Are there any 5-star all-inclusive resorts in Syracuse?

Our filter tool is the easiest way to find exactly what you want. Select "5-star" and "All inclusive" to show the most luxurious properties in Syracuse where your accommodations, meals, activities and entertainment are included in the price. At these retreats, your vacation is pure extravagance from the moment you check in.

What are the top 5-star spa hotels in Syracuse?

Syracuse has a range of 5-star spa accommodations that offer therapies designed to revitalize both the mind and body. Spend your next vacation at Minareto , Ortea Palace, Sicily, Autograph Collection or Grand Hotel Ortigia Siracusa and prioritize your health and well-being.

Are there any 5-star vacation rentals in Syracuse?

You won't find any 5-star vacation rentals in Syracuse on our site, but there are a few other highly rated properties worth checking out. Browse our vacation rentals in Syracuse to book the perfect place for your stay.

Are there any 5-star hotels in downtown Syracuse?

Book a room at Grand Hotel Ortigia Siracusa . This 5-star hotel is an excellent option if you want to experience Syracuse's exciting downtown scene.

The Best 5 Star Hotels in Syracuse from $132

A coastal fortress with a stone wall and a tiled-roof building.

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Our top choices for Syracuse 5-star hotels

1. Ortea Palace Hotel, Sicily, Autograph Collection

Ortigia

kira

$400 nightly

Aug 6 - Aug 7

Total with taxes and fees

2. Grand Hotel Ortigia Siracusa

Ortigia

Abby

$328 nightly

Aug 2 - Aug 3

Total with taxes and fees

Seasonal outdoor pool, pool umbrellas, sun loungers

3. Grand Hotel Des Ètrangers - The Leading Hotels of the World

Ortigia

Leanne

$589 nightly

Aug 16 - Aug 17

Total with taxes and fees

4. Caportigia Boutique Hotel

Santa Lucia

Alessia

$178 nightly

Aug 2 - Aug 3

Total with taxes and fees

5. Minareto

Syracuse

"Beyond the hotel’s stunning and breathtaking views, the customer service was truly exceptional—both attentive and highly responsive. I would easily rate them 120%! I absolutely loved the jacuzzi and its location, which made the experience even more special. Both of the rocky and sandy beaches were unique and incredibly relaxing. Their boat service also made commuting by sea to Ortigia a truly phenomenal experience. If interested, they offer scooter, e-bike, and kayak…"

Nariman

$542 nightly

Aug 26 - Aug 27

Total with taxes and fees

6. Wellness & Spa Hotel Principe di Fitalia

Syracuse

Jeffrey

$464 nightly

Aug 4 - Aug 5

Total with taxes and fees

Sauna, hot tub, Turkish bath, body treatments, body scrubs, facials

7. Dimora Caiammari Luxury Hotel & Spa

Syracuse

Jing

$304 nightly

Aug 11 - Aug 12

Total with taxes and fees

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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse.

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR

$210 nightly

$243 total

Aug 19 - Aug 20

Total with taxes and fees

9.6/10 Exceptional! (1,003 reviews)

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Pool Spa Hot tub Breakfast included Waterpark

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

See all hotels in Syracuse

An ancient amphitheater with stone ruins and a grassy field.

Top Syracuse Hotel Reviews

Grand Hotel Des Ètrangers - The Leading Hotels of the World

10/10 Excellent

"Beautiful hotel, breakfast spread was brilliant and room extremely clean. Staff were all so lovely and attentive. We had a great first afternoon at the pool bar and were very well looked after by a young man who went above and beyond - sorry we did not catch his name."

Ortea Palace Hotel, Sicily, Autograph Collection

10/10 Excellent

"Clean, good service, nice location"

Find out more about Syracuse

You enjoy the finer things in life, both at home and on vacation. Treat your every whim on your upcoming break. There's no reason to delay a getaway to Syracuse any longer. You'll join the multitudes of vacationers who have made Syracuse so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve an outstanding getaway. Book one of Expedia's luxurious 5-star hotels in Syracuse and get ready to be pampered like never before.

Get a Great Deal on 5-Star Hotels in Syracuse

You'll have a wonderful time at one of these 5-star hotels. Highly-rated eateries, concierges, and in-room spa sessions are all at the ready. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A deep-tissue massage to help your cares fall away? A concierge to help you plan every detail of your day? Fluffy down pillows, lip-smacking main courses, and even space for your family pet in some cases...these hotels are one-of-a-kind.

Can't wait to get outside? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Syracuse are the perfect place to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Make Your Escape

The results are in, and Syracuse 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Select one of Expedia's Syracuse 5-star hotels today and relax in luxe surroundings tomorrow.

Frequently asked questions

What are the best 5-star hotels in Syracuse?

Prepare for 5-star opulence at Grand Hotel Ortigia Siracusa, Ortea Palace, Sicily, Autograph Collection or Grand Hotel Des Ètrangers. These are some of the best stays in Syracuse based on Expedia customer reviews. Book one and get a taste of the finer life!

How much does it cost to stay in a 5-star hotel in Syracuse?

How much you pay for a 5-star hotel in Syracuse depends on factors like when you plan to go and the length of your vacation. Our insider tip for bagging the best deal? Use our pricing filters to compare all of the available hotels for your preferred dates.

Search for the lowest price per night from $132

What makes a hotel 5 stars in Syracuse?

From high-end restaurants and fitness centers to swimming pools and superior bedding, the 5-star experience in Syracuse is all about luxury and relaxation. But it calls for more than just upscale amenities to get a 5-star rating. Hotels also have to deliver outstanding guest services like massage treatments, laundry and dry cleaning and 24-hour room service.

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Syracuse Vacation Rentals

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Our top choices for Syracuse 5-star hotels