Feed your inner culture vulture at Karpeles Manuscript Library Museum. Check if any guided tours are available or ask museum staff to direct you to the collection highlights.
You'll have sightseeing choices galore when spending time in Downtown Charleston. Karpeles Manuscript Library Museum is an ideal place to kick off here, but there are plenty of other fine spots to appreciate. USS Yorktown, College of Charleston, and Charleston City Market are not far from the museum and will fill in your day nicely.