San Marco Vacations from $174
Book a Hotel + Flight or Car together to unlock savings
Your San Marco Vacation
Avoid the hassle of travel planning with a San Marco vacation package. With all the details locked in before you take off, all you have to do is enjoy this leafy neighborhood's bars and pubs, cafes and culture. Your trip to San Marco wouldn't be complete without stopping by popular attractions nearby such as Orange Park Place Shopping Center, Theatre Jacksonville and Fort Caroline Shopping Center. Stop daydreaming and start doing. When it's time to lock in your ideal vacation to San Marco, Expedia will help get you there.
The Latest San Marco Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Comfort Suites Baymeadows Near Butler Blvd
Price was $270, price is now $174 per person
$174
per person
Jan 11 - Jan 14
found 5 hours ago
Roundtrip flight included
Chicago (ORD) to Jacksonville (JAX)
8.2/10 Very Good! (1,004 reviews)
The staff was wonderful, the room was nice and clean. The breakfast cause have been better I don’t like sausage patties and we had that every morning. Would I stay there again yes I would.
Reviewed on Dec 1, 2025
Margaritaville Jacksonville Beach
Save 100% on your flight
Price was $485, price is now $298 per person
$298
per person
Feb 23 - Feb 27
found 18 hours ago
Roundtrip flight included
Boston (BOS) to Jacksonville (JAX)
9/10 Wonderful! (3,345 reviews)
Nice room. Nice relaxed Tropical feel and decorations. Food was good. Beautiful views!
Reviewed on Dec 2, 2025
Holiday Inn Express Jacksonville Beach by IHG
Save 100% on your flight
Price was $731, price is now $458 per person
$458
per person
Feb 11 - Feb 18
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
9.2/10 Wonderful! (1,002 reviews)
The check in was simple and a room was ready for us before check out time. We were able to rest and sleep well during our stay in Jacksonville Beach.
Reviewed on Nov 15, 2025
Hilton Jacksonville At Mayo Clinic
Save 100% on your flight
Price was $1,484, price is now $930 per person
$930
per person
Feb 11 - Feb 18
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Jacksonville (JAX)
9.4/10 Exceptional! (22 reviews)
Clean. Very friendly staff.
Reviewed on Dec 2, 2025
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Isle of Palms
Save 100% on your flight
Price was $983, price is now $629 per person
$629
per person
Jan 5 - Jan 12
found 16 hours ago
Roundtrip flight included
Chicago (CHI) to Jacksonville (JAX)
9.4/10 Exceptional! (437 reviews)
Marriot… a room refresh does not include making the bed? WTAF?! Also, no smoking means no smoking. A man smoked a cigar in the court yard without any interference from the staff. It’s too bad, the room was spacious and clean but the follow through in non existent.
Reviewed on Nov 10, 2025
Where to stay in San Marco
Find the best San Marco areas and neighborhoods for the activities you enjoy most. Learn more about San Marco
Downtown Jacksonville
2 out of top 10 points of interest in this area
4/5(845 area reviews)
Historic core with major corporations, Downtown Jacksonville offers diverse culinary and nightlife experiences at The Elbow. Explore attractions like Florida Theatre, TIAA Bank Field, and museums, while enjoying convenient transportation options.
San Marco Hotel Deals
Hilton Garden Inn Jacksonville Downtown Southbank
1201 Kings Avenue Jacksonville FL
$99 nightly
The price is $113 total per night from Dec 11 to Dec 12
$113 total
Dec 11 - Dec 12
Total with taxes and fees
8.2/10 Very Good! (1,020 reviews)
Amenties
Reviewed on Dec 2, 2025
Homewood Suites by Hilton Jacksonville Downtown-Southbank
1201 Kings Avenue Jacksonville FL
$127 nightly
The price is $144 total per night from Dec 11 to Dec 12
$144 total
Dec 11 - Dec 12
Total with taxes and fees
8.6/10 Excellent! (758 reviews)
Coffee maker didn’t work. Ice machines out on our floor. Clean but carpets need cleaning in hotel halls etc. staff very helpful
Reviewed on Nov 25, 2025
Margaritaville Jacksonville Beach
715 1st St N Jacksonville Beach FL
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $150 total per night from Dec 8 to Dec 9
$150 total
Dec 8 - Dec 9
Total with taxes and fees
8.8/10 Excellent! (3,397 reviews)
Rooms very clean, bottles of water disappeared since last stay. Staff is nice, great island decore. Its a shame that they dont serve breakfast. Just overpriced muffins and medicore coffee. Hottub would make it excellent and shrimp cocktail.
Reviewed on Nov 28, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in San Marco
Mayo Clinic Florida
4.5/5(433 reviews)
Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.
Jacksonville Naval Air Station
4/5(300 reviews)
After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the great live music or attend a sporting event in this family-friendly area.
Jacksonville Zoo and Gardens
4.5/5(463 reviews)
Admire thousands of animals and plants across entertaining exhibits in this family-friendly zoo that also has a children’s play area and a 4-D experience.
Things to do
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports
$140
per traveler
90% of travellers recommend
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.