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Vacation Rentals in St. Charles County

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Top Cities in St. Charles County

Top Vacation Rentals in St. Charles County

Vacation Home in St. Charles Historic District

10.0 out of 10, Exceptional, (136)
"We loved staying here in this adorable clean house that was only 1 block off of downtown Main Street shopping. "
United States
Lisa S.
The St. Charles Guest House, lovely historic home, fun for families and groups

Vacation Home in St. Charles Historic District

10.0 out of 10, Exceptional, (99)
"Check-in was easy and the house was lovely "
United States
Delfino A.
$314 nightly
The price is $320
Dec 23 - Dec 24
Total with taxes and fees
Stunning 1890's Home - Sleeps 8!

Cottage in St. Charles Historic District

10.0 out of 10, Exceptional, (210)
"Nice view of the Mississippi in the morning. Just off of the main street in old town St Charles, this place was perfect for our needs."
United States
Ralph
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

Apartment in St. Charles Historic District

9.6 out of 10, Exceptional, (13)
"Awesome place to stay"
United States
paul
$236 nightly
The price is $236
Dec 7 - Dec 8
Total with taxes and fees
Cozy Clark Suite in Frenchtown Saint Charles

Vacation Home in St. Charles Historic District

9.8 out of 10, Exceptional, (134)
"We will be back. Nice quiet stay. "
United States
Kathe H.
$237 nightly
The price is $237
Dec 7 - Dec 8
Total with taxes and fees
St. Charles 1860's Gem - Sleeps 6!

Vacation Home in Saint Charles

9.8 out of 10, Exceptional, (26)
"The place was great! "
United States
Melissa I.
$468 nightly
The price is $478
Dec 7 - Dec 8
Total with taxes and fees
Home Near Main Street-Covered Patio-Hot Tub!

Vacation Home in St. Charles Historic District

8.6 out of 10, Excellent, (14)
"The house was clean and well stocked, location was great, and plenty of street parking. "
United States
Brad K.
$213 nightly
The price is $239
Dec 14 - Dec 15
Total with taxes and fees
Madison House 1 -Walk to Main St

Vacation Home in St. Charles Historic District

9.8 out of 10, Exceptional, (60)
"We had a great weekend and enjoyed the house very much! We had everything we needed!"
United States
Laurie S.
$412 nightly
The price is $420
Dec 7 - Dec 8
Total with taxes and fees
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

Vacation Home in St Charles

9.4 out of 10, Exceptional, (144)
"House was very nice. Pictures were good and we knew what to expect. Location was great for where we wanted to go.Owner was punctual when we had any questions!"
United States
Anne L.
Residence on the Roundabout

Apartment in St. Charles Historic District

9.8 out of 10, Exceptional, (100)
"The loft was very nice, very clean, well appointed, and in a perfect location. I highly recommend this property!"
United States
Mary ann S.
$227 nightly
The price is $242
Jan 4 - Jan 5, 2026
Total with taxes and fees
Prime Loft of Main Street

Vacation Home in St. Charles Historic District

9.6 out of 10, Exceptional, (58)
"This is a fun property perfectly located just a couple blocks from Main Street and all its shops and restaurants. Very clean, very comfortable and a nice yard for our dogs.Thanks for sharing your home!"
United States
Barry K.
$322 nightly
The price is $322
Dec 7 - Dec 8
Total with taxes and fees
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

Vacation Home in St. Charles Historic District

9.0 out of 10, Wonderful, (19)
"Excellent location and a great space for 4 couples. The beds were exceptionally comfortable! "
United States
Kimberly C.
$351 nightly
The price is $395
Dec 7 - Dec 8
Total with taxes and fees
The Lewis & Clark Hangout

Vacation Home in St. Charles Historic District

10.0 out of 10, Exceptional, (241)
"The house was quite spacious for our needs. It was very nice and comfortable. Appreciate the care taken to restore this great property and decorated tastefully. "
United States
Eric S.
Charming Cottage on Main St. in Historic St. Charles! Jetted Tub, 2 Fireplaces!!

Vacation Home in St. Charles Historic District

9.8 out of 10, Exceptional, (74)
"Great location, lovely house.Easy to find restaurants, places to shop and nice area for strolling."
United States
Dianne P.
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟

Vacation Home in St. Charles Historic District

9.8 out of 10, Exceptional, (54)
"Comfortable home in a convenient, quiet location."
United States
Troy B.
$412 nightly
The price is $420
Dec 7 - Dec 8
Total with taxes and fees
Spacious, Beautiful St. Charles Home-Remodeled-Sleeps 10! New Patio!

Aparthotel in St. Charles Historic District

9.6 out of 10, Exceptional, (14)
"We really enjoyed our stay! The Hare was an amazing suite & the location was great!"
United States
Angela R.
The Hare Suite at Divine Otter

Apartment in St. Charles Historic District

8.2 out of 10, Very Good, (12)
"Just make sure you are fit and able to navigate steps. Great party place for the younger generation. The bar below has a nice back outside sitting area we were able to use. "
United States
Lisa W.
$284 nightly
The price is $288
Dec 7 - Dec 8
Total with taxes and fees
The Wild West Getaway- 204-1

Vacation Home in St. Charles Historic District

7.8 out of 10, Good, (7)
"This property was clean and offered basic amenities, but is a very old historic home and lacks the luster and comfort of most homes, but has needed repairs and improvements to have a 5 star rating. "
United States
Kimbelry D.
$213 nightly
The price is $239
Dec 11 - Dec 12
Total with taxes and fees
Madison House 2 -Walk to Main St

Vacation Home in St. Charles Historic District

9.8 out of 10, Exceptional, (102)
"The home is larger than is looks allows 3 groups to stay with their own bathrooms and space for privacy."
United States
Nicole B.
Clark Brick House w/ Pool - Historic St. Charles

Apartment in Grand Center

4.0 star property
8.6 out of 10, Excellent, (124)
"Very clean and very friendly people "
United States
Mary
$128 nightly
The price is $149
Dec 7 - Dec 8
Total with taxes and fees
White House at Grand Central
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top St. Charles County Hotel Reviews

Find out more about St. Charles County

Discover your perfect St. Charles County vacation rental with Expedia

How many vacation rentals are available in St. Charles County?


Expedia has plenty of vacation rentals to choose from in and around  St. Charles County, so you’re guaranteed to find the right one for you. 


How much is a vacation rental in St. Charles County?


The selection of St. Charles County vacation rentals we have selected for you start as low as $149 per night. Entering your travel dates in the search wizard you might find even better deals!


What type of vacation rental can I get in St. Charles County?


Vacation rentals in St. Charles County come in all shapes and sizes, and your options depend on your chosen travel dates. You could entertain in a blissful vacation home, chill in a private apartment, or find family fun at a resort. Expedia offers a superb choice of St. Charles County vacation rentals to suit everyone. 


Why should I choose a vacation rental in St. Charles County?


Expedia’s vacation rentals provide cozy comforts you can sink into on your own schedule. You’ll enjoy your own space in a property with a kitchen, a pool, a garden etc. Maybe you’ll prefer somewhere with a spa or kids activities. A St. Charles County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. 


How do I find the best deal on a vacation rental in St. Charles County?


Find vacation rentals in St. Charles County by viewing Expedia’s latest deals, or enter your travel dates and use the filters to select by amenities, price, or rating. Dive into the reviews to get a true feeling of which is your favorite vacation rental in St. Charles County.  


What amenities are available in a vacation rental in St. Charles County?


The choice is yours! Perhaps you love cooking in a well-equipped kitchen. Or maybe a late breakfast and a swimming pool is more your thing. Of course, there’s always the treat of having your own hot tub. Expedia has a vast range of amenities in St. Charles County vacation rentals designed to suit every budget and trip type.


When is the best time to stay in a vacation rental in St. Charles County?   


Everytime is a great time to head to St. Charles County! Staying in a St. Charles County vacation rentals you will always find lots going on to keep you entertained. 


Why book a vacation rental with Expedia?


Expedia has locked in amazing deals on a huge selection of impressive vacation rentals in St. Charles County. We give you the information and inspiration you need all in one place. With so many properties to choose from, you know you can book your perfect St. Charles County vacation rental with confidence. ANd don’t forget, if you bundle with a flight or a car rental in St. Charles County, you can save even more.


Can I cancel my vacation rental through Expedia?  


Yes, you can cancel or change your St. Charles County vacation rental by contacting your property manager directly. Contact details are easy to find on your itinerary in Trips. For more information, check out our Customer Service Portal and we’ll help you get everything sorted.