Beginning of main content

Search over 1,000,000 properties worldwide and 550 airlines worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Check prices on hotels in Chillicothe

Tonight Jun 18 - Jun 19
This weekend Jun 21 - Jun 23
Next weekend Jun 28 - Jun 30

Featured Chillicothe Luxury Hotels

See all 497 Properties in Chillicothe

Estimated price for 1 night/2 adults

Best Western Adena Inn
Best Western Adena Inn
2.5 out of 5.0 1250 N Bridge Street, Chillicothe, OH
Free Cancellation
3.9/5 (236 reviews)
$76/ night for 2 guests

Our room was very well cleaned. Huge walk in shower

Reviewed on May 26, 2019
Executive Inn
Executive Inn
2.5 out of 5.0 24 North Bridge Street, Chillicothe, OH
Free Cancellation
3.3/5 (85 reviews)
$60/ night for 2 guests

This was a very nice place I would rate it a 5 an go back on vacation here it was close to everything an very walkable

Reviewed on Jun 17, 2019
Christopher Inn and Suites
Christopher Inn and Suites
2.5 out of 5.0 30 North Plaza Boulevard, Chillicothe, OH
Free Cancellation
4.3/5 (391 reviews)
$120/ night for 2 guests

This is an older motel located right off the exit for Rt 35. We stayed in one of the King Suites. Large, 2 rooms quiet. Clean but a little dated (a chair and the bathroom door could use replacing).

Reviewed on Jun 10, 2019
Americas Best Value Inn Chillicothe
Americas Best Value Inn Chillicothe
2.0 out of 5.0 1135 East Main Street, Chillicothe, OH
3.0/5 (126 reviews)
$54/ night for 2 guests

The room was clean and comfortable. I liked being able to park right next to the room. The breakfast had much to be desired. It wasn't worth going to it the 2nd stay. It didn't have hardly anything available.

Reviewed on Nov 9, 2018
Map

Recently booked Luxury Hotels in Chillicothe

Christopher Inn and Suites
2.5 out of 5.0
Last booking: 5 hours ago
Best Western Adena Inn
2.5 out of 5.0
Last booking: 6 hours ago
Americas Best Value Inn Chillicothe
2.0 out of 5.0
Last booking: 11 hours ago

A few days away keeps your stress at bay, especially when you're visiting Chillicothe. Fascinating points of interest, divine eats, and opportunities to take fantastic photos: these are just a few of the reasons to take a trip to Chillicothe. You'll snag seats to the most popular performances, devour delicious eats, and get in line to see the coolest points of interest. Where else would you stay but in a luxury hotel? Extravagant experiences are right up your alley, so reserve your upscale hotel in Chillicothe on Expedia.com today, and your blissful vacation is off to a good start.

Plan a Luxury Chillicothe Vacation

It turns out plenty of folks love Chillicothe enough to have set down roots -- how is that for proof that Chillicothe is full of brilliant things to do? Whether you’re looking to spend your vacation dining on the best regional fare or exploring museums in Chillicothe, you'll never be disappointed. Chillicothe is full of impressive hotels as well as fantastic food, so you can count on a remarkable stay. Book early to get a room with a view!

A luxury retreat calls for massages, culture, and activities from your bucket list. When you save big by booking on Expedia.com, it's all at your fingertips. Thanks to our great rates on hotels, you'll still have money in your budget for the most popular adventures. After a day of exploration, your luxury accommodations will welcome you back to delightful amenities. Don't fall asleep before enjoying the view off your balcony or sipping on a glass of fine wine. The luxury rooms and suites in Chillicothe will have you basking in serenity in the blink of an eye.

Luxury Chillicothe Hotels

It's that time; you're prepared to get swept away in Chillicothe, and Expedia.com is here to make the process painless. Browse the abundance of ratings and reviews on fabulous hotels until you spot the perfect place to stay. Luxury accommodations offer amenities like elegant suites and VIP services. Many high-end accommodations in Chillicothe even feature upscale suites, and it's likely you'll enjoy incredible in-house dining in your hotel. Book your dream hotel in Chillicothe now, and before you know it you'll be feeling blissful in paradise!