Santo Domingo Vacations from $723

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Your Santo Domingo Vacation

Memorable adventures await when you book a Santo Domingo vacation package. Whether you're a foodie, history enthusiast or just a traveler who loves discovering new places, there's something for everyone in this interesting city. If your trip to Santo Domingo includes some sightseeing, don't miss well-known attractions like El Uverito Beach, Belisario Porras Park and Playa Las Comadres. That dream Santo Domingo vacation is just clicks away. Browse flights, hotels and more on Expedia for a getaway that's tailored to suit your travel style.

The Latest Santo Domingo vacation packages

Price found within the past 48 hours. Click for updated prices.
Mahogany Suites

Mahogany Suites

2 out of 5
Price was $1,237, price is now $723 per person
$723
per person
Apr 6 - Apr 10
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Panama City (PTY)
10/10 Exceptional! (1 review)
Excellent apartment on a golf resort. 5 Star.

Reviewed on Jan 28, 2026

Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B

3 out of 5
Save 100% on your flight
Price was $1,480, price is now $928 per person
$928
per person
Mar 25 - Apr 1
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
We stayed one night and it exceeded our expectations. The owners were incredibly friendly and easy to contact, making us feel right at home. Everything was spotless, and the atmosphere was warm and inviting. The homemade breakfast was a highlight—absolutely delicious and full of flavor. We will stay again longer next time.

Reviewed on Jan 22, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $1,571, price is now $1,114 per person
$1,114
per person
Apr 6 - Apr 10
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Panama City (PTY)
9/10 Wonderful! (1,002 reviews)
The beds and bedding were bad. The duvet wasn’t clean, the pillows overstuffed and hard and the bed was squeaky. I’d say the beds were a 2 star hotel level.

Reviewed on Feb 19, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $1,058, price is now $776 per person
$776
per person
May 1 - May 4
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Panama City (PTY)
8.4/10 Very Good! (1,204 reviews)
Every thing was awesome

Reviewed on Feb 18, 2026

Villa Marina Lodge & Condos

Villa Marina Lodge & Condos

3.5 out of 5
Price was $1,250, price is now $926 per person
$926
per person
May 4 - May 11
found 15 hours ago
Roundtrip flight included
New York (NYC) to Panama City (PTY)
9/10 Wonderful! (133 reviews)
Love that this property is at the other end of the beach from the late night partying. Walkable beach. Great restaurants nearby. The property was adding coffee makers and mini fridges the day we were leaving. Great staff, restaurant and drinks. We’ve been twice with our pooches. Will be back

Reviewed on Jul 14, 2025

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Discover the most popular places to visit in Santo Domingo

Cerro La Teta

Find out about the history of Santo Domingo when you spend time at Cerro La Teta. Wander the beaches and seaside while you're in the area.

Cerro La Teta

Santo Domingo Hotel Deals

Hotel Faranda Guayacanes, a member of Radisson Individuals

Hotel Faranda Guayacanes, a member of Radisson Individuals

3 out of 5
Via Circunvalacion S/n Chitre Herrera
Fully refundableReserve now, pay when you stay
$74 nightly
The price is $81 total per night from Feb 22 to Feb 23
$81 total
Feb 22 - Feb 23
Total with taxes and fees
8/10 Very Good! (305 reviews)
Room was spotless. It was very small but ok for an over night stay. Dinner in the restaurant was excellent. Seafood casserole was too top notch. Breakfast was good too.

Reviewed on Feb 6, 2026

Hotel Faranda Guayacanes, a member of Radisson Individuals
Hotel Presidente

Hotel Presidente

3.5 out of 5
Calle Moises Espino Las Tablas
$80 nightly
The price is $88 total per night from Feb 20 to Feb 21
$88 total
Feb 20 - Feb 21
Total with taxes and fees
9/10 Wonderful! (117 reviews)
We return year after year

Reviewed on Feb 2, 2026

Hotel Presidente
Casa Lajagua

Casa Lajagua

3 out of 5
Calle principal de Pedasi Pedasí Panama
$85 nightly
The price is $94 total per night from Feb 24 to Feb 25
$94 total
Feb 24 - Feb 25
Total with taxes and fees
9.2/10 Wonderful! (87 reviews)
April and staff have built up a wonderful rustic location with a lovely and peaceful atmosphere but close enough to town by foot. The Al Fresco breakfast was lovely especially the homemade chocolate cake! April was very attentive as i was a bit under the weather but she helped me out.

Reviewed on Jan 2, 2026

Casa Lajagua
See all 60 properties in Santo Domingo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santo Domingo Vacation Packages

Santo Domingo Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Chitre (CTD-Alonso Valderrama)
Population
1,750
Top Sights
El Uverito Beach, Playa Las Comadres and Refugio de Vida Silvestre Isla Iguana

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Frequently asked questions

How much does a Santo Domingo vacation package cost?
Offering great value package deals from $723 on Expedia, you'll be pleasantly surprised at how much a vacation to Santo Domingo costs! Expedia's packages make travel planning easier and save you more.
What are the cheapest months to go to Santo Domingo?
If you're hoping to book a cheap Santo Domingo vacation package, consider planning a trip in June, July and December. You'll usually find lower prices on flights and hotels during these quieter months — perfect for a budget-friendly getaway.
How many days is enough for Santo Domingo?
Generally, a handful of days is enough to see the major sights during your Santo Domingo vacation. However, if you want to have time to kick back or take day trips, think about extending your itinerary.
How to find the best Santo Domingo package deals?
Finding a cheap Santo Domingo package deal is a cinch with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your budget range, add some filters and see what's available. You can tailor your search by "Amenities," "Property type," "Popular locations" and more. Sort the results by "Price: low to high" to view the most economical Santo Domingo package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are usually lower.
Is it cheaper to book a Santo Domingo vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking hotels and flights individually. Better still, you can customize your Santo Domingo getaway to fit your exact needs. Pick your preferred flight time, select the hotel type and add a car rental. Check out our great deals to see how much you can save.
When to book a vacation package to Santo Domingo?
Land incredible bargains by reserving your flights ahead of time with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for an impromptu Santo Domingo getaway.
Does Expedia offer Book Now, Pay Later Santo Domingo vacation packages?
Secure your dream escape to Santo Domingo with help from Expedia's Book Now, Pay Later vacations. No need to save up or wait until the next payday — we've joined forces with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can spread the cost over 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stick to your budget and snap up cheap deals while they last.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.