Title: Visit Carlisle: 2026 Travel Guide for Carlisle, South Carolina | Expedia.com [Hotels in Carlisle](https://expedia.com/Carlisle-Hotels.d3000455877.Travel-Guide-Hotels)[Vacation Rentals in Carlisle](https://expedia.com/Carlisle-Vacation-Rentals.d3000455877.Travel-Guide-VacationRentals)[Flights to Carlisle](https://expedia.com/Cheap-Flights-To-Carlisle.d3000455877.Travel-Guide-Flights)[Car Rentals in Carlisle](https://expedia.com/Car-Rentals-In-Carlisle.d3000455877.Car-Rental-Guide)[Carlisle Vacation Packages](https://expedia.com/Carlisle.d3000455877.Destination-Travel-Guides) # Carlisle, SC ## Travel Guide ## Visit Carlisle - Carlisle Hotel Deals - Vacation Rentals in Carlisle ![A Taste of Southern Comfort](https://images.trvl-media.com/lodging/97000000/96720000/96717300/96717290/9704f243_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### A Taste of Southern Comfort Carlisle SC Stay at this vacation home in Carlisle. Enjoy a fitness center, laundry facilities, and patios. 9.6/10 Exceptional! (4 reviews) Welcome to SC This was my first opportunity to live in SC and everything was great and I wanted for nothing, I would recommend this house if you want tranquility in the evening Reviewed on Jun 28, 2025 [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F18%2F2026&endDate=4%2F19%2F2026&selected=96717290&PinnedHotelID=96717290&HadPinnedHotel=true®ionId=3000455877) [](https://expedia.com/Hotel-Search?startDate=4%2F18%2F2026&endDate=4%2F19%2F2026&selected=96717290&PinnedHotelID=96717290&HadPinnedHotel=true®ionId=3000455877) ![Quality Inn Clinton - Laurens I-26](https://images.trvl-media.com/lodging/1000000/30000/26900/26875/54b1a852_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Quality Inn Clinton - Laurens I-26 105 Trade St Clinton SC $56 nightly $63 total May 2 - May 3 Total with taxes and fees Book a stay at this business-friendly hotel in Clinton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ... 7.4/10 Good! (539 reviews) The particular room I had was spotless, clean and without any fragrances. The bed and sheets and pillows appeared to be almost new and very, very comfortable. Reviewed on Mar 21, 2026 [](https://expedia.com/Hotel-Search?startDate=5%2F2%2F2026&endDate=5%2F3%2F2026&selected=26875&PinnedHotelID=26875&HadPinnedHotel=true®ionId=3000455877) ![Holiday Inn Express & Suites Newberry by IHG](https://images.trvl-media.com/lodging/3000000/2810000/2803700/2803681/d098e4c5_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Holiday Inn Express & Suites Newberry by IHG 121 Truman Ave Newberry SC $122 nightly $132 total May 4 - May 5 Total with taxes and fees Book a stay at this business-friendly hotel in Newberry. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ... 9/10 Wonderful! (665 reviews) Clean room, great breakfast, and convenient parking! Reviewed on Apr 1, 2026 [](https://expedia.com/Hotel-Search?startDate=5%2F4%2F2026&endDate=5%2F5%2F2026&selected=2803681&PinnedHotelID=2803681&HadPinnedHotel=true®ionId=3000455877) [See all 55 properties in Carlisle](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=4%2F5%2F2026&endDate=4%2F6%2F2026®ionId=3000455877) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![A Taste of Southern Comfort](https://images.trvl-media.com/lodging/97000000/96720000/96717300/96717290/9704f243_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### A Taste of Southern Comfort Carlisle SC Stay at this vacation home in Carlisle. Enjoy a fitness center, laundry facilities, and patios. 9.6/10 Exceptional! (4 reviews) Welcome to SC This was my first opportunity to live in SC and everything was great and I wanted for nothing, I would recommend this house if you want tranquility in the evening Reviewed on Jun 28, 2025 [](https://expedia.com/Carlisle-Hotels-A-Taste-Of-Southern-Comfort.h96717290.Hotel-Information) ![Large late1800's home within walking distance to Opera House and downtown.](https://images.trvl-media.com/lodging/96000000/95130000/95125900/95125824/6400922f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Large late1800's home within walking distance to Opera House and downtown. Newberry SC Stay at this vacation home in Newberry. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions The Ritz Theater and Main Street Historic District ... 10/10 Exceptional! (43 reviews) Wonderful experience Reviewed on Mar 29, 2026 [](https://expedia.com/Newberry-Hotels-Large-Late1800s-Home-Within-Walking-Distance-To-Opera-House-And-Downtown.h95125824.Hotel-Information) ![1800’s Cabin with Hot Tub, Pet Friendly](https://images.trvl-media.com/lodging/92000000/91200000/91195900/91195817/w1169h772x0y1-59c75806_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### 1800’s Cabin with Hot Tub, Pet Friendly Rock Hill SC Stay at this cabin in Rock Hill. Enjoy free WiFi, patios, and an in-room coffeemaker. Popular attractions Historic Brattonsville and Rock Hill Sports & Event ... 9.8/10 Exceptional! (22 reviews) Cabin was clean & fun. Needs a nice knife set, extra light bulbs, more & better towels.Enjoyed our stay! Reviewed on Feb 20, 2026 [](https://expedia.com/Rock-Hill-Hotels-1800s-Cabin-With-Hot-Tub.h91195817.Hotel-Information) [See all properties in Carlisle](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=3000455877&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Carlisle hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000455877&startDate=2026-04-04&endDate=2026-04-05)[Apr 4 - Apr 5](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000455877&startDate=2026-04-04&endDate=2026-04-05) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000455877&startDate=2026-04-05&endDate=2026-04-06)[Apr 5 - Apr 6](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000455877&startDate=2026-04-05&endDate=2026-04-06) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000455877&startDate=4%2F10%2F2026&endDate=4%2F12%2F2026)[Apr 10 - Apr 12](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000455877&startDate=4%2F10%2F2026&endDate=4%2F12%2F2026) ## Cities near Carlisle ![sky and clouds sunset landscape over york south carolina](https://images.trvl-media.com/place/7209/e169d0fe-87c0-4252-bdd4-8ab1f4633ccf.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Chester ![architecture and buildings in union south carolina](https://images.trvl-media.com/place/56013/55ab68bf-0682-4a3a-ac49-dcbb669c8866.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Union ## Explore a world of travel with Expedia - 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[West Towne Plaza ](https://www.expedia.com/West-Towne-Plaza-Union.d553248621565028501.Vacation-Attraction) - [Visit Chester ](https://www.expedia.com/Chester.dx7209) - [Chester Vacations ](https://www.expedia.com/Chester.d7209.Destination-Travel-Guides) - [Cruse Vineyards and Winery ](https://www.expedia.com/Cruse-Vineyards-And-Winery-Chester.d553248621532657253.Vacation-Attraction) - [Chester County Historical Society Museum and Archives ](https://www.expedia.com/Chester-County-Historical-Society-Museum-And-Archives-Chester.d553248621560906806.Vacation-Attraction) - [Olde English District ](https://www.expedia.com/Olde-English-District-Chester.d553248621532657252.Vacation-Attraction) - [Visit Blackstock ](https://www.expedia.com/Blackstock.dx3000353090) - [Enoree River Vineyards and Winery ](https://www.expedia.com/Enoree-River-Vineyards-And-Winery-Newberry.d650065846682705920.Vacation-Attraction) - [Blackstock Vacations ](https://www.expedia.com/Blackstock.d3000353090.Destination-Travel-Guides) - [Visit Pomaria ](https://www.expedia.com/Pomaria.dx3000456053) - [Musgrove Mill State Historic Site ](https://www.expedia.com/Musgrove-Mill-State-Historic-Site-Clinton.d553248621532656795.Vacation-Attraction) - [Visit Cross Anchor ](https://www.expedia.com/Cross-Anchor.dx553248635519281641) - [Visit Kinards ](https://www.expedia.com/Kinards.dx3000455994) - [Visit McConnells ](https://www.expedia.com/McConnells.dx3000456026) - [Visit Joanna ](https://www.expedia.com/Joanna.dx3000455986) - [Car rentals near Whitmire ](https://www.expedia.com/Car-Rentals-In-Whitmire.d3000456164.Car-Rental-Guide) - [Car rentals near Monarch Mill ](https://www.expedia.com/Car-Rentals-In-Monarch-Mill.d553248634999119412.Car-Rental-Guide) - [Car rentals near Union ](https://www.expedia.com/Car-Rentals-In-Union.d56013.Car-Rental-Guide) - [Car rentals in Avis 3901 Quebec St ](https://www.expedia.com/Avis-at-3901-Quebec-St-Denver-Colorado-USA.v56013.Car-Rental-Guide-Location) - [Car rentals near Lockhart ](https://www.expedia.com/Car-Rentals-In-Lockhart.d553248634999092599.Car-Rental-Guide) - 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[Whitmire Vacation Rentals ](https://www.expedia.com/Whitmire-Vacation-Rentals.d3000456164.Travel-Guide-VacationRentals) - [Union Vacation Rentals ](https://www.expedia.com/Union-Vacation-Rentals.d56013.Travel-Guide-VacationRentals) - [Chester Vacation Rentals ](https://www.expedia.com/Chester-Vacation-Rentals.d7209.Travel-Guide-VacationRentals) - Cities near Carlisle - Places of interest [Chester](https://expedia.com/Chester.dx7209)[Union](https://expedia.com/Union.dx56013)[Blackstock](https://expedia.com/Blackstock.dx3000353090)[Whitmire](https://expedia.com/Whitmire.dx3000456164) - [Newberry Opera House ](https://expedia.com/Newberry-Opera-House-Newberry.d553248621532656685.Vacation-Attraction) - [Newberry College ](https://expedia.com/Newberry-College-Newberry.d650066027630927872.Vacation-Attraction) - [Veterans Memorial Park ](https://expedia.com/Veterans-Memorial-Park-Union.d553248621565028500.Vacation-Attraction) - [Musgrove Mill State Historic Site ](https://expedia.com/Musgrove-Mill-State-Historic-Site-Clinton.d553248621532656795.Vacation-Attraction) - [Cruse Vineyards and Winery ](https://expedia.com/Cruse-Vineyards-And-Winery-Chester.d553248621532657253.Vacation-Attraction) - [Rose Hill Plantation State Historic Site ](https://expedia.com/Rose-Hill-Plantation-State-Historic-Site-Union.d553248621532656797.Vacation-Attraction) - [Enoree River Vineyards and Winery ](https://expedia.com/Enoree-River-Vineyards-And-Winery-Newberry.d650065846682705920.Vacation-Attraction) - [Chester County Historical Society Museum and Archives ](https://expedia.com/Chester-County-Historical-Society-Museum-And-Archives-Chester.d553248621560906806.Vacation-Attraction) - [Historic Winnsboro Town Clock ](https://expedia.com/Historic-Winnsboro-Town-Clock-Winnsboro.d6319528.Vacation-Attraction) - [Olde English District ](https://expedia.com/Olde-English-District-Chester.d553248621532657252.Vacation-Attraction) - [Fairfield County Museum ](https://expedia.com/Fairfield-County-Museum-Winnsboro.d6319524.Vacation-Attraction) - [Historic Brattonsville ](https://expedia.com/Historic-Brattonsville-South-Carolina.d553248621532657259.Vacation-Attraction) - [South Carolina Bottle Museum ](https://expedia.com/South-Carolina-Bottle-Museum-Whitmire.d553248621532656796.Vacation-Attraction) - [West Towne Plaza ](https://expedia.com/West-Towne-Plaza-Union.d553248621565028501.Vacation-Attraction)