Luxury Hotels in Panama from $159

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Pick from 67 Panama Luxury Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Our top choices for Panama luxury hotels

JW Marriott Panama

5.0 star property
8.8 out of 10, Excellent, (1004)
"Always an exceptional stay. "
$254 nightly
The price is $280
Sep 6 - Sep 7
Total with taxes and fees
JW Marriott Panama

Bristol Panama, a Registry Collection Hotel

5.0 star property
9.2 out of 10, Wonderful, (1000)
"A lovely hotel and excellent food and rooms and service. "
$200 nightly
The price is $220
Sep 26 - Sep 27
Total with taxes and fees
Bristol Panama, a Registry Collection Hotel

Waldorf Astoria Panama

5.0 star property
9.0 out of 10, Wonderful, (1003)
"Great hotel for my recent stay in Panam "
$220 nightly
The price is $242
Sep 20 - Sep 21
Total with taxes and fees
Waldorf Astoria Panama

American Trade Hotel

4.5 star property
9.4 out of 10, Exceptional, (552)
"Beautiful property and friendly staff!"
$194 nightly
The price is $216
Sep 15 - Sep 16
Total with taxes and fees
American Trade Hotel

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

4.5 star property
8.8 out of 10, Excellent, (985)
"2nd stay at Sortis Hotel in Panama. Never disappoints. Breakfast Buffett incredible and staff pleasant and attentive! Will stay there again!"
$150 nightly
The price is $165
Sep 1 - Sep 2
Total with taxes and fees
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Hilton Panama

5.0 star property
8.8 out of 10, Excellent, (1003)
"The food was very good at the hotel. Several options to choose from at the hotel. "
$212 nightly
The price is $233
Sep 20 - Sep 21
Total with taxes and fees
Hilton Panama

Megapolis Hotel Panamá

5.0 star property
8.4 out of 10, Very Good, (1000)
"This is THE place to stay in Panama City... it's location, friendly accommodating staff, and the amenities are fantastic. The rooms were wonderful, clean and bright. We tried Tauro (steakhouse) and the Bazaar - they were both delicious and the service excellent. We literally partied like rock stars at their rooftop restaurant, and at the wonderful outdoor infinity pool as well. We will definitely be returning! "
Megapolis Hotel Panamá

The Buenaventura Golf & Beach Resort Panama, Autograph Collection

5.0 star property
9.2 out of 10, Wonderful, (653)
"I have stayed at some of the best resorts in the world. I must say that The Buenaventura Golf & Beach Resort Panama deserves to be in this category. The staff were so kind and helpful all of the time. The resort is beautiful and the food was excellent. "
$157 nightly
The price is $173
Sep 16 - Sep 17
Total with taxes and fees
The Buenaventura Golf & Beach Resort Panama, Autograph Collection

Las Americas Golden Tower Panama

4.0 star property
8.8 out of 10, Excellent, (1003)
"Great staff and accommodations "
$144 nightly
The price is $159
Sep 6 - Sep 7
Total with taxes and fees
Las Americas Golden Tower Panama

Marriott Panama Hotel

4.0 star property
9.0 out of 10, Wonderful, (1002)
"They made staying in the city enjoyable. Awesome service!"
$149 nightly
The price is $164
Sep 21 - Sep 22
Total with taxes and fees
Marriott Panama Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Panama Hotel Reviews