Luxury Hotels in Panama from $159
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Pick from 67 Panama Luxury Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Our top choices for Panama luxury hotels

JW Marriott Panama
JW Marriott Panama
8.8 out of 10, Excellent, (1004)
$254 nightly
The price is $280
Sep 6 - Sep 7
Total with taxes and fees

Bristol Panama, a Registry Collection Hotel
Bristol Panama, a Registry Collection Hotel
9.2 out of 10, Wonderful, (1000)
$200 nightly
The price is $220
Sep 26 - Sep 27
Total with taxes and fees

Waldorf Astoria Panama
Waldorf Astoria Panama
9.0 out of 10, Wonderful, (1003)
$220 nightly
The price is $242
Sep 20 - Sep 21
Total with taxes and fees

American Trade Hotel
American Trade Hotel
9.4 out of 10, Exceptional, (552)
$194 nightly
The price is $216
Sep 15 - Sep 16
Total with taxes and fees

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
8.8 out of 10, Excellent, (985)
$150 nightly
The price is $165
Sep 1 - Sep 2
Total with taxes and fees

Hilton Panama
Hilton Panama
8.8 out of 10, Excellent, (1003)
$212 nightly
The price is $233
Sep 20 - Sep 21
Total with taxes and fees

Megapolis Hotel Panamá
Megapolis Hotel Panamá
8.4 out of 10, Very Good, (1000)

The Buenaventura Golf & Beach Resort Panama, Autograph Collection
The Buenaventura Golf & Beach Resort Panama, Autograph Collection
9.2 out of 10, Wonderful, (653)
$157 nightly
The price is $173
Sep 16 - Sep 17
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Panama Hotel Reviews

Plaza Paitilla Inn Hotel
10/10 Excellent