Santo Domingo Vacations from $755

Book a Hotel + Flight or Car together to unlock savings

Your Santo Domingo Vacation

Memorable adventures await when you book a Santo Domingo vacation package. Whether you're a foodie, history enthusiast or just a traveler who loves discovering new places, there's something for everyone in this interesting city. If your trip to Santo Domingo includes some sightseeing, don't miss well-known attractions like El Uverito Beach, Belisario Porras Park and Playa Las Comadres. That dream Santo Domingo vacation is just clicks away. Browse flights, hotels and more on Expedia for a getaway that's tailored to suit your travel style.

The Latest Santo Domingo vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel San Pedro de Taboga

Hotel San Pedro de Taboga

3 out of 5
Price was $1,083, price is now $755 per person
$755
per person
Jan 11 - Jan 17
found 1 day ago
Roundtrip flight included
Kingston (KIN) to Panama City (PTY)
9.6/10 Exceptional! (5 reviews)
Peronal muy amable y dispuestos ayudar en todo momento.

Reviewed on Sep 21, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $1,663, price is now $1,010 per person
$1,010
per person
Jan 19 - Jan 23
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.6/10 Excellent! (1,803 reviews)

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $2,142, price is now $1,380 per person
$1,380
per person
Jan 19 - Jan 23
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,015 reviews)

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,308, price is now $951 per person
$951
per person
Jan 19 - Jan 23
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (6,099 reviews)
The hotel was great for our short stay! The star of the show was definitely the breakfast. There was so much to choose from, with a wonderful variety of options, including a section dedicated to local dishes, which was a nice touch. My only complaint was the musty smell coming from the hallway carpet leading to the rooms. It could definitely benefit from a good shampoo and deep cleaning. Thankfully, the room itself was clean, spacious and had no unpleasant odours. Overall, we had a pleasant stay, and the breakfast was definitely a highlight!

Reviewed on Nov 11, 2026

Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Bella Vista
Price was $1,534, price is now $1,119 per person
$1,119
per person
Jan 19 - Jan 23
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.6/10 Exceptional! (482 reviews)

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Stay near popular Santo Domingo attractions

Cerro La Teta

7.6/10 (5 reviews)
Find out about the history of Santo Domingo when you spend time at Cerro La Teta. Wander the beaches and seaside while you're in the area.
See properties

Santo Domingo Hotel Deals

Hotel Faranda Guayacanes, a member of Radisson Individuals

Hotel Faranda Guayacanes, a member of Radisson Individuals

3 out of 5
Via Circunvalacion S/n Chitre Herrera
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $90 total per night from Nov 27 to Nov 28
$90 total
Nov 27 - Nov 28
Total with taxes and fees
8/10 Very Good! (365 reviews)
"Clean room, good location but need I little remodel certain things"

Reviewed on Oct 31, 2026

Hotel Faranda Guayacanes, a member of Radisson Individuals
Hotel Presidente

Hotel Presidente

3.5 out of 5
Calle Moises Espino Las Tablas
$80 nightly
The price is $88 total per night from Nov 12 to Nov 13
$88 total
Nov 12 - Nov 13
Total with taxes and fees
Hotel Presidente
Casa Lajagua

Casa Lajagua

3 out of 5
Calle principal de Pedasi Pedasí Panama
$85 nightly
The price is $94 total per night from Nov 20 to Nov 21
$94 total
Nov 20 - Nov 21
Total with taxes and fees
Casa Lajagua
See all 70 properties in Santo Domingo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santo Domingo Vacation Packages

Santo Domingo Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Chitre (CTD-Alonso Valderrama)
Population
1,750
Top Sights
El Uverito Beach, Playa Las Comadres and Refugio de Vida Silvestre Isla Iguana

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Frequently asked questions

Is Santo Domingo better suited for a beach vacation or a cultural trip?
Santo Domingo is primarily an outdoor and nature destination, making it well-suited for a beach vacation. Its coastline is dotted with beautiful sandy stretches like El Uverito Beach, located about 3 miles from central Santo Domingo, and the more expansive Playa Blanca, about 13 miles away. These areas are perfect for travelers seeking sun, sand, and water activities.

Visitors can also enjoy the scenic views and adventure activities that complement a relaxing beach stay.
How can I save money on a Santo Domingo vacation package?
When you bundle, you can save up to 30%*. To save money on a Santo Domingo package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.
What are the top things to do in Santo Domingo?
A Santo Domingo vacation offers plenty of opportunities to enjoy Panama's beautiful Pacific coastline and natural scenery:

Browse and book things to do in Santo Domingo on Expedia.
Do you need to rent a car in Santo Domingo, or is public transport enough?
For a Santo Domingo vacation package, renting a car is generally recommended for exploring the area. While many resorts offer on-site dining and activities, the region's beautiful beaches and natural attractions, such as El Uverito Beach (about 3 miles away) and Playa Blanca (about 13 miles away), are spread out. A rental car provides the flexibility to visit these scenic spots at your own pace.

Travelers arriving via Panama City (PAC-Marcos A. Gelabert Intl.) or Rio Hato (RIH-Scarlett Martinez Intl.) may find local taxis or shuttle services available for transfers to their accommodations. However, for those planning to explore beyond their resort, a car is the most convenient option for a Santo Domingo vacation.
Can I change or cancel my Santo Domingo vacation package if my plans change?
Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.
Do One Key members get extra savings when booking Santo Domingo vacation packages?
Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.
Does Expedia offer Book Now, Pay Later Santo Domingo vacation packages?
Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Santo Domingo vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.
How do I find last-minute vacation packages to Santo Domingo?
To find last-minute vacation packages to Santo Domingo, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.
How does free cancellation work on Santo Domingo vacation packages?
Free cancellation on a Santo Domingo vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.
Is it cheaper to book a Santo Domingo vacation as a package or separately?
Booking flights and hotels together can unlock lower overall prices. Better still, you can tailor your Santo Domingo getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
Why should I book my Santo Domingo vacation package with Expedia?
Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.