Santo Domingo Vacations from $976
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Your Santo Domingo Vacation
Memorable adventures await when you book a Santo Domingo vacation package. Whether you're a foodie, history enthusiast or just a traveler who loves discovering new places, there's something for everyone in this interesting city. If your trip to Santo Domingo includes some sightseeing, don't miss well-known attractions like El Uverito Beach, Belisario Porras Park and Playa Las Comadres. That dream Santo Domingo vacation is just clicks away. Browse flights, hotels and more on Expedia for a getaway that's tailored to suit your travel style.
The Latest Santo Domingo vacation packages
Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City
San Francisco
$976
per person
Nov 25 - Dec 1
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.6/10 Excellent! (1,716 reviews)
The room could use a little more upgrade overall I enjoy my day. It was a little noisy, but not for long. Breakfast was good.
Reviewed on Sep 4, 2026
Central Hotel Panama Casco Viejo
Casco Viejo
$1,290
per person
Nov 10 - Nov 16
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,001 reviews)
Beautiful historic hotel we stayed there for 5 nights with a group of 33 people celebrating my brother’s 50 th birthday. very central, you can walk to go shopping or eating and dining at the roof top restaurants in the hotel or around Casco.
The cocktails at the bar delicious and the breakfast was great variety, food was fresh. I’d rate the hotel Uber from there quick and cheap…….,10/10 great experience. The staff was also nice and very accommodating.
Reviewed on Sep 2, 2026
Megapolis Hotel Panamá
San Francisco
$1,072
per person
Oct 5 - Oct 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,692 reviews)
Nice clean room bed sheets was white an clean. Staff was friendly, breakfast was awesome
Reviewed on Sep 3, 2026
Hotel Riu Plaza Panama
Bella Vista
$1,045
per person
Nov 25 - Dec 1
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (5,886 reviews)
Beautiful well kept property. Very ideal location, great food selection. Highly recommend this hotel.
Reviewed on Sep 4, 2026
Don't see what you're looking for?
See all available trips from Columbus to Santo Domingo
View all tripsStay near popular Santo Domingo attractions
Cerro La Teta
7.6/10 (5 reviews)
Find out about the history of Santo Domingo when you spend time at Cerro La Teta. Wander the beaches and seaside while you're in the area.
Santo Domingo Hotel Deals
Hotel Faranda Guayacanes, a member of Radisson Individuals
Via Circunvalacion S/n Chitre Herrera
Fully refundableReserve now, pay when you stay
$66 nightly
$71 total
Sep 14 - Sep 15
Total with taxes and fees
8/10 Very Good! (349 reviews)
"Habitación muy bien, cama acogedora, las almohadas un sueño. Desayuno completo, variado y sufiente. Parking disponibles. Lo único es el restaurante, se demoran demasiado por atenderte (y estaba vacío) y así mismo se demoró en llevarte los alimentos."
Reviewed on Aug 22, 2026
Casa Lajagua
Calle principal de Pedasi Pedasí Panama
$85 nightly
$94 total
Sep 8 - Sep 9
Total with taxes and fees
9.2/10 Wonderful! (92 reviews)
"A wonderful stay in a very convenient location. Looking forward to a return visit ."
Reviewed on Jun 24, 2026
Casa Magna Panama
Agustin Cano Castillero Las Tablas Provincia de Los Santos
$52 nightly
$58 total
Oct 5 - Oct 6
Total with taxes and fees
10/10 Exceptional! (11 reviews)
"Todo estuvo perfecto!!"
Reviewed on Sep 3, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Santo Domingo Vacation Packages
Santo Domingo Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Chitre (CTD-Alonso Valderrama) |
Population | 1,750 |
Top Sights | El Uverito Beach, Playa Las Comadres and Refugio de Vida Silvestre Isla Iguana |
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Frequently asked questions
How much does a Santo Domingo vacation package cost?
Offering great value package deals from $976 on Expedia, you'll be pleasantly surprised at how much a vacation to Santo Domingo costs! Expedia's packages make travel planning easier and save you more.
What are the cheapest months to go to Santo Domingo?
If you're hoping to book a cheap Santo Domingo vacation package, consider planning a trip in June, July and December. You'll usually find lower prices on flights and hotels during these quieter months — perfect for a budget-friendly getaway.
How many days is enough for Santo Domingo?
Generally, a handful of days is enough to see the major sights during your Santo Domingo vacation. However, if you want to have time to kick back or take day trips, think about extending your itinerary.
How to find the best Santo Domingo package deals?
Finding a cheap Santo Domingo package deal is a cinch with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your budget range, add some filters and see what's available. You can tailor your search by "Amenities," "Property type," "Popular locations" and more. Sort the results by "Price: low to high" to view the most economical Santo Domingo package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are usually lower.
Is it cheaper to book a Santo Domingo vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking hotels and flights individually. Better still, you can customize your Santo Domingo getaway to fit your exact needs. Pick your preferred flight time, select the hotel type and add a car rental. Check out our great deals to see how much you can save.
When to book a vacation package to Santo Domingo?
Land incredible bargains by reserving your flights ahead of time with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for an impromptu Santo Domingo getaway.
Does Expedia offer Book Now, Pay Later Santo Domingo vacation packages?
Secure your dream escape to Santo Domingo with help from Expedia's Book Now, Pay Later vacations. No need to save up or wait until the next payday — we've joined forces with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can spread the cost over 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stick to your budget and snap up cheap deals while they last.
Explore a world of travel with Expedia
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
