun loungers, beach umbrellas](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/400d9c2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/b126abef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch, dinner served; international cuisine, alfresco dining ](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/cc080552.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Grand Hotel Ortigia Siracusa

[](https://www.expedia.com/Syracuse-Hotels-Grand-Hotel-Ortigia-Siracusa.h1329454.Hotel-Information)

Ortigia

9.0/10

Wonderful

(576 reviews)

"Every aspect of our stay was superb. The staff were friendly and helpfull. Our room was spotless, and the decor of the entire hotel was harmonious. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Thomas

$188 nightly

$219 total

Feb 19 - Feb 20

Total with taxes and fees

[](https://www.expedia.com/Syracuse-Hotels-Grand-Hotel-Ortigia-Siracusa.h1329454.Hotel-Information)

![Rooftop terrace](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/83105a89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/f2d141d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Room | Minibar, in-room safe, individually decorated, individually furnished](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/2f1018dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Room, City View | Minibar, in-room safe, individually decorated, individually furnished](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/e1667130.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Caportigia Boutique Hotel

[](https://www.expedia.com/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information)

Santa Lucia

9.4/10

Exceptional

(260 reviews)

"Valentina & Malvina"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Andrew

$118 nightly

$142 total

Feb 15 - Feb 16

Total with taxes and fees

[](https://www.expedia.com/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information)

![Seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/cbf3a060.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Mediterranean cuisine](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/d1e57884.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/2e723fb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Building design](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/3abb85fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Grand Hotel Des Ètrangers - The Leading Hotels of the World

[](https://www.expedia.com/Syracuse-Hotels-Grand-Hotel-Des-Etrangers.h976389.Hotel-Information)

Ortigia

9.6/10

Exceptional

(73 reviews)

"Location, staff were amazing"

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Jared

[](https://www.expedia.com/Syracuse-Hotels-Grand-Hotel-Des-Etrangers.h976389.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/d439594a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor treatment areas](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/a7549475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/6824ea78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Luxury Villa, 2 Bedrooms, Sea View (The Suitest) | Bathroom | Shower, rainfall showerhead, designer toiletries, hair dryer](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/efec5cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Minareto

[](https://www.expedia.com/Syracuse-Hotels-Minareto.h2822343.Hotel-Information)

Syracuse

8.8/10

Excellent

(267 reviews)

"Very convenient for swimming and relaxing. "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Stanislau

[](https://www.expedia.com/Syracuse-Hotels-Minareto.h2822343.Hotel-Information)

![Sauna, hot tub, Turkish bath, body treatments, body scrubs, facials](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/77a257e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/5c45e57b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/ea5bf622.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/w5000h3331x0y3-d0f008d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Dimora Caiammari Luxury Hotel & Spa

[](https://www.expedia.com/Syracuse-Hotels-Caiammari-Boutique-Hotel-Spa.h915406.Hotel-Information)

Syracuse

9.4/10

Exceptional

(211 reviews)

"We experienced outstanding service from all of the staff, the breakfast buffet was lovely, lots of options and all homemade. We had a fantastic dinner in the restaurant one evening, which we booked ahead of our trip. "

![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg)

David

[](https://www.expedia.com/Syracuse-Hotels-Caiammari-Boutique-Hotel-Spa.h915406.Hotel-Information)

![Indoor pool, 2 outdoor pools, open 8:30 AM to 7:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/10000000/9390000/9388900/9388897/a2d4c1b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Beach nearby, free beach shuttle, beach umbrellas, beach towels](https://images.trvl-media.com/lodging/10000000/9390000/9388900/9388897/51043145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, 2 outdoor pools, open 8:30 AM to 7:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/10000000/9390000/9388900/9388897/0f4589a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, 2 outdoor pools, open 8:30 AM to 7:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/10000000/9390000/9388900/9388897/a7773f6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Wellness & Spa Hotel Principe di Fitalia

[](https://www.expedia.com/Syracuse-Hotels-Wellness-Spa-Hotel-Principe-Di-Fitalia.h9388897.Hotel-Information)

Syracuse

9.6/10

Exceptional

(94 reviews)

"This was such a wonderful stay! Spotless beautiful property with friendly staff and delicious breakfast!!! Very impressed!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jeffrey

$316 nightly

$359 total

Mar 5 - Mar 6

Total with taxes and fees

[](https://www.expedia.com/Syracuse-Hotels-Wellness-Spa-Hotel-Principe-Di-Fitalia.h9388897.Hotel-Information)

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse.

![Algila' Ortigia Charme Hotel](https://images.trvl-media.com/lodging/2000000/1890000/1883500/1883438/d402c8e9_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR

$193 nightly

$225 total

Feb 22 - Feb 23

Total with taxes and fees

9.4/10 Exceptional! (914 reviews)

[](https://expedia.com/Syracuse-Hotels-Algila-Ortigia-Charme-Hotel.h1883438.Hotel-Information)

![Mercure Siracusa Prometeo](https://images.trvl-media.com/lodging/2000000/1540000/1538700/1538612/b09648f6_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Mercure Siracusa Prometeo

Viale Teracati 20 Syracuse SR

$93 nightly

$118 total

Feb 21 - Feb 22

Total with taxes and fees

8.8/10 Excellent! (477 reviews)

[](https://expedia.com/Syracuse-Hotels-Mercure-Siracusa-Prometeo.h1538612.Hotel-Information)

![Grand Hotel Villa Politi](https://images.trvl-media.com/lodging/2000000/1230000/1220700/1220650/73408607_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Grand Hotel Villa Politi

Via Maria Politi Laudien 2 Syracuse SR

$92 nightly

$105 total

Feb 10 - Feb 11

Total with taxes and fees

8.6/10 Excellent! (923 reviews)

[](https://expedia.com/Syracuse-Hotels-Grand-Hotel-Villa-Politi.h1220650.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Syracuse.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=4912&star=50)

You can also use these popular filters to refine your search.

[Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=4912&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=4912&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=4912&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=4912&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F6%2F2026&endDate=2%2F7%2F2026&regionId=4912&star=50&star=50&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

[See all hotels in Syracuse](https://www.expedia.com/Hotel-Search?startDate=2026-02-19&endDate=2026-02-20&adults=2&regionId=4912)

![Syracuse, panoramic phot of the Roman Amphitheatre at Syracuse (Siracusa), UNESCO World Heritage Site, Sicily, Italy, Europe](https://images.trvl-media.com/place/4912/0fad57c8-f045-437c-be3c-817a684ac32e.jpg?impolicy=fcrop&w=900&h=300&p=1&q=high)

## Top Syracuse Hotel Reviews

![Caportigia Boutique Hotel](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/f4662c00_y.jpg)

### Caportigia Boutique Hotel

10/10 Excellent

"Valentina & Malvina"

[](https://expedia.com/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information)

![Ortea Palace Hotel, Sicily, Autograph Collection](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/3b8d7262_y.jpg)

### Ortea Palace Hotel, Sicily, Autograph Collection

10/10 Excellent

"Great hotel, great service. Well located, "

[](https://expedia.com/Syracuse-Hotels-Ortea-Palace-Luxury-Hotel.h17825841.Hotel-Information)

![Grand Hotel Ortigia Siracusa](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/206c3f7f_y.jpg)

### Grand Hotel Ortigia Siracusa

10/10 Excellent

"Stunning hotel and area on the waterfront in Ortigia. Strongly recommend everything except the restaurant. Food was marginal for the price with much better options close by"

[](https://expedia.com/Syracuse-Hotels-Grand-Hotel-Ortigia-Siracusa.h1329454.Hotel-Information)

![Grand Hotel Des Ètrangers - The Leading Hotels of the World](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/c9e03ff2_y.jpg)

### Grand Hotel Des Ètrangers - The Leading Hotels of the World

10/10 Excellent

"Great hotel and saff"

[](https://expedia.com/Syracuse-Hotels-Grand-Hotel-Des-Etrangers.h976389.Hotel-Information)

## Find out more about Syracuse

You enjoy the finer things in life, both at home and on vacation. Treat your every whim on your upcoming break. There's no reason to delay a getaway to Syracuse any longer. You'll join the multitudes of vacationers who have made Syracuse so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve an outstanding getaway. Book one of Expedia's luxurious 5-star hotels in Syracuse and get ready to be pampered like never before.

### Get a Great Deal on 5-Star Hotels in Syracuse

You'll have a wonderful time at one of these 5-star hotels. Highly-rated eateries, concierges, and in-room spa sessions are all at the ready. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A deep-tissue massage to help your cares fall away? A concierge to help you plan every detail of your day? Fluffy down pillows, lip-smacking main courses, and even space for your family pet in some cases...these hotels are one-of-a-kind. 

Can't wait to get outside? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Syracuse are the perfect place to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs. 

### Make Your Escape

The results are in, and Syracuse 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Select one of Expedia's Syracuse 5-star hotels today and relax in luxe surroundings tomorrow.

## Frequently asked questions

### What are the best 5-star hotels in Syracuse?

### How much does it cost to stay in a 5-star hotel in Syracuse?

> - Search for the lowest price per night from $105

### What makes a hotel 5 stars in Syracuse?

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- [Temple of Apollo ](https://www.expedia.com/Temple-Of-Apollo-Ortigia.d6103312.Vacation-Attraction)
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- [Palazzo Beneventano del Bosco ](https://www.expedia.com/Palazzo-Beneventano-Del-Bosco-Ortigia.d553248621533000263.Vacation-Attraction)
- [Church of St. Mary of the Immaculate Conception ](https://www.expedia.com/Church-Of-St-Mary-Of-The-Immaculate-Conception-Ortigia.d6327245.Vacation-Attraction)
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- [Hypogeum of Cathedral Square ](https://www.expedia.com/Hypogeum-Of-Cathedral-Square-Ortigia.d6329138.Vacation-Attraction)
- [Abbey Church of Saint Lucia ](https://www.expedia.com/Abbey-Church-Of-Saint-Lucia-Ortigia.d6327243.Vacation-Attraction)
- [Museum of the Sea of Syracuse ](https://www.expedia.com/Museum-Of-The-Sea-Of-Syracuse-Ortigia.d6326992.Vacation-Attraction)
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- [Fonte Aretusa ](https://www.expedia.com/Fonte-Aretusa-Ortigia.d6103292.Vacation-Attraction)
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- [Castello Maniace ](https://www.expedia.com/Castello-Maniace-Ortigia.d6103286.Vacation-Attraction)
- [Madonna delle Lacrime ](https://www.expedia.com/Madonna-Delle-Lacrime-Santa-Lucia.d6103310.Vacation-Attraction)
- [Catacombs of St. John ](https://www.expedia.com/Catacombs-Of-St-John-Syracuse.d6103288.Vacation-Attraction)
- [Altar of Hieron II ](https://www.expedia.com/Altar-Of-Hieron-II-Syracuse.d553248621533000251.Vacation-Attraction)
- [Roman Amphitheatre of Syracuse ](https://www.expedia.com/Roman-Amphitheatre-Of-Syracuse-Syracuse.d6103308.Vacation-Attraction)
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- [Sixt Rental Cars in Province of Syracuse ](https://www.expedia.com/Sixt-Destinations-In-Province-Of-Syracuse.d6052967-c35.Car-Rental-Destination-Suppliers)
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- [Car rentals near Porto Piccolo ](https://www.expedia.com/Car-Rentals-In-Porto-Piccolo.d6182490.Car-Rental-Guide)

- [Province of Syracuse Vacation Rentals ](https://www.expedia.com/Destinations-In-Province-Of-Syracuse.d6052967.Vacation-Rental-Destinations)

- [Things to do in Province of Syracuse ](https://www.expedia.com/Things-To-Do-In-Province-Of-Syracuse.d6052967.Travel-Guide-Activities)
- [Things to do in Ortygia ](https://www.expedia.com/Things-To-Do-In-Ortygia.d6182482.Travel-Guide-Activities)

- [Book 5 Star Hotels in Syracuse on Expedia.it ](https://www.expedia.it/5Stelle-Siracusa-Hotel.s50-0-d4912.Guida-Viaggi-Filtro-Hotel)