Search Vacation Homes in Mill Creek

Start date: Check-in selected.
To Date
End date: Check-out

Check prices for these dates

In two weeks
Dec 26 - Dec 28
In two months
Feb 6 - Feb 8
In three months
Mar 6 - Mar 8
In four months
Apr 3 - Apr 5

Our top choices for Mill Creek vacation homes

Exterior
Secluded treehouse with indoor fireplace

Secluded treehouse with indoor fireplace

Secluded treehouse with indoor fireplace
Makanda
10.0 out of 10, Exceptional, (16)
"Had a great stay. The treehouse was unique and a great get away spot while enjoying the local winery’s. We’ll be back for more fun this upcoming fall. "
United States
Nathaniel M.
$187 nightly
The price is $198
Dec 15 - Dec 16
Total with taxes and fees
Secluded treehouse with indoor fireplace
Interior
Charming 2-bedroom with AC, WiFi in lovely Jonesboro

Charming 2-bedroom with AC, WiFi in lovely Jonesboro

Charming 2-bedroom with AC, WiFi in lovely Jonesboro
Jonesboro
10.0 out of 10, Exceptional, (3)
"great place. wonderful host."
United States
Carla m.
$237 nightly
The price is $252
Dec 14 - Dec 15
Total with taxes and fees
Charming 2-bedroom with AC, WiFi in lovely Jonesboro
Interior
Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
2.0 star property
Anna
$139 nightly
The price is $148
Dec 14 - Dec 15
Total with taxes and fees
Cozy and Updated Farmhouse with King Suite
Living area
Little Blue Cottage on Spanish

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.6 out of 10, Excellent, (48)
"I would definitely stay here again!"
United States
Bonita
$101 nightly
The price is $101
Dec 15 - Dec 16
Total with taxes and fees
Little Blue Cottage on Spanish
Exterior
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.6 out of 10, Excellent, (36)
"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "
United States
Emily D.
$206 nightly
The price is $214
Dec 15 - Dec 16
Total with taxes and fees
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Dining
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
United States
Tracy H.
$229 nightly
The price is $245
Dec 14 - Dec 15
Total with taxes and fees
Serenity South -- Gardens, River-Views, and Refreshing Space
Exterior
Magical Victorian near hiking / wine trail

Magical Victorian near hiking / wine trail

Magical Victorian near hiking / wine trail
Anna
10.0 out of 10, Exceptional, (4)
"The house was beautiful! We were in awe of the decor and layout. This is a must-stay if you are in southern Illinois!"
United States
Lori C.
$333 nightly
The price is $378
Dec 14 - Dec 15
Total with taxes and fees
Magical Victorian near hiking / wine trail
Outdoor dining
Historic Farm Cottage on 800-Acre Orchard

Historic Farm Cottage on 800-Acre Orchard

Historic Farm Cottage on 800-Acre Orchard
Alto Pass
9.8 out of 10, Exceptional, (8)
"Awesome"
United States
Luke K.
$186 nightly
The price is $205
Jan 5 - Jan 6, 2026
Total with taxes and fees
Historic Farm Cottage on 800-Acre Orchard
Outdoor dining
Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass

Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass

Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass
2.0 star property
Alto Pass
$235 nightly
The price is $263
Dec 14 - Dec 15
Total with taxes and fees
Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass
Pool
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (7)
"Nice place, great times"
United States
Jace W.
$422 nightly
The price is $438
Dec 15 - Dec 16
Total with taxes and fees
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Smart TV, fireplace
Cozy Cabin on 140 Acres w/ Stunning Views

Cozy Cabin on 140 Acres w/ Stunning Views

Cozy Cabin on 140 Acres w/ Stunning Views
Buncombe
10.0 out of 10, Exceptional, (158)
"We had a wonderful stay at Rock Ridge. It’s a perfect peaceful place for friends to gather and explore the Shawnee National Forest."
United States
Melinda T.
$460 nightly
The price is $507
Dec 30 - Dec 31
Total with taxes and fees
Cozy Cabin on 140 Acres w/ Stunning Views
Meeting facility
Building at Cape Girardeau Regional Airport

Building at Cape Girardeau Regional Airport

Building at Cape Girardeau Regional Airport
Scott City
$571 nightly
The price is $611
Dec 14 - Dec 15
Total with taxes and fees
Building at Cape Girardeau Regional Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Mill Creek Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Very friendly staff and great breakfast"
Ray 1-night trip
Posted 3 days ago
Drury Inn & Suites Cape Girardeau

Find out more about Mill Creek

Mill Creek Vacation Homes information

Number of reviews
401
Accommodation
62 Vacation Homes
Lowest Price
$101
Highest Price
$611

Explore a world of travel with Expedia