A coastal fortress with a stone wall and a tiled-roof building.

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Check availability on Syracuse 5 Star Hotels

Tonight
Sep 23 - Sep 24
Tomorrow
Sep 24 - Sep 25
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Our top choices for Syracuse 5-star hotels

A large, historic building with multiple floors, a prominent tower, and a waterfront marina with boats.
A balcony with a view of the sea and a cityscape, furnished with two chairs and a small table with a vase of flowers.
A dining table with multiple plates and wine glasses, set against a backdrop of a scenic ocean view.
A balcony with a glass table and two red chairs, overlooking a coastal view with buildings and boats.

1. Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection
Ortigia
Mexico
ALFONSO
$583 nightly
$652 total
Sep 24 - Sep 25
Total with taxes and fees
Ortea Palace Hotel, Sicily, Autograph Collection
A balcony with a view of the sea, a cactus, and potted plants.
A large, classical building with multiple windows and balconies, surrounded by a calm body of water with several yachts docked.
A poolside area with lounge chairs and umbrellas, a clear pool, and a building with multiple windows in the background.
A large, multi-story building with a symmetrical facade, arched windows, and a central entrance with a colorful awning.

2. Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa
Ortigia
United States
NINA
$324 nightly
$368 total
Oct 7 - Oct 8
Total with taxes and fees
Grand Hotel Ortigia Siracusa
A poolside area with lounge chairs and umbrellas, a clear blue pool, and a building with balconies.
A grand hallway with ornate columns, a tiled floor, and large potted plants.
A grand hallway with a marble floor, ornate columns, and a staircase leading to an upper level.
A terrace with a view of the sea and a cruise ship, featuring outdoor seating and potted cacti.

3. Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World
Ortigia
United States
Laura
$610 nightly
$683 total
Oct 4 - Oct 5
Total with taxes and fees
Grand Hotel Des Ètrangers - The Leading Hotels of the World
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.
A modern hotel room with a stone accent wall, a grey sofa, a large mirror, a chandelier, and a neatly made bed with rolled towels.
A multi-story building with a rooftop terrace featuring outdoor seating and a hot tub.
A multi-story building with a rooftop terrace, balconies, and a street view.

4. Caportigia Boutique Hotel

Caportigia Boutique Hotel
Santa Lucia
Australia
Mandy
$189 nightly
$219 total
Oct 24 - Oct 25
Total with taxes and fees
Caportigia Boutique Hotel
An aerial view of a resort with multiple swimming pools, palm trees, and a clear view of the coastline.
A pathway lined with palm trees leading to a building with a red-tiled roof.
A modern bathroom with a freestanding bathtub, a round table with a magazine, and a view of a pool and greenery.
A modern bathroom with a freestanding bathtub, a small table with toiletries, and a view of the ocean.

5. Minareto

Minareto
Syracuse
United Kingdom
Lekhbiro
$376 nightly
$425 total
Oct 24 - Oct 25
Total with taxes and fees
Minareto
A large swimming pool with a modern building in the background.
A woman relaxing in a spa bath with a modern design, including a ceiling with blue lighting and a tiled floor.
A sauna with wooden benches and a central stone pillar.
A beach with clear turquoise water, sandy shore, and sparse vegetation.

6. Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia
Syracuse
United States
Jeffrey
$420 nightly
$474 total
Oct 1 - Oct 2
Total with taxes and fees
Wellness & Spa Hotel Principe di Fitalia
A spa room with a large window, a hot tub, and two candles.
A spacious living room with a high ceiling, white sofas, a coffee table, and a large mirror.
A stone building with arched walkways and outdoor seating areas.
A courtyard with a stone pathway, palm trees, and potted plants.

7. Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa
Syracuse
United Kingdom
Chris
$300 nightly
$342 total
Oct 21 - Oct 22
Total with taxes and fees
Dimora Caiammari Luxury Hotel & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse.
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR
$361 nightly
$408 total
Oct 17 - Oct 18
Total with taxes and fees
9.6/10 Exceptional! (1,000 reviews)
Algila' Ortigia Charme Hotel
Grande Albergo Alfeo

Grande Albergo Alfeo

Via Nino Bixio 5 Syracuse SR
$113 nightly
$129 total
Oct 20 - Oct 21
Total with taxes and fees
8.6/10 Excellent! (698 reviews)
Grande Albergo Alfeo
UNA Hotels One Siracusa Wellness & SPA

UNA Hotels One Siracusa Wellness & SPA

Via Diodoro Siculo 4 Syracuse SR
$145 nightly
$166 total
Oct 19 - Oct 20
Total with taxes and fees
8.6/10 Excellent! (551 reviews)
UNA Hotels One Siracusa Wellness & SPA
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

See all hotels in Syracuse
An ancient amphitheater with stone ruins and a grassy field.

Top Syracuse Hotel Reviews

Caportigia Boutique Hotel

Caportigia Boutique Hotel

10/10 Excellent
"Super friendly and helpful staff. Clean room. Close to everything. The only downside was parking. I wish they had a valet outside the hotel to park your car for you."
Claudio 1-night trip
Posted 2 days ago
Caportigia Boutique Hotel
Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

10/10 Excellent
"Adriano and his colleague at front desk were very helpful in planning and arranging trips. We were able to see surrounding towns and enjoy time in Syracuse because of their help. Two thumbs up."
Hadia 2-night trip
Posted 6 days ago
Grand Hotel Ortigia Siracusa
Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World

10/10 Excellent
"Clean & beautifully maintained hotel. Better for those who prefer a larger setting than a boutique hotel. Small but comfortable pool area. Great rooftop with amazing sunset views and kudos to our wonderful waiter Fabio."
Laura 3-night trip
Posted 8 days ago
Grand Hotel Des Ètrangers - The Leading Hotels of the World
Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection

10/10 Excellent
"I mean there is a reason for the price and its entirely justified with this stunning Marriot property. Everything was wonderfully curated, the spa was lovely, the breakfast was delicious, and the staff was attentive and went out of their way to make sure you were comfortable and had everything you needed. And im not just saying that, the front desk literally got on the phone same day as we were supposed to travel across sicily (we hadn't booked a car yet) and fought with like 3 different locations to get us a car. Everything was randomly sold out but they got it done for us. Just an incredible experience."
Anova 5-night trip
Posted 10 days ago
Ortea Palace Hotel, Sicily, Autograph Collection

Find out more about Syracuse

You enjoy the finer things in life, both at home and on vacation. Treat your every whim on your upcoming break. There's no reason to delay a getaway to Syracuse any longer. You'll join the multitudes of vacationers who have made Syracuse so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve an outstanding getaway. Book one of Expedia's luxurious 5-star hotels in Syracuse and get ready to be pampered like never before.

Get a Great Deal on 5-Star Hotels in Syracuse

You'll have a wonderful time at one of these 5-star hotels. Highly-rated eateries, concierges, and in-room spa sessions are all at the ready. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A deep-tissue massage to help your cares fall away? A concierge to help you plan every detail of your day? Fluffy down pillows, lip-smacking main courses, and even space for your family pet in some cases...these hotels are one-of-a-kind.

Can't wait to get outside? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Syracuse are the perfect place to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Make Your Escape

The results are in, and Syracuse 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Select one of Expedia's Syracuse 5-star hotels today and relax in luxe surroundings tomorrow.

Frequently asked questions

What are the best 5-star hotels in Syracuse?
Prepare for 5-star opulence at Grand Hotel Ortigia Siracusa, Ortea Palace, Sicily, Autograph Collection or Grand Hotel Des Ètrangers. These are some of the best stays in Syracuse based on Expedia customer reviews. Book one and get a taste of the finer life!
How much does it cost to stay in a 5-star hotel in Syracuse?
How much you pay for a 5-star hotel in Syracuse depends on factors like when you plan to go and the length of your vacation. Our insider tip for bagging the best deal? Use our pricing filters to compare all of the available hotels for your preferred dates.
  • Search for the lowest price per night from $129
What makes a hotel 5 stars in Syracuse?
From high-end restaurants and fitness centers to swimming pools and superior bedding, the 5-star experience in Syracuse is all about luxury and relaxation. But it calls for more than just upscale amenities to get a 5-star rating. Hotels also have to deliver outstanding guest services like massage treatments, laundry and dry cleaning and 24-hour room service.

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