Title: Visit San Cosme y Damian: 2026 Travel Guide for San Cosme y Damian, Itapúa Department | Expedia.com [Hotels in San Cosme y Damian](https://expedia.com/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels)[Vacation Rentals in San Cosme y Damian](https://expedia.com/San-Cosme-Y-Damian-Vacation-Rentals.d6348319.Travel-Guide-VacationRentals)[Flights to San Cosme y Damian](https://expedia.com/Cheap-Flights-To-San-Cosme-Y-Damian.d6348319.Travel-Guide-Flights)[Car Rentals in San Cosme y Damian](https://expedia.com/Car-Rentals-In-San-Cosme-Y-Damian.d6348319.Car-Rental-Guide)[San Cosme y Damian Vacation Packages](https://expedia.com/San-Cosme-Y-Damian.d6348319.Destination-Travel-Guides) # San Cosme y Damian ## Travel Guide ## Visit San Cosme y Damian Things to do ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX_SPRING_PROMO_6348319) - San Cosme y Damian Hotel Deals - Vacation Rentals in San Cosme y Damian ![Carnaval Hotel Casino](https://images.trvl-media.com/lodging/13000000/12600000/12599700/12599683/3c7f3c91_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Carnaval Hotel Casino Av. Irrazabal, 750 Encarnacion $68 nightly $74 total Mar 8 - Mar 9 Total with taxes and fees Book a stay at this spa hotel in Encarnacion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our reviews. Popular ... [](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=12599683&PinnedHotelID=12599683&HadPinnedHotel=true®ionId=6348319) ![Sun Hotel](https://images.trvl-media.com/lodging/43000000/42350000/42340300/42340209/297cb57c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Sun Hotel Encarnacion Itapúa $83 nightly $91 total Mar 2 - Mar 3 Total with taxes and fees Book a stay at this business-friendly hotel in Encarnacion. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Carnival Sambadrome and Costanera ... 9.2/10 Wonderful! (111 reviews) Excelent. Reviewed on Jan 11, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F2%2F2026&endDate=3%2F3%2F2026&selected=42340209&PinnedHotelID=42340209&HadPinnedHotel=true®ionId=6348319) ![Hotel Luxsur](https://images.trvl-media.com/lodging/14000000/13330000/13327300/13327276/fa70e6e0_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Luxsur Jorge Memmel 661 Encarnacion $61 nightly $68 total Mar 11 - Mar 12 Total with taxes and fees Stay at this hotel in Encarnacion. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Former House of Stroessner and Plaza de Armas are located ... 8.8/10 Excellent! (166 reviews) Amazing Reviewed on Feb 24, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F11%2F2026&endDate=3%2F12%2F2026&selected=13327276&PinnedHotelID=13327276&HadPinnedHotel=true®ionId=6348319) [See all 32 properties in Itapúa Department](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F2%2F2026&endDate=3%2F3%2F2026®ionId=553248635975176941) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Sun Hotel](https://images.trvl-media.com/lodging/43000000/42350000/42340300/42340209/297cb57c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Sun Hotel Encarnacion Itapúa Book a stay at this business-friendly hotel in Encarnacion. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Carnival Sambadrome and Costanera ... 9.2/10 Wonderful! (111 reviews) Excelent. Reviewed on Jan 11, 2026 [](https://expedia.com/Encarnacion-Hotels-SUN-HOTEL.h42340209.Hotel-Information) ![Encarnacion](https://images.trvl-media.com/lodging/100000000/99340000/99335800/99335734/b913dd8c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Encarnacion Carlos Antonio Lopez casi Curupayty Encarnacion Itapúa Department Stay at this aparthotel in Encarnacion. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Plaza de Armas and Former House of Stroessner ... [](https://expedia.com/Encarnacion-Hotels-Encarnacion.h99335734.Hotel-Information) ![Apartament central with river views pool](https://images.trvl-media.com/lodging/104000000/103160000/103150100/103150003/ea823cad_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Apartament central with river views pool Paraguayan Railways Encarnacion Itapúa Department Stay at this apartment in Encarnacion. Enjoy free WiFi. Popular attractions Carnival Sambadrome and Costanera de la Ciudad de Encarnacion Paraguay are located ... [](https://expedia.com/Encarnacion-Hotels-Apartament-Central-With-River-Views-Pool.h103150003.Hotel-Information) [See all 32 properties in Itapúa Department](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=553248635975176941&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check San Cosme y Damian hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6348319&startDate=2026-03-01&endDate=2026-03-02)[Mar 1 - Mar 2](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6348319&startDate=2026-03-01&endDate=2026-03-02) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6348319&startDate=2026-03-02&endDate=2026-03-03)[Mar 2 - Mar 3](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6348319&startDate=2026-03-02&endDate=2026-03-03) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6348319&startDate=3%2F6%2F2026&endDate=3%2F8%2F2026)[Mar 6 - Mar 8](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6348319&startDate=3%2F6%2F2026&endDate=3%2F8%2F2026) ### Popular places to visit #### Buenaventura Suarez Planetarium You can spend time browsing the exhibits at Buenaventura Suarez Planetarium during your travels in San Cosme y Damian. Take in the museums while you're in the area. [](https://expedia.com/Buenaventura-Suarez-Planetarium-San-Cosme-y-Damian.d553248621532463875.Vacation-Attraction) #### Guarani Jesuit Ruins of San Cosme and San Damián Find out about the history of San Cosme y Damian when you take a trip to Guarani Jesuit Ruins of San Cosme and San Damián. Take in the museums while you're in the area. [](https://expedia.com/Guarani-Jesuit-Ruins-Of-San-Cosme-And-San-Damian-San-Cosme-y-Damian.d812269535561961472.Vacation-Attraction) ## Cities near San Cosme y Damian ![Rock formation "El Arco" at Lake Posadas, Argentina](https://images.trvl-media.com/place/2887/d836a022-182c-4be3-ade6-4b3bb9158f9d.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Posadas ![Cathedral of St. John the Baptist which includes a statue or sculpture, a city and religious aspects](https://images.trvl-media.com/place/6242273/d008b947-67ce-40ae-9946-d58b99d0e06c.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Ituzaingo ![The Jesuit Ruins in Trinidad, Paraguay is the least visited UNESCO World Heritage site, in the world. It is a beautiful place and what makes it more so is that it is very likely you will have the place to yourself. The ruins are loacted near the city of Encarnacion and you can even visit, for the day, from the Argentinian city of Posadas. Check out my blog post below: http://endless-explorer.com/jesuit-mission-ruins-paraguay-one-least-visited-world-heritage-sites/](https://images.trvl-media.com/place/6141611/edf37f1b-ad9c-4440-9123-27afc3c40279.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Trinidad ![Mboi Kae beach in Encarnacion, Paraguay](https://images.trvl-media.com/place/6141802/ed937b4a-4d03-4853-a67e-57c0bf14e454.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Encarnacion ## Explore a world of travel with Expedia - Lodging - Packages - Cars - [Hotels near Buenaventura Suarez Planetarium ](https://www.expedia.com/Buenaventura-Suarez-Planetarium-Hotels.0-l553248621532463875-0.Travel-Guide-Filter-Hotels) - [Buenaventura Suarez Planetarium ](https://www.expedia.com/Buenaventura-Suarez-Planetarium-San-Cosme-y-Damian.d553248621532463875.Vacation-Attraction) - [Car rentals near Guarani Jesuit Ruins of San Cosme and San Damián ](https://www.expedia.com/Car-Rentals-In-Guarani-Jesuit-Ruins-Of-San-Cosme-And-San-Damian.d812269535561961472.Car-Rental-Guide) - Cities near San Cosme y Damian - Places of interest [Posadas](https://expedia.com/Posadas.dx2887)[Ituzaingo](https://expedia.com/Ituzaingo.dx6049974)[Trinidad](https://expedia.com/Trinidad.dx6141611)[Encarnacion](https://expedia.com/Encarnacion.dx6141802)[Puerto Valle](https://expedia.com/Puerto-Valle.dx6229952)[Jesús](https://expedia.com/Jesus.dx6353265)[Ayolas](https://expedia.com/Ayolas.dx3000472762) - [Buenaventura Suarez Planetarium ](https://expedia.com/Buenaventura-Suarez-Planetarium-San-Cosme-y-Damian.d553248621532463875.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app