Downtown Syracuse Vacations from $346
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Your Downtown Syracuse Vacation
A sought-after riverside neighborhood, Downtown Syracuse tempts travelers with its bars and pubs, nightlife and shopping. Lock in a vacation package to Downtown Syracuse and experience all the highlights for yourself. Some nearby attractions to visit during your trip to Downtown Syracuse include Museum of Science and Technology, Erie Canal Museum and Syracuse University. Stop dreaming and start doing. When you're ready to lock in your next vacation to Downtown Syracuse, Expedia will help you get there.
The Latest Downtown Syracuse Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Syracuse Grand
$346
per person
Nov 13 - Nov 16
found 22 hours ago
Roundtrip flight included
Boston (BOS) to Syracuse (SYR)
6.8/10 (1,032 reviews)
Our stay at the grand was fantastic đź‘Ź will continue to stay there whenever in the area. Staff was so helpful and friendly. Breakfast was a great start to our day.
Reviewed on Aug 30, 2026
Vanderkamp
$494
per person
Nov 2 - Nov 5
found 23 hours ago
Roundtrip flight included
New York (NYC) to Syracuse (SYR)
10/10 Exceptional! (1 review)
We had an amazing stay and can't wait to come back! The cabin was absolutely beautiful—spotlessly clean, cozy, and surrounded by peaceful forest views. Having lake access made our stay even more special, whether it was relaxing by the water or taking in the quiet scenery.
One of the highlights was the spa. The sauna, cold plunge, and wellness spaces were the perfect way to unwind after spending time outdoors. Everything about the property encourages you to slow down, disconnect, and enjoy nature.
If you're looking for a peaceful getaway with beautiful cabins, lake access, and wonderful spa amenities, Vanderkamp is the perfect destination. We left feeling refreshed, relaxed, and already planning our next visit!
Reviewed on Jul 11, 2026
Where to stay in Downtown Syracuse
Find the best Downtown Syracuse areas and neighborhoods for the activities you enjoy most. Learn more about Downtown Syracuse
Eastside
2 out of top 10 points of interest in this area
Bordering Downtown Syracuse and University Hill, Near Eastside boasts historic gems like the Gustav Stickley House and Collins House. Explore the rich history while staying close to downtown attractions.
Lakefront
1 out of top 10 points of interest in this area
Bordering Downtown Syracuse, Lakefront features the charming areas of Franklin Square and Inner Harbor. Explore the historic O.M. Edwards Building, listed on the National Register of Historic Places.
Northside
While visiting Northside, you might make a stop by sights like Museum of International Masks and Puppets and ArtRage Gallery.
Southside
While Southside isn't home to many top sights, Rosamond Gifford Zoo and Everson Museum of Art are some notable places to visit nearby.
Westside
1 out of top 10 points of interest in this area
Explore Middle Ages Brewing Company and shop for souvenirs near Leavenworth Park. Discover historic sites like Harriet May Mills House and St. Paul's Armenian Apostolic Church, or unwind at Frazer Park. Accessible by three major bus corridors.
Downtown Syracuse Hotel Deals
Marriott Syracuse Downtown
100 East Onondaga Street Syracuse NY
Fully refundableReserve now, pay when you stay
$149 nightly
$175 total
Sep 20 - Sep 21
Total with taxes and fees
8.6/10 Excellent! (1,004 reviews)
"The room was very comfortable. The restaurants were understaffed."
Reviewed on Aug 31, 2026
Best Western Syracuse Downtown Hotel and Suites
416 S Clinton St Syracuse NY
Fully refundableReserve now, pay when you stay
$128 nightly
$150 total
Sep 6 - Sep 7
Total with taxes and fees
8.4/10 Very Good! (733 reviews)
"Clean room, good breakfast, and great location downtown."
Reviewed on Aug 29, 2026
Courtyard by Marriott Syracuse Downtown at Armory Square
300 West Fayette Street Syracuse NY
Fully refundableReserve now, pay when you stay
$135 nightly
$158 total
Sep 13 - Sep 14
Total with taxes and fees
8.6/10 Excellent! (758 reviews)
"Great location. Clean hotel. Great staff. The only negative is the parking which is. Wet limited & difficult to park in."
Reviewed on Aug 28, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Downtown Syracuse attractions
Armory Square
8.8/10 (680 reviews)
Home to Syracuse’s highest concentration of bars and restaurants, this lively city square is the perfect place for a night out in Central New York.
Landmark Theatre
8.4/10 (270 reviews)
See Broadway musicals, comedy or rock shows at this beautiful and supposedly haunted 1920s venue just off Syracuse’s Armory Square.
Clinton Square
8.6/10 (51 reviews)
Nestled in the heart of Syracuse’s downtown, this historic plaza is known for its civic mindedness, hosting countless festivals and a community ice skating rink.
Museum of Science and Technology
8.2/10 (81 reviews)
Kids and adults will love this Syracuse museum, featuring an IMAX theater, interactive exhibits and possibly the world’s largest collection of toothpick sculptures.
Everson Museum of Art
8.0/10 (51 reviews)
Brutalist architecture, American art and one of the world’s finest ceramics collections come together at this small but mighty museum in Syracuse’s downtown.
The Oncenter
8.4/10 (308 reviews)
Learn about the events happening at The Oncenter during your trip to Syracuse. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Erie Canal Museum
8.6/10 (93 reviews)
You can browse the exhibits at Erie Canal Museum, a museum with a story of its own, during your trip to Syracuse. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Onondaga County War Memorial
8.8/10 (17 reviews)
Learn about the local history of Syracuse when you take a trip to Onondaga County War Memorial. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Things to do
1-Hour Walk-In Axe Throwing Experience Syracuse
$37
per adult
100% of travellers recommend
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- Le Moyne College
- Onondaga County War Memorial
- Destiny USA
- Suny Upstate Medical University
- Nbt Bank Stadium
- Visit Downtown Syracuse
- Where to stay in Syracuse
- New York Vacations
- Solvay Vacations
- Erie Canal Museum
- Lake Onondaga
- Everson Museum of Art
- Dewitt Vacations
- Clinton Square
- Syracuse VA Medical Center
- East Syracuse Vacations
- Syracuse University
- St. Joseph's Hospital Health Center
- Sainte Marie among the Iroquois
- Green Lakes State Park
- Visit Syracuse
- Onondaga Lake Visitors Center
- Onondaga Lake Park
- Visit New York
- Armory Square
- Museum of International Masks and Puppets
- Rosamond Gifford Zoo
- E.m. Mills Rose Garden
- Wonderworks
- Salt Museum
- Landmark Theatre
- Museum of Science and Technology
- Crouse Hospital
- New York State Fairgrounds
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.