Los Santos Vacations & Trips from $805

Book a Hotel + Flight or Car together to unlock savings

Photo by Lissa Guzman

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to $1,045 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Your Los Santos Vacation

Embark on a journey full of discovery and excitement with a vacation package to Los Santos. Known for its festivals and so much more, this destination will surprise and delight at every step. A trip to Los Santos wouldn't be complete without spending some time in its best cities, starting with Pedasi. Some of the top attractions here include Iguana Island National Park and Playa El Arenal. Las Tablas is another favorite with Los Santos travelers. Visitors to this exciting city enjoy El Uverito Beach and Playa Las Comadres. Expedia has everything you need for organizing your Los Santos vacation. From flights and accommodations, to rental cars and activities, we're here to help you curate a travel experience like no other.

Top destinations in Los Santos

Mil Polleras Festival! #lifeatexpedia
FlightsFlightsHotelsHotels

Las Tablas

Las Tablas

The Latest Los Santos Vacation Packages

Price found within the past 48 hours. Click for updated prices.
MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel

3.5 out of 5
Amador
per person
Oct 18 - Oct 25
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Panama City (PTY)
8/10 Very Good! (111 reviews)
I liked that there were plenty activities and food options nearby. The staff were very friendly and helpful. Property and room was always clean. Just a wonderful overall experience.

Reviewed on Jul 24, 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
per person
Oct 18 - Oct 25
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Panama City (PTY)
9/10 Wonderful! (932 reviews)
Nuestra experiencia en el hotel fue excelente. Las instalaciones se mantienen impecablemente limpias y bien cuidadas, lo que hace que la estadía sea muy agradable. El personal es sumamente atento y gentil, siempre dispuesto a ayudar y hacer sentir a los huéspedes bienvenidos. Nos encantó la música en vivo que ofrecen, creando un ambiente relajado y acogedor. Además, la ubicación es perfecta: está muy cerca de los principales lugares turísticos, lo que facilita explorar la zona sin complicaciones. ¡Definitivamente volveríamos!

Reviewed on Jul 25, 2025

Hotel Plaza Herrera

Hotel Plaza Herrera

3 out of 5
Casco Viejo
Save 100% on your flight
per person
Oct 18 - Oct 25
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Panama City (PTY)
10/10 Exceptional! (3 reviews)
Staying at Hotel Herrera in Casco Viejo was truly unforgettable-one of those rare experiences where everything just feels right from the moment you arrive. Nestled right in the heart of Plaza Herrera, the hotel’s beautifully restored colonial façade immediately drew me in, but it was the warm welcome from the staff that really set the tone for my stay. My suite was a perfect blend of historic charm and modern comfort, with gorgeous handcrafted furniture, and a balcony that overlooked the lively Plaza Herrera below. Every detail, from the plush bedding to the luxurious marble bathroom, made it feel like a boutique retreat. I loved waking up to the sounds of the city and sipping coffee while watching the world go by from my private balcony. The hotel’s location made it easy to explore the best of Casco Viejo on foot-charming cafes, art galleries, and vibrant nightlife were all just steps away. The staff went above and beyond, offering great recommendations and even arranging a guided tour to the Panama Canal and a day trip to the Emberá community, which was a highlight of my trip. Dining at Hotel Herrera was another standout. I treated myself to a special dinner in THEcellar, their exclusive private dining room, and it was an experience I’ll never forget. The food was incredible, and the intimate setting made it feel truly special. If you’re looking for a place that combines history, luxury, and genuine hospitality, I can’t recommend Hotel Herrera enough.

Reviewed on May 5, 2025

La Coralina Island House

La Coralina Island House

3.5 out of 5
per person
Sep 17 - Sep 21
found 2 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.4/10 Exceptional! (82 reviews)
Wow! This resort is absolutely amazing! Bekar went above and beyond for us! He even brought in a TV to the lobby so we could watch the NHL playoff game! Food is 10/10 as well. We will definitely go back!

Reviewed on May 18, 2025

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
per person
Oct 18 - Oct 25
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Panama City (PTY)
8.4/10 Very Good! (936 reviews)
The property was pretty good

Reviewed on Jul 27, 2025

Best Places to Vacation in Los Santos

1. Find your perfect Las Escobas del Venado vacation

Las Escobas del Venado in Los Santos, Panama offers the perfect atmosphere for a beach vacation. With its secluded and pristine beaches, it is an ideal destination for those looking to relax and enjoy nature. The area is also known for its great surfing opportunities, with waves that cater to both beginners and experienced surfers. Visitors can take long walks along the shoreline, bask in the warm sun, and admire breathtaking sunsets. For those seeking a lively atmosphere, there are beach bars where you can sip on refreshing drinks and soak in the vibrant marina scene.

  • Travelers tend to stay 3 days in Las Escobas del Venado

2. Escape to Pedasi with a vacation package

Pedasi in Los Santos, Panama, offers a perfect atmosphere for a beach vacation. With its stunning geographic location and beautiful beaches, it is an ideal destination for relaxation. The locals in Pedasi are known for their friendliness and welcoming nature, making visitors feel right at home. The town also offers a variety of dining options, allowing travelers to indulge in delicious local cuisine. Some popular activities for travelers to enjoy here are vacation packages that include beach activities and exploring the natural beauty of the area. Overall, Pedasi promises a memorable and enjoyable beach vacation experience.

  • The peak season is from January to March
  • The off-peak season is from August to October
  • Travelers tend to stay 3 days in Pedasi

3. Discover Las Tablas with our vacation deals

Las Tablas, located in Los Santos, Panama, is the perfect destination for a beach vacation. With its budget-friendly options and abundance of excursions, visitors can enjoy the stunning sandy beaches and crystal-clear waters. Seafood lovers will delight in the fresh and delicious seafood options available, while adventure enthusiasts can partake in activities like walking and exploring the natural parks. Las Tablas is also a family-friendly destination, offering a range of activities suitable for all ages. Whether you're looking for relaxation or adventure, Las Tablas has it all.

  • The peak season is from December to February
  • The off-peak season is from April to June
  • Travelers tend to stay 2 days in Las Tablas

4. Enjoy Cambutal with a travel package

Cambutal, located in Los Santos, Panama, offers a serene and picturesque beach vacation experience. Nestled within stunning geographic affinities, this coastal destination is perfect for relaxation and rejuvenation. With its pristine sandy beaches and crystal-clear turquoise waters, Cambutal is ideal for sunbathing, swimming, and water sports. The local atmosphere is laid-back and welcoming, allowing travelers to unwind and immerse themselves in the natural beauty of the surroundings. Whether you choose to explore the lush rainforests nearby or simply bask in the sun, Cambutal provides an idyllic beach getaway for travelers seeking tranquility and natural splendor.

  • Travelers tend to stay 4 days in Cambutal

6. Plan your dream getaway to Guanico Abajo

Guanico Abajo in Los Santos, Panama, offers a delightful beach vacation experience. With its beautiful coastline and picturesque surroundings, it is the perfect destination for relaxation and fun in the sun. The local atmosphere is laid-back and friendly, allowing travelers to immerse themselves in the tranquil vibes of this coastal town. Whether you want to lounge on the sandy beaches, go swimming in the crystal-clear waters, or explore the nearby nature reserves, Guanico Abajo has something for everyone. Experience the beauty and charm of this beach paradise during your vacation stay.

  • Travelers tend to stay 3 days in Guanico Abajo

5. Explore Canas with a vacation package

Canas, located in the beautiful region of Los Santos, Panama, offers an idyllic beach vacation experience. With its pristine white sand beaches and crystal-clear turquoise waters, it's the perfect destination for relaxation and rejuvenation. The local atmosphere is laid-back and welcoming, with friendly locals and a peaceful ambiance. Whether you want to soak up the sun, enjoy water activities like snorkeling and swimming, or simply unwind with a book by the shore, Canas has it all. Immerse yourself in the local culture, indulge in delicious seafood, and savor breathtaking sunsets over the Pacific Ocean for an unforgettable beach vacation.

  • Travelers tend to stay 2 days in Canas

Find the Best Los Santos Vacation Packages

Best months to visit Los Santos

Looking for the best time to visit Los Santos? Our table will help you. Los Santos boasts a year-round average temperature of 78.6°F, reaching a peak of 80.4°F in April, its warmest month, and dropping to an average low of 77.2°F in November, the coolest month. The annual rainfall averages 200.2mm, with October experiencing the heaviest showers, while February is the driest month.

Monthcalendar iconTemperature (Fahrenheit)temperature iconRainfallrain iconCloud coveragecloud icon
January78.1No Rain (Dry)Mostly Sunny
February78.8No Rain (Dry)Sunny
March79.5No Rain (Dry)Mostly Sunny
April80.4Light RainMostly Sunny
May79.9Moderate RainMostly Cloudy
June79.0Frequent RainMostly Cloudy
July78.6Moderate RainMostly Cloudy
August78.6Frequent RainMostly Cloudy
September78.4Frequent RainMostly Cloudy
October77.5Frequent RainMostly Cloudy
November77.2Frequent RainMostly Cloudy
December77.5Light RainMostly Sunny

How to save money on a vacation to Los Santos

  • Combine your flights with hotels or car rentals to save money, especially in Los Santos.
  • Take advantage of Expedia's OneKey program to collect points and save money on your trip to Los Santos.
  • Utilize the helpful search filters on Expedia to find the perfect accommodation within your price range.
  • Consider traveling during the off-peak season in Los Santos, which is from December to February, for better deals.
  • Use the search filter for price limits on Expedia to find a package deal that suits your budget.
  • Discover the best vacation experience for you by using the travel experience filter on Expedia, whether it's a family, romantic, or adventurous getaway.

Los Santos Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)
Top Sights
Venao Beach, El Uverito Beach and Playa El Toro

Los Santos Hotel Deals

Playa Venao Hotel Resort

Playa Venao Hotel Resort

3.5 out of 5
Playa Venao, Las Escobas del Venado, Los Santos
Fully refundableReserve now, pay when you stay
$200 nightly
The price is $220 total per night from Aug 4 to Aug 5
$220 total
Aug 4 - Aug 5
Total includes taxes and fees
9/10 Wonderful! (141 reviews)
"Was very nice location and our room was great"

Reviewed on May 28, 2025

Playa Venao Hotel Resort
Hotel Posada Destiladeros

Hotel Posada Destiladeros

3 out of 5
Calle principal Los Destiladeros, Los Destiladeros Pedasi, Punta Mala, Provincia de los Santos
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $99 total per night from Aug 1 to Aug 2
$99 total
Aug 1 - Aug 2
Total includes taxes and fees
9/10 Wonderful! (35 reviews)
"it was in a great location, the staff was great.I highly recommend visiting."

Reviewed on Jul 17, 2025

Hotel Posada Destiladeros
Villa Marina Lodge & Condos

Villa Marina Lodge & Condos

3.5 out of 5
Playa Venao, Las Escobas del Venado, Los Santos
Fully refundableReserve now, pay when you stay
$239 nightly
The price is $264 total per night from Aug 17 to Aug 18
$264 total
Aug 17 - Aug 18
Total includes taxes and fees
8.8/10 Excellent! (127 reviews)
"Love that this property is at the other end of the beach from the late night partying. Walkable beach. Great restaurants nearby. The property was adding coffee makers and mini fridges the day we were leaving. Great staff, restaurant and drinks. We’ve been twice with our pooches. Will be back"

Reviewed on Jul 14, 2025

Villa Marina Lodge & Condos
See all 375 properties in Los Santos
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Los Santos vacation package cost?
Our Los Santos packages, which begin from just $805, are an awesome way to save precious money. Select your favorite hotels, flights and more to create your ideal trip.
How do I get a cheap travel package to Los Santos?
Combine your hotel and flight bookings, throw in extras such as activities or a rental car, and save with a Los Santos vacation package. You won't just land big discounts on your adventure — you'll have a world of choice within your reach too. When you book with Expedia, you can choose from more than 550 air carriers and 1,000,000 properties globally. Your next big adventure starts right here, right now!
What are the top hotels in Los Santos?
For properties in Las Escobas del Venado with cozy beds and friendly service, you can't beat Hotel Presidente and Villa Marina Lodge And Condos. If you're swinging by Pedasi as well, you'll get a good night's sleep at Hotel Punta Franca or Selina Playa Venao - Hostel.
How far in advance should I book my Los Santos vacation?
While prices change frequently, we generally recommend reserving your seat as soon as possible. Most international airfares can be compared on Expedia up to a year in advance. If circumstances have left you booking last minute, you might still get lucky. Cheap tickets to Los Santos sometimes appear only weeks before departure.
What does an Expedia Los Santos travel package include?
Flights, hotels and a reliable car for all your fun road trip adventures. Simply select your preferred bundle and get access to great discounts. Once you've made your booking, add on some experiences and tours and watch your savings pile up. When it comes to planning your Los Santos trip, you're the boss!
What should I know before booking a Los Santos travel package?
When you book your hotels, flights and car rentals together, you'll pick up awesome discounts. Whether you're planning an island getaway in a villa or would rather stay in a fancy hotel in the city, Expedia can help make it happen.
Can I choose my airline with a Los Santos Expedia vacation package?
With a vacation package, you're the one in charge. Whether you'd like to fly to Los Santos in first class or coach, simply select from the available airline options. Expedia has access to over 550 airline partners around the world.
Does Expedia offer Book Now, Pay Later Los Santos vacation packages?
Thanks to our partnership with online lender Affirm, vacationers booking via Expedia can now pay off their journey in easy installments that won't hurt your savings. Book Now, Pay Later and begin your dream vacation today!
If I'm not able to travel, can I cancel my Los Santos vacation package?
Your situation can change suddenly, so yes, you can. You may be able to amend or cancel your Los Santos vacation package at no cost within 24 hours of booking. For bookings made more than 24 hours ago, you can still cancel or make changes, but your car rental company, airline or hotel may impose a charge. Want more information? Look up our Customer Service Portal. We're here to help make sure your getaway goes off without a hitch.

Discover the most popular places to visit in Los Santos

Selina Hostels at Playa Venao The hostel is new and not finished yet, but it has a great design, is located directly at the beach and the staff is really cool. A con is that there is only one shop which has basically nothing and is really expensive; so you either have to bring your food or eat at the bar in the hostel. The beach itself is good for surfers, but you can also enjoy the waves without a board. There are only two (or maybe three; nobody knows) buses from Pedasí to Playa Venao: once in the morning (I think at 7) and once at 12 o'clock. It takes around 1.5 hours. Keep your eyes open and when you see the sign of the hostel, shout

Los Destiladeros Beach

If a restful vacation is part of your travel plans, Los Destiladeros Beach might be the perfect place to seek out during your trip to Punta Mala.

Los Destiladeros Beach
Playa El Arenal

Playa El Arenal

If a restful vacation is part of your travel plans, Playa El Arenal might be the perfect place to seek out during your trip to Pedasí.

Playa El Arenal
Sunset at Sansara

Los Buzos Beach

If a restful vacation is part of your travel plans, Los Buzos Beach might be the perfect place to seek out during your trip to Cambutal.

Los Buzos Beach
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.