A coastal fortress with a stone wall and a tiled-roof building.

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Check availability on Syracuse 5 Star Hotels

Tonight
Sep 16 - Sep 17
Tomorrow
Sep 17 - Sep 18
This weekend
Sep 18 - Sep 20
Next weekend
Sep 25 - Sep 27

Our top choices for Syracuse 5-star hotels

A large, historic building with multiple floors, a prominent tower, and a waterfront marina with boats.
A balcony with a glass table and two red chairs, overlooking a coastal view with buildings and boats.
A balcony with a view of the sea and a cityscape, furnished with two chairs and a small table with a vase of flowers.
A dining table with multiple plates and wine glasses, set against a backdrop of a scenic ocean view.

1. Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection
Ortigia
United States
kira
$587 nightly
$658 total
Sep 17 - Sep 18
Total with taxes and fees
Ortea Palace Hotel, Sicily, Autograph Collection
A balcony with a view of the sea, a cactus, and potted plants.
A large, multi-story building with a symmetrical facade, arched windows, and a central entrance with a colorful awning.
A dining area with a table set for two, overlooking a coastal view.
A large, classical building with multiple windows and balconies, surrounded by a calm body of water with several yachts docked.

2. Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa
Ortigia
United States
NINA
$318 nightly
$361 total
Oct 2 - Oct 3
Total with taxes and fees
Grand Hotel Ortigia Siracusa
A poolside area with lounge chairs and umbrellas, a clear blue pool, and a building with balconies.
A grand hallway with ornate columns, a tiled floor, and large potted plants.
A spacious dining area with round tables and blue chairs, large windows offering a city view, and a wooden ceiling structure.
A grand hallway with a marble floor, ornate columns, and a staircase leading to an upper level.

3. Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World
Ortigia
Australia
Leanne
$643 nightly
$719 total
Oct 4 - Oct 5
Total with taxes and fees
Grand Hotel Des Ètrangers - The Leading Hotels of the World
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.
A modern hotel room with a stone accent wall, a grey sofa, a large mirror, a chandelier, and a neatly made bed with rolled towels.
A multi-story building with a rooftop terrace featuring outdoor seating and a hot tub.
A multi-story building with a rooftop terrace, balconies, and a street view.

4. Caportigia Boutique Hotel

Caportigia Boutique Hotel
Santa Lucia
Australia
Mandy
$245 nightly
$282 total
Oct 7 - Oct 8
Total with taxes and fees
Caportigia Boutique Hotel
An aerial view of a resort with multiple swimming pools, palm trees, and a clear view of the coastline.
A table set with breakfast items overlooking a coastal view.
A modern bathroom with a freestanding bathtub, a small table with toiletries, and a view of the ocean.
A pathway lined with palm trees leading to a building with a red-tiled roof.

5. Minareto

Minareto
Syracuse
United Kingdom
Lekhbiro
$407 nightly
$460 total
Sep 21 - Sep 22
Total with taxes and fees
Minareto
A large swimming pool with a modern building in the background.
A beach with clear turquoise water, sandy shore, and sparse vegetation.
A sauna with wooden benches and a central stone pillar.
A woman relaxing in a spa bath with a modern design, including a ceiling with blue lighting and a tiled floor.

6. Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia
Syracuse
United States
Jeffrey
$579 nightly
$648 total
Sep 19 - Sep 20
Total with taxes and fees
Wellness & Spa Hotel Principe di Fitalia
A spa room with a large window, a hot tub, and two candles.
A courtyard with a stone pathway, palm trees, and potted plants.
A spacious living room with a high ceiling, white sofas, a coffee table, and a large mirror.
A stone building with arched walkways and outdoor seating areas.

7. Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa
Syracuse
United Kingdom
Chris
$315 nightly
$358 total
Sep 19 - Sep 20
Total with taxes and fees
Dimora Caiammari Luxury Hotel & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse.
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR
$363 nightly
$411 total
Oct 17 - Oct 18
Total with taxes and fees
9.6/10 Exceptional! (1,000 reviews)
Algila' Ortigia Charme Hotel
Grande Albergo Alfeo

Grande Albergo Alfeo

Via Nino Bixio 5 Syracuse SR
$119 nightly
$135 total
Sep 28 - Sep 29
Total with taxes and fees
8.6/10 Excellent! (696 reviews)
Grande Albergo Alfeo
UNA Hotels One Siracusa Wellness & SPA

UNA Hotels One Siracusa Wellness & SPA

Via Diodoro Siculo 4 Syracuse SR
$156 nightly
$178 total
Sep 28 - Sep 29
Total with taxes and fees
8.6/10 Excellent! (551 reviews)
UNA Hotels One Siracusa Wellness & SPA
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

See all hotels in Syracuse
An ancient amphitheater with stone ruins and a grassy field.

Top Syracuse Hotel Reviews

Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World

10/10 Excellent
"Clean & beautifully maintained hotel. Better for those who prefer a larger setting than a boutique hotel. Small but comfortable pool area. Great rooftop with amazing sunset views and kudos to our wonderful waiter Fabio."
Laura 3-night trip
Posted 1 day ago
Grand Hotel Des Ètrangers - The Leading Hotels of the World
Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection

10/10 Excellent
"I mean there is a reason for the price and its entirely justified with this stunning Marriot property. Everything was wonderfully curated, the spa was lovely, the breakfast was delicious, and the staff was attentive and went out of their way to make sure you were comfortable and had everything you needed. And im not just saying that, the front desk literally got on the phone same day as we were supposed to travel across sicily (we hadn't booked a car yet) and fought with like 3 different locations to get us a car. Everything was randomly sold out but they got it done for us. Just an incredible experience."
Anova 5-night trip
Posted 3 days ago
Ortea Palace Hotel, Sicily, Autograph Collection
Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

10/10 Excellent
"Old world Italian charm and great service. Would have preferred something more centrally located with a pool and better breakfast."
Karen 3-night trip
Posted 3 weeks ago
Grand Hotel Ortigia Siracusa

Find out more about Syracuse

You enjoy the finer things in life, both at home and on vacation. Treat your every whim on your upcoming break. There's no reason to delay a getaway to Syracuse any longer. You'll join the multitudes of vacationers who have made Syracuse so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve an outstanding getaway. Book one of Expedia's luxurious 5-star hotels in Syracuse and get ready to be pampered like never before.

Get a Great Deal on 5-Star Hotels in Syracuse

You'll have a wonderful time at one of these 5-star hotels. Highly-rated eateries, concierges, and in-room spa sessions are all at the ready. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A deep-tissue massage to help your cares fall away? A concierge to help you plan every detail of your day? Fluffy down pillows, lip-smacking main courses, and even space for your family pet in some cases...these hotels are one-of-a-kind.

Can't wait to get outside? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Syracuse are the perfect place to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Make Your Escape

The results are in, and Syracuse 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Select one of Expedia's Syracuse 5-star hotels today and relax in luxe surroundings tomorrow.

Frequently asked questions

What are the best 5-star hotels in Syracuse?
Prepare for 5-star opulence at Grand Hotel Ortigia Siracusa, Ortea Palace, Sicily, Autograph Collection or Grand Hotel Des Ètrangers. These are some of the best stays in Syracuse based on Expedia customer reviews. Book one and get a taste of the finer life!
How much does it cost to stay in a 5-star hotel in Syracuse?
How much you pay for a 5-star hotel in Syracuse depends on factors like when you plan to go and the length of your vacation. Our insider tip for bagging the best deal? Use our pricing filters to compare all of the available hotels for your preferred dates.
  • Search for the lowest price per night from $135
What makes a hotel 5 stars in Syracuse?
From high-end restaurants and fitness centers to swimming pools and superior bedding, the 5-star experience in Syracuse is all about luxury and relaxation. But it calls for more than just upscale amenities to get a 5-star rating. Hotels also have to deliver outstanding guest services like massage treatments, laundry and dry cleaning and 24-hour room service.

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