Downtown Syracuse Vacations from $378
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Your Downtown Syracuse Vacation
A sought-after riverside neighborhood, Downtown Syracuse tempts travelers with its bars and pubs, nightlife and shopping. Lock in a vacation package to Downtown Syracuse and experience all the highlights for yourself. Some nearby attractions to visit during your trip to Downtown Syracuse include Museum of Science and Technology, Erie Canal Museum and Syracuse University. Stop dreaming and start doing. When you're ready to lock in your next vacation to Downtown Syracuse, Expedia will help you get there.
The Latest Downtown Syracuse Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Cresthill Suites Syracuse
$378
per person
Dec 4 - Dec 7
found 13 hours ago
Roundtrip flight included
Raleigh (RDU) to Syracuse (SYR)
7.8/10 Good! (1,306 reviews)
The room was clean, but dated. There was a huge gap in the door to the hall where light came through. I’m not sure how secure that made the door. The breakfast had many choices. I appreciated that various choices of drinks were available all day.
Reviewed on Oct 14, 2026
Baldwinsville B&B
$1,704
per person
Dec 26 - Jan 2
found 1 day ago
Roundtrip flight included
Fairbanks (FAI) to Syracuse (SYR)
10/10 Exceptional! (204 reviews)
Phyllis and Jim were great hosts. They went out of their way to accommodate. Enjoyed the conversations and the friendly atmosphere. Will definitely stay there again.
Reviewed on Oct 10, 2026
Where to stay in Downtown Syracuse
Find the best Downtown Syracuse areas and neighborhoods for the activities you enjoy most. Learn more about Downtown Syracuse
Eastside
2 out of top 10 points of interest in this area
Bordering Downtown Syracuse and University Hill, Near Eastside boasts historic gems like the Gustav Stickley House and Collins House. Explore the rich history while staying close to downtown attractions.
Northside
While visiting Northside, you might make a stop by sights like Museum of International Masks and Puppets and ArtRage Gallery.
Southside
While Southside isn't home to many top sights, Syracuse Convention and Visitors Bureau and Rosamond Gifford Zoo are some notable places to visit nearby.
Lakefront
1 out of top 10 points of interest in this area
Bordering Downtown Syracuse, Lakefront features the charming areas of Franklin Square and Inner Harbor. Explore the historic O.M. Edwards Building, listed on the National Register of Historic Places.
Westside
1 out of top 10 points of interest in this area
Explore Middle Ages Brewing Company and shop for souvenirs near Leavenworth Park. Discover historic sites like Harriet May Mills House and St. Paul's Armenian Apostolic Church, or unwind at Frazer Park. Accessible by three major bus corridors.
Downtown Syracuse Hotel Deals
Marriott Syracuse Downtown
100 East Onondaga Street Syracuse NY
Fully refundableReserve now, pay when you stay
$127 nightly
$148 total
Nov 15 - Nov 16
Total with taxes and fees
Best Western Syracuse Downtown Hotel and Suites
416 S Clinton St Syracuse NY
Fully refundableReserve now, pay when you stay
$120 nightly
$140 total
Nov 15 - Nov 16
Total with taxes and fees
Courtyard by Marriott Syracuse Downtown at Armory Square
300 West Fayette Street Syracuse NY
$144 nightly
$168 total
Oct 25 - Oct 26
Total with taxes and fees
8.6/10 Excellent! (772 reviews)
"We loved the convenience and impeccable cleanliness of this hotel"
Reviewed on Oct 13, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Downtown Syracuse attractions
Armory Square
8.8/10 (680 reviews)
Home to Syracuse’s highest concentration of bars and restaurants, this lively city square is the perfect place for a night out in Central New York.
Landmark Theatre
8.4/10 (270 reviews)
See Broadway musicals, comedy or rock shows at this beautiful and supposedly haunted 1920s venue just off Syracuse’s Armory Square.
Clinton Square
8.6/10 (51 reviews)
Nestled in the heart of Syracuse’s downtown, this historic plaza is known for its civic mindedness, hosting countless festivals and a community ice skating rink.
Museum of Science and Technology
8.2/10 (81 reviews)
Kids and adults will love this Syracuse museum, featuring an IMAX theater, interactive exhibits and possibly the world’s largest collection of toothpick sculptures.
Everson Museum of Art
8.0/10 (51 reviews)
Brutalist architecture, American art and one of the world’s finest ceramics collections come together at this small but mighty museum in Syracuse’s downtown.
The Oncenter
8.4/10 (308 reviews)
Learn about the events happening at The Oncenter during your trip to Syracuse. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Erie Canal Museum
8.6/10 (93 reviews)
You can browse the exhibits at Erie Canal Museum, a museum with a story of its own, during your trip to Syracuse. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Onondaga County War Memorial
8.8/10 (17 reviews)
Learn about the local history of Syracuse when you take a trip to Onondaga County War Memorial. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.