A coastal fortress with a stone wall and a tiled-roof building.

Find 5 Star Hotels in Syracuse from $106

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Syracuse 5 Star Hotels

Tonight
Sep 9 - Sep 10
Tomorrow
Sep 10 - Sep 11
This weekend
Sep 11 - Sep 13
Next weekend
Sep 18 - Sep 20

Our top choices for Syracuse 5-star hotels

A historic building with a central entrance, multiple balconies, and a large potted plant in front.
A spacious living area with a large mirror, a chandelier, and a fireplace. There are multiple seating options including a sofa and chairs.
A rooftop terrace with outdoor seating, a view of the sea, and parked cars.
An interior view of a restaurant with stone arches, wooden beams, and tables set for dining.

1. Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel
Ortigia
United Kingdom
Rachael
$286 nightly
$327 total
Sep 26 - Sep 27
Total with taxes and fees
Algila' Ortigia Charme Hotel
A large, historic building with multiple floors, a prominent tower, and a waterfront marina with boats.
A grand atrium with a central column, ornate railings, and a large mural on the wall.
A balcony with a view of the sea and a cityscape, furnished with two chairs and a small table with a vase of flowers.
A balcony with a glass table and two red chairs, overlooking a coastal view with buildings and boats.

2. Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection
Ortigia
United States
kira
$507 nightly
$570 total
Sep 12 - Sep 13
Total with taxes and fees
Ortea Palace Hotel, Sicily, Autograph Collection
A poolside area with lounge chairs and umbrellas, a clear blue pool, and a building with balconies.
A spacious dining area with round tables and blue chairs, large windows offering a city view, and a wooden ceiling structure.
A grand hallway with a marble floor, ornate columns, and a staircase leading to an upper level.
A grand hallway with ornate columns, a tiled floor, and large potted plants.

3. Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World
Ortigia
Australia
Leanne
$597 nightly
$669 total
Sep 25 - Sep 26
Total with taxes and fees
Grand Hotel Des Ètrangers - The Leading Hotels of the World
A balcony with a view of the sea, a cactus, and potted plants.
A large, classical building with multiple windows and balconies, surrounded by a calm body of water with several yachts docked.
A poolside area with lounge chairs and umbrellas, a clear pool, and a building with multiple windows in the background.
A dining area with a table set for two, overlooking a coastal view.

4. Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa
Ortigia
United States
NINA
$308 nightly
$351 total
Sep 15 - Sep 16
Total with taxes and fees
Grand Hotel Ortigia Siracusa
A woman holding a wine glass on a balcony overlooking a street with historic buildings and a clock tower.
A building with three balconies, a central entrance with an archway, and a sign indicating it is a small luxury hotel.
A bar with a stone ceiling, a marble countertop, and shelves stocked with liquor bottles.
A grand lobby with arched ceilings, marble columns, a chandelier, and a reception desk.

5. Palazzo Artemide - VRetreats, SLH Collection

Palazzo Artemide - VRetreats, SLH Collection
Ortigia
United States
Kathryn
$371 nightly
$419 total
Sep 27 - Sep 28
Total with taxes and fees
Palazzo Artemide - VRetreats, SLH Collection
A coastal terrace with wicker furniture, striped umbrellas, and a rocky backdrop.
A grand staircase with marble steps and red carpet, flanked by wooden balustrades and potted plants, leading to a room with ornate decor and a chandelier.
A grand lobby with a central red seating area, a staircase, and a high ceiling with skylights.
A swimming pool with lounge chairs and umbrellas, surrounded by buildings with a staircase and a view of the city skyline.

6. Grand Hotel Villa Politi

Grand Hotel Villa Politi
Grottasanta
France
abdulrahman
$165 nightly
$188 total
Sep 18 - Sep 19
Total with taxes and fees
Grand Hotel Villa Politi
A large, multi-story building with a grand staircase leading to the entrance, stone walls, and multiple illuminated windows.
A waterfront promenade with clear water, a stone walkway, and a row of beach umbrellas.
A swimming pool with water features, outdoor seating, and a bar area.
A modern spa with a large indoor pool, a separate relaxation area with a whirlpool, and a glass partition.

7. Dolce by Wyndham Siracusa I Monasteri Golf & Spa

Dolce by Wyndham Siracusa I Monasteri Golf & Spa
Syracuse
United States
Myrnalyn
$87 nightly
$99 total
Sep 21 - Sep 22
Total with taxes and fees
Dolce by Wyndham Siracusa I Monasteri Golf & Spa
A beach with white umbrellas and lounge chairs arranged in rows.
A wooden deck with sun loungers and umbrellas overlooking a calm sea.
A spacious indoor area with high ceilings and large windows, featuring multiple seating arrangements and a modern design.
An aerial view of a resort with two swimming pools, a beach, and a coastal backdrop.

8. VOI Arenella Resort

VOI Arenella Resort
Syracuse
United States
Frank
VOI Arenella Resort
An aerial view of a resort with multiple swimming pools, palm trees, and a clear view of the coastline.
A table set with breakfast items overlooking a coastal view.
A pathway lined with palm trees leading to a building with a red-tiled roof.
A modern bathroom with a freestanding bathtub, a round table with a magazine, and a view of a pool and greenery.

9. Minareto

Minareto
Syracuse
United Kingdom
Lekhbiro
$410 nightly
$463 total
Sep 21 - Sep 22
Total with taxes and fees
Minareto
A balcony with a view of the sea, featuring a metal railing and potted plants.
A corridor with a tiled floor, a door with a glass panel, and a plant near the entrance.
A view of the ocean through a balcony railing with a clear sky.
An arched entrance with a wooden floor leading into a corridor.

10. Domus Mariae Albergo

Domus Mariae Albergo
Ortigia
United Kingdom
Hilda
$106 nightly
$121 total
Sep 13 - Sep 14
Total with taxes and fees
Domus Mariae Albergo
An open door leading to an outdoor patio with a table and chairs.
A historic building with a reception area, large arched windows, and two potted plants at the entrance.
An arched doorway leading to a staircase with a glass railing and a metal frame structure in the foreground.

11. Lanterne Magiche Ortigia Suites

Lanterne Magiche Ortigia Suites
Ortigia
United States
Roxana
$236 nightly
$269 total
Sep 14 - Sep 15
Total with taxes and fees
Lanterne Magiche Ortigia Suites
A large swimming pool with a modern building in the background.
A sauna with wooden benches and a central stone pillar.
A woman relaxing in a spa bath with a modern design, including a ceiling with blue lighting and a tiled floor.
A beach with clear turquoise water, sandy shore, and sparse vegetation.

12. Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia
Syracuse
United States
Jeffrey
$409 nightly
$461 total
Sep 28 - Sep 29
Total with taxes and fees
Wellness & Spa Hotel Principe di Fitalia
A balcony with a hot tub, a lounge chair, and a view of the sea.
A modern hotel room with a sofa, a TV, and a neatly made bed.
A modern kitchen with a built-in sink and a balcony with a view of the sea.

13. Archinuè Suite & Apartments

Archinuè Suite & Apartments
Syracuse
Canada
Carla
Archinuè Suite & Apartments
A hot tub with a view of the sea, wicker chairs, and a table with drinks and flowers.
A modern interior with stone walls, round tables, and cushioned seating areas.
A hotel room with a large bed, a view of the waterfront, and a distinctive circular architectural feature above the bed.
A stone pathway flanked by palm trees and small shrubs, leading to a central structure.

14. Maniace Boutique Hotel Ortigia UNA Esperienze

Maniace Boutique Hotel Ortigia UNA Esperienze
Ortigia
United States
Asha
$364 nightly
$412 total
Oct 1 - Oct 2
Total with taxes and fees
Maniace Boutique Hotel Ortigia UNA Esperienze
A clear view of a beach with rocky formations in the water.
A hotel lobby with a reception desk, seating area, and decorative plants.
A table set with a plate of food, a glass of orange juice, a glass of red drink, a white vase, and a cup.
A table set with various foods and drinks, including a bottle of champagne, plates of appetizers, and glasses of water and juice, by a poolside.

15. Hotel Villamare

Hotel Villamare
Syracuse
United Kingdom
Ceri
$188 nightly
$215 total
Sep 14 - Sep 15
Total with taxes and fees
Hotel Villamare
An outdoor swimming pool with a wooden deck, surrounded by white umbrellas and lounge chairs.
A hotel room with a bed, a TV mounted on the wall, and a window with curtains.
A spacious restaurant with high wooden ceilings and large windows.
A hotel with a prominent sign reading "Mercure Hotel" and a modern facade with horizontal blue lighting.

16. Mercure Siracusa Prometeo

Mercure Siracusa Prometeo
Neapolis
United States
John
$144 nightly
$176 total
Oct 2 - Oct 3
Total with taxes and fees
Mercure Siracusa Prometeo
A riverside walkway with people walking and sitting, overlooking a body of water.
A buffet with various food items, including pastries, fruits, and beverages.
A stone staircase with a large urn on the landing, leading to a balcony with a metal railing overlooking the sea.
A view from an open window overlooking a body of water with a distant shoreline.

17. Charme Hotel Henry's House

Charme Hotel Henry's House
Ortigia
United States
Komal
$366 nightly
$414 total
Oct 9 - Oct 10
Total with taxes and fees
Charme Hotel Henry's House
A stone building with arched doorways and a lit entrance.
A modern staircase with glass railings and a wooden geometric wall design.
A hot tub on a wooden deck with two chairs and a table, surrounded by greenery and a clear sky.
A modern reception desk with a laptop, a decorative wall piece, and a vase with white flowers.

18. Palazzo Salomone

Palazzo Salomone
Ortigia
United States
Aaron
$175 nightly
$200 total
Oct 9 - Oct 10
Total with taxes and fees
Palazzo Salomone
A swimming pool with a curved edge, surrounded by lounge chairs and umbrellas, with buildings and palm trees in the background.
A bedroom with a bed, a window with curtains, and a view of the outside.
An aerial view of a coastal residential area with a row of houses, a swimming pool, and a clear view of the ocean.
A view through a window of a landscape with trees and a clear sky.

19. Residence Archimede

Residence Archimede
Syracuse
Canada
Angela
$119 nightly
$132 total
Oct 7 - Oct 8
Total with taxes and fees
Residence Archimede
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.
A multi-story building with a rooftop terrace featuring outdoor seating and a hot tub.
A modern hotel room with a stone accent wall, a grey sofa, a large mirror, a chandelier, and a neatly made bed with rolled towels.
A multi-story building with a rooftop terrace, balconies, and a street view.

20. Caportigia Boutique Hotel

Caportigia Boutique Hotel
Santa Lucia
Australia
Mandy
$223 nightly
$256 total
Oct 8 - Oct 9
Total with taxes and fees
Caportigia Boutique Hotel
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse.
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR
$286 nightly
$327 total
Sep 26 - Sep 27
Total with taxes and fees
9.6/10 Exceptional! (1,000 reviews)
Algila' Ortigia Charme Hotel
Grande Albergo Alfeo

Grande Albergo Alfeo

Via Nino Bixio 5 Syracuse SR
$93 nightly
$106 total
Sep 13 - Sep 14
Total with taxes and fees
8.6/10 Excellent! (693 reviews)
Grande Albergo Alfeo
UNA Hotels One Siracusa Wellness & SPA

UNA Hotels One Siracusa Wellness & SPA

Via Diodoro Siculo 4 Syracuse SR
$154 nightly
$176 total
Sep 17 - Sep 18
Total with taxes and fees
8.6/10 Excellent! (551 reviews)
UNA Hotels One Siracusa Wellness & SPA
Still don't see what you're looking for?
See all properties in Syracuse.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

See all hotels in Syracuse
An ancient amphitheater with stone ruins and a grassy field.

Top Syracuse Hotel Reviews

Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

10/10 Excellent
"Old world Italian charm and great service. Would have preferred something more centrally located with a pool and better breakfast."
Karen 3-night trip
Posted 11 days ago
Grand Hotel Ortigia Siracusa

Find out more about Syracuse

You enjoy the finer things in life, both at home and on vacation. Treat your every whim on your upcoming break. There's no reason to delay a getaway to Syracuse any longer. You'll join the multitudes of vacationers who have made Syracuse so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve an outstanding getaway. Book one of Expedia's luxurious 5-star hotels in Syracuse and get ready to be pampered like never before.

Get a Great Deal on 5-Star Hotels in Syracuse

You'll have a wonderful time at one of these 5-star hotels. Highly-rated eateries, concierges, and in-room spa sessions are all at the ready. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A deep-tissue massage to help your cares fall away? A concierge to help you plan every detail of your day? Fluffy down pillows, lip-smacking main courses, and even space for your family pet in some cases...these hotels are one-of-a-kind.

Can't wait to get outside? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Syracuse are the perfect place to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Make Your Escape

The results are in, and Syracuse 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Select one of Expedia's Syracuse 5-star hotels today and relax in luxe surroundings tomorrow.

Frequently asked questions

What are the best 5-star hotels in Syracuse?
Prepare for 5-star opulence at Grand Hotel Ortigia Siracusa, Ortea Palace, Sicily, Autograph Collection or Grand Hotel Des Ètrangers. These are some of the best stays in Syracuse based on Expedia customer reviews. Book one and get a taste of the finer life!
How much does it cost to stay in a 5-star hotel in Syracuse?
How much you pay for a 5-star hotel in Syracuse depends on factors like when you plan to go and the length of your vacation. Our insider tip for bagging the best deal? Use our pricing filters to compare all of the available hotels for your preferred dates.
  • Search for the lowest price per night from $106
What makes a hotel 5 stars in Syracuse?
From high-end restaurants and fitness centers to swimming pools and superior bedding, the 5-star experience in Syracuse is all about luxury and relaxation. But it calls for more than just upscale amenities to get a 5-star rating. Hotels also have to deliver outstanding guest services like massage treatments, laundry and dry cleaning and 24-hour room service.

Explore a world of travel with Expedia