St. Charles Vacation Rentals

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Our top choices for St. Charles vacation rentals

Two Bedroom Townhome near Streets

Two Bedroom Townhome near Streets
Saint Charles
9.0 out of 10, Wonderful, (10 reviews)
"Great location, clean, and management was informative and reacted to any needs quickly. Would recommend to anyone."
United States
Nathan D.
$278 nightly
The price is $307
Feb 23 - Feb 24
Total with taxes and fees
Two Bedroom Townhome near Streets

Casa de Saint Charles

Casa de Saint Charles
Saint Charles
9.2 out of 10, Wonderful, (17 reviews)
"The home was perfect for our multi-family gathering. There was lots of room for everyone and the location was great for our needs."
United States
Karla Z.
$303 nightly
The price is $303
Feb 23 - Feb 24
Total with taxes and fees
Casa de Saint Charles

Main Street Balcony Apartment by StayLage!

Main Street Balcony Apartment by StayLage!
St. Charles Historic District
9.6 out of 10, Exceptional, (36 reviews)
"Great location for shopping and a lot of restaurants nearby. Beds were very comfortable. "
United States
Brooke I.
$403 nightly
The price is $444
Feb 23 - Feb 24
Total with taxes and fees
Main Street Balcony Apartment by StayLage!

The Below Deck Suite

The Below Deck Suite
Saint Charles
9.0 out of 10, Wonderful, (2 reviews)
"Overall good place for a family. The neighborhood is quiet and there is a good amount of space. Easy to find and to get places. You will hear the people upstairs and one bed was very squeaky. It was very clean and the couches are very comfy. "
United States
Amy B.
$213 nightly
The price is $213
Feb 23 - Feb 24
Total with taxes and fees
The Below Deck Suite

Home Near Main Street-Covered Patio-Hot Tub!

Home Near Main Street-Covered Patio-Hot Tub!
Saint Charles
9.8 out of 10, Exceptional, (29 reviews)
"We absolutely loved our stay in St. Charles. This property was perfect for our family with plenty of space and very clean! Great communication and responsiveness from owner. We would definitely book this property again in the future. "
United States
Danielle T.
$443 nightly
The price is $501
Feb 23 - Feb 24
Total with taxes and fees
Home Near Main Street-Covered Patio-Hot Tub!

Charming open 4bd and screen-in porch! Sleeps 10!

Charming open 4bd and screen-in porch! Sleeps 10!
Saint Charles
9.2 out of 10, Wonderful, (35 reviews)
"Stay here for 3 weeks. Place was just as described. Would recommend. Thank you "
United States
Eddy
$443 nightly
The price is $501
Feb 26 - Feb 27
Total with taxes and fees
Charming open 4bd and screen-in porch! Sleeps 10!

Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (35 reviews)
"Great Stay and great location! "
United States
Angela
$340 nightly
The price is $375
Feb 25 - Feb 26
Total with taxes and fees
Historic Main St. Customs House Upstairs Apartment

St. Charles 1860's Gem - Sleeps 6!

St. Charles 1860's Gem - Sleeps 6!
St. Charles Historic District
9.8 out of 10, Exceptional, (141 reviews)
"Another great stay! "
United States
Kate G.
$247 nightly
The price is $247
Mar 2 - Mar 3
Total with taxes and fees
St. Charles 1860's Gem - Sleeps 6!

Spacious 2 Bedroom Townhome by StayLage

Spacious 2 Bedroom Townhome by StayLage
Saint Charles
7.8 out of 10, Good, (12 reviews)
"Perfect size"
United States
Barbie D.
$272 nightly
The price is $299
Feb 23 - Feb 24
Total with taxes and fees
Spacious 2 Bedroom Townhome by StayLage

The Cul-de-Sac Retreat

The Cul-de-Sac Retreat
Saint Charles
8.4 out of 10, Very Good, (9 reviews)
"Great house, great location - close to the St. Charles convention center"
United States
Joe H.
$246 nightly
The price is $246
Feb 23 - Feb 24
Total with taxes and fees
The Cul-de-Sac Retreat

The Original Custom House!

The Original Custom House!
St. Charles Historic District
9.8 out of 10, Exceptional, (36 reviews)
"Location is perfect. Clean and exactly what we were looking for in a weekend get away. The common areas (living room and kitchen) are on the smaller side if you are wanting a place to gather but we were out and about most of the time so it was perfect for us. "
United States
Amanda G.
$340 nightly
The price is $375
Feb 23 - Feb 24
Total with taxes and fees
The Original Custom House!

The Olive House - Near Main Street- Fully rehabbed

The Olive House - Near Main Street- Fully rehabbed
Saint Charles
8.8 out of 10, Excellent, (9 reviews)
"Great place to stay for the weekend. Only 1 bathroom can be a stretch if you’re used to having access to multiple. However, it’s a quick walk to Upshot or Lady Di’s for coffee or breakfast. "
United States
Rachel Y.
$310 nightly
The price is $349
Feb 23 - Feb 24
Total with taxes and fees
The Olive House - Near Main Street- Fully rehabbed

Stay on Main Historic Studio

Stay on Main Historic Studio
St. Charles Historic District
9.0 out of 10, Wonderful, (33 reviews)
"Nice property.. Clean. "
United States
Belinda J.
$186 nightly
The price is $205
Feb 23 - Feb 24
Total with taxes and fees
Stay on Main Historic Studio

New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!
St. Charles Historic District
9.6 out of 10, Exceptional, (68 reviews)
"The neighborhood was beautiful, close to shopping and activities!"
United States
Tami B.
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (58 reviews)
"Great place and location. Owners were easy to work with."
United States
Cory M.
$236 nightly
The price is $252
Feb 25 - Feb 26
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street

Historic 4‑BR Farmhouse • Steps to Main Street

Historic 4‑BR Farmhouse • Steps to Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (22 reviews)
"The house was perfect for our stay. "
United States
Susan F.
$549 nightly
The price is $612
Mar 10 - Mar 11
Total with taxes and fees
Historic 4‑BR Farmhouse • Steps to Main Street

Madison House 1 -Walk to Main St

Madison House 1 -Walk to Main St
St. Charles Historic District
8.6 out of 10, Excellent, (17 reviews)
"The house was clean and well stocked, location was great, and plenty of street parking. "
United States
Brad K.
$219 nightly
The price is $247
Feb 24 - Feb 25
Total with taxes and fees
Madison House 1 -Walk to Main St

The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (163 reviews)
"Very nice place near all the action. "
United States
Weston G.
$208 nightly
The price is $222
Feb 23 - Feb 24
Total with taxes and fees
The Lofts of North Main Street

1st Capitol Mansion - Suite 401

1st Capitol Mansion - Suite 401
St. Charles Historic District
7.6 out of 10, Good, (8 reviews)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
$219 nightly
The price is $247
Feb 23 - Feb 24
Total with taxes and fees
1st Capitol Mansion - Suite 401

Winter SALE,Cozy 2BR Chalet, Hot Tub 1.2 Acres!

Winter SALE,Cozy 2BR Chalet, Hot Tub 1.2 Acres!
Saint Charles
8.8 out of 10, Excellent, (3 reviews)
"We loved the location for our travel needs and we had everything we needed for a family of two adults and two dogs. "
United States
Leslie R.
$494 nightly
The price is $589
Feb 23 - Feb 24
Total with taxes and fees
Winter SALE,Cozy 2BR Chalet, Hot Tub 1.2 Acres!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Top St. Charles Hotel Reviews

Find out more about St. Charles

Everything you need to know about St. Charles vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the St. Charles vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect St. Charles vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

St. Charles vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in St. Charles. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit St. Charles in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $143 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on St. Charles rentals

At Expedia, we put the best St. Charles vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top St. Charles rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream St. Charles vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around St. Charles. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find vacation rentals in St. Charles?

Yes, you can find vacation rentals near popular attractions in St. Charles, or you can choose a secluded option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in St. Charles. The live music and theater scene are some other things you might like to check out during your trip.

What are some of the best vacation rentals that St. Charles has to offer?

St. Charles 1860's Gem - Sleeps 6!: This St. Charles vacation home rental is located on a river and has a garden, a selection of books, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. Some other top choices in St. Charles are 🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟 and 1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo..

How many vacation rentals are there in St. Charles?

Expedia has 87 vacation rentals for your stay in St. Charles.

What can I see and do in St. Charles?

Katy Trail and Mississippi River are a couple of scenic spots to enjoy the outdoors, whereas Missouri Artists on Main is one of the cultural attractions. Other places in town to visit include Historic Main Street and Lewis & Clark Boathouse and Nature Center.

What are vacation rentals like in St. Charles?

Vacation rentals are privately owned accommodations you can book for several days or more in St. Charles. Vacation rentals provide amenities such as laundry facilities and kitchens to help you enjoy your stay. If you're concerned about a clean environment, vacation rentals can offer a sense of privacy away from shared hotel elevators and lobbies packed with people while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which makes a vacation rental an attractive option for a family getaway.