Photo by Caroline Nunez

Find luxury hotels in Mayesville, SC

Start date: Check-in selected.
To Date
End date: Check-out
  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
  • Be picky

    Search almost a million properties worldwide

Check availability on Mayesville Luxury Hotels

No exact matches found, but these alternatives could be just right

Recommended hotels in Mayesville

1912 Bed and Breakfast

1912 Bed and Breakfast
3.5 star property
Sumter
10.0 out of 10, Exceptional, (283)
"This is a beautiful property. The host was very kind and personable. The breakfast was quite yummy! "
United States
Donna
$132 nightly
The price is $132
Dec 15 - Dec 16
Total with taxes and fees
1912 Bed and Breakfast

Hyatt Place Sumter / Downtown

Hyatt Place Sumter / Downtown
3.0 star property
Sumter
9.2 out of 10, Wonderful, (879)
"Clean room and staff was very nice."
United States
Ishara
$114 nightly
The price is $128
Dec 21 - Dec 22
Total with taxes and fees
Hyatt Place Sumter / Downtown

Hampton Inn Manning

Hampton Inn Manning
2.5 star property
Manning
8.4 out of 10, Very Good, (1000)
"Clean, great staff, and comfortable beds. "
United States
Micah
$116 nightly
The price is $129
Dec 18 - Dec 19
Total with taxes and fees
Hampton Inn Manning

Holiday Inn Express Sumter by IHG

Holiday Inn Express Sumter by IHG
2.5 star property
Sumter
8.8 out of 10, Excellent, (695)
"Clean room, nice staff good area "
United States
Latesha
$98 nightly
The price is $110
Dec 21 - Dec 22
Total with taxes and fees
Holiday Inn Express Sumter by IHG

Woodspring Suites Sumter Near Shaw Afb

Woodspring Suites Sumter Near Shaw Afb
2.5 star property
Sumter
8.2 out of 10, Very Good, (135)
"The staff was very friendly and the rooms were clean. "
United States
Kevin
$104 nightly
The price is $116
Dec 14 - Dec 15
Total with taxes and fees
Woodspring Suites Sumter Near Shaw Afb

SpringHill Suites Sumter

SpringHill Suites Sumter
2.5 star property
Sumter
9.4 out of 10, Exceptional, (451)
"Room is perfect"
United States
Sandy
$112 nightly
The price is $125
Dec 28 - Dec 29
Total with taxes and fees
SpringHill Suites Sumter

Comfort Suites Sumter near Shaw AFB

Comfort Suites Sumter near Shaw AFB
2.5 star property
Sumter
7.2 out of 10, Good, (597)
"Very nice rooms"
United States
Seth
$92 nightly
The price is $103
Jan 1 - Jan 2, 2026
Total with taxes and fees
Comfort Suites Sumter near Shaw AFB

TownePlace Suites by Marriott Sumter

TownePlace Suites by Marriott Sumter
3.0 star property
Sumter
10.0 out of 10, Exceptional, (13)
"Great place for a family"
United States
Christer
$151 nightly
The price is $169
Dec 21 - Dec 22
Total with taxes and fees
TownePlace Suites by Marriott Sumter

Creekside Country Cottage- minutes away from I-95

Creekside Country Cottage- minutes away from I-95
Manning
10.0 out of 10, Exceptional, (9)
"Great place beautiful and the dogs loved it"
United States
Jennifer T.
$394 nightly
The price is $437
Dec 15 - Dec 16
Total with taxes and fees
Creekside Country Cottage- minutes away from I-95

Baymont by Wyndham Manning

Baymont by Wyndham Manning
2.5 star property
Manning
6.8 out of 10, (1001)
"Easy access to highway and plenty of parking"
United States
Jim
$80 nightly
The price is $89
Dec 14 - Dec 15
Total with taxes and fees
Baymont by Wyndham Manning
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Mayesville Hotel Reviews

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Mayesville?
Let Expedia help you arrange your flight to Florence, SC (FLO-Florence Regional) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are an important consideration when you plan a trip, so we make it easy to get what you'd like to make your stay special. If you want a posh hotel with fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Mayesville has to offer.
When can I expect good weather in Mayesville?
Planning for the weather is an important factor for making your trip to Mayesville a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 50°F. Average annual precipitation for Mayesville is 52 inches.
What's there to see and do in Mayesville?
Enjoy all that Mayesville has to offer when you visit Riley Field, O'Donnell House, and Sumter Mall. If you have a little extra time during your trip, you might want to make a stop at Palmetto Tennis Center and Swan Lake Iris Gardens.

Explore a world of travel with Expedia