St. Charles Vacation Rentals

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Our top choices for St. Charles vacation rentals

Charming open 4bd and screen-in porch! Sleeps 10!

Charming open 4bd and screen-in porch! Sleeps 10!
Saint Charles
9.2 out of 10, Wonderful, (36 reviews)
"Stay here for 3 weeks. Place was just as described. Would recommend. Thank you "
United States
Eddy
$446 nightly
The price is $504
Apr 12 - Apr 13
Total with taxes and fees
Charming open 4bd and screen-in porch! Sleeps 10!

Walk to St. Charles Entertainment

Walk to St. Charles Entertainment
Saint Charles
9.0 out of 10, Wonderful, (10 reviews)
"We really enjoyed our stay. The house was clean, spacious, and very accommodating. We stayed for a dance competition and the proximity to the convention center was unbeatable. "
United States
Chloe
$265 nightly
The price is $292
Apr 14 - Apr 15
Total with taxes and fees
Walk to St. Charles Entertainment

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
St. Charles Historic District
9.6 out of 10, Exceptional, (75 reviews)
"Great communication from host, cute house in an awesome location. Will definitely be staying again!"
United States
Sydney W.
$210 nightly
The price is $225
Apr 12 - Apr 13
Total with taxes and fees
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

Duplex Hideaway in St. Charles, MO

Duplex Hideaway in St. Charles, MO
St. Charles Historic District
10.0 out of 10, Exceptional, (5 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
$216 nightly
The price is $237
Apr 12 - Apr 13
Total with taxes and fees
Duplex Hideaway in St. Charles, MO

Spacious 2 Bedroom Townhome

Spacious 2 Bedroom Townhome
Saint Charles
8.0 out of 10, Very Good, (13 reviews)
"The stay here was amazing!! Live the little townhouse so much. Host was amazing!!"
United States
Tina W.
$262 nightly
The price is $288
Apr 12 - Apr 13
Total with taxes and fees
Spacious 2 Bedroom Townhome

The Original Custom House!

The Original Custom House!
St. Charles Historic District
9.8 out of 10, Exceptional, (36 reviews)
"The location is excellent. "
United States
McRay H.
$326 nightly
The price is $359
Apr 12 - Apr 13
Total with taxes and fees
The Original Custom House!

Main Street Balcony Apartment

Main Street Balcony Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (36 reviews)
"Great location for shopping and a lot of restaurants nearby. Beds were very comfortable. "
United States
Brooke I.
$397 nightly
The price is $437
Apr 13 - Apr 14
Total with taxes and fees
Main Street Balcony Apartment

Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (59 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
$261 nightly
The price is $279
Apr 12 - Apr 13
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street

New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!
St. Charles Historic District
9.6 out of 10, Exceptional, (69 reviews)
"Very clean and comfortable. Enjoyed our stay"
United States
Dana S.
$431 nightly
The price is $487
Apr 14 - Apr 15
Total with taxes and fees
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

Cottage on Main st- Low Cleaning Fee

Cottage on Main st- Low Cleaning Fee
St. Charles Historic District
10.0 out of 10, Exceptional, (7 reviews)
"Good location. Decorated very nicely. "
United States
Debbie A.
$262 nightly
The price is $280
Apr 12 - Apr 13
Total with taxes and fees
Cottage on Main st- Low Cleaning Fee

The Bourbon & Brass | Speakeasy-Inspired 2BDR

The Bourbon & Brass | Speakeasy-Inspired 2BDR
St. Charles Historic District
$285 nightly
The price is $314
Apr 12 - Apr 13
Total with taxes and fees
The Bourbon & Brass | Speakeasy-Inspired 2BDR

Stay on Main Historic Studio

Stay on Main Historic Studio
St. Charles Historic District
9.0 out of 10, Wonderful, (33 reviews)
"Nice property.. Clean. "
United States
Belinda J.
$178 nightly
The price is $197
Apr 13 - Apr 14
Total with taxes and fees
Stay on Main Historic Studio

St. Charles 1860's Gem - Sleeps 6!

St. Charles 1860's Gem - Sleeps 6!
St. Charles Historic District
9.8 out of 10, Exceptional, (148 reviews)
"Another great stay! "
United States
Kate G.
$247 nightly
The price is $264
Apr 14 - Apr 15
Total with taxes and fees
St. Charles 1860's Gem - Sleeps 6!

Spacious, Beautiful St. Charles Home-Remodeled-Sleeps 10! New Patio!

Spacious, Beautiful St. Charles Home-Remodeled-Sleeps 10! New Patio!
St. Charles Historic District
9.8 out of 10, Exceptional, (59 reviews)
"Last minute trip to visit our son. Great location and plenty of space. We LOVE UpShots Coffee located just a mile from here!"
United States
Kate G.
$434 nightly
The price is $490
Apr 13 - Apr 14
Total with taxes and fees
Spacious, Beautiful St. Charles Home-Remodeled-Sleeps 10! New Patio!

The Historic Bricks on Main

The Historic Bricks on Main
St. Charles Historic District
9.0 out of 10, Wonderful, (17 reviews)
"Host was very welcoming and helpful when we have any questions no matter what time of day. The place was very quaint and comfy. We would highly recommend. "
United States
Chelsea L.
$199 nightly
The price is $219
Apr 12 - Apr 13
Total with taxes and fees
The Historic Bricks on Main

St. Charles Manor | 4BR Getaway Home+HotTub+GameRm .6 acres

St. Charles Manor | 4BR Getaway Home+HotTub+GameRm .6 acres
Saint Charles
10.0 out of 10, Exceptional, (5 reviews)
"Wonderful place to stay for a group trip! Lots of space and activities for everyone to do. The hosts are very accommodating and quick to respond for any last minute questions. "
United States
Scott S.
$673 nightly
The price is $748
Apr 12 - Apr 13
Total with taxes and fees
St. Charles Manor | 4BR Getaway Home+HotTub+GameRm .6 acres

The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (168 reviews)
"Host was very responsive and location was perfect"
United States
Peggy K.
$245 nightly
The price is $262
Apr 12 - Apr 13
Total with taxes and fees
The Lofts of North Main Street

Stylish1BRStudioCleanQuietandCozy

Stylish1BRStudioCleanQuietandCozy
Saint Charles
$228 nightly
The price is $254
Apr 12 - Apr 13
Total with taxes and fees
Stylish1BRStudioCleanQuietandCozy

1st Capitol Mansion - Suite 401

1st Capitol Mansion - Suite 401
St. Charles Historic District
7.6 out of 10, Good, (8 reviews)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
$272 nightly
The price is $305
Apr 12 - Apr 13
Total with taxes and fees
1st Capitol Mansion - Suite 401

The Olive House - Near Main Street- Fully rehabbed

The Olive House - Near Main Street- Fully rehabbed
Saint Charles
8.6 out of 10, Excellent, (11 reviews)
"This was the perfect place to stay and the property was great"
United States
Stephen L.
$306 nightly
The price is $344
Apr 12 - Apr 13
Total with taxes and fees
The Olive House - Near Main Street- Fully rehabbed
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top St. Charles Hotel Reviews

Find out more about St. Charles

Everything you need to know about St. Charles vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the St. Charles vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect St. Charles vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

St. Charles vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in St. Charles. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit St. Charles in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $120 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on St. Charles rentals

At Expedia, we put the best St. Charles vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top St. Charles rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream St. Charles vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around St. Charles. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find vacation rentals in St. Charles?

Yes, you can find vacation rentals near popular attractions in St. Charles, or you can choose a secluded option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in St. Charles. The live music and theater scene are some other things you might like to check out during your trip.

What are some of the best vacation rentals that St. Charles has to offer?

St. Charles 1860's Gem - Sleeps 6!: This St. Charles vacation home rental is located on a river and has a garden, a selection of books, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. Some other top choices in St. Charles are 🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟 and 1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo..

How many vacation rentals are there in St. Charles?

Expedia has 87 vacation rentals for your stay in St. Charles.

What can I see and do in St. Charles?

Katy Trail and Mississippi River are a couple of scenic spots to enjoy the outdoors, whereas Missouri Artists on Main is one of the cultural attractions. Other places in town to visit include Historic Main Street and Lewis & Clark Boathouse and Nature Center.

What are vacation rentals like in St. Charles?

Vacation rentals are privately owned accommodations you can book for several days or more in St. Charles. Vacation rentals provide amenities such as laundry facilities and kitchens to help you enjoy your stay. If you're concerned about a clean environment, vacation rentals can offer a sense of privacy away from shared hotel elevators and lobbies packed with people while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which makes a vacation rental an attractive option for a family getaway.