Title: Top Independent in Irene, SD  - Expedia.com

[Irene Travel Guide](https://expedia.com/Irene.dx3000353315)[Hotels in Irene](https://expedia.com/Irene-Hotels.d3000353315.Travel-Guide-Hotels)[Vacation Rentals in Irene](https://expedia.com/Irene-Vacation-Rentals.d3000353315.Travel-Guide-VacationRentals)[Flights to Irene](https://expedia.com/Cheap-Flights-To-Irene.d3000353315.Travel-Guide-Flights)[Car Rentals in Irene](https://expedia.com/Car-Rentals-In-Irene.d3000353315.Car-Rental-Guide)[Irene Vacation Packages](https://expedia.com/Irene.d3000353315.Destination-Travel-Guides)

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## Check prices for these dates

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[Mar 13 - Mar 14](https://www.expedia.com/Hotel-Search?regionId=3000353315&startDate=2026-03-13&endDate=2026-03-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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Next weekend

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## Top Irene Hotel Reviews

![Lewis and Clark Resort](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/d9482fb8_y.jpg)

### Lewis and Clark Resort

10/10 Excellent

"Pet-friendly, friendly staff, & clean."

[](https://expedia.com/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information)

![Fairfield Inn & Suites by Marriott Yankton](https://images.trvl-media.com/lodging/87000000/86190000/86189100/86189086/7b3b8474_y.jpg)

### Fairfield Inn & Suites by Marriott Yankton

2/10 Terrible

"yes"

[](https://expedia.com/Yankton-Hotels-Fairfield-Inn-Suites-By-Marriott-Yankton.h86189086.Hotel-Information)

![Best Western Kelly Inn](https://images.trvl-media.com/lodging/7000000/6850000/6847000/6846956/889752b7_y.jpg)

### Best Western Kelly Inn

6/10 Okay

"Honestly we would not stay here again if we dint really have too. Our room still had a sticker on the t.v from pervious people. That tells me it did not get cleaned very well along with crumbs still on the floor. Our sliding door to the pool the handle was broken so it was hard to open and close. Breakfasts was ok not much kid friendly food."

[](https://expedia.com/Vermillion-Hotels-Best-Western-Kelly-Inn.h6846956.Hotel-Information)

![Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!](https://images.trvl-media.com/lodging/123000000/122880000/122874900/122874900/d4549250_y.jpg)

### Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

10/10 Excellent

"Our family had a wonderful time staying in this lovely house. It is so full of light and spacious. We were able to put the littles to bed early on a different floor while the adults played loud games. The ping pong table was great entertainment to keep kids off their phones too! We would stay here again!"

[](https://expedia.com/Crofton-Hotels-Modern-Lewis-And-Clark-Lakefront-Home-With-Panoramic-Water-Views.h122874900.Hotel-Information)

![Comfort Inn Yankton SD](https://images.trvl-media.com/lodging/11000000/10450000/10440200/10440162/7f61cbcd_y.jpg)

### Comfort Inn Yankton SD

10/10 Excellent

"We love this hotel!!! Always clean, friendly, and quiet!"

[](https://expedia.com/Vermillion-Hotels-Econo-Lodge.h10440162.Hotel-Information)

![Spacious Lakeview Cabin Minutes from Private Beach](https://images.trvl-media.com/lodging/105000000/104180000/104179200/104179194/59c44551_y.jpg)

### Spacious Lakeview Cabin Minutes from Private Beach

10/10 Excellent

"Great place to stay with a large group. Awesome view of the lake. "

[](https://expedia.com/Crofton-Hotels-Spacious-Lakeview-Cabin-Minutes-From-Private-Beach.h104179194.Hotel-Information)

![Econo Lodge Inn & Suites Yankton](https://images.trvl-media.com/lodging/1000000/30000/27300/27232/34e7ebe1_y.jpg)

### Econo Lodge Inn & Suites Yankton

8/10 Good

"Good hotel. Clean room, good breakfast, and good rate."

[](https://expedia.com/Vermillion-Hotels-Days-Inn-By-Wyndham-Yankton-SD.h27232.Hotel-Information)

![Yankton Inn](https://images.trvl-media.com/lodging/1000000/860000/855600/855512/cfaf7734_y.jpg)

### Yankton Inn

10/10 Excellent

"It was good for what I needed"

[](https://expedia.com/Vermillion-Hotels-Yankton-Inn.h855512.Hotel-Information)

![Super 8 by Wyndham Beresford](https://images.trvl-media.com/lodging/1000000/860000/856100/856095/2977116e_y.jpg)

### Super 8 by Wyndham Beresford

4/10 Poor

"Extremely low budget. Dirty, stained linens. Just bad."

[](https://expedia.com/Sioux-Falls-Hotels-Super-8-By-Wyndham-Beresford.h856095.Hotel-Information)

## Explore a world of travel with Expedia

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- [Visit Wakonda ](https://www.expedia.com/Wakonda.dx3000353331)
- [Visit Viborg ](https://www.expedia.com/Viborg.dx3000353329)
- [Visit Volin ](https://www.expedia.com/Volin.dx3000456439)
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- [Spirit Mound ](https://www.expedia.com/Spirit-Mound-Vermillion.d553248621532648839.Vacation-Attraction)
- [Riverside Park ](https://www.expedia.com/Riverside-Park-Yankton.d6303846.Vacation-Attraction)
- [Visit Yankton ](https://www.expedia.com/Yankton.dx3984)
- [Yankton Vacations ](https://www.expedia.com/Yankton.d3984.Destination-Travel-Guides)

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