Title: Top Independent in Irene, SD - Expedia.com [Irene Travel Guide](https://expedia.com/Irene.dx3000353315)[Hotels in Irene](https://expedia.com/Irene-Hotels.d3000353315.Travel-Guide-Hotels)[Vacation Rentals in Irene](https://expedia.com/Irene-Vacation-Rentals.d3000353315.Travel-Guide-VacationRentals)[Flights to Irene](https://expedia.com/Cheap-Flights-To-Irene.d3000353315.Travel-Guide-Flights)[Car Rentals in Irene](https://expedia.com/Car-Rentals-In-Irene.d3000353315.Car-Rental-Guide)[Irene Vacation Packages](https://expedia.com/Irene.d3000353315.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 29 - Mar 30](https://www.expedia.com/Hotel-Search?regionId=3000353315&startDate=2026-03-29&endDate=2026-03-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 30 - Mar 31](https://www.expedia.com/Hotel-Search?regionId=3000353315&startDate=2026-03-30&endDate=2026-03-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=3000353315&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=3000353315&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FIrene-Hotels-Independent.0-0-d3000353315--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FIrene-Hotels-Independent.0-0-d3000353315--bIndependent.Travel-Guide-Filter-Hotels) ## Top Irene Hotel Reviews ![Comfort Inn Yankton SD](https://images.trvl-media.com/lodging/11000000/10450000/10440200/10440162/7f61cbcd_y.jpg) ### Comfort Inn Yankton SD 10/10 Excellent "Everything was clean and up to date. Spacious room and comfortable bed. All staff we encountered were friendly. The breakfast was great - something for everyone. We chose here because it was less expensive than other places, and I’m really glad we did. It was a great experience, and we will definitely stay here again!" [](https://expedia.com/Vermillion-Hotels-Econo-Lodge.h10440162.Hotel-Information) ![Best Western Kelly Inn](https://images.trvl-media.com/lodging/7000000/6850000/6847000/6846956/889752b7_y.jpg) ### Best Western Kelly Inn 2/10 Terrible "Room had feces all over the toilet, other people’s dirty socks and belongings in the room, hair in the bed sheets.. we changed rooms.. the new room had blood on the toilet then a clogged toilet that over flowed. 2x. The new room k had a smell to it and dirty sheets shoved under the bed. Zero stars if I could " [](https://expedia.com/Vermillion-Hotels-Best-Western-Kelly-Inn.h6846956.Hotel-Information) ![Lewis and Clark Resort](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/d9482fb8_y.jpg) ### Lewis and Clark Resort 10/10 Excellent "Always a clean place!" [](https://expedia.com/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information) ![Super 8 by Wyndham Beresford](https://images.trvl-media.com/lodging/1000000/860000/856100/856095/2977116e_y.jpg) ### Super 8 by Wyndham Beresford 10/10 Excellent "This was a nice place to sleep. Good beds" [](https://expedia.com/Sioux-Falls-Hotels-Super-8-By-Wyndham-Beresford.h856095.Hotel-Information) ![Holiday Inn Express & Suites Yankton by IHG](https://images.trvl-media.com/lodging/1000000/970000/966200/966127/2e36e17b_y.jpg) ### Holiday Inn Express & Suites Yankton by IHG 10/10 Excellent "The hotel was under construction, but otherwise clean. Decent breakfast " [](https://expedia.com/Vermillion-Hotels-Holiday-Inn-Express-Suites-Yankton.h966127.Hotel-Information) ![Econo Lodge Inn & Suites Yankton](https://images.trvl-media.com/lodging/1000000/30000/27300/27232/34e7ebe1_y.jpg) ### Econo Lodge Inn & Suites Yankton 6/10 Okay "Sink did not drain and remote for tv did not work. Staff and check in was great." [](https://expedia.com/Vermillion-Hotels-Days-Inn-By-Wyndham-Yankton-SD.h27232.Hotel-Information) ![Fairfield Inn & Suites by Marriott Yankton](https://images.trvl-media.com/lodging/87000000/86190000/86189100/86189086/7b3b8474_y.jpg) ### Fairfield Inn & Suites by Marriott Yankton 2/10 Terrible "yes" [](https://expedia.com/Yankton-Hotels-Fairfield-Inn-Suites-By-Marriott-Yankton.h86189086.Hotel-Information) ![Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!](https://images.trvl-media.com/lodging/123000000/122880000/122874900/122874900/d4549250_y.jpg) ### Modern Lewis and Clark lake home with lake views and 3 min drive to the beach! 10/10 Excellent "Our family had a wonderful time staying in this lovely house. It is so full of light and spacious. We were able to put the littles to bed early on a different floor while the adults played loud games. The ping pong table was great entertainment to keep kids off their phones too! We would stay here again!" [](https://expedia.com/Crofton-Hotels-Modern-Lewis-And-Clark-Lakefront-Home-With-Panoramic-Water-Views.h122874900.Hotel-Information) ![Spacious Lakeview Cabin Minutes from Private Beach](https://images.trvl-media.com/lodging/105000000/104180000/104179200/104179194/59c44551_y.jpg) ### Spacious Lakeview Cabin Minutes from Private Beach 10/10 Excellent "Great place to stay with a large group. Awesome view of the lake. " [](https://expedia.com/Crofton-Hotels-Spacious-Lakeview-Cabin-Minutes-From-Private-Beach.h104179194.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Wakonda Hotels ](https://www.expedia.com/Wakonda-Hotels.d3000353331.Travel-Guide-Hotels) - [Apartments in Wakonda ](https://www.expedia.com/Wakonda-Apartments.d3000353331-aaApartments.Travel-Guide-Accommodation) - [3 Star Hotels in Wakonda ](https://www.expedia.com/3Star-Wakonda-Hotels.s30-0-d3000353331.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Wakonda ](https://www.expedia.com/5Star-Wakonda-Hotels.s50-0-d3000353331.Travel-Guide-Filter-Hotels) - [Viborg Hotels ](https://www.expedia.com/Viborg-Hotels.d3000353329.Travel-Guide-Hotels) - [Motels in Viborg ](https://www.expedia.com/Viborg-Motels.d3000353329-aaMotels.Travel-Guide-Accommodation) - [Volin Hotels ](https://www.expedia.com/Volin-Hotels.d3000456439.Travel-Guide-Hotels) - [Apartments in Volin ](https://www.expedia.com/Volin-Apartments.d3000456439-aaApartments.Travel-Guide-Accommodation) - 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