Title: Cape Girardeau County Vacation Rentals from $108: Search Short-Term Rentals | Expedia.com

[Cape Girardeau County Hotels](https://expedia.com/Destinations-In-Cape-Girardeau-County.d553248635976430467.Hotel-Destinations)[Cape Girardeau County Flights](https://expedia.com/Destinations-In-Cape-Girardeau-County.d553248635976430467.Flight-Destinations)[Car Rentals in Cape Girardeau County](https://expedia.com/Destinations-In-Cape-Girardeau-County.d553248635976430467.Car-Rental-Destinations)[Cape Girardeau County Vacations](https://expedia.com/Cape-Girardeau-County.d553248635976430467.Destination-Travel-Guides)

![Beautiful city by the Mississippi River](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Alice Burghart

![](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg)  
###  
Bundle & Save  
Get more, spend less whenever you see Bundle & Save deals
- ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg)  
###  
OneKeyCash  
Earn OneKeyCash on all your eligible bookings
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg)  
###  
Upfront pricing  
We are not like the others - we include taxes and fees

## Top Cities in Cape Girardeau County

![Aerial Photo of Cape Girardeau, Missouri, USA](https://images.trvl-media.com/place/820/34f5c59a-7e57-4244-94c6-c657830fc4ab.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Cape Girardeau

[](https://expedia.com/Cape-Girardeau-Vacation-Rentals.d820.Travel-Guide-VacationRentals)

![Aerial view of Jefferson City, Missouri. Jefferson City is the capital of the U.S. state of Missouri](https://images.trvl-media.com/place/55765/5f6b269f-10cd-40c4-92f0-0144e4b2f10b.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Jackson

[](https://expedia.com/Jackson-Vacation-Rentals.d55765.Travel-Guide-VacationRentals)

## Our top choices for Cape Girardeau County vacation rentals

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/469a5901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/a97a55c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/6a739ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/d33a9d5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

[](https://www.expedia.com/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

Cape Girardeau

8.8/10

Excellent

(39 reviews)

"Will definitely book again! Great location, comfortable stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Pynktoria !.

$208 nightly

$219 total

Mar 25 - Mar 26

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/1c1368ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/c5155680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/b8327ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/f4fbd89f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Twisted Sassafras Treehouse 

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

Cape Girardeau

10/10

Exceptional

(32 reviews)

"Beautiful space indoors and out, can’t wait to come back when the weather allows more time for the outdoor amenities! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jordan R.

$295 nightly

$310 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/3867ac72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/927199d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Little Blue Cottage on Spanish

[](https://www.expedia.com/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

Cape Girardeau

8.2/10

Very Good

(53 reviews)

"Cozy and perfect for a couple. Great communication with the host"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beth G.

$101 nightly

$108 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0c802aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/5f66921b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/860b4de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/60c56f2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming Secluded Getaway Cabin within minutes of amenities 

[](https://www.expedia.com/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information)

Cape girardeau

10/10

Exceptional

(18 reviews)

"We had a great time at Blair and her family's property. The cabin was very comfortable and as advertised. I would be happy to recommend it to others "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tammy M.

$292 nightly

$307 total

Mar 24 - Mar 25

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/426ccc72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/c31730ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/fcf2830c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/04f26ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  Villa B offers peace and quiet with beautiful views of the countryside.

[](https://www.expedia.com/Jackson-Hotels-Villa-B-Offers-Peace-And-Quiet-With-Beautiful-Views-Of-The-Countryside.h93056190.Hotel-Information)

Jackson

10/10

Exceptional

(11 reviews)

"It was great. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Benjamin Q.

$170 nightly

$179 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Jackson-Hotels-Villa-B-Offers-Peace-And-Quiet-With-Beautiful-Views-Of-The-Countryside.h93056190.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w691h683x160y0-35462827.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w693h683x174y0-32d2f409.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w677h639x174y44-d15b07a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w675h683x175y0-e472cb80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Relax in the country at Countryside Villas! - Villa A

[](https://www.expedia.com/Jackson-Hotels-Relax-In-The-Country-At-Countryside-Villas.h80794106.Hotel-Information)

Jackson

10/10

Exceptional

(33 reviews)

"Great place to stay, felt like home away from home. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brittany

$172 nightly

$181 total

Mar 26 - Mar 27

Total with taxes and fees

[](https://www.expedia.com/Jackson-Hotels-Relax-In-The-Country-At-Countryside-Villas.h80794106.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/f432dafb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/564d6e43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6d0c8b74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Serenity South -- Gardens, River-Views, and Refreshing Space

[](https://www.expedia.com/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

Cape Girardeau

10/10

Exceptional

(151 reviews)

"Wonderful location! WonderfulStay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alison C.

$229 nightly

$248 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/2c8cc497.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/bb974ed1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/3619a392.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/8932b23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Gorgeous 1856 Log Cabin, Completely Renovated

[](https://www.expedia.com/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

Jackson

10/10

Exceptional

(3 reviews)

"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chandler G.

$311 nightly

$311 total

Mar 29 - Mar 30

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

![1 bedroom, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/add99418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/b0435fb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/1862bab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/2aecac3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Cottage, Rusted Route Farms

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

Jackson

10/10

Exceptional

(2 reviews)

"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Renee C.

$198 nightly

$198 total

Mar 24 - Mar 25

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557550/68e05443.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557550/fdaf0304.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557550/a4370343.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557550/b4eaf9f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Modern 2BR Apt w Electric Fireplace By KeenStays

[](https://www.expedia.com/Cape-Girardeau-Hotels-Modern-2BR-Apt-W-Electric-Fireplace-By-KeenStays.h127557550.Hotel-Information)

Cape Girardeau

$200 nightly

$209 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Modern-2BR-Apt-W-Electric-Fireplace-By-KeenStays.h127557550.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557548/e671b9f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557548/ada31fc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557548/ae9b919f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557548/7a844c3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fresh & Cozy Retreat w/ King Bed · By KeenStays

[](https://www.expedia.com/Cape-Girardeau-Hotels-Fresh-Cozy-Retreat-W-King-Bed-By-KeenStays.h127557548.Hotel-Information)

Cape Girardeau

$171 nightly

$179 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Fresh-Cozy-Retreat-W-King-Bed-By-KeenStays.h127557548.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/w1440h810x0y3-bf19009e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/f1c736a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/a7fa16a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/62582c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

[](https://www.expedia.com/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(8 reviews)

"Nice place, great times"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jace W.

$419 nightly

$440 total

Mar 25 - Mar 26

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557541/c4e4597e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557541/470e2ce0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557541/a552cbde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/128000000/127560000/127557600/127557541/7f0c9c8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays

[](https://www.expedia.com/Cape-Girardeau-Hotels-Luxe-2KBR-Apt-W-Electric-Fireplace-By-KeenStays.h127557541.Hotel-Information)

Cape Girardeau

$200 nightly

$209 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Luxe-2KBR-Apt-W-Electric-Fireplace-By-KeenStays.h127557541.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/3d5ec048.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/853dbdda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/48434221.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/6e1fe8fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

[](https://www.expedia.com/Makanda-Hotels-3-Minutes-To-Giant-City-6-Minutes-To-SIU-4-Minutes-To-Shawnee-Winetrail.h88869111.Hotel-Information)

Makanda

9.8/10

Exceptional

(62 reviews)

"Stephen very friendly and accomadations excellent!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Walter H.

$175 nightly

$193 total

Mar 24 - Mar 25

Total with taxes and fees

[](https://www.expedia.com/Makanda-Hotels-3-Minutes-To-Giant-City-6-Minutes-To-SIU-4-Minutes-To-Shawnee-Winetrail.h88869111.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/93000000/92510000/92506300/92506203/3bde84d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/93000000/92510000/92506300/92506203/b90dbe0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, coffee/tea maker, toaster](https://images.trvl-media.com/lodging/93000000/92510000/92506300/92506203/0957896f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/93000000/92510000/92506300/92506203/e8ac4a1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Minutes to Giant City - SIU - Shawnee Winetrail - Shawnee Forest - Wi-Fi

[](https://www.expedia.com/Makanda-Hotels-Minutes-To-Giant-City-SIU-Shawnee-Winetrail-Shawnee-Forest-Wi-Fi.h92506203.Hotel-Information)

Makanda

9.4/10

Exceptional

(46 reviews)

"Great place to stay and host was wonderful! Definitely would stay again in the future."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Teal B.

$175 nightly

$193 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Makanda-Hotels-Minutes-To-Giant-City-SIU-Shawnee-Winetrail-Shawnee-Forest-Wi-Fi.h92506203.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/d22aee4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/12dcf221.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/2c1a0ed0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/b0f0a7b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Rest, Relax and Renew. Our log cabin experience awaits your arrival. 

[](https://www.expedia.com/Anna-Hotels-Rest.h31189922.Hotel-Information)

Anna

10/10

Exceptional

(407 reviews)

"Great location. Cozy cabin. Would stay there again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

jeffrey s

$190 nightly

$201 total

Mar 24 - Mar 25

Total with taxes and fees

[](https://www.expedia.com/Anna-Hotels-Rest.h31189922.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/f8286145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/249ed696.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/8a8ad86a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/63184534.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

[](https://www.expedia.com/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information)

Makanda

9.6/10

Exceptional

(44 reviews)

"Host was very welcoming and kind. All amenities included covered everything anyone would need. The cabin was spacious, clean and welcoming. Our little dog loved it too. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Barbara M.

$205 nightly

$226 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/124000000/123380000/123379000/123378902/9d870958.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/124000000/123380000/123379000/123378902/277407ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, internet, bed sheets](https://images.trvl-media.com/lodging/124000000/123380000/123379000/123378902/078ea3f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/124000000/123380000/123379000/123378902/a79b8818.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pet-Friendly Lakeside Gem 4 Mi to Dtwn Murphysboro

[](https://www.expedia.com/Murphysboro-Hotels-Lakefront.h123378902.Hotel-Information)

Murphysboro

8.0/10

Very Good

(3 reviews)

"Perfect but beware if you are a sensitive sleeper as the mattress on the queen bed is saggy and in need of replacing. Probably fine for 1 person but 2 people easily roll into the middle making for a not-so-good night's sleep."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Pamela S.

$218 nightly

$237 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Murphysboro-Hotels-Lakefront.h123378902.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/804f0425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/aa7536c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Queen Bed with Sofa bed, Pets Allowed | Interior](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/d395df9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/127000000/126620000/126617400/126617355/9e44784b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Atrium - A Boutique Hotel

[](https://www.expedia.com/Perryville-Hotels-The-Atrium-A-Boutique-Hotel.h126617355.Hotel-Information)

Perryville

$126 nightly

$146 total

Mar 30 - Mar 31

Total with taxes and fees

[](https://www.expedia.com/Perryville-Hotels-The-Atrium-A-Boutique-Hotel.h126617355.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/09707f79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/30627e31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/c221a56c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/7bfe8087.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming cottage overlooking Lake Acre

[](https://www.expedia.com/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

Dongola

10/10

Exceptional

(102 reviews)

"Enjoyed our stay great hospitality, everything we needed was addressed. We would highly recommend staying there. Great location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

carlton h.

$264 nightly

$280 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-05&endDate=2026-04-06&regionId=553248635976430467&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=VACATION_HOME)

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=CABIN)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=APART_HOTEL)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=APARTMENT)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=COTTAGE)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in

](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Cape-Girardeau-County.d553248635976430467.Vacation-Rental-Destinations)[

Sign up, it's free

](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Cape-Girardeau-County.d553248635976430467.Vacation-Rental-Destinations)

## Top Cape Girardeau County Hotel Reviews

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg)

### Drury Inn & Suites Cape Girardeau

10/10 Excellent

"LOVED EVERYTHING ABOUT THIS PLACE"

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![Holiday Inn Express & Suites Perryville by IHG](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/469821a6_y.jpg)

### Holiday Inn Express & Suites Perryville by IHG

2/10 Terrible

"I was told i could check in when im 18 but i got their and they would not let me after already paying the price for it. Rip off. Very disrespectful."

[](https://expedia.com/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information)

![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg)

### Drury Inn & Suites Jackson MO

10/10 Excellent

"We have never stayed at a Drury hotel before and we were pleasantly surprised by amenities that are different from the usual hotel chains. Such as complimentary supper along with breakfast. Definitely a great deal when traveling with a family! Since we travel through the area often, we’ll definitely make this hotel our usual overnight stop."

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

8/10 Good

"Beds were clean and well made however carpet in room was stained. There was a chicken nugget on the floor in the elevator upon arrival and was still there the next morning. Breakfast was good except for preparer wiping her nose with her plastic serving gloves on. Good coffee and easy check in."

[](https://expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg)

### Candlewood Suites Cape Girardeau by IHG

6/10 Okay

"Yes"

[](https://expedia.com/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information)

![Quality Inn Cape Girardeau North](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg)

### Quality Inn Cape Girardeau North

8/10 Good

"The office chair did not move up or down. The water in the shower was just lukewarm when it was hot at the sink. The drain mechanism didn't let the water drain out."

[](https://expedia.com/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information)

![Town House Inn Cape Giradreau](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/c3f8959c_y.jpg)

### Town House Inn Cape Giradreau

10/10 Excellent

"Clean room, good location "

[](https://expedia.com/Sikeston-Hotels-Town-House-Inn-Cape-Giradreau.h11613884.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf_y.jpg)

### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Hotel staff were friendly and helpful. Store and restaurants were a short drive away."

[](https://expedia.com/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg)

### The Riverview

10/10 Excellent

"Room was nice and roomy. Staff friendly and heat worked well"

[](https://expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

## Find out more about Cape Girardeau County

## Discover your perfect Cape Girardeau County vacation rental with Expedia

#### How many vacation rentals are available in Cape Girardeau County? 
  
Expedia has plenty of vacation rentals to choose from in and around Cape Girardeau County, so you’re guaranteed to find the right one for you. 
  
#### How much is a vacation rental in Cape Girardeau County? 
  
The selection of Cape Girardeau County vacation rentals we have selected for you start as low as $108 per night. Entering your travel dates in the search wizard you might find even better deals! 
  
#### What type of vacation rental can I get in Cape Girardeau County? 
  
Vacation rentals in Cape Girardeau County come in all shapes and sizes, and your options depend on your chosen travel dates. You could entertain in a blissful vacation home, chill in a private apartment, or find family fun at a resort. Expedia offers a superb choice of Cape Girardeau County vacation rentals to suit everyone. 
  
#### Why should I choose a vacation rental in Cape Girardeau County? 
  
 Expedia’s vacation rentals provide cozy comforts you can sink into on your own schedule. You’ll enjoy your own space in a property with a kitchen, a pool, a garden etc. Maybe you’ll prefer somewhere with a spa or kids activities. A Cape Girardeau County vacation rental often works out to be a fantastic, cost-effective option for [groups](https://www.expedia.com/lp/b/vr/large) and [families](https://www.expedia.com/lp/b/vr/family) visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. 
  
#### How do I find the best deal on a vacation rental in Cape Girardeau County? 
  
 Find vacation rentals in Cape Girardeau County by viewing Expedia’s latest deals, or enter your travel dates and use the filters to select by amenities, price, or rating. Dive into the reviews to get a true feeling of which is your favorite vacation rental in Cape Girardeau County. 
  
#### What amenities are available in a vacation rental in Cape Girardeau County? 
  
 The choice is yours! Perhaps you love cooking in a well-equipped kitchen. Or maybe a late breakfast and a [swimming pool](https://www.expedia.com/lp/b/vr/private-pool) is more your thing. Of course, there’s always the treat of having [your own hot tub](https://www.expedia.com/lp/b/vr/hot-tub). Expedia has a vast range of amenities in Cape Girardeau County vacation rentals designed to suit every budget and trip type. 
  
#### When is the best time to stay in a vacation rental in Cape Girardeau County? 
  
 Everytime is a great time to head to Cape Girardeau County! Staying in a Cape Girardeau County vacation rentals you will always find lots going on to keep you entertained. 
  
#### Why book a vacation rental with Expedia? 
  
 Expedia has locked in amazing deals on a huge selection of impressive vacation rentals in Cape Girardeau County. We give you the information and inspiration you need all in one place. With so many properties to choose from, you know you can book your perfect Cape Girardeau County vacation rental with confidence. ANd don’t forget, if you bundle with a flight or a car rental in Cape Girardeau County, you can save even more. 
  
#### Can I cancel my vacation rental through Expedia? 
  
 Yes, you can cancel or change your Cape Girardeau County vacation rental by contacting your property manager directly. Contact details are easy to find on your itinerary in Trips. For more information, check out our Customer Service Portal and we’ll help you get everything sorted. 
  
## Explore a world of travel with Expedia

- Popular Cape Girardeau County Cities
- All accommodation types in Cape Girardeau County

- [Cape Girardeau Vacation Rentals ](https://expedia.com/Cape-Girardeau-Vacation-Rentals.d820.Travel-Guide-VacationRentals)
- [Jackson Vacation Rentals ](https://expedia.com/Jackson-Vacation-Rentals.d55765.Travel-Guide-VacationRentals)
- [Dutchtown Vacation Rentals ](https://expedia.com/Dutchtown-Vacation-Rentals.d3000349346.Travel-Guide-VacationRentals)
- [Friedheim Vacation Rentals ](https://expedia.com/Friedheim-Vacation-Rentals.d3000349372.Travel-Guide-VacationRentals)

- [Vacation Homes in Cape Girardeau County ](https://expedia.com/Cape-Girardeau-County-Private-Vacation-Homes.d553248635976430467-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cabin Rentals in Cape Girardeau County ](https://expedia.com/Cape-Girardeau-County-Cabins.d553248635976430467-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Cape Girardeau County ](https://expedia.com/Cape-Girardeau-County-Apartments.d553248635976430467-aaApartments.Travel-Guide-Accommodation)
- [Cottages in Cape Girardeau County ](https://expedia.com/Cape-Girardeau-County-Cottages.d553248635976430467-aaCottages.Travel-Guide-Accommodation)
- [Lodges in Cape Girardeau County ](https://expedia.com/Cape-Girardeau-County-Lodges.d553248635976430467-aaLodges.Travel-Guide-Accommodation)
- [RV Parks in Cape Girardeau County ](https://expedia.com/Cape-Girardeau-County-RV-Parks.d553248635976430467-aaRVParks.Travel-Guide-Accommodation)
- [Farmstay in Cape Girardeau County ](https://expedia.com/Cape-Girardeau-County-Agritourism.d553248635976430467-aaAgritourism.Travel-Guide-Accommodation)
- [B&B in Cape Girardeau County ](https://expedia.com/Cape-Girardeau-County-Bed-And-Breakfast.d553248635976430467-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Motels in Cape Girardeau County ](https://expedia.com/Cape-Girardeau-County-Motels.d553248635976430467-aaMotels.Travel-Guide-Accommodation)
- [Aparthotels in Cape Girardeau County ](https://expedia.com/Cape-Girardeau-County-Apart-Hotels.d553248635976430467-aaApartHotels.Travel-Guide-Accommodation)