A coastal fortress with a stone wall and a tiled-roof building.

Find 5 Star Hotels in Syracuse from $148

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Check availability on Syracuse 5 Star Hotels

Tonight
Oct 18 - Oct 19
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Oct 19 - Oct 20
Next weekend
Oct 23 - Oct 25
In two weeks
Oct 30 - Nov 1

Our top choices for Syracuse 5-star hotels

A large, historic building with multiple floors, a prominent tower, and a waterfront marina with boats.
A grand atrium with a central column, ornate railings, and a large mural on the wall.
A dining table with multiple plates and wine glasses, set against a backdrop of a scenic ocean view.
A balcony with a glass table and two red chairs, overlooking a coastal view with buildings and boats.

1. Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection
Ortigia
Mexico
ALFONSO
$293 nightly
$334 total
Nov 8 - Nov 9
Total with taxes and fees
Ortea Palace Hotel, Sicily, Autograph Collection
A balcony with a view of the sea, a cactus, and potted plants.
A large, multi-story building with a symmetrical facade, arched windows, and a central entrance with a colorful awning.
A dining area with a table set for two, overlooking a coastal view.
A large, classical building with multiple windows and balconies, surrounded by a calm body of water with several yachts docked.

2. Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa
Ortigia
United States
SEAN
$237 nightly
$272 total
Nov 16 - Nov 17
Total with taxes and fees
Grand Hotel Ortigia Siracusa
A poolside area with lounge chairs and umbrellas, a clear blue pool, and a building with balconies.
A grand hallway with a marble floor, ornate columns, and a staircase leading to an upper level.
A grand hallway with ornate columns, a tiled floor, and large potted plants.
A spacious dining area with round tables and blue chairs, large windows offering a city view, and a wooden ceiling structure.

3. Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World
Ortigia
United States
nadia
$640 nightly
$715 total
Oct 30 - Oct 31
Total with taxes and fees
Grand Hotel Des Ètrangers - The Leading Hotels of the World
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.
A multi-story building with a rooftop terrace featuring outdoor seating and a hot tub.
A modern hotel room with a stone accent wall, a grey sofa, a large mirror, a chandelier, and a neatly made bed with rolled towels.
A modern hotel room with a stone wall, a staircase, a seating area with two chairs, a small table, and a desk with a phone and a lamp.

4. Caportigia Boutique Hotel

Caportigia Boutique Hotel
Santa Lucia
Canada
Dena
$126 nightly
$149 total
Nov 18 - Nov 19
Total with taxes and fees
Caportigia Boutique Hotel
A spa room with a large window, a hot tub, and two candles.
A stone building with arched walkways and outdoor seating areas.
A spacious lobby with arched ceilings, a central round table with decorative items, and a modern chandelier.
A courtyard with a stone pathway, palm trees, and potted plants.

5. Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa
Syracuse
United Kingdom
Chris
$324 nightly
$367 total
Nov 1 - Nov 2
Total with taxes and fees
Dimora Caiammari Luxury Hotel & Spa
An aerial view of a resort with multiple swimming pools, palm trees, and a clear view of the coastline.
A table set with breakfast items overlooking a coastal view.
A pathway lined with palm trees leading to a building with a red-tiled roof.
A modern bathroom with a freestanding bathtub, a round table with a magazine, and a view of a pool and greenery.

6. Minareto

Minareto
Syracuse
United States
Luis Alberto
$251 nightly
$287 total
Nov 8 - Nov 9
Total with taxes and fees
Minareto
A large swimming pool with a modern building in the background.
A woman relaxing in a spa bath with a modern design, including a ceiling with blue lighting and a tiled floor.
An outdoor dining area with tables and chairs, a pool, and palm trees in the background.
A beach with clear turquoise water, sandy shore, and sparse vegetation.

7. Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia
Syracuse
Australia
Nicholas
$330 nightly
$374 total
Nov 5 - Nov 6
Total with taxes and fees
Wellness & Spa Hotel Principe di Fitalia
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse.
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR
$178 nightly
$207 total
Nov 17 - Nov 18
Total with taxes and fees
Algila' Ortigia Charme Hotel
UNA Hotels One Siracusa Wellness & SPA

UNA Hotels One Siracusa Wellness & SPA

Via Diodoro Siculo 4 Syracuse SR
$130 nightly
$148 total
Nov 18 - Nov 19
Total with taxes and fees
8.6/10 Excellent! (555 reviews)
UNA Hotels One Siracusa Wellness & SPA
Palazzo Artemide - VRetreats, SLH Collection

Palazzo Artemide - VRetreats, SLH Collection

Via Roma 66 Syracuse SR
$198 nightly
$229 total
Nov 18 - Nov 19
Total with taxes and fees
9.4/10 Exceptional! (694 reviews)
Palazzo Artemide - VRetreats, SLH Collection
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

See all hotels in Syracuse
An ancient amphitheater with stone ruins and a grassy field.

Top Syracuse Hotel Reviews

Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World

10/10 Excellent
"Absolutely beautiful hotel and in a perfect location with beautiful sea view. Wonderful and attentive staff."
nadia 3-night trip
Posted 3 days ago
Grand Hotel Des Ètrangers - The Leading Hotels of the World
Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

10/10 Excellent
"A splendid, classic property with first rate service, comfortable beds and a glorious breakfast on a breathtaking outdoor terrace. Wish we could have stayed longer."
Richard 1-night trip
Posted 6 days ago
Grand Hotel Ortigia Siracusa

Find out more about Syracuse

You enjoy the finer things in life, both at home and on vacation. Treat your every whim on your upcoming break. There's no reason to delay a getaway to Syracuse any longer. You'll join the multitudes of vacationers who have made Syracuse so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve an outstanding getaway. Book one of Expedia's luxurious 5-star hotels in Syracuse and get ready to be pampered like never before.

Get a Great Deal on 5-Star Hotels in Syracuse

You'll have a wonderful time at one of these 5-star hotels. Highly-rated eateries, concierges, and in-room spa sessions are all at the ready. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A deep-tissue massage to help your cares fall away? A concierge to help you plan every detail of your day? Fluffy down pillows, lip-smacking main courses, and even space for your family pet in some cases...these hotels are one-of-a-kind.

Can't wait to get outside? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Syracuse are the perfect place to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Make Your Escape

The results are in, and Syracuse 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Select one of Expedia's Syracuse 5-star hotels today and relax in luxe surroundings tomorrow.

Frequently asked questions

What are the best 5-star hotels in Syracuse?
Prepare for 5-star opulence at Grand Hotel Ortigia Siracusa, Ortea Palace, Sicily, Autograph Collection or Grand Hotel Des Ètrangers. These are some of the best stays in Syracuse based on Expedia customer reviews. Book one and get a taste of the finer life!
How much does it cost to stay in a 5-star hotel in Syracuse?
How much you pay for a 5-star hotel in Syracuse depends on factors like when you plan to go and the length of your vacation. Our insider tip for bagging the best deal? Use our pricing filters to compare all of the available hotels for your preferred dates.
  • Search for the lowest price per night from $148
What makes a hotel 5 stars in Syracuse?
From high-end restaurants and fitness centers to swimming pools and superior bedding, the 5-star experience in Syracuse is all about luxury and relaxation. But it calls for more than just upscale amenities to get a 5-star rating. Hotels also have to deliver outstanding guest services like massage treatments, laundry and dry cleaning and 24-hour room service.

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