Find 5 Star Hotels in Syracuse from $107

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Check availability on Syracuse 5 Star Hotels

Tonight
Apr 2 - Apr 3
Tomorrow
Apr 3 - Apr 4
This weekend
Apr 3 - Apr 5
Next weekend
Apr 10 - Apr 12

Our top choices for Syracuse 5-star hotels

Terrace/patio

Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa
5.0 star property
Ortigia
9.0 out of 10, Wonderful, (585 reviews)
"Great location and beautiful scenery "
United States
Yuqi
$256 nightly
The price is $293
Apr 9 - Apr 10
Total with taxes and fees
Grand Hotel Ortigia Siracusa
Exterior

Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection
5.0 star property
Ortigia
9.4 out of 10, Exceptional, (259 reviews)
"The hotel itself is a beautiful building with an interesting heritage as the main post office. The location is excellent offering a great starting point for a walking tour of Ortigia. Great stay."
Canada
Craig
$345 nightly
The price is $391
Apr 3 - Apr 4
Total with taxes and fees
Ortea Palace Hotel, Sicily, Autograph Collection
Rooftop terrace

Caportigia Boutique Hotel

Caportigia Boutique Hotel
5.0 star property
Santa Lucia
9.4 out of 10, Exceptional, (268 reviews)
"Excellent modern property, staff are all amazing. Walkable to everything."
Canada
Brian
$215 nightly
The price is $249
Apr 8 - Apr 9
Total with taxes and fees
Caportigia Boutique Hotel
Seasonal outdoor pool, pool umbrellas, sun loungers

Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World
5.0 star property
Ortigia
9.6 out of 10, Exceptional, (73 reviews)
"Location, staff were amazing"
Canada
Jared
$571 nightly
The price is $640
May 3 - May 4
Total with taxes and fees
Grand Hotel Des Ètrangers - The Leading Hotels of the World
Sauna, hot tub, Turkish bath, body treatments, body scrubs, facials

Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa
5.0 star property
Syracuse
9.4 out of 10, Exceptional, (211 reviews)
"We experienced outstanding service from all of the staff, the breakfast buffet was lovely, lots of options and all homemade. We had a fantastic dinner in the restaurant one evening, which we booked ahead of our trip. "
United Kingdom
David
$323 nightly
The price is $367
Apr 6 - Apr 7
Total with taxes and fees
Dimora Caiammari Luxury Hotel & Spa
Exterior

Minareto

Minareto
5.0 star property
Syracuse
8.8 out of 10, Excellent, (267 reviews)
"Very convenient for swimming and relaxing. "
Canada
Stanislau
$345 nightly
The price is $391
May 3 - May 4
Total with taxes and fees
Minareto
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse.
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR
$270 nightly
The price is $308 total per night from Apr 6 to Apr 7
$308 total
Apr 6 - Apr 7
Total with taxes and fees
9.6/10 Exceptional! (937 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

See all hotels in Syracuse
Syracuse, panoramic phot of the Roman Amphitheatre at Syracuse (Siracusa), UNESCO World Heritage Site, Sicily, Italy, Europe

Top Syracuse Hotel Reviews

Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

10/10 Excellent
"Beautiful facility, classic. Wonderful restaurant for breakfast and dinner."
Kyle 3-night trip
Posted 17 hours ago
Grand Hotel Ortigia Siracusa

Find out more about Syracuse

You enjoy the finer things in life, both at home and on vacation. Treat your every whim on your upcoming break. There's no reason to delay a getaway to Syracuse any longer. You'll join the multitudes of vacationers who have made Syracuse so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve an outstanding getaway. Book one of Expedia's luxurious 5-star hotels in Syracuse and get ready to be pampered like never before.

Get a Great Deal on 5-Star Hotels in Syracuse

You'll have a wonderful time at one of these 5-star hotels. Highly-rated eateries, concierges, and in-room spa sessions are all at the ready. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A deep-tissue massage to help your cares fall away? A concierge to help you plan every detail of your day? Fluffy down pillows, lip-smacking main courses, and even space for your family pet in some cases...these hotels are one-of-a-kind.

Can't wait to get outside? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Syracuse are the perfect place to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Make Your Escape

The results are in, and Syracuse 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Select one of Expedia's Syracuse 5-star hotels today and relax in luxe surroundings tomorrow.

Frequently asked questions

What are the best 5-star hotels in Syracuse?
Prepare for 5-star opulence at Grand Hotel Ortigia Siracusa, Ortea Palace, Sicily, Autograph Collection or Grand Hotel Des Ètrangers. These are some of the best stays in Syracuse based on Expedia customer reviews. Book one and get a taste of the finer life!
How much does it cost to stay in a 5-star hotel in Syracuse?
How much you pay for a 5-star hotel in Syracuse depends on factors like when you plan to go and the length of your vacation. Our insider tip for bagging the best deal? Use our pricing filters to compare all of the available hotels for your preferred dates.

  • Search for the lowest price per night from $107

What makes a hotel 5 stars in Syracuse?
From high-end restaurants and fitness centers to swimming pools and superior bedding, the 5-star experience in Syracuse is all about luxury and relaxation. But it calls for more than just upscale amenities to get a 5-star rating. Hotels also have to deliver outstanding guest services like massage treatments, laundry and dry cleaning and 24-hour room service.

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