Cape Girardeau Vacations from $379

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Your Cape Girardeau Vacation

Food, history, entertainment and more … There's so much to immerse yourself in with a Cape Girardeau vacation package. And with the ability to easily customize your city break, it's guaranteed to be one that's memorable. If sightseeing is on the agenda during your trip to Cape Girardeau, swing by major attractions like Isle Casino Cape Girardeau, Cape Rock Park and Cape Girardeau Conservation Nature Center. Expedia will help you escape your routine. Tailor your vacation to Cape Girardeau to suit your travel style, whatever that may be.

The Latest Cape Girardeau vacation packages

Price found within the past 48 hours. Click for updated prices.
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

3 out of 5
Price was $383, price is now $379 per person
$379
per person
Sep 18 - Sep 20
found 1 day ago
Roundtrip flight included
Chicago (ORD) to Cape Girardeau (CGI)
9.4/10 Exceptional! (941 reviews)

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
Price was $422, price is now $404 per person
$404
per person
Sep 18 - Sep 20
found 1 day ago
Roundtrip flight included
Chicago (ORD) to Cape Girardeau (CGI)
9.4/10 Exceptional! (1,004 reviews)
Pancake machine was not

Reviewed on Aug 3, 2026

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
Price was $420, price is now $403 per person
$403
per person
Sep 18 - Sep 20
found 1 day ago
Roundtrip flight included
Chicago (ORD) to Cape Girardeau (CGI)
9.6/10 Exceptional! (1,006 reviews)
Loved the hotel! Super clean, friendly staff, large rooms

Reviewed on Aug 6, 2026

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

3 out of 5
Price was $426, price is now $419 per person
$419
per person
Sep 18 - Sep 20
found 1 day ago
Roundtrip flight included
Chicago (ORD) to Cape Girardeau (CGI)
9.4/10 Exceptional! (212 reviews)
I had a great stay! Everything looked new and well maintained. The room was very clean, comfortable, and inviting. The hotel's location was perfect—it was close to everything I needed, which made getting around easy. I would definitely stay here again and recommend it to anyone visiting the area.

Reviewed on Aug 2, 2026

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 out of 5
Price was $550, price is now $541 per person
$541
per person
Sep 24 - Sep 28
found 12 hours ago
Roundtrip non-stop flight included
Ontario Intl. Airport (ONT) to Cape Girardeau (CGI)
9.2/10 Wonderful! (607 reviews)
Breakfast did not live up to the your hype. The pancake maker/ waffle maker and cinnamon rolls were not available. So was very limited choices. Big disappointment with how important that weekend is for Perryville Community. You would think everything would be functioning at it's peak. Too bad. Everything else was great!

Reviewed on Aug 3, 2026

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Stay near popular Cape Girardeau attractions

A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Cape Girardeau Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $113 total per night from Aug 16 to Aug 17
$113 total
Aug 16 - Aug 17
Total with taxes and fees
9.6/10 Exceptional! (1,011 reviews)
"Loved the hotel! Super clean, friendly staff, large rooms"

Reviewed on Aug 6, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $117 total per night from Aug 10 to Aug 11
$117 total
Aug 10 - Aug 11
Total with taxes and fees
The Riverview
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street Cape Girardeau MO
Fully refundable
$103 nightly
The price is $116 total per night from Sep 6 to Sep 7
$116 total
Sep 6 - Sep 7
Total with taxes and fees
9.4/10 Exceptional! (1,004 reviews)
"Pancake machine was not"

Reviewed on Aug 3, 2026

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
See all 189 properties in Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Cape Girardeau Vacation Packages

Cape Girardeau Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Cape Girardeau Municipal Airport (CGI)
Population
39,500
Max Temp Winter
45ºF
Max Temp Summer
85ºF
Top Sights
Cape Splash Family Aquatic Center, Hunter Valley Winery and Steele Crest Winery

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Frequently asked questions

How much does a Cape Girardeau vacation package cost?
Offering excellent value package deals from $379 on Expedia, you'll be pleasantly surprised at how much a vacation to Cape Girardeau costs! Expedia's packages make travel planning easier and save you more.
What are the cheapest months to go to Cape Girardeau?
If you're looking to score a cheap Cape Girardeau vacation package, consider traveling in March, September and November. You're likely to find lower prices on hotels and airfares during these months — perfect for a budget-friendly getaway.
How many days is enough for Cape Girardeau?
With a well-planned schedule, you can easily hit the main Cape Girardeau sights in a handful of days. But if you'd like to discover lesser-known spots or take day trips, think about booking your Cape Girardeau vacation for longer.
Is it worth booking a vacation package to Cape Girardeau?
Cape Girardeau has everything you need for the perfect break — history, culture and family-friendly attractions are just the start. Whether you want to visit sights such as Cape Rock Park and Fort D Historic Site, or venture off the beaten track, you'll have plenty to experience on your Cape Girardeau vacation.
How to find the best Cape Girardeau package deals?
Start your search for a Cape Girardeau package deal by entering your preferred travel dates and destination under our "Packages" tab. Then select some filters, like "Popular locations" and "Property type," to fine-tune the results to your exact style. You can also sort by "Package discount" and discover offers that come with unbeatable savings. If you don't find the perfect Cape Girardeau package deal right away, simply change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Cape Girardeau adventure underway.
Is it cheaper to book a Cape Girardeau vacation as a package?
You can enjoy significant savings on your Cape Girardeau retreat by booking a tailored vacation package. Click on the "Package" heading, then enter your destination and travel dates to view the best flight and hotel prices. Bundling can save travelers hundreds of dollars. Consider adding a car rental and you may land a better deal.
When to book a vacation package to Cape Girardeau?
If you're planning a spontaneous Cape Girardeau trip, browse our last-minute deals that can be booked up to one week before you go. Prefer not to wait until the last minute? You can land awesome deals on your flights and hotels by booking well in advance.
Does Expedia offer Book Now, Pay Later Cape Girardeau vacation packages?
If you're like us, you love exploring new places but don't love the price tag that can come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the total cost of your Cape Girardeau trip over 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure great vacation packages with payment plans as soon as you see them.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.