Title: Visit Santa Fe: 2026 Travel Guide for Santa Fe, Darién Province | Expedia.com [Hotels in Santa Fe](https://expedia.com/Santa-Fe-Hotels.d553248623287535268.Travel-Guide-Hotels)[Vacation Rentals in Santa Fe](https://expedia.com/Santa-Fe-Vacation-Rentals.d553248623287535268.Travel-Guide-VacationRentals)[Flights to Santa Fe](https://expedia.com/Cheap-Flights-To-Santa-Fe.d553248623287535268.Travel-Guide-Flights)[Car Rentals in Santa Fe](https://expedia.com/Car-Rentals-In-Santa-Fe.d553248623287535268.Car-Rental-Guide)[Santa Fe Vacation Packages](https://expedia.com/Santa-Fe.d553248623287535268.Destination-Travel-Guides) # Santa Fe ## Travel Guide ## Visit Santa Fe - Santa Fe Hotel Deals - Vacation Rentals in Santa Fe ![Hospedaje casa cultural wounaan](https://images.trvl-media.com/lodging/45000000/44970000/44968200/44968162/54c12b87_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hospedaje casa cultural wounaan Panama canal, Puerto lara Darien Santa Fe Darien Fully refundable $17 nightly $19 total Feb 16 - Feb 17 Total with taxes and fees Stay at this hotel in Santa Fe. Enjoy an outdoor pool, breakfast (surcharge), and WiFi (surcharge). 7.6/10 Good! (4 reviews) Good but they need better communicatiy We had a great time during our visit. Apart from walking the village there isn’t much to do. We still made the most of our time and made friends with many locals. We did feel a little uncomfortable at the end of our trip as the president was complaining that we had paid in advance and he expected ... Reviewed on Aug 22, 2025 [](https://expedia.com/Hotel-Search?startDate=2%2F16%2F2026&endDate=2%2F17%2F2026&selected=44968162&PinnedHotelID=44968162&HadPinnedHotel=true®ionId=553248623287535268) [See all 3 properties in Santa Fe](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=2%2F11%2F2026&endDate=2%2F12%2F2026®ionId=553248623287535268) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama](https://images.trvl-media.com/lodging/121000000/120040000/120034500/120034445/0b910251_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama Guna Yala Comarca Guna Yala Comarca Stay at this houseboat in Comarca Kuna de Madugandí. Enjoy free breakfast, free WiFi, and a fitness center. [](https://expedia.com/Fabulous-4-Bedroom-Catamaran-In-San-Blas-Panama.h120034445.Hotel-Information) ![San Blas Big Orange Island "Narasgandub Dummad"](https://images.trvl-media.com/lodging/27000000/26600000/26596500/26596401/2f590283_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### San Blas Big Orange Island "Narasgandub Dummad" Guna Yala Guna Yala Comarca Stay at this vacation home in Ailigandí. [](https://expedia.com/San-Blas-Big-Orange-Island-Narasgandub-Dummad.h26596401.Hotel-Information) ![BouMou Sailboat ](https://images.trvl-media.com/lodging/72000000/71030000/71029500/71029414/8d384d06_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### BouMou Sailboat Guna Yala Comarca Guna Yala Comarca Stay at this houseboat in Ailigandí. Enjoy free breakfast, free WiFi, and patios. [](https://expedia.com/BouMou-Sailboat.h71029414.Hotel-Information) [See all 10 properties in Darién Province](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=642836248323325952&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Santa Fe hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248623287535268&startDate=2026-02-10&endDate=2026-02-11)[Feb 10 - Feb 11](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248623287535268&startDate=2026-02-10&endDate=2026-02-11) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248623287535268&startDate=2026-02-11&endDate=2026-02-12)[Feb 11 - Feb 12](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248623287535268&startDate=2026-02-11&endDate=2026-02-12) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248623287535268&startDate=2%2F13%2F2026&endDate=2%2F15%2F2026)[Feb 13 - Feb 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248623287535268&startDate=2%2F13%2F2026&endDate=2%2F15%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248623287535268&startDate=2%2F20%2F2026&endDate=2%2F22%2F2026)[Feb 20 - Feb 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248623287535268&startDate=2%2F20%2F2026&endDate=2%2F22%2F2026) - Cities near Santa Fe - Places of interest [La Palma](https://expedia.com/La-Palma.dx829297393309585408)[Metetí](https://expedia.com/Meteti.dx829297497563209728)[Río Iglesias](https://expedia.com/Rio-Iglesias.dx829297548421255168)[Agua Fría](https://expedia.com/Agua-Fria.dx829297553955622912)[Río Congo Arriba](https://expedia.com/Rio-Congo-Arriba.dx829297558596644864)[Río Congo](https://expedia.com/Rio-Congo.dx829297566746157056)[Cucunatí](https://expedia.com/Cucunati.dx829297574912471040) - [Pirre Station ](https://expedia.com/Pirre-Station-La-Palma.d553248621532964867.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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