Santo Domingo Vacations from $928
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Santo Domingo Vacation
Memorable adventures await when you book a Santo Domingo vacation package. Whether you're a foodie, history enthusiast or just a traveler who loves discovering new places, there's something for everyone in this interesting city. If your trip to Santo Domingo includes some sightseeing, don't miss well-known attractions like El Uverito Beach, Belisario Porras Park and Playa Las Comadres. That dream Santo Domingo vacation is just clicks away. Browse flights, hotels and more on Expedia for a getaway that's tailored to suit your travel style.
The Latest Santo Domingo vacation packages
Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá
San Francisco
$1,110
per person
Dec 13 - Dec 17
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,693 reviews)
loved my family suite !!! very spacious and cute ! awesome views… the pool was such a vibe even on the days it did rain the bar was still open. great location in the city
Reviewed on Sep 27, 2026
Casa Mallet by Wynwood House
Casco Viejo
$1,993
per person
Nov 16 - Nov 23
found 9 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.8/10 Exceptional! (29 reviews)
I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect.
The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us.
I would stay here again in a heart beat.
It’s a must stay!
Reviewed on Sep 16, 2026
Don't see what you're looking for?
See all available trips from Columbus to Santo Domingo
View all tripsStay near popular Santo Domingo attractions
Cerro La Teta
7.6/10 (5 reviews)
Find out about the history of Santo Domingo when you spend time at Cerro La Teta. Wander the beaches and seaside while you're in the area.
Santo Domingo Hotel Deals
Hotel Faranda Guayacanes, a member of Radisson Individuals
Via Circunvalacion S/n Chitre Herrera
Fully refundableReserve now, pay when you stay
$81 nightly
$89 total
Sep 29 - Sep 30
Total with taxes and fees
8/10 Very Good! (357 reviews)
"The redeeming feature of this hotel is the staff. Everyone from check in, dining room, housekeeping and maintenance is top notice, friendly and helpful. But be warned if you have any physical limitations this place is not for you. There are steps up the side of a mountain, mostly uneven with no handrails. ..."
Reviewed on Sep 22, 2026
Casa Lajagua
Calle principal de Pedasi Pedasí Panama
$85 nightly
$94 total
Sep 29 - Sep 30
Total with taxes and fees
9.2/10 Wonderful! (93 reviews)
"Room was very clean and spacious. Lots of room in the showers, though controlling the temp was a little challenging. Beto (owner) was very nice, hospitable, and helpful. Lots of fruit trees on property along with 3 friendly pups. Breakfast was fantastic. Best we had in Panama. When arriving, you ..."
Reviewed on Sep 12, 2026
Alaya Panama – Private Retreat & Wellness Resort
Venao Canas Los Santos
$272 nightly
$299 total
Sep 29 - Sep 30
Total with taxes and fees
9.4/10 Exceptional! (18 reviews)
"Fantastic place to stay. Everything was premium. Bed was spectacular left after two years feeling super replaced. Would recommend highly."
Reviewed on Feb 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Santo Domingo Vacation Packages
Santo Domingo Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Chitre (CTD-Alonso Valderrama) |
Population | 1,750 |
Top Sights | El Uverito Beach, Playa Las Comadres and Refugio de Vida Silvestre Isla Iguana |
More vacations you might like
Frequently asked questions
How much does a Santo Domingo vacation package cost?
Offering great value package deals from $928 on Expedia, you'll be pleasantly surprised at how much a vacation to Santo Domingo costs! Expedia's packages make travel planning easier and save you more.
What are the cheapest months to go to Santo Domingo?
If you're hoping to book a cheap Santo Domingo vacation package, consider planning a trip in June, July and December. You'll usually find lower prices on flights and hotels during these quieter months — perfect for a budget-friendly getaway.
How many days is enough for Santo Domingo?
Generally, a handful of days is enough to see the major sights during your Santo Domingo vacation. However, if you want to have time to kick back or take day trips, think about extending your itinerary.
How to find the best Santo Domingo package deals?
Finding a cheap Santo Domingo package deal is a cinch with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your budget range, add some filters and see what's available. You can tailor your search by "Amenities," "Property type," "Popular locations" and more. Sort the results by "Price: low to high" to view the most economical Santo Domingo package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are usually lower.
Is it cheaper to book a Santo Domingo vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking hotels and flights individually. Better still, you can customize your Santo Domingo getaway to fit your exact needs. Pick your preferred flight time, select the hotel type and add a car rental. Check out our great deals to see how much you can save.
When to book a vacation package to Santo Domingo?
Land incredible bargains by reserving your flights ahead of time with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for an impromptu Santo Domingo getaway.
Does Expedia offer Book Now, Pay Later Santo Domingo vacation packages?
Secure your dream escape to Santo Domingo with help from Expedia's Book Now, Pay Later vacations. No need to save up or wait until the next payday — we've joined forces with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can spread the cost over 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stick to your budget and snap up cheap deals while they last.
Explore a world of travel with Expedia
- Apartments in Las Tablas
- Bedandbreakfast in Las Tablas
- 5 Star Hotels in Las Tablas
- Dining in Las Tablas
- Family Friendly in Las Tablas
- Romantic in Las Tablas
- 2 Star Hotels in Pocrí
- 5 Star Hotels in Guarare
- Apartments in Guarare
- Hotels in Pocrí
- Bar in Las Tablas
- Pool in Las Tablas
- Hostels in Las Tablas
- Pet Friendly in Las Tablas
- 5 Star Hotels in Santo Domingo
- 2 Star Hotels in Las Tablas
- Hotels in La Palma
- 3 Star Hotels in Guarare
- Independent Hotels in Pocrí
- Hotels in Guarare
- Resorts in Guarare
- Independent Hotels in Guarare
- Hotels in Santo Domingo
- Hotels in Las Tablas
- Budget in Las Tablas
- Hostels in Guarare
- Beach in Las Tablas
- 3 Star Hotels in Pocrí
- Privatevacationhomes in Las Tablas
- Car rentals in Guarare
- Car rentals in La Palma
- Auto Rent Rental Cars in Las Tablas
- Right-Cars Rental Cars in Las Tablas
- Enterprise Rental Cars in Las Tablas
- Avis Rental Cars in Las Tablas
- Dollar Rent A Car Rental Cars in Las Tablas
- Thrifty Car Rental Cars in Las Tablas
- Firefly EU Rental Cars in Las Tablas
- Drive Car Rental Cars in Las Tablas
- Europcar Rental Cars in Las Tablas
- Whiz Rental Cars in Las Tablas
- Hawk Rental Cars in Las Tablas
- Unidas Rental Cars in Las Tablas
- Drive on Holidays Rental Cars in Las Tablas
- Get Your Car Rental Cars in Las Tablas
- Goldcar Rental Cars in Las Tablas
- Discount Car Rentals Rental Cars in Las Tablas
- Hertz Rental Cars in Las Tablas
- Budget Israel Rental Cars in Las Tablas
- Discount Quebec Rental Cars in Las Tablas
- Car rentals in Las Tablas
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
