Name: Hotel Museo Spa Casa Santo Domingo
Price range: $256 total
Rating: 9.2

Your Central Highlands Vacation

Leave all the planning up to us with a Central Highlands vacation package. With everything organized before you depart, all you need to do is sit back, chill out and enjoy this destination's culture and charm. Your trip to Central Highlands wouldn't be complete without spending some time in its most renowned cities, starting with Guatemala City. A couple of the top attractions here include Paseo Cayala and La Aurora Zoo. Chiquimula is another favorite city with Central Highlands travelers. Visitors to this destination enjoy Ismael Cerna Park and Nuestra Senora del Transito Church. Expedia is your one-stop shop when it comes to planning your Central Highlands vacation. From hotels and flights, to activities and more, we know how to curate a travel experience like no other.

The Latest Central Highlands vacation packages

Price found within the past 48 hours. Click for updated prices.

Hotel Atitlán

Save 100% on your flight

$498

per person

Oct 23 - Oct 26

found 1 day ago

Roundtrip flight included

Fort Lauderdale (FLL) to Guatemala City (GUA)

9/10 Wonderful! (678 reviews)

The property is surrounded by beautiful botanical gardens and breathtaking views of Lake Atitlán. The decor throughout is stunning. and we can’t compliment the staff and restaurant enough. Kimberly recommended ‘pepian de res’ which is my new favorite Guatemalan dish. We very much look forward to returning

Reviewed on Aug 24, 2025

Hotel Soleil La Antigua

Save 100% on your flight

$767

per person

Oct 16 - Oct 19

found 1 day ago

Roundtrip flight included

Miami (MIA) to Guatemala City (GUA)

8.6/10 Excellent! (1,002 reviews)

This place was amazing and i enjoyed my stay . Staff was good , breakfast was off the chain. They offer transportation to and from the airport for 70us for 3 peoples. I hate the fact that we couldn’t get outfood or drink. I don’t think its fair .

Reviewed on Aug 25, 2025

Casa Santa Margarita

Save 100% on your flight

$1,765

per person

Nov 19 - Nov 23

found 16 hours ago

Roundtrip non-stop flight included

New York (JFK) to Guatemala City (GUA)

10/10 Exceptional! (13 reviews)

Everything was great, specially the service, they were always really attentive and their breakfast is really good (homemade). Quiet and safe, it’s set on a closed community and has a guard on the gates. Uber is very accessible. 10/10 would visit again!

Reviewed on Aug 17, 2025

Kula Maya Boutique Hotel & Spa

Save 100% on your flight

$556

per person

Oct 23 - Oct 27

found 16 hours ago

Roundtrip flight included

Fort Lauderdale (FLL) to Guatemala City (GUA)

9.6/10 Exceptional! (92 reviews)

I absolutely loved the hotel and property. The area of San Marcos wasn’t for me personally but I enjoyed the amenities of the hotel and the staff were always amazing and so sweet. The views are also … breathtaking

Reviewed on Aug 19, 2025

El Carmen Hotel

Historic Center

Save 100% on your flight

$795

per person

Nov 19 - Nov 23

found 16 hours ago

Roundtrip non-stop flight included

New York (JFK) to Guatemala City (GUA)

8.8/10 Excellent! (633 reviews)

Excellent location. Central to most Antigua attractions. Wonderful staff. The rooms are well kept. Nice restaurant with view on roof.

Reviewed on Aug 25, 2025

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Where to stay in Central Highlands

Find the best Central Highlands areas and neighborhoods for the activities you enjoy most. Learn more about Central Highlands

Zona 10

2 out of top 10 points of interest in this area

4.5/5(505 area reviews)

Zona 10 is known for its ample dining options, and you can make a stop by Oakland Mall and Plaza Fontabella Shopping Center while in the area.

Discover the most popular places to visit in Central Highlands

Ruins of Old Mayan Monastery destroyed during earthquake in 15th century !

Casa Santo Domingo Museum

You can browse the exhibits at Casa Santo Domingo Museum, a museum with a story of its own, during your travels to Antigua Guatemala. Discover the volcano viewpoints and shops in this romantic area.

Central Park

Enjoy the volcano viewpoints and explore Central Park, a lovely green space in Antigua Guatemala. Discover the area's shops, or seek out its local tours.

Antigua Guatemala Cathedral

You can find out about the history of Antigua Guatemala with a visit to Antigua Guatemala Cathedral. Discover the area's shops, or seek out its local tours.

Central Highlands Hotel Deals

Barceló Guatemala City

7 Avenida 15-45, Zona 9, Guatemala City, Guatemala

Fully refundableReserve now, pay when you stay

$81 nightly

$99 total

Sep 1 - Sep 2

Total with taxes and fees

9/10 Wonderful! (2,979 reviews)

"Very friendly staff I had a great experience."

Reviewed on Aug 24, 2025

Tikal Futura Hotel & Convention Center

Calzada Roosevelt 22-43, Zona 11, Guatemala City, Guatemala

Fully refundableReserve now, pay when you stay

$106 nightly

$129 total

Sep 12 - Sep 13

Total with taxes and fees

8.8/10 Excellent! (1,002 reviews)

"Check in took a long time but overran was very good experience"

Reviewed on Aug 21, 2025

Hotel Museo Spa Casa Santo Domingo

3a Calle Oriente No 28 A, Antigua Guatemala, Sacatepequez

$210 nightly

$256 total

Aug 31 - Sep 1

Total with taxes and fees

9.2/10 Wonderful! (1,006 reviews)

Great Family Vacation

"We had a wonderful stay at this hotel! The service was amazing and we ate the breakfast every morning and swam in the pool several times a day. All of the views from the room were amazing. The hotel was clean and smelled great. The layout of the room and the amenities were thoughtful and it seemed ..."

Reviewed on Aug 25, 2025

See all 1,207 properties in Central Highlands

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.