Santee Vacations from $368

Book a Hotel + Flight or Car together to unlock savings

Your Santee Vacation

Enjoy unforgettable adventures when you book a vacation package to Santee. Whether you're a foodie, art buff or just a traveler who loves discovering new places, there's something for everyone in this lively city. If your trip to Santee includes some sightseeing, don't miss famous attractions like Santee State Park, Santee Cooper Country Club and Santee Outlets. Stop daydreaming and start traveling. Browse the many options on Expedia today and put your Santee vacation plans into action!

The Latest Santee vacation packages

Price found within the past 48 hours. Click for updated prices.
Sleep Inn Columbia

Sleep Inn Columbia

2.5 out of 5
Seven Oaks
Price was $546, price is now $368 per person
$368
per person
Mar 7 - Mar 14
found 16 hours ago
Roundtrip non-stop flight included
New York (NYC) to Columbia (CAE)
8.2/10 Very Good! (1,005 reviews)
The room was clean, the staff was very attentive and courteous!

Reviewed on Dec 13, 2025

Graduate by Hilton Columbia SC

Graduate by Hilton Columbia SC

4 out of 5
Downtown Columbia
Save 100% on your flight
Price was $971, price is now $668 per person
$668
per person
Mar 7 - Mar 14
found 16 hours ago
Roundtrip non-stop flight included
New York (NYC) to Columbia (CAE)
9.4/10 Exceptional! (1,003 reviews)
Room was not only beautiful but very clean. Staff was gracious - it was a perfect stay.

Reviewed on Dec 9, 2025

Hilton Columbia Center

Hilton Columbia Center

3.5 out of 5
Downtown Columbia
Save 100% on your flight
Price was $1,196, price is now $843 per person
$843
per person
Mar 7 - Mar 14
found 16 hours ago
Roundtrip non-stop flight included
New York (NYC) to Columbia (CAE)
8.8/10 Excellent! (1,003 reviews)
Room was clean but bathroom floor could have been cleaned a little better. Overall, great stay, friendly staff and great location. It can get loud with obnoxious cars driving along the street, but 'perk' of being downtown. Still, I would definitely stay here again.

Reviewed on Nov 21, 2025

Hilton Garden Inn Columbia Airport

Hilton Garden Inn Columbia Airport

3 out of 5
Save 100% on your flight
Price was $795, price is now $563 per person
$563
per person
Mar 7 - Mar 14
found 16 hours ago
Roundtrip non-stop flight included
New York (NYC) to Columbia (CAE)
9/10 Wonderful! (1,003 reviews)
Nice hotel Quiet and clean

Reviewed on Dec 13, 2025

Hampton Inn Columbia I-26/Harbison Blvd.

Hampton Inn Columbia I-26/Harbison Blvd.

2.5 out of 5
St. Andrews
Price was $735, price is now $522 per person
$522
per person
Mar 7 - Mar 14
found 16 hours ago
Roundtrip non-stop flight included
New York (NYC) to Columbia (CAE)
9/10 Wonderful! (1,002 reviews)
Yes and yes. Room was immaculate and staff was friendly.

Reviewed on Dec 7, 2025

Don't see what you're looking for?
See all available trips from Oskaloosa to Santee
View all trips

Discover the most popular places to visit in Santee

Santee State Park

4/5(43 reviews)

You can take time to visit Santee State Park during your travels to Santee. While you're here, you can savor the top-notch restaurants.

Santee State Park

Santee Cooper Country Club

4/5(12 reviews)

Enjoy a round of golf in Santee at Santee Cooper Country Club. While you're here, you can savor the top-notch restaurants.

Santee Cooper Country Club

Santee National Golf Club

3.5/5(19 reviews)

Enjoy a round of golf in Santee at Santee National Golf Club. While you're here, you can savor the top-notch restaurants.

Santee National Golf Club

Santee Hotel Deals

Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $107 total per night from Jan 4 to Jan 5
$107 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
9/10 Wonderful! (632 reviews)
Brie greeted us, was very professional & thoughtful we have my service dog with us gave us a room on the first floor in between 2 exits for easy walks. The room is immaculate the entire property is very well taken care of. We’ll be back ! Thanks Brie

Reviewed on Dec 9, 2025

Tru By Hilton Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $89 total per night from Dec 16 to Dec 17
$89 total
Dec 16 - Dec 17
Total with taxes and fees
7.8/10 Good! (1,412 reviews)
Had to be moved different room

Reviewed on Dec 10, 2025

Baymont by Wyndham Santee
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

2.5 out of 5
9074 Old Number Six Hwy Santee SC
$121 nightly
The price is $134 total per night from Dec 21 to Dec 22
$134 total
Dec 21 - Dec 22
Total with taxes and fees
9.6/10 Exceptional! (1,001 reviews)
Yes

Reviewed on Dec 8, 2025

Fairfield Inn & Suites by Marriott Santee
See all 306 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santee Vacation Packages

Santee Essential Information

Language
English
Currency
U.S dollars
Population
940
Max Temp Winter
55ºF
Max Temp Summer
90ºF
Top Sights
Santee State Park, Santee Cooper Country Club and Santee National Golf Club

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Santee vacation package cost?
Offering excellent value package deals from $368 on Expedia, you'll be surprised at how little a vacation to Santee costs! Our packages make travel planning easier and your savings go further.
What are the cheapest months to go to Santee?
If you're hoping to snag a cheap Santee vacation package, consider visiting in January, September and October. You're likely to find better prices on accommodations and flights during these quieter months — ideal for budget-conscious travelers.
How many days is enough for Santee?
The ideal length for your Santee vacation depends on what you'd like to see and do. Usually, a few days to a week will give you time to hit all the leading attractions and explore some hidden treasures along the way.
Is it worth booking a vacation package to Santee?
It's no wonder a Santee vacation is on the to-do list of many travelers. Major attractions like Santee State Park are just the beginning of things to see and do here.
How to find the best Santee package deals?
Use Expedia's handy filters to help you find some fabulous Santee package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or search for Santee package deals in the low season. Switch up your travel dates and you may land even better discounts. As a rule of thumb, it's typically best to lock in your vacation package as early as possible.
Is it cheaper to book a Santee vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking stays and flights individually. Better still, you can customize your Santee trip to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Browse our great deals to see how much you can save.
When to book a vacation package to Santee?
If you have your Santee vacation dates locked in, book as soon as you can to score some incredible deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for quick escapes.
Does Expedia offer Book Now, Pay Later Santee vacation packages?
If you're anything like us, you love discovering new places but don't love the price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With help from online lender Affirm, you can spread the total cost of your Santee trip across 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can snap up cheap vacation packages with payment plans as soon as you spot them.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.